Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer

Clinical Cancer Research

Volumn 11, Issue 3, 2005, Pages 1028-1036

  Ogishima, Tatsuya ^a   Shiina, Hiroaki ^a,b   Breault, Julia E ^a   Tabatabai, Laura ^a   Bassett, William W ^a   Enokida, Hideki ^a   Li, Long Cheng ^a   Kawakami, Toshifumi ^a   Urakami, Shinji ^a,b   Ribeiro Filho, Leopoldo A ^a   Terashima, Masaharu ^b   Fujime, Makoto ^c   Igawa, Mikio ^b   Dahiya, Rajvir ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b SHIMANE UNIVERSITY   (Japan)

^c JUNTENDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EARLY GROWTH RESPONSE FACTOR 1; HEPARANASE; MESSENGER RNA; TRANSCRIPTION FACTOR SP1;

ADULT; AGED; ARTICLE; CELL CULTURE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; MALE; METHYLATION; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; PROSTATE HYPERTROPHY; PROTEIN EXPRESSION; PROTEIN MOTIF; TRANSCRIPTION INITIATION; UPREGULATION;

AGED; AGED, 80 AND OVER; AZACITIDINE; BASE SEQUENCE; CELL LINE, TUMOR; CPG ISLANDS; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 1; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCURONIDASE; HUMANS; IMMEDIATE-EARLY PROTEINS; MALE; MIDDLE AGED; PROMOTER REGIONS (GENETICS); PROSTATIC HYPERPLASIA; PROSTATIC NEOPLASMS; REGRESSION ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 19944432186     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Sato N, Maehara N, Su GH, Goggins M. Effects of 5-aza-2′- deoxycytidine on matrix metalloproteinase expression and pancreatic cancer cell invasiveness. J Natl Cancer Inst 2003;95:327-30.
2. Guo Y, Pakneshan P, Gladu J, Slack A, Szyf M, Rabbani SA. Regulation of DNA methylation in human breast cancer. Effect on the urokinase-type plasminogen activator gene production and tumor invasion. J Biol Chem 2002;277:41571-9.
3. Vlodavsky I, Goldshmidt O, Zcharia E, et al. Molecular properties and involvement of heparanase in cancer progression and normal development. Biochimie 2001;83:831-9.
4. Vlodavsky I, Friedmann Y. Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis. J Clin Invest 2001;108:341-7.
5. Mikami S, Ohashi K, Usui Y, et al. Loss of syndecan-1 and increased expression of heparanase in invasive esophageal carcinomas. Jpn J Cancer Res 2001;92:1062-73.
6. Rohloff J, Zinke J, Schoppmeyer K, et al. Heparanase expression is a prognostic indicator for postoperative survival in pancreatic adenocarcinoma. Br J Cancer 2002;86:1270-5.
7. Marchetti D, McQuillan DJ, Spohn WC, Carson DD, Nicolson GL. Neurotrophin stimulation of human melanoma cell invasion: selected enhancement of heparanase activity and heparanase degradation of specific heparan sulfate subpopulations. Cancer Res 1996;56:2856-63.
8. Gohji K, Okamoto M, Kitazawa S, et al. Heparanase protein and gene expression in bladder cancer. J Urol 2001;166:1286-90.
9. Gohji K, Hirano H, Okamoto M, et al. Expression of three extracellular matrix degradative enzymes in bladder cancer. Int J Cancer 2001;95:295-301.
10. Kosir MA, Quinn CC, Zukowski KL, et al. Human prostate carcinoma cells produce extracellular heparanase. J Surg Res 1997;67:98-105.
11. Kosir MA, Wang W, Zukowski KL, et al. Degradation of basement membrane by prostate tumor heparanase. J Surg Res 1999;81:42-7.
12. Kelly T, Miao HQ, Yang Y, et al. High heparanase activity in multiple myeloma is associated with elevated microvessel density. Cancer Res 2003;63:8749-56.
13. Takaoka M, Naomoto Y, Ohkawa T, et al. Heparanase expression correlates with invasion and poor prognosis in gastric cancers. Lab Invest 2003;83:613-22.
14. Jones PA, Takai D. The role of DNA methylation in mammalian epigenetics. Science 2001;293:1068-70.
15. Gonzalez-Zulueta M, Bender CM, Yang AS, et al. Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res 1995;55:4531-5.
16. Herman JG, Merlo A, Mao L, et al. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 1995;55:4525-30.
17. Bearzatto A, Szadkowski M, Macpherson P, Jiricny J, Karran P. Epigenetic regulation of the MGMT and hMSH6 DNA repair genes in cells resistant to methylating agents. Cancer Res 2000;60:3262-70.
18. Jang SJ, Soria JC, Wang L, et al. Activation of melanoma antigen tumor antigens occurs early in lung carcinogenesis. Cancer Res 2001;61:7959-63.
19. Rosty C, Ueki T, Argani P, et al. Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation. Am J Pathol 2002;160:45-50.
20. Sato N, Maitra A, Fukushima N, et al. Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma. Cancer Res 2003;63:4158-66.
21. De Mestre AM, Khachigian LM, Santiago FS, Staykova MA, Hulett MD. Regulation of inducible heparanase gene transcription in activated T cells by early growth response 1. J Biol Chem 2003;278:50377-85.
22. Abdulkadir SA, Qu Z, Garabedian E, et al. Impaired prostate tumorigenesis in Egrl-deficient mice. Nat Med 2001;7:101-7.
23. The Japanese Urological Association, the Japanese Society of Pathology. General rules for clinical and pathological studies on prostate cancer. 2nd ed. Tokyo, Japan: Kanahara-Shuppan Co.;1992.
24. Shigeno K, Igawa M, Shiina H, Wada H, Yoneda T. The role of colour Doppler ultrasonography in detecting prostate cancer. BJU Int 2003;86:229-33.
25. Dahiya R, Lee C, McCarville J, Hu W, Kaur G, Deng G. High frequency of genetic instability of microsatellites in human prostatic adenocarcinoma. Int J Cancer 1997;72:762-7.
26. Jiang P, Kumar A, Parrillo SE, et al. Cloning and characterization of the human heparanase-1 (HPR1) gene promoter: role of GA-binding protein and Sp1 in regulating HPR1 basal promoter activity. J Biol Chem 2002;277:8989-98.
27. Li LC, Dahiya R. MethPrimer: designing primers for methylation PCRs. Bioinformatics 2002;18:1427-31.
28. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A 1996;93:9821-6.
29. Enokida H, Shiina H, Igawa M, et al. CpG hypermethylation of MDR1 gene contributes to the pathogenesis and progression of human prostate cancer. Cancer Res 2004;64:5956-62.
30. Umbricht CB, Evron E, Gabrielson E, Ferguson A, Marks J, Sukumar S. Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer. Oncogene 2001;20:3348-53.
31. Vlodavsky I, Michaeli RI, Bar-Ner M, et al. Involvement of heparanase in tumor metastasis and angiogenesis. Isr J Med Sci 1998;24:464-70.
32. Hulett MD, Freeman C, Hamdorf BJ, Baker RT, Harris MJ, Parish CR. Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis. Nat Med 1999;5:803-9.
33. Vlodavsky I, Friedmann Y, Elkin M, et al. Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis. Nat Med 1999;5:793-802.
34. Stadlmann S, Moser PL, Pollheimer J, et al. Heparanase-1 gene expression in normal, hyper plastic and neoplastic prostatic tissue. Eur J Cancer 2003;39:2229-33.
35. Shteper PJ, Zcharia E, Ashhab Y, Peretz T, Vlodavsky I, Ben-Yehuda D. Role of promoter methylation in regulation of the mammalian heparanase gene. Oncogene 2003;22:7737-49.
36. Lu WC, Liu YN, Kang BB, Chen JH. Trans-activation of heparanase promoter by ETS transcription factors. Oncogene 2003;22:919-23.
37. Adamson E, de Belle I, Mittal S, et al. Egr1 signaling in prostate cancer. Cancer Biol Ther 2003;2:617-22.
38. Yang SZ, Abdulkadir SA. Early growth response 1 modulate androgen receptor signaling in prostate carcinoma cells. J Biol Chem 2003;278:39906-11.
39. Ohtani-Fujita N, Fujita T, Aoike A, et al. CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene. Oncogene 1993;8:1063-7.
40. Cip1 promoter. Mol Cell Biol 2003;23:4056-65.