DNA methylation, smooth muscle cells, and atherogenesis

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 23, Issue 10, 2003, Pages 1750-1753

  Hiltunen, Mikko O ^a   Ylä Herttuala, Seppo ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

5 Methylcytosine; Atherogenesis; DNA methylation; Epigenetic gene regulation; Gene expression

Indexed keywords

DNA;

ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CELL PROLIFERATION; CPG ISLAND; DNA METHYLATION; DNA MODIFICATION; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENOME; HUMAN; MALIGNANT NEOPLASTIC DISEASE; MALIGNANT TRANSFORMATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SHORT SURVEY; SMOOTH MUSCLE FIBER; VASCULAR TUMOR;

ARTERIOSCLEROSIS; CELL DIVISION; DNA METHYLATION; GENE EXPRESSION REGULATION; MYOCYTES, SMOOTH MUSCLE; TRANSCRIPTION, GENETIC;

EID: 17344378331     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000092871.30563.41     Document Type: Short Survey

References (43)

1. Benditt EP, Benditt JM. Evidence for a monoclonal origin of human atherosclerotic plaques. Proc Natl Acad Sci U S A. 1973;70:1753-1756.
2. Penn A, Garte SJ, Warren L, Nesta D, Mindich B. Transforming gene in human atherosclerotic plaque DNA. Proc Natl Acad Sci U S A. 1986;83: 7951-7955.
3. Ylä-Herttuala S, Nikkari T, Hirvonen J, Laaksonen H, Möttönen M, Pesonen E, Raekallio J, Åkerblom HK. Biochemical composition of coronary arteries in Finnish children. Arteriosclerosis. 1986;6:230-236.
4. Haust MD. The natural history of human atherosclerotic lesions. In: Moore S, ed. Vascular Injury and Atherosclerosis. New York: Dekker; 1981:1-23.
5. Campbell GR, Chamley-Campbell JH. Smooth muscle phenotypic modulation: role in atherogenesis. Med Hypotheses. 1981;7:729-735.
6. Hiltunen MO, Turunen MP, Hakkinen TP, Rutanen J, Hedman M, Makinen K, Turunen AM, Aalto-Setala K, Yla-Herttuala S. DNA hypomethylation and methyltransferase expression in atherosclerotic lesions. Vasc Med. 2002;7:5-11.
7. Nikol S, Huehns TY, Hofling B. Molecular biology and post-angioplasty restenosis. Atherosclerosis. 1996;123:17-31.
8. Bestor TH, Tycko B. Creation of genomic methylation patterns. Nat Genet. 1996;12:363-367.
9. Ramsahoye BH, Davies CS, Mills KI. DNA methylation: biology and significance. Blood Rev. 1996;10:249-261.
10. Razin A, Shemer R. DNA methylation in early development. Hum Mol Genet. 1995;4:1751-1755.
11. Greger V, Passarge E, Hopping W, Messmer E, Horsthemke B. Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma. Hum Genet. 1989;83:155-158.
12. Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet. 2002;3:415-428.
13. Mayer W, Niveleau A, Walter J, Fundele R, Haaf T. Demethylation of the zygotic paternal genome. Nature. 2000;403:501-502.
14. Goelz SE, Vogelstein B, Hamilton SR, Feinberg AP. Hypomethylation of DNA from benign and malignant human colon neoplasms. Science. 1985; 228:187-190.
15. Gama-Sosa MA, Slagel VA, Trewyn RW, Oxenhandler R, Kuo KC, Gehrke CW, Ehrlich M. The 5-methylcytosine content of DNA from human tumors. Nucleic Acids Res. 1983;11:6883-6894.
16. Feinberg AP. Genomic imprinting and gene activation in cancer. Nat Genet. 1993;4:110-113.
17. Counts JL, Goodman JI. Alterations in DNA methylation may play a variety of roles in carcinogenesis. Cell. 1995;83:13-15.
18. Gaudet F, Hodgson JG, Eden A, Jackson-Grusby L, Dausman J, Gray JW, Leonhardt H, Jaenisch R. Induction of tumors in mice by genomic hypomethylation. Science. 2003;300:489-492.
19. Laird PW. Mouse models in DNA-methylation research. Curr Top Microbiol Immunol. 2000;249:119-134.
20. Ehrlich M. DNA methylation in cancer: too much, but also too little. Oncogene. 2002;21:5400-5413.
21. Laukkanen MO, Mannermaa S, Hiltunen MO, Aittomaki S, Airenne K, Janne J, Yla-Herttuala S. Local hypomethylation in atherosclerosis found in rabbit ec-sod gene. Arterioscler Thromb Vasc Biol. 1999;19: 2171-2178.
22. Post WS, Goldschmidt-Clermont PJ, Wilhide CC, Heldman AW, Sussman MS, Ouyang P, Milliken EE, Issa JP. Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system. Cardiovasc Res. 1999;43:985-991.
23. Dong C, Yoon W, Goldschmidt-Clermont PJ. DNA methylation and atherosclerosis. J Nutr. 2002;132:2406S-2409S.
24. Ying AK, Hassanain HH, Roos CM, Smiraglia DJ, Issa JJ, Michler RE, Caligiuri M, Plass C, Goldschmidt-Clermont PJ. Methylation of the estrogen receptor-alpha gene promoter is selectively increased in proliferating human aortic smooth muscle cells. Cardiovasc Res. 2000;46: 172-179.
25. Marin ML, Gordon RE, Veith FJ, Tulchin N, Panetta TF. Distribution of c-myc oncoprotein in healthy and atherosclerotic human carotid arteries. J Vasc Surg. 1993;18:170-176.
26. Wilcox JN, Smith KM, Williams LT, Schwartz SM, Gordon D. Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization. J Clin Invest. 1988;82:1134-1143.
27. Shi Y, Hutchinson HG, Hall DJ, Zalewski A. Downregulation of c-myc expression by antisense oligonucleotides inhibits proliferation of human smooth muscle cells. Circulation. 1993;88:1190-1195.
28. Haaf T. The effects of 5-azacytidine and 5-azadeoxycytidine on chromosome structure and function: implications for methylation-associated cellular processes. Pharmacol Ther. 1995;65:19-46.
29. Laird PW, Jaenisch R. DNA methylation and cancer. Hum Mol Genet. 1994;3:1487-1495.
30. Lee PJ, Washer LL, Law DJ, Boland CR, Horon IL, Feinberg AP. Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation. Proc Natl Acad Sci USA. 1996; 93:10366-10370.
31. Issa JP, Vertino PM, Wu J, Sazawal S, Celano P, Nelkin BD, Hamilton SR, Baylin SB. Increased cytosine DNA-methyltransferase activity during colon cancer progression. J Natl Cancer Inst. 1993;85:1235-1240.
32. Hartwell L. Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells. Cell. 1992;71:543-546.
33. Spandidos DA, Ergazaki M, Arvanitis D, Kiaris H. Microsatellite instability in human atherosclerotic plaques. Biochem Biophys Res Commun. 1996;220:137-140.
34. Hatzistamou J, Kiaris H, Ergazaki M, Spandidos DA. Loss of heterozygosity and microsatellite instability in human atherosclerotic plaques. Biochem Biophys Res Commun. 1996;225:186-190.
35. Watson JD. Origin of concatameric T7 DNA. Nat New Biol. 1972;239: 197-201.
36. Counter CM, Avilion AA, LeFeuvre CE, Stewart NG, Greider CW, Harley CB, Bacchetti S. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 1992;11:1921-1929.
37. de Bono DP. Olovnikov's clock: telomeres and vascular biology. Heart. 1998;80:110-111.
38. White GP, Watt PM, Holt BJ, Holt PG. Differential patterns of methylation of the IFN-gamma promoter at CpG and non-CpG sites underlie differences in IFN-gamma gene expression between human neonatal and adult CD45RO-T cells. J Immunol. 2002;168:2820-2827.
39. Lin XH, Guo C, Gu LJ, Deuel TF. Site-specific methylation inhibits transcriptional activity of platelet-derived growth factor A-chain promoter. J Biol Chem. 1993;268:17334-17340.
40. Sato N, Maehara N, Su GH, Goggins M. Effects of 5-aza-2′ -deoxycytidine on matrix metalloproteinase expression and pancreatic cancer cell invasiveness. J Natl Cancer Inst. 2003;95:327-330.
41. Wild A, Ramaswamy A, Langer P, Celik I, Fendrich V, Chaloupka B, Simon B, Bartsch DK. Frequent methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene in pancreatic endocrine tumors. J Clin Endocrinol Metab. 2003;88:1367-1373.
42. Tanaka Y, Fukudome K, Hayashi M, Takagi S, Yoshie O. Induction of ICAM-1 and LFA-3 by Tax1 of human T-cell leukemia virus type 1 and mechanism of down-regulation of ICAM-1 or LFA-1 in adult-T-cell-leukemia cell lines. Int J Cancer. 1995;60:554-561.
43. Schroeder M, Mass MJ. CpG methylation inactivates the transcriptional activity of the promoter of the human p53 tumor suppressor gene. Biochem Biophys Res Commun. 1997;235:403-406.