Activation of c-Jun N-terminal kinase (JNK) by widely used specific p38 MAPK inhibitors SB202190 and SB203580: A MLK-3-MKK7-dependent mechanism

Cellular Signalling

Volumn 20, Issue 4, 2008, Pages 675-683

  Muniyappa, Harish ^a   Das, Kumuda C ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

ATF 2; Jun N terminal Kinase; MLK 3; p38 MAP Kinase; SB202190; SB203580

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACTIVATING PROTEIN 1; ACTIVATING TRANSCRIPTION FACTOR 2; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; MIXED LINEAGE KINASE 3; NUCLEIC ACID BINDING PROTEIN; SB202190; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ACTIVATING TRANSCRIPTION FACTOR 2; CELL LINE, TUMOR; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ENZYME ACTIVATION; ENZYME ACTIVATORS; HUMANS; IMIDAZOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 7; MAP KINASE KINASE KINASES; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-JUN; PYRIDINES; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSCRIPTION FACTOR AP-1; TRANSFECTION;

EID: 39149122494     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellsig.2007.12.003     Document Type: Article

References (24)

1. Kumar S., Boehm J., and Lee J.C. Nat. Rev. Drug Discov. 2 9 (2003) 717
2. Karin M., and Gallagher E. IUBMB Life 57 4-5 (2005) 283
3. Davis R.J. Cell 103 2 (2000) 239
4. Kaminska B. Biochim. Biophys. Acta 1754 1-2 (2005) 253
5. Karin M. Proc. Am. Thorac. Soc. 2 4 (2005) 386 discussion 394
6. Davis R.J. Biochem. Soc. Symp. 64 (1999) 1
7. Liu J., and Lin A. Cell Res. 15 1 (2005) 36
8. Swenson K.I., Winkler K.E., and Means A.R. Mol. Biol. Cell 14 1 (2003) 156
9. Rana A., Gallo K., Godowski P., Hirai S., Ohno S., Zon L., Kyriakis J.M., and Avruch J. J. Biol. Chem. 271 32 (1996) 19025
10. Teramoto H., Coso O.A., Miyata H., Igishi T., Miki T., and Gutkind J.S. J. Biol. Chem. 271 44 (1996) 27225
11. Brancho D., Ventura J.J., Jaeschke A., Doran B., Flavell R.A., and Davis R.J. Mol. Cell. Biol. 25 9 (2005) 3670
12. Zhang H., and Gallo K.A. J. Biol. Chem. 276 49 (2001) 45598
13. Tibbles L.A., Ing Y.L., Kiefer F., Chan J., Iscove N., Woodgett J.R., and Lassam N.J. Embo J. 15 24 (1996) 7026
14. Burbelo P.D., Drechsel D., and Hall A. J. Biol. Chem. 270 49 (1995) 29071
15. Zhang Y.L., and Dong C. Cell. Mol. Immunol. 2 1 (2005) 20
16. Wang W., Shi L., Xie Y., Ma C., Li W., Su X., Huang S., Chen R., Zhu Z., Mao Z., Han Y., and Li M. Neurosci. Res. 48 2 (2004) 195
17. Das K.C. J. Biol. Chem. 276 7 (2001) 4662
18. Das K.C., Lewis-Molock Y., and White C.W. Am. J. Physiol. 269 5 Pt 1 (1995) L588
19. Gupta S., Campbell D., Derijard B., and Davis R.J. Science 267 5196 (1995) 389
20. Livingstone C., Patel G., and Jones N. Embo J. 14 8 (1995) 1785
21. van Dam H., Wilhelm D., Herr I., Steffen A., Herrlich P., and Angel P. Embo J. 14 8 (1995) 1798
22. Karin M. J. Biol. Chem. 270 28 (1995) 16483
23. Takeda K., Matsuzawa A., Nishitoh H., and Ichijo H. Cell Struct. Funct. 28 1 (2003) 23
24. Schachter K.A., Du Y., Lin A., and Gallo K.A. J. Biol. Chem. 281 28 (2006) 19134