Non-classical p38 map kinase functions: Cell cycle checkpoints and survival

International Journal of Biological Sciences

Volumn 5, Issue 1, 2009, Pages 44-52

  Thornton, Tina M ^a   Rincon, Mercedes ^a,b  

^a UNIVERSITY OF VERMONT   (United States)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

Cell cycle checkpoint; p38 MAPK; Survival

Indexed keywords

BETA CATENIN; CYCLIN D; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYTOKINE; GELATINASE B; GLYCOGEN SYNTHASE KINASE 3BETA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN MDM2; PROTEIN P53; PROTEIN TYROSINE PHOSPHATASE; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL STRESS; CELL SURVIVAL; DNA DAMAGE; HUMAN; REGULATORY MECHANISM; REVIEW; STIMULUS RESPONSE;

EID: 60149093582     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.5.44     Document Type: Review

References (72)

1. Raman M, Chen W, and Cobb M.H. Differential regulation and properties of MAPKs. Oncogene. 2007; 26(22): 3100.
2. Iñesta-Vaquera F, Sabio G, Kuma Y, and Cuenda A. Alternative p38 Pathways MAPK. In: Stress-Activated Protein Kinases. Heidelberg: Springer Berlin. 2008:17.
3. Adams R.H, et al. Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Mol Cell. 2000; 6(1): 109.
4. Allen M, et al. Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells. J Exp Med. 2000; 191(5): 859.
5. Mudgett J.S, et al. Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Proc Natl Acad Sci U S A. 2000; 97(19): 10454.
6. Tamura K, et al. Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell. 2000; 102(2): 221.
7. Zarubin T and Han J. Activation and signaling of the p38 MAP kinase pathway. Cell Res. 2005; 15(1): 11.
8. Ashwell J.D. The many paths to p38 mitogen-activated protein kinase activation in the immune system. Nat Rev Immunol. 2006; 6(7): 532.
9. Salvador J.M, et al. Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases. Nat Immunol. 2005; 6(4): 390.
10. Ge B, et al. MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science. 2002; 295(5558): 1291.
11. Han J and Sun P. The pathways to tumor suppression via route p38. Trends Biochem Sci. 2007; 32(8): 364.
12. Hui L, Bakiri L, Stepniak E, and Wagner E.F. p38alpha: a suppressor of cell proliferation and tumorigenesis. Cell Cycle. 2007; 6(20): 2429.
13. Zhou B.B and Elledge S.J. The DNA damage response: putting checkpoints in perspective. Nature. 2000; 408(6811): 433.
14. Bulavin D.V, Amundson S.A, and Fornace A.J. p38 and Chk1 kinases: different conductors for the G(2)/M checkpoint symphony. Curr Opin Genet Dev. 2002; 12(1): 92.
15. Mikhailov A, Shinohara M, and Rieder C.L. Topoisomerase II and histone deacetylase inhibitors delay the G2/M transition by triggering the p38 MAPK checkpoint pathway. J Cell Biol. 2004; 166(4): 517.
16. Reinhardt H.C, Aslanian A.S, Lees J.A, and Yaffe M.B. p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell. 2007; 11(2): 175.
17. Raman M, et al. TAO kinases mediate activation of p38 in response to DNA damage. Embo J. 2007; 26(8): 2005.
18. Bulavin D.V, et al. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. Embo J. 1999; 18(23): 6845.
19. She Q.B, et al. Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase. Cancer Res. 2001; 61(4): 1604.
20. She Q.B, Chen N, and Dong Z. ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation. J Biol Chem. 2000; 275(27): 20444.
21. Huang C, et al. p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389. J Biol Chem. 1999; 274(18): 12229.
22. Jin S, et al. Gadd45a contributes to p53 stabilization in response to DNA damage. Oncogene. 2003; 22(52): 8536.
23. Bulavin D.V, Kovalsky O, Hollander M.C, and Fornace A.J. Jr, Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a. Mol Cell Biol. 2003; 23(11): 3859.
24. Zhan Q, et al. Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45. Oncogene. 1999; 18(18): 2892.
25. el-Deiry W.S, et al. WAF1, a potential mediator of p53 tumor suppression. Cell. 1993; 75(4): 817.
26. Hermeking H, et al. 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell. 1997; 1(1): 3.
27. Bulavin D.V, et al. Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. Nature. 2001; 411(6833): 102.
28. Morris M.C, et al. An essential phosphorylation-site domain of human cdc25C interacts with both 14-3-3 and cyclins. J Biol Chem. 2000; 275(37): 28849.
29. Lopez-Girona A, Furnari B, Mondesert O, and Russell P. Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein. Nature. 1999; 397(6715): 172.
30. Manke I.A, et al. MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. Mol Cell. 2005; 17(1): 37.
31. Lemaire M, et al. CDC25B phosphorylation by p38 and MK-2. Cell Cycle. 2006; 5(15): 1649.
32. Wang X, et al. Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. Mol Cell Biol. 2000; 20(13): 4543.
33. Kim G.Y, et al. The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation. J Biol Chem. 2002; 277(33): 29792.
34. Kishi H, et al. Osmotic shock induces G1 arrest through p53 phosphorylation at Ser33 by activated p38MAPK without phosphorylation at Ser15 and Ser20. J Biol Chem. 2001; 276(42): 39115.
35. Lavoie J.N, et al. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J Biol Chem. 1996; 271(34): 20608.
36. Yee A.S, et al. The HBP1 transcriptional repressor and the p38 MAP kinase: unlikely partners in G1 regulation and tumor suppression. Gene. 2004; 336(1): 1.
37. Casanovas O, et al. Osmotic stress regulates the stability of cyclin D1 in a p38SAPK2-dependent manner. J Biol Chem. 2000; 275(45): 35091.
38. Zhao H, Watkins J.L, and Piwnica-Worms H. Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. Proc Natl Acad Sci U S A. 2002; 99(23): 14795.
39. Jinno S, et al. Cdc25A is a novel phosphatase functioning early in the cell cycle. Embo J. 1994; 13(7): 1549.
40. Blomberg I and Hoffmann I. Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases. Mol Cell Biol. 1999; 19(9): 6183.
41. Goloudina A, et al. Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint. Cell Cycle. 2003; 2(5): 473.
42. Roussel M.F. The INK4 family of cell cycle inhibitors in cancer. Oncogene. 1999; 18(38): 5311.
43. Weber J.D, et al. Nucleolar Arf sequesters Mdm2 and activates p53. Nat Cell Biol. 1999; 1(1): 20.
44. Tao W and Levine A.J. P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2. Proc Natl Acad Sci U S A. 1999; 96(12): 6937.
45. Faust D, et al. p38alpha MAPK is required for contact inhibition. Oncogene. 2005; 24(53): 7941.
46. Bulavin D.V, et al. Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. Nat Genet. 2004; 36(4): 343.
47. Ito K, et al. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med. 2006; 12(4): 446.
48. Cappellini A, et al. Antiapoptotic role of p38 mitogen activated protein kinase in Jurkat T cells and normal human T lymphocytes treated with 8-methoxypsoralen and ultraviolet-A radiation. Apoptosis. 2005; 10(1): 141.
49. Kurosu T, et al. p38 MAP kinase plays a role in G2 checkpoint activation and inhibits apoptosis of human B cell lymphoma cells treated with etoposide. Apoptosis. 2005; 10(5): 1111.
50. Cosaceanu D, et al. Ionizing radiation activates IGF-1R triggering a cytoprotective signaling by interfering with Ku-DNA binding and by modulating Ku86 expression via a p38 kinase-dependent mechanism. Oncogene. 2007; 26(17): 2423.
51. Hirose Y, et al. The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agents. Mol Cell Biol. 2003; 23(22): 8306.
52. Pedraza-Alva G, et al. Activation of p38 MAP kinase by DNA double-strand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint. Embo J. 2006; 25(4): 763.
53. Ringshausen I, et al. Constitutive activation of the MAPkinase p38 is critical for MMP-9 production and survival of B-CLL cells on bone marrow stromal cells. Leukemia. 2004; 18(12): 1964.
54. Suarez-Cuervo C, et al. Breast cancer cells with inhibition of p38alpha have decreased MMP-9 activity and exhibit decreased bone metastasis in mice. Clin Exp Metastasis. 2004; 21(6): 525.
55. Xia Z, et al. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 1995; 270(5240): 1326.
56. Mao Z and Wiedmann M. Calcineurin enhances MEF2 DNA binding activity in calcium-dependent survival of cerebellar granule neurons. J Biol Chem. 1999; 274(43): 31102.
57. Zechner D, et al. MKK6 activates myocardial cell NF-kappaB and inhibits apoptosis in a p38 mitogen-activated protein kinase-dependent manner. J Biol Chem. 1998; 273(14): 8232.
58. Alvarado-Kristensson M, et al. p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils. J Exp Med. 2004; 199(4): 449.
59. Alvarado-Kristensson M, et al. p38 Mitogen-activated protein kinase and phosphatidylinositol 3-kinase activities have opposite effects on human neutrophil apoptosis. Faseb J. 2002; 16(1): 129.
60. Kankaanranta H, et al. SB 203580, an inhibitor of p38 mitogen-activated protein kinase, enhances constitutive apoptosis of cytokine-deprived human eosinophils. J Pharmacol Exp Ther. 1999; 290(2): 621.
61. He T.C, et al. Identification of c-MYC as a target of the APC pathway. Science. 1998; 281(5382): 1509.
62. Liu C, et al. Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell. 2002; 108(6): 837.
63. Doble B.W and Woodgett J.R. GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci. 2003; 116(Pt 7): 1175.
64. Hildesheim J, et al. Gadd45a regulates matrix metalloproteinases by suppressing DeltaNp63alpha and beta-catenin via p38 MAP kinase and APC complex activation. Oncogene. 2004; 23(10): 1829.
65. Rane M.J, et al. p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils. J Biol Chem. 2001; 276(5): 3517.
66. Wang Y, et al. The role of the NADPH oxidase complex, p38 MAPK, and Akt in regulating human monocyte/macrophage survival. Am J Respir Cell Mol Biol. 2007; 36(1): 68.
67. Cross D.A, et al. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature. 1995; 378(6559): 785.
68. Thornton T.M, et al. Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation. Science. 2008; 320(5876): 667.
69. Comes F, et al. A novel cell type-specific role of p38alpha in the control of autophagy and cell death in colorectal cancer cells. Cell Death Differ. 2007; 14(4): 693.
70. Simone C. Signal-dependent control of autophagy and cell death in colorectal cancer cell: the role of the p38 pathway. Autophagy. 2007; 3(5): 468.
71. Heasley L.E and Han S.Y. JNK regulation of oncogenesis. Mol Cells. 2006; 21(2): 167.
72. Weston C.R and Davis R.J. The JNK signal transduction pathway. Curr Opin Cell Biol. 2007; 19(2): 142.