Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

Nature Genetics

Volumn 31, Issue 2, 2002, Pages 210-215

  Bulavin, Dmitry V ^a   Demidov, Oleg N ^b   Saito, Shin’ichi ^b   Kauraniemi, Paivikki ^a,c   Phillips, Crissy ^a   Amundson, Sally A ^a   Ambrosino, Concetta ^d   Sauter, Guido ^e   Nebreda, Angel R ^d   Anderson, Carl W ^f   Kallioniemi, Anne ^a   Fornace, Albert J ^a   Appella, Ettore ^b  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF TAMPERE   (Finland)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^e UNIVERSITY OF BASEL   (Switzerland)

^f BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATASE; PROTEIN DERIVATIVE; PROTEIN P53; PROTEIN PPM1D; SERINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GENETICS; CELL CYCLE; CHROMOSOME 17Q; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENZYME ACTIVITY; GENE AMPLIFICATION; GENE INACTIVATION; GENE INDUCTION; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUDE MOUSE; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TUMOR SUPPRESSOR GENE;

ANIMALS; BREAST NEOPLASMS; CHROMOSOMES, HUMAN, PAIR 17; FEMALE; FIBROBLASTS; GENE AMPLIFICATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM PROTEINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; MUS MUSCULUS; UNIDENTIFIED RETROVIRUS;

EID: 0036613212     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng894     Document Type: Article

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