Heteromeric HCN1-HCN4 channels: A comparison with native pacemaker channels from the rabbit sinoatrial node

Journal of Physiology

Volumn 549, Issue 2, 2003, Pages 347-359

  Altomare, Claudia ^a   Terragni, Benedetta ^a   Brioschi, Chiara ^a   Milanesi, Raffaella ^a   Pagliuca, Cinzia ^a   Viscomi, Carlo ^a   Moroni, Anna ^a   Baruscotti, Mirko ^a   DiFrancesco, Dario ^a  

^a INFM   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; ION CHANNEL; ISOPROTEIN; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL 1; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL 4; MINK RELATED PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CELL LINE; CONTROLLED STUDY; GENETIC TRANSFECTION; HEART MUSCLE CONDUCTION SYSTEM; HEART RATE; HUMAN; HUMAN CELL; KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; RABBIT; SINUS NODE; CARBOXY TERMINAL SEQUENCE; CELL ACTIVATION; CELL KINETICS; ELECTRIC POTENTIAL; EMBRYO; FREQUENCY MODULATION; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE STEADY POTENTIAL; HETEROLOGOUS EXPRESSION; MEMBRANE CHANNEL; PACEMAKER ELECTRODE; PROTEIN FUNCTION;

EID: 0037834607     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2002.027698     Document Type: Article

References (48)

1. f) of rabbit SA node myocytes by niflumic acid. Pflugers Arch 431, 757-762.
2. Accili EA, Proenza C, Baruscotti M & DiFrancesco D (2002). From funny current to HCN channels: 20 years of excitation. News Physiol Sci 17, 32-37.
3. f in newborn versus adult cardiac SA node. Am J Physiol 272, H1549-1552.
4. Altomare C, Bucchi A, Camatini E, Baruscotti M, Viscomi C, Moroni A & DiFrancesco D (2001). Integrated allosteric model of voltage gating of HCN channels. J Gen Physiol 117, 519-532.
5. Barbuti A, Baruscotti M, Altomare C, Moroni A & DiFrancesco D (1999). Action of internal pronase on the f-channel kinetics in the rabbit SA node. J Physiol 520, 737-744.
6. h channels. Nat Neurosci 3, 133-141.
7. Bois P, Renaudon B, Baruscotti M, Lenfant J & DiFrancesco D (1997). Activation of f-channels by cAMP analogues in macropatches from rabbit sino-atrial node myocytes. J Physiol 501, 565-571.
8. Brown H & DiFrancesco D (1980). Voltage-clamp investigations of membrane currents underlying pace-maker activity in rabbit sino-atrial node. J Physiol 308, 331-351.
9. Brown HF, DiFrancesco D & Noble SJ (1979). How does adrenaline accelerate the heart? Nature 280, 235-236.
10. Chen S, Wang J & Siegelbaum SA (2001). Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide. J Gen Physiol 117, 491-504.
11. Clapham DE (1998). Not so funny anymore: pacing channels are cloned. Neuron 21, 5-7.
12. Demontis GC, Longoni B, Barcaro U & Cervetto L (1999). Properties and functional roles of hyperpolarization-gated currents in guinea-pig retinal rods. J Physiol 515, 813-828.
13. Demontis GC, Moroni A, Gravante B, Altomare C, Longoni B, Cervetto L & Difrancesco D (2002). Functional characterisation and subcellular localisation of HCN1 channels in rabbit retinal rod photoreceptors. J Physiol 542, 470-473.
14. DiFrancesco D (1986). Characterization of single pacemaker channels in cardiac sino-atrial node cells. Nature 324, 470-473.
15. DiFrancesco D (1993). Pacemaker mechanisms in cardiac tissue. Annu Rev Physiol 55, 455-472.
16. f) in cells isolated from the rabbit sino-atrial node. J Physiol 377, 61-88.
17. DiFrancesco D & Mangoni M (1994). Modulation of single hyperpolarization-activated channels (i(f)) by cAMP in the rabbit sino-atrial node. J Physiol 474, 473-482.
18. f and its contribution to cardiac pacemaking. In Neuronal and Cellular Oscillators, ed. Jacklet JW, pp. 31-57. M. Dekker, New York.
19. DiFrancesco D & Tortora P (1991). Direct activation of cardiac pacemaker channels by intracellular cyclic AMP. Nature 351, 145-147.
20. h) in central neurons. Eur J Neurosci 12, 2685-2693.
21. Gauß R, Seifert R & Kaupp BU (1998). Molecular identification of a hyperpolarization-activated channel in sea urchin sperm. Nature 393, 583-587.
22. Ho S, Hunt H, Horton R, Pullen J & Pease L (1989). Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77, 51-59.
23. Ishii TM, Takano M, Xie LH, Noma A & Ohmori H (1999). Molecular characterization of the hyperpolarization-activated cation channel in rabbit heart sinoatrial node. J Biol Chem 274, 12835-12839.
24. Kaupp UB & Seifert R (2001). Molecular diversity of pacemaker ion channels. Annu Rev Physiol 63, 235-257.
25. Kinsella TM & Nolan GP (1996). Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. Human Gene Therapy 7, 1405-1413.
26. Kupershmidt S, Yang T, Anderson ME, Wessels A, Niswender KD, Magnuson MA & Roden DM (1999). Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system. Circ Res 84, 146-152.
27. Ludwig A, Zong X, Jeglitsch M, Hofmann F & Biel M (1998). A family of hyperpolarization-activated mammalian cation channels. Nature 393, 587-591.
28. Ludwig A, Zong X, Stieber J, Hullin R, Hofmann F & Biel M (1999). Two pacemaker channels from human heart with profoundly different activation kinetics. EMBO J 18, 2323-2329.
29. Maccaferri G, Mangoni M, Lazzari A & DiFrancesco D (1993). Properties of the hyperpolarization-activated current in rat hippocampal CA1 pyramidal cells. J Neurophysiol 69, 2129-2136.
30. h channels. Science 295, 143-147.
31. Moosmang S, Biel M, Hofmann F & Ludwig A (1999). Differential distribution of four hyperpolarization-activated cation channels in mouse brain. Biol Chem 380, 975-980.
32. Moosmang S, Stieber J, Zong X, Biel M, Hofmann F & Ludwig A (2001). Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues. Eur J Biochem 268, 1646-1652.
33. Moroni A, Barbuti A, Altomare C, Viscomi C, Morgan J, Baruscotti M & DiFrancesco D (2000). Kinetic and ionic properties of the human HCN2 pacemaker channel. Pflugers Arch 439, 618-626.
34. f. J Biol Chem 276, 29233-29241.
35. Pape HC (1996). Queer current and pacemaker: the hyperpolarization-activated cation current in neurons. Annu Rev Physiol 58, 299-327.
36. Qu J, Altomare C, Bucchi A, DiFrancesco D & Robinson RB (2002). Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells. Pflugers Arch 444, 597-601.
37. Qu J, Barbuti A, Protas L, Santoro B, Cohen IS & Robinson RB (2001). HCN2 overexpression in newborn and adult ventricular myocytes: distinct effects on gating and excitability. Circ Res 89, E8-14.
38. Santoro B, Grant SG, Bartsch D & Kandel ER (1997). Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A 94, 14815-14820.
39. Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA & Tibbs GR (1998). Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell 93, 717-729.
40. Santoro B & Tibbs GR (1999). The HCN gene family: molecular basis of the hyperpolarization-activated pacemaker channels. Ann N Y Acad Sci 868, 741-764.
41. Seifert R, Scholten A, Gauss R, Mincheva A, Lichter P & Kaupp UB (1999). Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis. Proc Natl Acad Sci U S A 96, 9391-9396.
42. Shi W, Wymore R, Yu H, Wu J, Wymore RT, Pan Z, Robinson RB, Dixon JE, McKinnon D & Cohen IS (1999). Distribution and prevalence of hyperpolarization-activated cation channel (HCN). mRNA expression in cardiac tissues. Circ Res 85, E1-6.
43. Stevens DR, Seifert R, Bufe B, Muller F, Kremmer E, Gauss R, Meyerhof W, Kaupp UB & Lindemann B (2001). Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli. Nature 413, 631-635.
44. Ulens C & Tytgat J (2001). Functional heteromerization of HCN1 and HCN2 pacemaker channels. J Biol Chem 276, 6069-6072.
45. Vaccari T, Moroni A, Rocchi M, Gorza L, Bianchi ME, Beltrame M & DiFrancesco D (1999). The human gene coding for HCN2, a pacemaker channel of the heart. Biochim Biophys Acta 1446, 419-425.
46. Viscomi C, Altomare C, Bucchi A, Camatini E, Baruscotti M, Moroni A & DiFrancesco D (2001). C terminus-mediated control of voltage and cAMP gating of hyperpolarization-activated cyclic nucleotide-gated channels. J Biol Chem 276, 29930-29934.
47. Wainger BJ, Degennaro M, Santoro B, Siegelbaum SA & Tibbs GR (2001). Molecular mechanism of cAMP modulation of HCN pacemaker channels. Nature 411, 805-810.
48. Yu H, Wu J, Potapova I, Wymore RT, Holmes B, Zuckerman J, Pan Z, Wang H, Shi W, Robinson RB, El Maghrabi MR, Benjamin W, Dixon J, Mckinnon D, Cohen IS & Wymore R (2001). MinK-related peptide 1: a beta subunit for the HCN ion channel subunit family enhances expression and speeds activation. Circ Res 88, E84-87.