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Volumn 10, Issue 3, 2004, Pages 125-129

p38 MAP kinase: A convergence point in cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 6 (4 FLUOROPHENYL) 2,3 DIHYDRO 5 (4 PYRIDYL)IMIDAZO[2,1 B]THIAZOLE; ANTINEOPLASTIC AGENT; CISPLATIN; MITOGEN ACTIVATED PROTEIN KINASE P38; NOCODAZOLE; PACLITAXEL; RETINOID; VINBLASTINE; VINCRISTINE;

EID: 1442274808     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2004.01.007     Document Type: Article
Times cited : (284)

References (46)
  • 1
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signalling cascades
    • Chang L., Karin M. Mammalian MAP kinase signalling cascades. Nature. 410:2001;37-40.
    • (2001) Nature , vol.410 , pp. 37-40
    • Chang, L.1    Karin, M.2
  • 2
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia Z., et al. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 270:1995;1326-1331.
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1
  • 3
    • 0027994002 scopus 로고
    • An osmosensing signal transduction pathway in mammalian cells
    • Galcheva-Gargova Z., et al. An osmosensing signal transduction pathway in mammalian cells. Science. 265:1994;806-808.
    • (1994) Science , vol.265 , pp. 806-808
    • Galcheva-Gargova, Z.1
  • 4
    • 0029055761 scopus 로고
    • Components of a new human protein kinase signal transduction pathway
    • Zhou G., et al. Components of a new human protein kinase signal transduction pathway. J. Biol. Chem. 270:1995;12665-12669.
    • (1995) J. Biol. Chem. , vol.270 , pp. 12665-12669
    • Zhou, G.1
  • 5
    • 0029162078 scopus 로고
    • Primary structure of BMK1: A new mammalian map kinase
    • Lee J.D., et al. Primary structure of BMK1: a new mammalian map kinase. Biochem. Biophys. Res. Commun. 213:1995;715-724.
    • (1995) Biochem. Biophys. Res. Commun. , vol.213 , pp. 715-724
    • Lee, J.D.1
  • 6
    • 0032958382 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth
    • Abe M.K., et al. Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth. Mol. Cell. Biol. 19:1999;1301-1312.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1301-1312
    • Abe, M.K.1
  • 7
    • 0037053403 scopus 로고    scopus 로고
    • ERK8, a new member of the mitogen-activated protein kinase family
    • Abe M.K., et al. ERK8, a new member of the mitogen-activated protein kinase family. J. Biol. Chem. 277:2002;16733-16743.
    • (2002) J. Biol. Chem. , vol.277 , pp. 16733-16743
    • Abe, M.K.1
  • 8
    • 0142059045 scopus 로고    scopus 로고
    • ERK inhibitor PD98059 enhances docetaxel-induced apoptosis of androgen-independent human prostate cancer cells
    • Zelivianski S., et al. ERK inhibitor PD98059 enhances docetaxel-induced apoptosis of androgen-independent human prostate cancer cells. Int. J. Cancer. 107:2003;478-485.
    • (2003) Int. J. Cancer , vol.107 , pp. 478-485
    • Zelivianski, S.1
  • 9
    • 0027936755 scopus 로고
    • A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
    • Han J., et al. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science. 265:1994;808-811.
    • (1994) Science , vol.265 , pp. 808-811
    • Han, J.1
  • 10
    • 0028605318 scopus 로고
    • A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
    • Lee J.C., et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature. 372:1994;739-746.
    • (1994) Nature , vol.372 , pp. 739-746
    • Lee, J.C.1
  • 11
    • 0028022750 scopus 로고
    • A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
    • Rouse J., et al. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell. 78:1994;1027-1037.
    • (1994) Cell , vol.78 , pp. 1027-1037
    • Rouse, J.1
  • 12
    • 0028157664 scopus 로고
    • Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution
    • Zhang F., et al. Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution. Nature. 367:1994;704-711.
    • (1994) Nature , vol.367 , pp. 704-711
    • Zhang, F.1
  • 13
    • 0029998541 scopus 로고    scopus 로고
    • Crystal structure of p38 mitogen-activated protein kinase
    • Wilson K.P., et al. Crystal structure of p38 mitogen-activated protein kinase. J. Biol. Chem. 271:1996;27696-27700.
    • (1996) J. Biol. Chem. , vol.271 , pp. 27696-27700
    • Wilson, K.P.1
  • 14
    • 0032792161 scopus 로고    scopus 로고
    • Okadaic acid and anisomycin are protective and stimulate the SAPK/JNK pathway
    • Barancik M., et al. Okadaic acid and anisomycin are protective and stimulate the SAPK/JNK pathway. J. Cardiovasc. Pharmacol. 34:1999;182-190.
    • (1999) J. Cardiovasc. Pharmacol. , vol.34 , pp. 182-190
    • Barancik, M.1
  • 15
    • 0037362372 scopus 로고    scopus 로고
    • Role of PP2A in the regulation of p38 MAPK activation in bovine aortic endothelial cells exposed to cyclic strain
    • Lee T., et al. Role of PP2A in the regulation of p38 MAPK activation in bovine aortic endothelial cells exposed to cyclic strain. J. Cell. Physiol. 194:2003;349-355.
    • (2003) J. Cell. Physiol. , vol.194 , pp. 349-355
    • Lee, T.1
  • 16
    • 0142091663 scopus 로고    scopus 로고
    • Overexpression of the dual-specificity MAPK phosphatase PYST2 in acute leukemia
    • Levy-Nissenbaum O., et al. Overexpression of the dual-specificity MAPK phosphatase PYST2 in acute leukemia. Cancer Lett. 199:2003;185-192.
    • (2003) Cancer Lett. , vol.199 , pp. 185-192
    • Levy-Nissenbaum, O.1
  • 17
    • 0031916832 scopus 로고    scopus 로고
    • Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6
    • Enslen H., et al. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. J. Biol. Chem. 273:1998;1741-1748.
    • (1998) J. Biol. Chem. , vol.273 , pp. 1741-1748
    • Enslen, H.1
  • 18
    • 0038636455 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinases on the body surface - A function for p38δ
    • Eckert R.L., et al. p38 mitogen-activated protein kinases on the body surface - a function for p38δ J. Invest. Dermatol. 120:2003;823-828.
    • (2003) J. Invest. Dermatol. , vol.120 , pp. 823-828
    • Eckert, R.L.1
  • 19
    • 0030051528 scopus 로고    scopus 로고
    • MKK3- and MKK6- regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
    • Raingeaud J., et al. MKK3- and MKK6- regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol. Cell. Biol. 16:1996;1247-1255.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1247-1255
    • Raingeaud, J.1
  • 20
    • 0029938805 scopus 로고    scopus 로고
    • Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase
    • Wang X.Z., Ron D. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase. Science. 272:1996;1347-1349.
    • (1996) Science , vol.272 , pp. 1347-1349
    • Wang, X.Z.1    Ron, D.2
  • 21
    • 0030894683 scopus 로고    scopus 로고
    • Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
    • Han J., et al. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature. 386:1997;296-299.
    • (1997) Nature , vol.386 , pp. 296-299
    • Han, J.1
  • 22
    • 0037032817 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
    • Johnson G.L., Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science. 298:2002;1911-1912.
    • (2002) Science , vol.298 , pp. 1911-1912
    • Johnson, G.L.1    Lapadat, R.2
  • 23
    • 0007570010 scopus 로고    scopus 로고
    • The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation
    • van der Houven van Oordt W., et al. The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation. J. Cell Biol. 149:2000;307-316.
    • (2000) J. Cell Biol. , vol.149 , pp. 307-316
    • Van Der Houven Van Oordt, W.1
  • 24
    • 0033485261 scopus 로고    scopus 로고
    • Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
    • Bulavin D.V., et al. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J. 18:1999;6845-6854.
    • (1999) EMBO J. , vol.18 , pp. 6845-6854
    • Bulavin, D.V.1
  • 25
    • 0037115421 scopus 로고    scopus 로고
    • Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53
    • Hildesheim J., et al. Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53. Cancer Res. 62:2002;7305-7315.
    • (2002) Cancer Res. , vol.62 , pp. 7305-7315
    • Hildesheim, J.1
  • 26
    • 85047696046 scopus 로고    scopus 로고
    • Regulation of p73 by c-Abl through the p38 MAP kinase pathway
    • Sanchez-Prieto R., et al. Regulation of p73 by c-Abl through the p38 MAP kinase pathway. Oncogene. 21:2002;974-979.
    • (2002) Oncogene , vol.21 , pp. 974-979
    • Sanchez-Prieto, R.1
  • 27
    • 0142026209 scopus 로고    scopus 로고
    • P38 MAP kinases: Key signalling molecules as therapeutic targets for inflammatory diseases
    • Kumar S., et al. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nat. Rev. Drug Discov. 2:2003;717-726.
    • (2003) Nat. Rev. Drug Discov. , vol.2 , pp. 717-726
    • Kumar, S.1
  • 28
    • 0027761036 scopus 로고
    • Bicyclic imidazoles as a novel class of cytokine biosynthesis inhibitors
    • Lee J.C., et al. Bicyclic imidazoles as a novel class of cytokine biosynthesis inhibitors. Ann. New York Acad. Sci. 696:1993;149-170.
    • (1993) Ann. New York Acad. Sci. , vol.696 , pp. 149-170
    • Lee, J.C.1
  • 29
    • 0033030207 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase inhibitors - Mechanisms and therapeutic potentials
    • Lee J.C., et al. p38 mitogen-activated protein kinase inhibitors - mechanisms and therapeutic potentials. Pharmacol. Ther. 82:1999;389-397.
    • (1999) Pharmacol. Ther. , vol.82 , pp. 389-397
    • Lee, J.C.1
  • 30
    • 0042967678 scopus 로고    scopus 로고
    • BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect
    • Hallahan A.R., et al. BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect. Nat. Med. 9:2003;1033-1038.
    • (2003) Nat. Med. , vol.9 , pp. 1033-1038
    • Hallahan, A.R.1
  • 31
    • 0142135505 scopus 로고    scopus 로고
    • Early events in the induction of apoptosis in ovarian carcinoma cells by CD437: Activation of the p38 MAP kinase signal pathway
    • Holmes W.F., et al. Early events in the induction of apoptosis in ovarian carcinoma cells by CD437: activation of the p38 MAP kinase signal pathway. Oncogene. 22:2003;6377-6386.
    • (2003) Oncogene , vol.22 , pp. 6377-6386
    • Holmes, W.F.1
  • 32
    • 0038247837 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest
    • Deacon K., et al. p38 mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest. Mol. Biol. Cell. 14:2003;2071-2087.
    • (2003) Mol. Biol. Cell , vol.14 , pp. 2071-2087
    • Deacon, K.1
  • 33
    • 0038339253 scopus 로고    scopus 로고
    • Role of the p38 MAPK pathway in cisplatin-based therapy
    • Losa J.H., et al. Role of the p38 MAPK pathway in cisplatin-based therapy. Oncogene. 22:2003;3998-4006.
    • (2003) Oncogene , vol.22 , pp. 3998-4006
    • Losa, J.H.1
  • 34
    • 10744222950 scopus 로고    scopus 로고
    • Suppression of extracellular signal-related kinase and activation of p38 mitogen-activated protein kinase are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells
    • Park M.T., et al. Suppression of extracellular signal-related kinase and activation of p38 mitogen-activated protein kinase are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells. J. Biol. Chem. 278:2003;50624- 50634.
    • (2003) J. Biol. Chem. , vol.278 , pp. 50624-50634
    • Park, M.T.1
  • 35
    • 0038011249 scopus 로고    scopus 로고
    • Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis
    • Shimada K., et al. Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis. Carcinogenesis. 24:2003;1067-1075.
    • (2003) Carcinogenesis , vol.24 , pp. 1067-1075
    • Shimada, K.1
  • 36
    • 0036734148 scopus 로고    scopus 로고
    • Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells
    • Weijzen S., et al. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat. Med. 8:2002;979-986.
    • (2002) Nat. Med. , vol.8 , pp. 979-986
    • Weijzen, S.1
  • 37
    • 0141482096 scopus 로고    scopus 로고
    • P38 kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cells
    • Kim M.S., et al. p38 kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cells. Cancer Res. 63:2003;5454-5461.
    • (2003) Cancer Res. , vol.63 , pp. 5454-5461
    • Kim, M.S.1
  • 38
    • 0345832090 scopus 로고    scopus 로고
    • Activation of the pro-survival phosphatidylinositol 3-kinase/AKT pathway by transforming growth factor β1 in mesenchymal cells is mediated by p38 MAPK-dependent induction of an autocrine growth factor
    • Horowitz J.C., et al. Activation of the pro-survival phosphatidylinositol 3-kinase/AKT pathway by transforming growth factor β1 in mesenchymal cells is mediated by p38 MAPK-dependent induction of an autocrine growth factor. J. Biol. Chem. 279:2004;1359-1367.
    • (2004) J. Biol. Chem. , vol.279 , pp. 1359-1367
    • Horowitz, J.C.1
  • 39
    • 0037067716 scopus 로고    scopus 로고
    • Down-regulation of the phosphatidylinositol 3-kinase/Akt pathway is involved in retinoic acid-induced phosphorylation, degradation, and transcriptional activity of retinoic acid receptor γ2
    • Gianni M., et al. Down-regulation of the phosphatidylinositol 3-kinase/Akt pathway is involved in retinoic acid-induced phosphorylation, degradation, and transcriptional activity of retinoic acid receptor γ2. J. Biol. Chem. 277:2002;24859-24862.
    • (2002) J. Biol. Chem. , vol.277 , pp. 24859-24862
    • Gianni, M.1
  • 40
    • 0034162714 scopus 로고    scopus 로고
    • Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells
    • Puri P.L., et al. Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells. Genes Dev. 14:2000;574-584.
    • (2000) Genes Dev. , vol.14 , pp. 574-584
    • Puri, P.L.1
  • 41
    • 0038390661 scopus 로고    scopus 로고
    • Involvement of the p38 mitogen-activated protein kinase cascade in hepatocellular carcinoma
    • Iyoda K., et al. Involvement of the p38 mitogen-activated protein kinase cascade in hepatocellular carcinoma. Cancer. 97:2003;3017-3026.
    • (2003) Cancer , vol.97 , pp. 3017-3026
    • Iyoda, K.1
  • 42
    • 0041380813 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase regulates Bax translocation in cyanide-induced apoptosis
    • Shou Y., et al. p38 mitogen-activated protein kinase regulates Bax translocation in cyanide-induced apoptosis. Toxicol. Sci. 75:2003;99-107.
    • (2003) Toxicol. Sci. , vol.75 , pp. 99-107
    • Shou, Y.1
  • 43
    • 0041630601 scopus 로고    scopus 로고
    • P38 MAPK inhibition is critically involved in VEGFR-2-mediated endothelial cell survival
    • Yilmaz A., et al. p38 MAPK inhibition is critically involved in VEGFR-2-mediated endothelial cell survival. Biochem. Biophys. Res. Commun. 306:2003;730-736.
    • (2003) Biochem. Biophys. Res. Commun. , vol.306 , pp. 730-736
    • Yilmaz, A.1
  • 44
    • 0035677777 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is upregulated by interleukin-1β in human vascular smooth muscle cells via the p38 mitogen-activated protein kinase pathway
    • Jung Y.D., et al. Vascular endothelial growth factor is upregulated by interleukin-1β in human vascular smooth muscle cells via the p38 mitogen-activated protein kinase pathway. Angiogenesis. 4:2001;155-162.
    • (2001) Angiogenesis , vol.4 , pp. 155-162
    • Jung, Y.D.1
  • 45
    • 1442278553 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-mediated activation of p38 is dependent upon Src and RAFTK/Pyk2
    • doi:10.1038/sj.onc.1207243
    • McMullen M., et al. Vascular endothelial growth factor-mediated activation of p38 is dependent upon Src and RAFTK/Pyk2. Oncogene. 2004;. doi:10.1038/sj.onc.1207243.
    • (2004) Oncogene
    • McMullen, M.1
  • 46
    • 0037313641 scopus 로고    scopus 로고
    • P38 MAP kinase - A molecular switch between VEGF-induced angiogenesis and vascular hyperpermeability
    • Issbrucker K., et al. p38 MAP kinase - a molecular switch between VEGF-induced angiogenesis and vascular hyperpermeability. FASEB J. 17:2003;262-264.
    • (2003) FASEB J. , vol.17 , pp. 262-264
    • Issbrucker, K.1


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