-
1
-
-
0023216891
-
CpG islands in vertebrate genomes
-
Gardiner-Garden M, Frommer M: CpG islands in vertebrate genomes. J. Mol. Biol. 196(2), 261-282 (1987).
-
(1987)
J. Mol. Biol
, vol.196
, Issue.2
, pp. 261-282
-
-
Gardiner-Garden, M.1
Frommer, M.2
-
2
-
-
0034305821
-
DNA methylation in health and disease
-
Robertson KD, Wolffe AP: DNA methylation in health and disease. Nat. Rev. Genet. 1(1), 11-19 (2000).
-
(2000)
Nat. Rev. Genet
, vol.1
, Issue.1
, pp. 11-19
-
-
Robertson, K.D.1
Wolffe, A.P.2
-
3
-
-
23844451055
-
Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer
-
Tokizane T, Shlina H, Igawa M et al.: Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer. Clin. Cancer Res. 11(16), 5793-5801 (2005).
-
(2005)
Clin. Cancer Res
, vol.11
, Issue.16
, pp. 5793-5801
-
-
Tokizane, T.1
Shlina, H.2
Igawa, M.3
-
4
-
-
0024673303
-
CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation
-
Iguchi-Ariga SM, Schaffner W: CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation. Genes Dev. 3(5), 612-619 (1989).
-
(1989)
Genes Dev
, vol.3
, Issue.5
, pp. 612-619
-
-
Iguchi-Ariga, S.M.1
Schaffner, W.2
-
5
-
-
0027535235
-
Effects of DNA methylation on DNA-binding proteins and gene expression
-
Tate PH, Bird AP: Effects of DNA methylation on DNA-binding proteins and gene expression. Curr. Opin. Genet. Dev. 3(2), 226-231 (1993).
-
(1993)
Curr. Opin. Genet. Dev
, vol.3
, Issue.2
, pp. 226-231
-
-
Tate, P.H.1
Bird, A.P.2
-
6
-
-
0031104930
-
DNA methylation directs a time-dependent repression of transcription initiation
-
Kass SU, Landsberger N, Wolffe AP: DNA methylation directs a time-dependent repression of transcription initiation. Curr. Biol. 7(3), 157-165 (1997).
-
(1997)
Curr. Biol
, vol.7
, Issue.3
, pp. 157-165
-
-
Kass, S.U.1
Landsberger, N.2
Wolffe, A.P.3
-
7
-
-
0242300612
-
DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation
-
Martinowich K, Hattori D, Wu H et al.: DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science 302(5646), 890-893 (2003).
-
(2003)
Science
, vol.302
, Issue.5646
, pp. 890-893
-
-
Martinowich, K.1
Hattori, D.2
Wu, H.3
-
8
-
-
0038243168
-
The role of DNA methylation in setting up chromatin structure during development
-
Hashimshony T, Zhang J, Keshet I, Bustin M, Cedar H: The role of DNA methylation in setting up chromatin structure during development. Nat. Genet. 34(2), 187-192 (2003).
-
(2003)
Nat. Genet
, vol.34
, Issue.2
, pp. 187-192
-
-
Hashimshony, T.1
Zhang, J.2
Keshet, I.3
Bustin, M.4
Cedar, H.5
-
9
-
-
0035839057
-
The role of DNA methylation in mammalian epigenetics
-
Jones PA, Takai D: The role of DNA methylation in mammalian epigenetics. Science 293(5532), 1068-1070 (2001).
-
(2001)
Science
, vol.293
, Issue.5532
, pp. 1068-1070
-
-
Jones, P.A.1
Takai, D.2
-
10
-
-
24744453331
-
Methyl-CpG-binding proteins in cancer: Blaming the DNA methylation messenger
-
Ballestar E, Esteller M: Methyl-CpG-binding proteins in cancer: blaming the DNA methylation messenger. Biochem. Cell Biol. 83(3), 374-384 (2005).
-
(2005)
Biochem. Cell Biol
, vol.83
, Issue.3
, pp. 374-384
-
-
Ballestar, E.1
Esteller, M.2
-
11
-
-
0032574977
-
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
-
Nan X, Ng HH, Johnson CA et al.: Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393(6683), 386-389 (1998).
-
(1998)
Nature
, vol.393
, Issue.6683
, pp. 386-389
-
-
Nan, X.1
Ng, H.H.2
Johnson, C.A.3
-
12
-
-
12744271900
-
Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer
-
Frigola J, Sole X, Paz MF et al.: Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer. Hum. Mol. Genet. 14(2), 319-326 (2005).
-
(2005)
Hum. Mol. Genet
, vol.14
, Issue.2
, pp. 319-326
-
-
Frigola, J.1
Sole, X.2
Paz, M.F.3
-
13
-
-
0037068353
-
DNA methylation in cancer: Too much, but also too little
-
Ehrlich M: DNA methylation in cancer: too much, but also too little. Oncogene 21(35), 5400-5413 (2002).
-
(2002)
Oncogene
, vol.21
, Issue.35
, pp. 5400-5413
-
-
Ehrlich, M.1
-
14
-
-
33749037187
-
chromosomal instability correlates with genome-wide dna demethylation in human primary colorectal cancers
-
Rodriguez J, Frigola J, Vendrell E et al.: chromosomal instability correlates with genome-wide dna demethylation in human primary colorectal cancers. Cancer Res. 66(17), 8462-9468 (2006).
-
(2006)
Cancer Res
, vol.66
, Issue.17
, pp. 8462-9468
-
-
Rodriguez, J.1
Frigola, J.2
Vendrell, E.3
-
15
-
-
0037379199
-
The relationship between hypomethylation and CpG island methylation in colorectal neoplasia
-
Bariol C, Suter C, Cheong K et al.: The relationship between hypomethylation and CpG island methylation in colorectal neoplasia. Am. J. Pathol. 162(4), 1361-1371 (2003).
-
(2003)
Am. J. Pathol
, vol.162
, Issue.4
, pp. 1361-1371
-
-
Bariol, C.1
Suter, C.2
Cheong, K.3
-
16
-
-
22544437866
-
Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: Aberrant genomic DNA methylation and K-ras oncogene activation
-
Benbrahim-Tallaa L, Waterland RA, Styblo M, Achanzar WE, Webber MM, Waalkes MP: Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation. Toxicol. Appl. Pharmacol. 206(3), 288-298 (2005).
-
(2005)
Toxicol. Appl. Pharmacol
, vol.206
, Issue.3
, pp. 288-298
-
-
Benbrahim-Tallaa, L.1
Waterland, R.A.2
Styblo, M.3
Achanzar, W.E.4
Webber, M.M.5
Waalkes, M.P.6
-
17
-
-
16844384464
-
Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays
-
Nishigaki M, Aoyagi K, Danjoh I et al.: Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays. Cancer Res. 65(6), 2115-2124 (2005).
-
(2005)
Cancer Res
, vol.65
, Issue.6
, pp. 2115-2124
-
-
Nishigaki, M.1
Aoyagi, K.2
Danjoh, I.3
-
18
-
-
33646372471
-
BRAF mutation, CpG island methylator phenotype and microsatellite instability occur more frequently and concordantly in mucinous than non-mucinous colorectal cancer
-
Tanaka H, Deng G, Matsuzaki K et al.: BRAF mutation, CpG island methylator phenotype and microsatellite instability occur more frequently and concordantly in mucinous than non-mucinous colorectal cancer. Int. J. Cancer. 118(11), 2765-2771 (2006).
-
(2006)
Int. J. Cancer
, vol.118
, Issue.11
, pp. 2765-2771
-
-
Tanaka, H.1
Deng, G.2
Matsuzaki, K.3
-
19
-
-
18344390653
-
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
-
Rhee I, Bachman KE, Park BH et al.: DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 416(6880), 552-556 (2002).
-
(2002)
Nature
, vol.416
, Issue.6880
, pp. 552-556
-
-
Rhee, I.1
Bachman, K.E.2
Park, B.H.3
-
20
-
-
16444370423
-
Epigenetic inactivation of the human sprouty2 (hSPRY2) homologue in prostate cancer
-
McKie AB, Douglas DA, Olijslagers, S et al.: Epigenetic inactivation of the human sprouty2 (hSPRY2) homologue in prostate cancer. Oncogene 24(13), 2166-2174 (2005).
-
(2005)
Oncogene
, vol.24
, Issue.13
, pp. 2166-2174
-
-
McKie, A.B.1
Douglas, D.A.2
Olijslagers, S.3
-
21
-
-
31544473786
-
Promoter hypermethylation of the potential tumor suppressor DAL-1/4.1B gene in renal clear cell carcinoma
-
Yamada D, Kikuchi S, Williams YN et al.: Promoter hypermethylation of the potential tumor suppressor DAL-1/4.1B gene in renal clear cell carcinoma. Int. J. Cancer. 118(4), 916-923 (2006).
-
(2006)
Int. J. Cancer
, vol.118
, Issue.4
, pp. 916-923
-
-
Yamada, D.1
Kikuchi, S.2
Williams, Y.N.3
-
22
-
-
0029011539
-
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
-
Merlo A, Herman JG, Mao L et al.: 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat. Med. 1(7), 686-692 (1995).
-
(1995)
Nat. Med
, vol.1
, Issue.7
, pp. 686-692
-
-
Merlo, A.1
Herman, J.G.2
Mao, L.3
-
23
-
-
0031771497
-
The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53
-
Robertson KD, Jones PA: The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53. Mol. Cell Biol. 18(11), 6457-6473 (1998).
-
(1998)
Mol. Cell Biol
, vol.18
, Issue.11
, pp. 6457-6473
-
-
Robertson, K.D.1
Jones, P.A.2
-
24
-
-
0041779528
-
Genetic unmasking of epigenetically silenced tumor suppressor genes in colon cancer cells deficienf in DNA methyltransferases
-
Paz MF, Wei S, Cigudosa JC et al.: Genetic unmasking of epigenetically silenced tumor suppressor genes in colon cancer cells deficienf in DNA methyltransferases. Hum. Mol. Genet 12(17), 2209-2219 (2003).
-
(2003)
Hum. Mol. Genet
, vol.12
, Issue.17
, pp. 2209-2219
-
-
Paz, M.F.1
Wei, S.2
Cigudosa, J.C.3
-
25
-
-
0035360824
-
Loss of expression and aberrant methylation of the CDH13 (H-cadherin) gene in breast and lung carcinomas
-
Toyooka KO, Toyooka S, Virmani AK et al.: Loss of expression and aberrant methylation of the CDH13 (H-cadherin) gene in breast and lung carcinomas. Cancer Res. 61(11), 4556-4560 (2001).
-
(2001)
Cancer Res
, vol.61
, Issue.11
, pp. 4556-4560
-
-
Toyooka, K.O.1
Toyooka, S.2
Virmani, A.K.3
-
26
-
-
13844320649
-
Aberrant DNA methylation as a cancer-inducing mechanism
-
Esteller M: Aberrant DNA methylation as a cancer-inducing mechanism. Annu. Rev. Pharmacol. Toxicol. 45 629-656 (2005).
-
(2005)
Annu. Rev. Pharmacol. Toxicol
, vol.45
, pp. 629-656
-
-
Esteller, M.1
-
27
-
-
3543121233
-
CpG methylation of the mouse CYP1A2 promoter
-
Jin B, Park DW, Nam KW, Oh GT, Lee YS, Ryu DY: CpG methylation of the mouse CYP1A2 promoter. Toxicol. Lett. 152(1), 11-18 (2004).
-
(2004)
Toxicol. Lett
, vol.152
, Issue.1
, pp. 11-18
-
-
Jin, B.1
Park, D.W.2
Nam, K.W.3
Oh, G.T.4
Lee, Y.S.5
Ryu, D.Y.6
-
28
-
-
0029938610
-
Developmental expression of CYP2E1 in the human liver. Hypermethylation control of gene expression during the neonatal period
-
Vieira I, Sonnier M, Cresteil T: Developmental expression of CYP2E1 in the human liver. Hypermethylation control of gene expression during the neonatal period. Eur. J. Biochem. 238(2), 476-483 (1996).
-
(1996)
Eur. J. Biochem
, vol.238
, Issue.2
, pp. 476-483
-
-
Vieira, I.1
Sonnier, M.2
Cresteil, T.3
-
29
-
-
0035816343
-
Specific site methylation in the 5′-flanking region of CYP1A2 interindividual differences in human livers
-
Hammons GJ, Yan-Sanders Y, Jin B, Blann E, Kadlubar FF, Lyn-Cook BD: Specific site methylation in the 5′-flanking region of CYP1A2 interindividual differences in human livers. Life Sci. 69(7), 839-845 (2001).
-
(2001)
Life Sci
, vol.69
, Issue.7
, pp. 839-845
-
-
Hammons, G.J.1
Yan-Sanders, Y.2
Jin, B.3
Blann, E.4
Kadlubar, F.F.5
Lyn-Cook, B.D.6
-
30
-
-
2442679411
-
Expression of cytochrome P450 in tumor tissues and its association with cancer development
-
Oyama T, Kagawa N, Kunugita N et al.: Expression of cytochrome P450 in tumor tissues and its association with cancer development. Front. Biosci. 9 1967-1976 (2004).
-
(2004)
Front. Biosci
, vol.9
, pp. 1967-1976
-
-
Oyama, T.1
Kagawa, N.2
Kunugita, N.3
-
31
-
-
0030812372
-
Tumor-specific expression of cytochrome P450 CYP1B1
-
Murray GI, Taylor MC, McFadyen MC et al.: Tumor-specific expression of cytochrome P450 CYP1B1. Cancer Res. 57(14), 3026-3031 (1997).
-
(1997)
Cancer Res
, vol.57
, Issue.14
, pp. 3026-3031
-
-
Murray, G.I.1
Taylor, M.C.2
McFadyen, M.C.3
-
32
-
-
1942532186
-
Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma
-
Rieger MA, Ebner R, Bell DR et al.: Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma. Cancer Res. 64(7), 2357-2364 (2004).
-
(2004)
Cancer Res
, vol.64
, Issue.7
, pp. 2357-2364
-
-
Rieger, M.A.1
Ebner, R.2
Bell, D.R.3
-
33
-
-
21144459060
-
Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors
-
Jiang JG, Chen CL, Card JW et al.: Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors. Cancer Res. 65(11), 4707-4715 (2005).
-
(2005)
Cancer Res
, vol.65
, Issue.11
, pp. 4707-4715
-
-
Jiang, J.G.1
Chen, C.L.2
Card, J.W.3
-
34
-
-
31444443707
-
Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1
-
Karlgren M, Gomez A, Stark K et al.: Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1. Biochem. Biophys. Res. Commun. 341(2), 451-458 (2006).
-
(2006)
Biochem. Biophys. Res. Commun
, vol.341
, Issue.2
, pp. 451-458
-
-
Karlgren, M.1
Gomez, A.2
Stark, K.3
-
35
-
-
1642538952
-
Different structural requirements of the ligand binding domain of the aryl hydrocarbon receptor for high- and low-affinity ligand binding and receptor activation
-
Backlund M, Ingelman-Sundberg M: Different structural requirements of the ligand binding domain of the aryl hydrocarbon receptor for high- and low-affinity ligand binding and receptor activation. Mol. Pharmacol. 65(2), 416-425 (2004).
-
(2004)
Mol. Pharmacol
, vol.65
, Issue.2
, pp. 416-425
-
-
Backlund, M.1
Ingelman-Sundberg, M.2
-
36
-
-
0034816629
-
Identification of a single nucleotide polymorphism in the TATA box of the CYP2A6 gene: Impairment of its promoter activity
-
Pitarque M, von Richter O, Oke B, Berkkan H, Oscarson M, Ingelman-Sundberg M: Identification of a single nucleotide polymorphism in the TATA box of the CYP2A6 gene: impairment of its promoter activity. Biochem. Biophys. Res. Commun. 284(2), 455-460 (2001).
-
(2001)
Biochem. Biophys. Res. Commun
, vol.284
, Issue.2
, pp. 455-460
-
-
Pitarque, M.1
von Richter, O.2
Oke, B.3
Berkkan, H.4
Oscarson, M.5
Ingelman-Sundberg, M.6
-
37
-
-
1242272848
-
Characterization and time distribution of a novel human cytochrome P450-CYP2U1
-
Karlgren M, Backlund M, Johansson I, Oscarson M, Ingelman-Sundberg M: Characterization and time distribution of a novel human cytochrome P450-CYP2U1. Biochem. Biophys. Res. Commun. 315(3), 679-685 (2004).
-
(2004)
Biochem. Biophys. Res. Commun
, vol.315
, Issue.3
, pp. 679-685
-
-
Karlgren, M.1
Backlund, M.2
Johansson, I.3
Oscarson, M.4
Ingelman-Sundberg, M.5
-
39
-
-
33745137491
-
Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1
-
Wu Z, Sohl C, Shimada T, Guengerich F: Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1. Mol. Pharmacol. 69(6), 2007-2014 (2006).
-
(2006)
Mol. Pharmacol
, vol.69
, Issue.6
, pp. 2007-2014
-
-
Wu, Z.1
Sohl, C.2
Shimada, T.3
Guengerich, F.4
-
40
-
-
33645116164
-
Cytochrome P450 pharmacogenetics and cancel
-
Rodriguez-Antona C, Ingelman-Sundberg M: Cytochrome P450 pharmacogenetics and cancel. Oncogene 25(11), 1679-1691 (2006).
-
(2006)
Oncogene
, vol.25
, Issue.11
, pp. 1679-1691
-
-
Rodriguez-Antona, C.1
Ingelman-Sundberg, M.2
-
41
-
-
0013797617
-
Specific carcinoembryonic antigens of the human digestive system
-
Gold P, Freedman SO: Specific carcinoembryonic antigens of the human digestive system. J. Exp. Med. 122(3), 467-481 (1965).
-
(1965)
J. Exp. Med
, vol.122
, Issue.3
, pp. 467-481
-
-
Gold, P.1
Freedman, S.O.2
-
42
-
-
14944385553
-
Global cancer statistics, 2002
-
Parkin DM, Bray F, Ferlay J, Pisani P: Global cancer statistics, 2002. CA Cancer J. Clin. 55(2), 74-108 (2005).
-
(2005)
CA Cancer J. Clin
, vol.55
, Issue.2
, pp. 74-108
-
-
Parkin, D.M.1
Bray, F.2
Ferlay, J.3
Pisani, P.4
-
43
-
-
18844370604
-
Cytochrome P450 profile of colorectal cancer: Identification of markers of prognosis
-
Kumarakulasingham M, Rooney PH, Dundas SR et al.: Cytochrome P450 profile of colorectal cancer: identification of markers of prognosis. Clin. Cancer Res. 11(10), 3758-3765.
-
Clin. Cancer Res
, vol.11
, Issue.10
, pp. 3758-3765
-
-
Kumarakulasingham, M.1
Rooney, P.H.2
Dundas, S.R.3
|