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Volumn 46, Issue 8, 2007, Pages 591-598

The functional contrariety of JNK

Author keywords

Cancer; JNK; MAP kinase; Signal transduction

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE 1;

EID: 34547857049     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20348     Document Type: Conference Paper
Times cited : (236)

References (66)
  • 2
    • 0344393408 scopus 로고    scopus 로고
    • Regulation of MAP kinase signaling modules by scaffold proteins in mammals
    • Morrison DK, Davis RJ. Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu Rev Cell Dev Biol 2003;19:91-118.
    • (2003) Annu Rev Cell Dev Biol , vol.19 , pp. 91-118
    • Morrison, D.K.1    Davis, R.J.2
  • 3
    • 0029885419 scopus 로고    scopus 로고
    • Selective interaction of JNK protein kinase isoforms with transcription factors
    • Guota S, Barrett T, Whitmarsh AJ, et al. Selective interaction of JNK protein kinase isoforms with transcription factors. EMBOJ 1996;15:2760-2770.
    • (1996) EMBOJ , vol.15 , pp. 2760-2770
    • Guota, S.1    Barrett, T.2    Whitmarsh, A.J.3
  • 4
    • 0036730122 scopus 로고    scopus 로고
    • Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts
    • Hess P, Pihan G, Sawyers CL, Flavell RA, Davis RJ. Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts. Nat Genet 2002;32:201-205.
    • (2002) Nat Genet , vol.32 , pp. 201-205
    • Hess, P.1    Pihan, G.2    Sawyers, C.L.3    Flavell, R.A.4    Davis, R.J.5
  • 6
    • 15644381250 scopus 로고    scopus 로고
    • Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/ stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1
    • Maundrell K, Antonsson B, Magnenat E, et al. Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/ stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1. J Biol Chem 1997;272:25238-25242.
    • (1997) J Biol Chem , vol.272 , pp. 25238-25242
    • Maundrell, K.1    Antonsson, B.2    Magnenat, E.3
  • 7
    • 1242316958 scopus 로고    scopus 로고
    • JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD
    • Yu C, Minemoto Y, Zhang J, et al. JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell 2004;13:329-340.
    • (2004) Mol Cell , vol.13 , pp. 329-340
    • Yu, C.1    Minemoto, Y.2    Zhang, J.3
  • 9
    • 0027423418 scopus 로고
    • Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain
    • Hibi M, Lin A, Smeal T, Minden A, Karin M. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev 1993;7:2135-2148.
    • (1993) Genes Dev , vol.7 , pp. 2135-2148
    • Hibi, M.1    Lin, A.2    Smeal, T.3    Minden, A.4    Karin, M.5
  • 10
    • 0031283180 scopus 로고    scopus 로고
    • c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors
    • Fuchs SY, Xie B, Adler V, Fried VA, Davis RJ, Ronai Z. c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors. J Biol Chem 1997;272: 32163-32168.
    • (1997) J Biol Chem , vol.272 , pp. 32163-32168
    • Fuchs, S.Y.1    Xie, B.2    Adler, V.3    Fried, V.A.4    Davis, R.J.5    Ronai, Z.6
  • 11
    • 0032703216 scopus 로고    scopus 로고
    • Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase
    • Noguchi K, Kitanaka C, Yamana H, Kokubu A, Mochizuki T, Kuchino Y. Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase. J Biol Chem 1999;274:32580-32587.
    • (1999) J Biol Chem , vol.274 , pp. 32580-32587
    • Noguchi, K.1    Kitanaka, C.2    Yamana, H.3    Kokubu, A.4    Mochizuki, T.5    Kuchino, Y.6
  • 12
    • 0034745050 scopus 로고    scopus 로고
    • Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress
    • Buschmann T, Potapova O, Bar-Shira A, et al. Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress. Mol Cell Biol 2001;21:2743-2754.
    • (2001) Mol Cell Biol , vol.21 , pp. 2743-2754
    • Buschmann, T.1    Potapova, O.2    Bar-Shira, A.3
  • 13
    • 0035815716 scopus 로고    scopus 로고
    • Activated JNK phosphorylates the c-terminal domain of MLK2 that is required for MLK2-induced apoptosis
    • Phelan DR, Price G, Liu YF, Dorow DS. Activated JNK phosphorylates the c-terminal domain of MLK2 that is required for MLK2-induced apoptosis. J Biol Chem 2001; 276:10801-10810.
    • (2001) J Biol Chem , vol.276 , pp. 10801-10810
    • Phelan, D.R.1    Price, G.2    Liu, Y.F.3    Dorow, D.S.4
  • 14
    • 20144383657 scopus 로고    scopus 로고
    • c-Jun NH2-terminal kinase (JNK) positively regulates NFATc2 transactivation through phosphorylation within the N-terminal regulatory domain
    • Ortega-Perez I, Cano E, Were F, Villar M, Vazquez J, Redondo JM. c-Jun NH2-terminal kinase (JNK) positively regulates NFATc2 transactivation through phosphorylation within the N-terminal regulatory domain. J Biol Chem 2005; 280: 20867-20878.
    • (2005) J Biol Chem , vol.280 , pp. 20867-20878
    • Ortega-Perez, I.1    Cano, E.2    Were, F.3    Villar, M.4    Vazquez, J.5    Redondo, J.M.6
  • 15
    • 17444430871 scopus 로고    scopus 로고
    • The nucleolus asa stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis
    • Mayer C, Bierhoff H, Grummt I. The nucleolus asa stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis. Genes Dev 2005;19:933-941.
    • (2005) Genes Dev , vol.19 , pp. 933-941
    • Mayer, C.1    Bierhoff, H.2    Grummt, I.3
  • 16
    • 2442429306 scopus 로고    scopus 로고
    • JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins
    • Tsuruta F, Sunayama J, Mori Y, et al. JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins. EMBO J 2004;23:1889-1899.
    • (2004) EMBO J , vol.23 , pp. 1889-1899
    • Tsuruta, F.1    Sunayama, J.2    Mori, Y.3
  • 17
    • 5044225158 scopus 로고    scopus 로고
    • Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch
    • Gao M, Labuda T, Xia Y, et al. Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. Science 2004;306:271-275.
    • (2004) Science , vol.306 , pp. 271-275
    • Gao, M.1    Labuda, T.2    Xia, Y.3
  • 18
    • 3142712947 scopus 로고    scopus 로고
    • Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK)
    • Yoshida H, Hastie CJ, McLauchlan H, Cohen P, Goedert M. Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK). J Neurochem 2004;90:352-358.
    • (2004) J Neurochem , vol.90 , pp. 352-358
    • Yoshida, H.1    Hastie, C.J.2    McLauchlan, H.3    Cohen, P.4    Goedert, M.5
  • 19
    • 0035918301 scopus 로고    scopus 로고
    • MAP kinases mediate UVB-induced phosphorylation of histone H3 at serine 28
    • Zhong S, Zhang Y, Jansen C, Goto H, Inagaki M, Dong Z. MAP kinases mediate UVB-induced phosphorylation of histone H3 at serine 28. J Biol Chem 2001;276:12932-12937.
    • (2001) J Biol Chem , vol.276 , pp. 12932-12937
    • Zhong, S.1    Zhang, Y.2    Jansen, C.3    Goto, H.4    Inagaki, M.5    Dong, Z.6
  • 20
    • 33745487368 scopus 로고    scopus 로고
    • Cell apoptosis: Requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3
    • Lu C, Zhu F, Cho YY, et al. Cell apoptosis: Requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3. Mol Cell 2006;23:121-132.
    • (2006) Mol Cell , vol.23 , pp. 121-132
    • Lu, C.1    Zhu, F.2    Cho, Y.Y.3
  • 21
    • 4043073652 scopus 로고    scopus 로고
    • An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue
    • Jaeschke A, Czech MP, Davis RJ. An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. Genes Dev 2004;18:1976-1980.
    • (2004) Genes Dev , vol.18 , pp. 1976-1980
    • Jaeschke, A.1    Czech, M.P.2    Davis, R.J.3
  • 22
    • 22844450212 scopus 로고    scopus 로고
    • Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators
    • Song JJ, Lee YJ. Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators. J Biol Chem 2005;280:26845-26855.
    • (2005) J Biol Chem , vol.280 , pp. 26845-26855
    • Song, J.J.1    Lee, Y.J.2
  • 23
    • 0032169459 scopus 로고    scopus 로고
    • JNK targets p53 ubiquitination and degradation in nonstressed cells
    • Fuchs SY, Adler V, Buschmann T, et al. JNK targets p53 ubiquitination and degradation in nonstressed cells. Genes Dev 1998;12:2658-2663.
    • (1998) Genes Dev , vol.12 , pp. 2658-2663
    • Fuchs, S.Y.1    Adler, V.2    Buschmann, T.3
  • 24
    • 0029829562 scopus 로고    scopus 로고
    • Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinase
    • Fuchs SY, Dolan L, Davis RJ, Ronai Z. Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinase. Oncogene 1996;13:1531-1535.
    • (1996) Oncogene , vol.13 , pp. 1531-1535
    • Fuchs, S.Y.1    Dolan, L.2    Davis, R.J.3    Ronai, Z.4
  • 25
    • 0034652718 scopus 로고    scopus 로고
    • p53 phosphorylation and association with murine double minute 2, c-Jun NH2-terminal kinase, p14ARF, and p300/CBP during the cell cycle and after exposure to ultraviolet irradiation
    • Buschmann T, Adler V, Matusevich E, Fuchs SY, Ronai Z. p53 phosphorylation and association with murine double minute 2, c-Jun NH2-terminal kinase, p14ARF, and p300/CBP during the cell cycle and after exposure to ultraviolet irradiation. Cancer Res 2000;60:896-900.
    • (2000) Cancer Res , vol.60 , pp. 896-900
    • Buschmann, T.1    Adler, V.2    Matusevich, E.3    Fuchs, S.Y.4    Ronai, Z.5
  • 26
    • 21244472677 scopus 로고    scopus 로고
    • JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53
    • Tafolla E, Wang S, Wong B, Leong J, Kapila YL. JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53. J Biol Chem 2005;280:19992-19999.
    • (2005) J Biol Chem , vol.280 , pp. 19992-19999
    • Tafolla, E.1    Wang, S.2    Wong, B.3    Leong, J.4    Kapila, Y.L.5
  • 27
    • 26944446209 scopus 로고    scopus 로고
    • The tumor suppressor p16(INK4a) prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activity
    • Choi BY, Choi HS, Ko K, et al. The tumor suppressor p16(INK4a) prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activity. Nat Struct Mol Biol 2005;12:699-707.
    • (2005) Nat Struct Mol Biol , vol.12 , pp. 699-707
    • Choi, B.Y.1    Choi, H.S.2    Ko, K.3
  • 28
    • 0034677210 scopus 로고    scopus 로고
    • A nuclear tyrosine phosphorylation circuit: C-Jun as an activator and substrate of c-Abl and JNK
    • Barila D, Mangano R, Gonfloni S, et al. A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK. EMBO J 2000;19:273-281.
    • (2000) EMBO J , vol.19 , pp. 273-281
    • Barila, D.1    Mangano, R.2    Gonfloni, S.3
  • 29
    • 0026725899 scopus 로고
    • Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts
    • Baker SJ, Kerppola TK, Luk D, et al. Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts. Mol Cell Biol 1992;12:4694-4705.
    • (1992) Mol Cell Biol , vol.12 , pp. 4694-4705
    • Baker, S.J.1    Kerppola, T.K.2    Luk, D.3
  • 30
    • 0026705482 scopus 로고
    • Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity
    • Lin A, Frost J, Deng T, et al. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Cell 1992; 70:777-789.
    • (1992) Cell , vol.70 , pp. 777-789
    • Lin, A.1    Frost, J.2    Deng, T.3
  • 31
    • 0026029808 scopus 로고
    • Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity
    • Boyle WJ, Smeal T, Defize LH, et al. Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell 1991;64: 573-584.
    • (1991) Cell , vol.64 , pp. 573-584
    • Boyle, W.J.1    Smeal, T.2    Defize, L.H.3
  • 32
    • 0027230415 scopus 로고
    • c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif
    • Bannister AJ, Gottlieb TM, Kouzarides T, Jackson SP. c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif. Nucleic Acids Res 1993;21:1289-1295.
    • (1993) Nucleic Acids Res , vol.21 , pp. 1289-1295
    • Bannister, A.J.1    Gottlieb, T.M.2    Kouzarides, T.3    Jackson, S.P.4
  • 33
    • 33745242921 scopus 로고    scopus 로고
    • COOH-terminal Src kinase-mediated c-Jun phosphorylation promotes c-Jun degradation and inhibits cell transformation
    • Zhu F, Choi BY, Ma WY, et al. COOH-terminal Src kinase-mediated c-Jun phosphorylation promotes c-Jun degradation and inhibits cell transformation. Cancer Res 2006;66: 5729-5736.
    • (2006) Cancer Res , vol.66 , pp. 5729-5736
    • Zhu, F.1    Choi, B.Y.2    Ma, W.Y.3
  • 34
    • 0025720735 scopus 로고
    • The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
    • Angel P, Karin M. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1991;1072:129-157.
    • (1991) Biochim Biophys Acta , vol.1072 , pp. 129-157
    • Angel, P.1    Karin, M.2
  • 35
    • 0035971572 scopus 로고    scopus 로고
    • Function and regulation of AP-1 subunits in skin physiology and pathology
    • Angel P, Szabowski A, Schorpp-Kistner M. Function and regulation of AP-1 subunits in skin physiology and pathology. Oncogene 2001;20:2413-2423.
    • (2001) Oncogene , vol.20 , pp. 2413-2423
    • Angel, P.1    Szabowski, A.2    Schorpp-Kistner, M.3
  • 36
    • 0028079661 scopus 로고
    • Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells
    • Dong Z, Birrer MJ, Watts RG, Matrisian LM, Colburn NH. Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells. Proc Natl Acad Sci USA 1994;91:609-613.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 609-613
    • Dong, Z.1    Birrer, M.J.2    Watts, R.G.3    Matrisian, L.M.4    Colburn, N.H.5
  • 37
    • 0033104956 scopus 로고    scopus 로고
    • Control of cell cycle progression by c-Jun is p53 dependent
    • Schreiber M, Kolbus A, Piu F, et al. Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev 1999; 13:607-619.
    • (1999) Genes Dev , vol.13 , pp. 607-619
    • Schreiber, M.1    Kolbus, A.2    Piu, F.3
  • 38
    • 0034607702 scopus 로고    scopus 로고
    • Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
    • Tournier C, Hess P, Yang DD, et al. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 2000;288:870-874.
    • (2000) Science , vol.288 , pp. 870-874
    • Tournier, C.1    Hess, P.2    Yang, D.D.3
  • 39
    • 17144371848 scopus 로고    scopus 로고
    • JN K2: A negative regulator of cellular proliferation
    • Sabapathy K, Wagner EF. JN K2: A negative regulator of cellular proliferation. Cell Cycle 2004;3:1520-1523.
    • (2004) Cell Cycle , vol.3 , pp. 1520-1523
    • Sabapathy, K.1    Wagner, E.F.2
  • 40
    • 33748436341 scopus 로고    scopus 로고
    • JNK2 is a positive regulator of the cJun transcription factor
    • Jaeschke A, Karasarides M, Ventura JJ, et al. JNK2 is a positive regulator of the cJun transcription factor. Mol Cell 2006; 23:899-911.
    • (2006) Mol Cell , vol.23 , pp. 899-911
    • Jaeschke, A.1    Karasarides, M.2    Ventura, J.J.3
  • 41
    • 0033118607 scopus 로고    scopus 로고
    • The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
    • Kuan CY, Yang DD, Samanta Roy DR, Davis RJ, Rakic P, Flavell RA. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 1999;22:667-676.
    • (1999) Neuron , vol.22 , pp. 667-676
    • Kuan, C.Y.1    Yang, D.D.2    Samanta Roy, D.R.3    Davis, R.J.4    Rakic, P.5    Flavell, R.A.6
  • 42
    • 4444341881 scopus 로고    scopus 로고
    • Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation
    • Sabapathy K, Hochedlinger K, Nam SY, Bauer A, Karin M, Wagner EF. Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol Cell 2004;15:713-725.
    • (2004) Mol Cell , vol.15 , pp. 713-725
    • Sabapathy, K.1    Hochedlinger, K.2    Nam, S.Y.3    Bauer, A.4    Karin, M.5    Wagner, E.F.6
  • 43
    • 0034744305 scopus 로고    scopus 로고
    • The c-Jun NH2-terminal kinase3 (JNK3) gene: Genomic structure, chromosomal assignment, and loss of expression in brain tumors
    • Yoshida S, Fukino K, Harada H, et al. The c-Jun NH2-terminal kinase3 (JNK3) gene: Genomic structure, chromosomal assignment, and loss of expression in brain tumors. J Hum Genet 2001;46:182-187.
    • (2001) J Hum Genet , vol.46 , pp. 182-187
    • Yoshida, S.1    Fukino, K.2    Harada, H.3
  • 44
    • 0032100617 scopus 로고    scopus 로고
    • Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene
    • Su GH, Hilgers W, Shekher MC, et al. Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. Cancer Res 1998;58:2339-2342.
    • (1998) Cancer Res , vol.58 , pp. 2339-2342
    • Su, G.H.1    Hilgers, W.2    Shekher, M.C.3
  • 45
    • 0037112512 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase kinase 4 (MKK4) acts as a metastasis suppressor gene in human ovarian carcinoma
    • Yamada SD, Hickson JA, Hrobowski Y, et al. Mitogen-activated protein kinase kinase 4 (MKK4) acts as a metastasis suppressor gene in human ovarian carcinoma. Cancer Res 2002;62:6717-6723.
    • (2002) Cancer Res , vol.62 , pp. 6717-6723
    • Yamada, S.D.1    Hickson, J.A.2    Hrobowski, Y.3
  • 46
    • 0035872409 scopus 로고    scopus 로고
    • Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice
    • Chen N, Nomura M, She QB, et al. Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice. Cancer Res 2001;61:3908-3912.
    • (2001) Cancer Res , vol.61 , pp. 3908-3912
    • Chen, N.1    Nomura, M.2    She, Q.B.3
  • 47
    • 0037430452 scopus 로고    scopus 로고
    • Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer
    • Wang HY, Cheng Z, Malbon CC. Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer. Cancer Lett 2003;191:229-237.
    • (2003) Cancer Lett , vol.191 , pp. 229-237
    • Wang, H.Y.1    Cheng, Z.2    Malbon, C.C.3
  • 48
    • 0030946366 scopus 로고    scopus 로고
    • Hyperexpression of mitogen-activated protein kinase in human breast cancer
    • Sivaraman VS, Wang H, Nuovo GJ, Malbon CC. Hyperexpression of mitogen-activated protein kinase in human breast cancer. J Clin Invest 1997;99:1478-1483.
    • (1997) J Clin Invest , vol.99 , pp. 1478-1483
    • Sivaraman, V.S.1    Wang, H.2    Nuovo, G.J.3    Malbon, C.C.4
  • 49
    • 0034680011 scopus 로고    scopus 로고
    • High levels of phosphorylated c-Jun, Fra-1, Fra-2 and ATF-2 proteins correlate with malignant phenotypes in the multistage mouse skin carcinogenesis model
    • Zoumpourlis V, Papassava P, Linardopoulos S, Gillespie D, Balmain A, Pintzas A. High levels of phosphorylated c-Jun, Fra-1, Fra-2 and ATF-2 proteins correlate with malignant phenotypes in the multistage mouse skin carcinogenesis model. Oncogene 2000;19:4011-4021.
    • (2000) Oncogene , vol.19 , pp. 4011-4021
    • Zoumpourlis, V.1    Papassava, P.2    Linardopoulos, S.3    Gillespie, D.4    Balmain, A.5    Pintzas, A.6
  • 50
    • 0043091963 scopus 로고    scopus 로고
    • Elevated c-Jun expression in acute myeloid leukemias inhibits C/EBPalpha DNA binding via leucine zipper domain interaction
    • Rangatia J, Vangala RK, Singh SM, et al. Elevated c-Jun expression in acute myeloid leukemias inhibits C/EBPalpha DNA binding via leucine zipper domain interaction. Oncogene 2003;22:4760-4764.
    • (2003) Oncogene , vol.22 , pp. 4760-4764
    • Rangatia, J.1    Vangala, R.K.2    Singh, S.M.3
  • 51
    • 0029887278 scopus 로고    scopus 로고
    • Constitutively activated JNK is associated with HTLV-1 mediated tumorigenesis
    • Xu X, Heidenreich O, Kitajima I, et al. Constitutively activated JNK is associated with HTLV-1 mediated tumorigenesis. Oncogene 1996;13:135-142.
    • (1996) Oncogene , vol.13 , pp. 135-142
    • Xu, X.1    Heidenreich, O.2    Kitajima, I.3
  • 52
    • 0033969883 scopus 로고    scopus 로고
    • Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner
    • Potapova O, Gorospe M, Dougherty RH, Dean NM, Gaarde WA, Holbrook NJ. Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner. Moi Cell Biol 2000;20:1713-1722.
    • (2000) Moi Cell Biol , vol.20 , pp. 1713-1722
    • Potapova, O.1    Gorospe, M.2    Dougherty, R.H.3    Dean, N.M.4    Gaarde, W.A.5    Holbrook, N.J.6
  • 53
    • 0025788098 scopus 로고
    • Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73
    • Smeal T, Binetruy B, Mercola DA, Birrer M, Karin M. Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature 1991;354:494-496.
    • (1991) Nature , vol.354 , pp. 494-496
    • Smeal, T.1    Binetruy, B.2    Mercola, D.A.3    Birrer, M.4    Karin, M.5
  • 54
    • 0034682264 scopus 로고    scopus 로고
    • Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation
    • Behrens A, Jochum W, Sibilia M, Wagner EF. Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation. Oncogene 2000;19:2657-2663.
    • (2000) Oncogene , vol.19 , pp. 2657-2663
    • Behrens, A.1    Jochum, W.2    Sibilia, M.3    Wagner, E.F.4
  • 55
    • 24644478136 scopus 로고    scopus 로고
    • Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development
    • Nateri AS, Spencer-Dene B, Behrens A. Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature 2005;437:281-285.
    • (2005) Nature , vol.437 , pp. 281-285
    • Nateri, A.S.1    Spencer-Dene, B.2    Behrens, A.3
  • 56
    • 0032980723 scopus 로고    scopus 로고
    • The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells
    • Bost F, McKay R, Bost M, Potapova O, Dean NM, Mercola D. The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells. Mol Cell Biol 1999;19:1938-1949.
    • (1999) Mol Cell Biol , vol.19 , pp. 1938-1949
    • Bost, F.1    McKay, R.2    Bost, M.3    Potapova, O.4    Dean, N.M.5    Mercola, D.6
  • 57
    • 0037237136 scopus 로고    scopus 로고
    • C-Jun NH(2)-terminal kinase mediates proliferation and tumor growth of human prostate carcinoma
    • Yang YM, Bost F, Charbono W, et al. C-Jun NH(2)-terminal kinase mediates proliferation and tumor growth of human prostate carcinoma. Clin Cancer Res 2003;9:391-401.
    • (2003) Clin Cancer Res , vol.9 , pp. 391-401
    • Yang, Y.M.1    Bost, F.2    Charbono, W.3
  • 58
    • 0037224587 scopus 로고    scopus 로고
    • Constitutively active forms of c-Jun NH2-terminal kinase are expressed in primary glial tumors
    • Tsuiki H, Tnani M, Okamoto I, et al. Constitutively active forms of c-Jun NH2-terminal kinase are expressed in primary glial tumors. Cancer Res 2003;63:250-255.
    • (2003) Cancer Res , vol.63 , pp. 250-255
    • Tsuiki, H.1    Tnani, M.2    Okamoto, I.3
  • 59
    • 1642523573 scopus 로고    scopus 로고
    • Inhibition of cell proliferation and cell cycle progression by specific inhibition of basal JNK activity: Evidence that mitotic Bcl-2 phosphorylation is JNK-independent
    • Du L, Lyle CS, Obey TB, et al. Inhibition of cell proliferation and cell cycle progression by specific inhibition of basal JNK activity: Evidence that mitotic Bcl-2 phosphorylation is JNK-independent. J Biol Chem 2004;279:11957-11966.
    • (2004) J Biol Chem , vol.279 , pp. 11957-11966
    • Du, L.1    Lyle, C.S.2    Obey, T.B.3
  • 60
    • 4544371122 scopus 로고    scopus 로고
    • Inhibition of JNK2 disrupts anaphase and produces aneuploidy in mammalian cells
    • MacCorkle RA, Tan TH. Inhibition of JNK2 disrupts anaphase and produces aneuploidy in mammalian cells. J Biol Chem 2004;279:40112-40121.
    • (2004) J Biol Chem , vol.279 , pp. 40112-40121
    • MacCorkle, R.A.1    Tan, T.H.2
  • 61
    • 0036494195 scopus 로고    scopus 로고
    • Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate
    • She QB, Chen N, Bode AM, Flavell RA, Dong Z. Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res 2002;62:1343-1348.
    • (2002) Cancer Res , vol.62 , pp. 1343-1348
    • She, Q.B.1    Chen, N.2    Bode, A.M.3    Flavell, R.A.4    Dong, Z.5
  • 62
    • 2542418258 scopus 로고    scopus 로고
    • Activation of c-Jun N-terminal kinase 1 and caspase 3 in the tamoxifen-induced apoptosis of rat glioma cells
    • Tseng SH, Wang CH, Lin SM, Chen CK, Huang HY, Chen Y. Activation of c-Jun N-terminal kinase 1 and caspase 3 in the tamoxifen-induced apoptosis of rat glioma cells. J Cancer Res Clin Oncol 2004;130:285-293.
    • (2004) J Cancer Res Clin Oncol , vol.130 , pp. 285-293
    • Tseng, S.H.1    Wang, C.H.2    Lin, S.M.3    Chen, C.K.4    Huang, H.Y.5    Chen, Y.6
  • 63
    • 0034650759 scopus 로고    scopus 로고
    • A dominant role for the c-Jun NH2-terminal kinase in oncogenic ras-induced morphologic transformation of human lung carcinoma cells
    • Xiao L, Lang W. A dominant role for the c-Jun NH2-terminal kinase in oncogenic ras-induced morphologic transformation of human lung carcinoma cells. Cancer Res 2000;60: 400-408.
    • (2000) Cancer Res , vol.60 , pp. 400-408
    • Xiao, L.1    Lang, W.2
  • 64
    • 4644241746 scopus 로고    scopus 로고
    • The c-Jun NH2-terminal kinase is essential for epiderma growth factor expression during epidermal morphogenesis
    • Weston CR, Wong A, Hall JP, Goad ME, Flavell RA, Davis RJ. The c-Jun NH2-terminal kinase is essential for epiderma growth factor expression during epidermal morphogenesis. Proc Natl Acad Sci USA 2004;101:14114-14119.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 14114-14119
    • Weston, C.R.1    Wong, A.2    Hall, J.P.3    Goad, M.E.4    Flavell, R.A.5    Davis, R.J.6
  • 65
    • 0036494564 scopus 로고    scopus 로고
    • Differential gene expression profiles of Jnk1- and Jnk2-deficient murine fibroblast cells
    • Chen N, She QB, Bode AM, Dong Z. Differential gene expression profiles of Jnk1- and Jnk2-deficient murine fibroblast cells. Cancer Res 2002;62:1300-1304.
    • (2002) Cancer Res , vol.62 , pp. 1300-1304
    • Chen, N.1    She, Q.B.2    Bode, A.M.3    Dong, Z.4
  • 66
    • 0036606371 scopus 로고    scopus 로고
    • Targets of c-Jun NH(2)-terminal kinase 2-mediated tumor growth regulation revealed by serial analysis of gene expression
    • Potapova O, Anisimov SV, Gorospe M, et al. Targets of c-Jun NH(2)-terminal kinase 2-mediated tumor growth regulation revealed by serial analysis of gene expression. Cancer Res 2002;62:3257-3263.
    • (2002) Cancer Res , vol.62 , pp. 3257-3263
    • Potapova, O.1    Anisimov, S.V.2    Gorospe, M.3


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