IKKβ is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFα

Immunity

Volumn 19, Issue 5, 2003, Pages 725-737

  Maeda, Shin ^a,b   Chang, Lufen ^a,b   Li, Zhi Wei ^a,b   Luo, Jun Li ^a,b   Leffert, Hyam ^a   Karin, Michael ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b San Diego   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONCANAVALIN A; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; PROTEIN SUBUNIT; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; CHUK PROTEIN, MOUSE; IKBKB PROTEIN, MOUSE; IKBKE PROTEIN, MOUSE; LEUKOCYTE ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CIRCULATION; CONTROLLED STUDY; CYTOTOXICITY; DISEASE PREDISPOSITION; EMBRYO; ENZYME ACTIVATION; HEALTH STATUS; LIVER CELL; LIVER FUNCTION; LIVER INJURY; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; T LYMPHOCYTE ACTIVATION; ANIMAL; C57BL MOUSE; GENETICS; LIVER; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD; APOPTOSIS; CONCANAVALIN A; I-KAPPA B KINASE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0344496062     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(03)00301-7     Document Type: Article

References (60)

1. Beg A.A., Sha W.C., Bronson R.T., Ghosh S., Baltimore D. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature. 376:1995;167-169.
2. Bird G.L., Sheron N., Goka A.K., Alexander G.J., Williams R.S. Increased plasma tumor necrosis factor in severe alcoholic hepatitis. Ann. Intern. Med. 112:1990;917-920.
3. Bradham C.A., Plumpe J., Manns M.P., Brenner D.A., Trautwein C. Mechanisms of hepatic toxicity. I. TNF-induced liver injury. Am. J. Physiol. 275:1998;G387-G392.
4. Chaisson M.L., Brooling J.T., Ladiges W., Tsai S., Fausto N. Hepatocyte-specific inhibition of NF-κB leads to apoptosis after TNF treatment, but not after partial hepatectomy. J. Clin. Invest. 110:2002;193-202.
5. Chan F.K., Lenardo M.J. A crucial role for p80 TNF-R2 in amplifying p60 TNF-R1 apoptosis signals in T lymphocytes. Eur. J. Immunol. 30:2000;652-660.
6. Chang L., Jones Y., Ellisman M.H., Goldstein L.S., Karin M. JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Dev. Cell. 4:2003;521-523.
7. Chen L.-W., Egan L., Li Z.-W., Greten F.R., Kagnoff M.F., Karin M. The two faces of IKK and NF-κB inhibition. prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion Nat. Med. 9:2003;575-581.
8. Cressman D.E., Greenbaum L.E., Haber B.A., Taub R. Rapid activation of post-hepatectomy factor/NF-κB in hepatocytes, a primary response in the regenerating liver. J. Biol. Chem. 269:1994;30429-30435.
9. De Smaele E., Zazzeroni F., Papa S., Nguyen D.U., Jin R., Jones J., Cong R., Franzoso G. Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling. Nature. 414:2001;308-313.
10. Decker, K., and Keppler, D. (1974). Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death. Rev. Physiol. Biochem. Pharmacol., 77-106.
11. DiDonato J.A., Hayakawa M., Rothwarf D.M., Zandi E., Karin M. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature. 388:1997;548-554.
12. Doi T.S., Marino M.W., Takahashi T., Yoshida T., Sakakura T., Old L.J., Obata Y. Absence of TNF rescues RelA-deficient mice from embryonic lethality. Proc. Natl. Acad. Sci. USA. 96:1999;2994-2999.
13. Eissner G., Kohlhuber F., Grell M., Ueffing M., Scheurich P., Hieke A., Multhoff G., Bornkamm G.W., Holler E. Critical involvement of transmembrane TNF-α in endothelial programmed cell death mediated by ionizing radiation and bacterial endotoxin. Blood. 86:1995;4184-4193.
14. Fotin-Mleczek M., Henkler F., Samel D., Reichwein M., Hausser A., Parmryd I., Scheurich P., Schmid J.A., Wajant H. Apoptotic crosstalk of TNF receptors. TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8 J. Cell Sci. 115:2002;2757-2770.
15. Gantner F., Leist M., Lohse A.W., Germann P.G., Tiegs G. Concanavalin A-induced T-cell-mediated hepatic injury in mice. the role of tumor necrosis factor Hepatology. 21:1995;190-198.
16. Ghosh S., Karin M. Missing pieces in the NF-κB puzzle. Cell. 109:2002;S81-S96.
17. Gonzalez-Amaro R., Garcia-Monzon C., Garcia-Buey L., Moreno-Otero R., Alonso J.L., Yague E., Pivel J.P., Lopez-Cabrera M., Fernandez-Ruiz E., Sanchez-Madrid F. Induction of tumor necrosis factor alpha production by human hepatocytes in chronic viral hepatitis. J. Exp. Med. 179:1994;841-848.
18. Grell M., Douni E., Wajant H., Lohden M., Clauss M., Maxeiner B., Georgopoulos S., Lesslauer W., Kollias G., Pfizenmaier K., et al. The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Cell. 83:1995;793-802.
19. Grell M., Wajant H., Zimmermann G., Scheurich P. The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor. Proc. Natl. Acad. Sci. USA. 95:1998;570-575.
20. Haefner B. Nf-κb. arresting a major culprit in cancer Drug Discov. Today. 7:2002;653-663.
21. Hatano E., Bennett B.L., Manning A.M., Qian T., Lemasters J.J., Brenner D.A. NF-κB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-α- and Fas-mediated apoptosis. Gastroenterology. 120:2001;1251-1262.
22. Hibi M., Lin A., Smeal T., Minden A., Karin M. Identification of an oncoprotein-responsive and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 7:1993;2135-2148.
23. Higgins G.M., Anderson R.M. Experimental pathology of the liver I. restoration of the liver of white rat following partial surgical removal Arch. Pathol. 12:1931;186-189.
24. Hsu H., Shu H.B., Pan M.G., Goeddel D.V. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell. 84:1996;299-308.
25. Hu Y., Baud V., Delhase M., Zhang P., Deerinck T., Ellisman M., Johnson R., Karin M. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of the IκB kinase. Science. 284:1999;316-320.
26. Iimuro Y., Nishiura T., Hellerbrand C., Behrns K.E., Schoonhoven R., Grisham J.W., Brenner D.A. NF-κB prevents apoptosis and liver dysfunction during liver regeneration. J. Clin. Invest. 101:1998;802-811.
27. Karin M., Lin A. NF-κB at the crossroads of life and death. Nat. Immunol. 3:2002;221-227.
28. Kusters S., Gantner F., Kunstle G., Tiegs G. Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A. Gastroenterology. 111:1996;462-471.
29. Kusters S., Tiegs G., Alexopoulou L., Pasparakis M., Douni E., Kunstle G., Bluethmann H., Wendel A., Pfizenmaier K., Kollias G., et al. In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis. Eur. J. Immunol. 27:1997;2870-2875.
30. Lamb J.A., Ventura J.J., Hess P., Flavell R.A., Davis R.J. JunD mediates survival signaling by the JNK signal transduction pathway. Mol. Cell. 11:2003;1479-1489.
31. Lavon I., Goldberg I., Amit S., Landsman L., Jung S., Tsuberi B.Z., Barshack I., Kopolovic J., Galun E., Bujard H., et al. High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-κB activation. Nat. Med. 6:2000;573-577.
32. Leffert H.L., Koch K.S., Moran T., Williams M. Liver cells. Methods Enzymol. 58:1979;536-544.
33. Li Q., Van Antwerp D., Mercurio F., Lee K.-F., Verma I.M. Severe liver degeneration in mice lacking the IκB kinase 2 gene. Science. 284:1999;321-325. a.
34. Li Z.-W., Chu W., Hu Y., Delhase M., Deerinck T., Ellisman M., Johnson R., Karin M. The IKKβ subunit of IκB kinase (IKK) is essential for NF-κB activation and prevention of apoptosis. J. Exp. Med. 189:1999;1839-1845. b.
35. Li X., Yang Y., Ashwell J.D. TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature. 416:2002;345-347.
36. Li Z.-W., Omori S.A., Labuda T., Karin M., Rickert R.C. IKKβ is required for peripheral B cell proliferation and survival. J. Immunol. 170:2003;4630-4637.
37. Liu P., Kimmoun E., Legrand A., Sauvanet A., Degott C., Lardeux B., Bernuau D. Activation of NF-κB, AP-1 and STAT transcription factors is a frequent and early event in human hepatocellular carcinomas. J. Hepatol. 37:2002;63-71.
38. Liu Z.-G., Hu H., Goeddel D.V., Karin M. Dissection of TNF receptor 1 effector functions. JNK activation is not linked to apoptosis, while NF-κB activation prevents cell death Cell. 87:1996;565-576.
39. Makris C., Godfrey V.L., Krähn-Senftleben G., Takahashi T., Roberts J.L., Schwarz T., Feng L., Johnson R.S., Karin M. Female mice heterozygote for IKKγ/NEMO deficiencies develop a genodermatosis similar to the human X-linked disorder Incontinentia Pigmenti. Mol. Cell I. 5:2000;969-979.
40. Muto Y., Nouri-Aria K.T., Meager A., Alexander G.J., Eddleston A.L., Williams R. Enhanced tumour necrosis factor and interleukin-1 in fulminant hepatic failure. Lancet. 2:1988;72-74.
41. Natoli G., Costanzo A., Ianni A., Templeton D.J., Woodgett J.R., Balsano C., Levrero M. Activation of SAPK/JNK by TNFR1 through a noncytotoxic TRAF2-dependent pathway. Science. 275:1997;200-203.
42. Nowak M., Gaines G.C., Rosenberg J., Minter R., Bahjat F.R., Rectenwald J., MacKay S.L., Edwards C.K. 3rd, Moldawer L.L. LPS-induced liver injury in D-galactosamine-sensitized mice requires secreted TNF-α and the TNF-p55 receptor. Am. J. Physiol. Regul. Integr. Comp. Physiol. 278:2000;R1202-R1209.
43. Okuda K. Hepatocellular carcinoma. J. Hepatol. 32(Suppl 1):2000;225-237.
44. Park J.M., Greten F.R., Li Z.-W., Karin M. Macrophage apoptosis by Anthrax Lethal Factor and p38 MAP kinase inhibition. Science. 297:2002;2048-2051.
45. Postic C., Magnuson M.A. DNA excision in liver by an albumin-Cre transgene occurs progressively with age. Genesis. 26:2000;149-150.
46. Postic C., Shiota M., Niswender K.D., Jetton T.L., Chen Y., Moates J.M., Shelton K.D., Lindner J., Cherrington A.D., Magnuson M.A. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J. Biol. Chem. 274:1999;305-315.
47. Sabapathy K., Jochum W., Hochedlinger K., Chang L., Karin M., Wagner E.F. Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech. Dev. 89:1999;115-124.
48. Sakon S., Xue X., Takekawa M., Sasazuki T., Okazaki T., Kojima Y., Piao J.H., Yagita H., Okumura K., Doi T., et al. NF-κB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO J. 22:2003;3898-3909.
49. Senftleben U., Cao Y., Xiao G., Greten F., Krahn G., Bonizzi G., Chen Y., Hu Y., Fong A., Sun S.-C., et al. Activation by IKKα of a second, evolutionary conserved, NF-κB signaling pathway. Science. 293:2001;1495-1499.
50. Solorzano C.C., Ksontini R., Pruitt J.H., Hess P.J., Edwards P.D., Kaibara A., Abouhamze A., Auffenberg T., Galardy R.E., Vauthey J.N., et al. Involvement of 26-kDa cell-associated TNF-α in experimental hepatitis and exacerbation of liver injury with a matrix metalloproteinase inhibitor. J. Immunol. 158:1997;414-419.
51. Takeda K., Takeuchi O., Tsujimura T., Itami S., Adachi O., Kawai T., Sanjo H., Yoshikawa K., Terada N., Akira S. Limb and skin abnormalities in mice lacking IKKα Science. 284:1999;313-316.
52. Takeda K., Hayakawa Y., Van Kaer L., Matsuda H., Yagita H., Okumura K. Critical contribution of liver natural killer T cells to a murine model of hepatitis. Proc. Natl. Acad. Sci. USA. 97:2000;5498-5503.
53. Tanaka M., Fuentes M.E., Yamaguchi K., Durnin M.H., Dalrymple S.A., Hardy K.L., Goeddel D.V. Embryonic lethality, liver degeneration, and impaired NF-κB activation in IKKβ-deficient mice. Immunity. 10:1999;421-429.
54. Tang G., Minemoto Y., Dibling B., Purcell N.H., Li Z.-W., Karin M., Lin A. Inhibition of JNK activation through NF-κB target genes. Nature. 414:2001;313-317.
55. Tartaglia L.A., Goeddel D.V. Two TNF receptors. Immunol. Today. 13:1992;151-153.
56. Tiegs G., Hentschel J., Wendel A. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J. Clin. Invest. 90:1992;196-203.
57. Trautwein C., Rakemann T., Brenner D.A., Streetz K., Licato L., Manns M.P., Tiegs G. Concanavalin A-induced liver cell damage. activation of intracellular pathways triggered by tumor necrosis factor in mice Gastroenterology. 114:1998;1035-1045.
58. Wang C.Y., Mayo M.W., Korneluk R.G., Goeddel D.V., Baldwin A.S. Jr. NF-κB antiapoptosis. induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation Science. 281:1998;1680-1683.
59. Xu Y., Bialik S., Jones B.E., Iimuro Y., Kitsis R.N., Srinivasan A., Brenner D.A., Czaja M.J. NF-κB inactivation converts a hepatocyte cell line TNF-α response from proliferation to apoptosis. Am. J. Physiol. 275:1998;C1058-C1066.
60. Zandi E., Chen Y., Karin M. Direct phosphorylation of IκB by IKKα and IKKβ discrimination between free and NF-κB-bound substrate Science. 281:1998;1360-1363.