Characterization of the human HCN1 channel and its inhibition by capsazepine

British Journal of Pharmacology

Volumn 143, Issue 3, 2004, Pages 411-421

  Gill, Catherine H ^a   Randall, Andrew ^a   Bates, Stewart A ^a   Hill, Kerstin ^a   Owen, Davina ^a   Larkman, Phil M ^b   Cairns, William ^a   Yusaf, Shahnaz P ^a   Murdock, Paul R ^a   Strijbos, Paul J L M ^a   Powell, Andrew J ^a   Benham, Christopher D ^a   Davies, Ceri H ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Capsazepine; Human HCN1; I h; Recombinant HCN

Indexed keywords

4 (N ETHYL N PHENYLAMINO) 1,2 DIMETHYL 6 (METHYLAMINO)PYRIMIDINIUM CHLORIDE; CAPSAZEPINE; CESIUM; COMPLEMENTARY DNA; CYCLIC AMP; ION CHANNEL; POTASSIUM ION; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR ANTAGONIST; ZATEBRADINE;

ANIMAL CELL; ARTICLE; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; HYPERPOLARIZATION; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED ION CHANNEL; MEMBRANE ELECTROPHYSIOLOGY; MEMBRANE POTENTIAL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL;

ANIMALS; BENZAZEPINES; CAPSAICIN; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; HUMANS; ION CHANNELS; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; POTASSIUM; PYRIMIDINES; TIME FACTORS; TRANSFECTION;

EID: 7044221810     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705945     Document Type: Article

References (35)

1. ALTOMARE, C., BUCCHI, A., CAMATINI, E., BARUSCOTTI, M., VISCOMI, C. MORONI, A. & DIFRANCESCO, D. (2001). Integrated allosteric model of voltage-gating of HCN channels. J. Gen. Physiol., 117, 519-532.
2. h channels. Nature, 3, 133-141.
3. BEVAN, S., HOTHI, S., HUGHES, G., JAMES, I.F., RANG, H.P., SHAH, K., WALPOLE, C.S. & YEATS, J.C. (1992). Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin. Br. J. Pharmacol., 107, 544-552.
4. f) in guinea-pig dissociated sinoatrial node cells. Br. J. Pharmacol., 110, 343-349.
5. CHAPLAN, S.R., GUO, H.Q., LEE, D.H., LUO, L., LIU, C., KUEI, C., VELUMIAN, A.A., BUTLER, M.P., BROWN, S.M. & DUBIN, A.E. (2003). Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain. J. Neurosci., 23, 1169-1178.
6. h channels in synaptic transmission and mossy fibre LTP. Proc. Natl. Acad. Sci. U.S.A., 99, 9538-9543.
7. h current in isolated peripheral nerve: a novel model of peripheral antinociception? Muscle Nerve. 24, 254-261.
8. DOCHERTY, R.J., YEATS, J.C. & PIPER, A.S. (1997). Capsazepine block of voltage-activated calcium channels in adult rat dorsal root ganglion neurones in culture. Br. J. Pharmacol., 121, 1461-1467.
9. GUNTHORPE, M.J., BENHAM, C.D., RANDALL, A. & DAVIS, J.B. (2002). The diversity in the vanilloid (TRPV) receptor family of ion channels. TIPS. 23, 183-191.
10. GUNTHORPE, M.J., KAMI, H.K., JERMAN, J., SMART, D., GILL, C.H., SOFFIN, E.M., LUIS HANNAN, S., LAPPIN, S.C., EGERTON, J., SMITH, G.D., WORBY, A., HOWETT, L., OWEN, D., NASIR, S., DAVIES, C.H., THOMPSON, M., WYMAN, P.A., RANDALL, A.D. & DAVIS, J.B. (2004). Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist. Neuropharmacology, 46, 133-149.
11. HARRIS, N.C. & CONSTANTI, A. (1995). Mechanism of block by ZD 7288 of the hyperpolarization-activated inward rectifying current in guinea-pig substantia nigra neurons in vitro. J. Neurophysiol., 74, 2366-2378.
12. HUDSON, L.J., BEVAN, S., WOTHERSPOON, G., GENTRY, C., FOX, A. & WINTER, J. (2001). VR1 protein expression increases in undamaged DRG neurons after partial nerve injury. Eur. J. Neurosci., 13, 2105-2114.
13. ISHII, T.M., TAKANO, M. & OHMORI, H. (2001). Determinants of activation kinetics in mammalian hyperpolarization-activated cation channels. J. Physiol., 537, 93-100.
14. KAUPP, U.B. & SEIFERT, R. (2001). Molecular diversity of pacemaker ion channels. Annu. Rev. Physiol., 63, 235-257.
15. KUENZI, F.M. & DALE, N. (1996). Effect of capsaicin and analogues on potassium and calcium currents and vanilloid receptors in Xenopus embryo spinal neurones. Br. J. Pharmacol., 119, 81-90.
16. LIU, L. & SIMON, S.A. (1997). Capsazepine, a vanilloid receptor antagonist, inhibits nicotinic acetylcholine receptors in rat trigeminal ganglia. Neurosci. Lett., 228, 29-32.
17. LUDWIG, A., ZONG, X., JEGLITSCH, M., HOFMANN, F. & BIEL, M. (1998). A family of hyperpolarization-activated mammalian cation channels. Nature, 393, 587-591.
18. h. J. Neuophysiol., 79, 3284-3289.
19. h. Neuron. 20, 553-563.
20. MAGEE, J.C. (1998). Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons. J. Neurosci., 18, 7613-7624.
21. h normalizes temporal summation in hippocampal CA1 neurones. Nat. Neurosci., 2, 508-514.
22. PAPE, H.C. (1996). Queer current and pacemaker: the hyperpolarization- activated cation current in neurons. Annu. Rev. Physiol., 58, 299-327.
23. h in mouse dorsal root ganglion neurons by sinus node inhibitors. Br. J. Pharmacol., 125, 741-750.
24. REES, S., COOTE, J., STABLES, J., GOODSON, S., HARRIS, S. & LEE, M.G. (1996). Bicistronic vector for the creation of stable mammalian cell lines that predisposes all antibiotic-resistant cells to express recombinant protein. Biotechniques. 20, 102-104, 106, 108-110.
25. ROBINSON, R.B. & SIEGELBAUM, S.A. (2003). Hyperpolarization-activated cation currents: from molecules to physiological function. Annu. Rev. Physiol., 65, 453-480.
26. SANTORO, B., CHEN, S., LUTHI, A., PAVLIDIS, P., SHUMYATSKY, O.P., TIBBS, G.R. & SIEGELBAUM, S.A. (2000). Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS. J. Neurosci., 20, 5264-5275.
27. SANTORO, B., GRANT, S.G.N., BARTSCH, D. & KANDEL, E.R. (1997). Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to Eag and cyclic nucleotide-gated channels. Proc. Natl. Acad. Sci. U.S.A., 94, 14815-14820.
28. SANTORO, B., LIU, D.T., YAO, H., BARTSCH, D., KANDEL, E.R., SIEGLEBAUM, S.A. & TIBBS, G.R. (1998). Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell. 93, 717-729.
29. 2+-dependent conductances in rat neocortical pyramidal neurons. J. Neurophysiol., 78, 187-198.
30. SEIFERT, R., SCHOLTEN, A., GAUSS, R., MINCHEVA, A., LICHTER, P. & KAUPP, U.B. (1999). Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart and testis. Proc. Natl. Acad. Sci. U.S.A., 96, 9391-9396.
31. SHIN, K.S., ROTHBERG, B.S. & YELLEN, G. (2001). Blocker state dependence and trapping in hyperpolarization-activated cation channels: evidence for an intracellular activation gate. J. Gen. Physiol., 117, 91-101.
32. SOUTHAN, A.P., MORRIS, N.P., STEPHENS, G.J. & ROBERTSON, B. (2000). Hyperpolarization-activated currents in presynaptic terminals of mouse cerebellar basket cells. J. Physiol., 526, 91-97.
33. VANBOGAERT, P.P., GOETHALS, M. & SIMOENS, C. (1990). Use- and frequency-dependent blockade by UL-FS 49 of the pacemaker current in cardiac Purkinje fibres. Eur. J. Pharmacol., 187, 241-256.
34. WAHL, P., FOGED, C., TULLIN, S. & THOMSEN, C. (2001). Iodoresiniferatoxin, a new potent vanilloid receptor antagonist. Mol. Pharmacol., 59, 9-15.
35. WALKER, K.M., URBAN, L., MEDHURST, S.J., PATEL, S., FOX, A.J. & MCINTYRE, P. (2003). The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain. J. Pharmacol. Exp. Ther., 304, 56-62.