The chemical genomic portrait of yeast: Uncovering a phenotype for all genes

Science

Volumn 320, Issue 5874, 2008, Pages 362-365

  Hillenmeyer, Maureen E ^a,b   Fung, Eula ^a   Wildenhain, Jan ^c,g   Pierce, Sarah E ^a,b   Hoon, Shawn ^a,b   Lee, William ^a,b   Proctor, Michael ^a   St Onge, Robert P ^a   Tyers, Mike ^c,d,g   Koller, Daphne ^e   Altman, Russ B ^b   Davis, Ronald W ^b   Nislow, Corey ^d,f   Giaever, Guri ^d,f  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

^c MOUNT SINAI HOSPITAL   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e Stanford University   (United States)

^f UNIVERSITY OF TORONTO   (Canada)

^g UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALVERINE CITRATE; ARSENATE SODIUM; CHAPERONIN; DYCLONINE; FENPROPIMORPH; PARAQUAT;

ENVIRONMENTAL STRESS; GENE; GENOMICS; GENOTYPE; GROWTH; PHENOTYPE; YEAST;

ARTICLE; CHEMICAL STRESS; ENVIRONMENTAL STRESS; FUNGAL GENETICS; FUNGUS GROWTH; GENE DELETION; GENE INTERACTION; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; MULTIDRUG RESISTANCE; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL;

CULTURE MEDIA; DRUG RESISTANCE, MULTIPLE, FUNGAL; GENE DELETION; GENES, ESSENTIAL; GENES, FUNGAL; GENES, MDR; GENOME, FUNGAL; GENOMICS; HETEROZYGOTE; HOMOZYGOTE; METABOLIC NETWORKS AND PATHWAYS; MULTIGENE FAMILY; PHENOTYPE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES;

EID: 42349100173     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1150021     Document Type: Article

References (31)

1. S. L. Schreiber, Nat. Chem. Biol. 1, 64 (2005).
2. E. A. Winzeler et al., Science 285, 901 (1999).
3. G. Giaever et al., Nature 418, 387 (2002).
4. G. Giaever et al., Proc. Natl. Acad. Sci. U.S.A. 101, 793 (2004).
5. Z. Gu et al., Nature 421, 63 (2003).
6. D. Deutscher, I. Meilijson, M. Kupiec, E. Ruppin, Nat. Genet. 38, 993 (2006).
7. B. Papp, C. Pal, L. D. Hurst, Nature 429, 661 (2004).
8. Materials and methods are available as supporting material on Science Online and at http://chemogenomics.stanford.edu/supplements/ global.
9. A. M. Deutschbauer et al., Genetics 169, 1915 (2005).
10. www.yeastgenome.org/.
11. L. David et al., Proc. Natl. Acad. Sci. U.S.A. 103, 5320 (2006).
12. M. Kellis, B. W. Birren, E. S. Lander, Nature 428, 617 (2004).
13. A. B. Parsons et al., Nat. Biotechnol. 22, 62 (2004).
14. A. B. Parsons et al., Cell 126, 611 (2006).
15. R. C. Fry, T. J. Begley, L. D. Samson, Annu. Rev. Microbiol. 59, 357 (2005).
16. H. Jungwirth, K. Kuchler, FEBS Lett. 580, 1131 (2006).
17. E. I. Boyle et al., Bioinformatics 20, 3710 (2004).
18. D. J. Katzmann, G. Odorizzi, S. D. Emr, Nat. Rev. Mol. Cell Biol. 3, 893 (2002).
19. A. M. Dudley, D. M. Janse, A. Tanay, R. Shamir, G. McDonald Church, Mol. Systems Biol. 1 (2005); www.nature.com/msb/journal/v1/n1/ full/msb4100004.html.
20. X. J. Liang, S. Mukherjee, D. W. Shen, F. R. Maxfield, M. M. Gottesman, Cancer Res. 66, 2346 (2006).
21. A. Rajagopal, S. M. Simon, Mol. Biol. Cell 14, 3389 (2003).
22. R. D. Bagshaw, D. J. Mahuran, J. W. Callahan, Mol. Cell. Proteomics 4, 133 (2005).
23. Y. Gong, M. Duvvuri, J. P. Krise, J. Biol. Chem. 278, 50234 (2003).
24. R. Egner, K. Kuchler, FEBS Lett. 378, 177 (1996).
25. J. Ferte, Eur. J. Biochem. 267, 277 (2000).
26. G. Chua, M. D. Robinson, Q. Morris, T. R. Hughes, Curr. Opin. Microbiol. 7, 638 (2004).
27. M. Schrader, H. D. Fahimi, Histochem. Cell Biol. 122, 383 (2004).
28. A. H. Y. Tong et al., Science 303, 808 (2004).
29. J. R. Sharom, D. S. Bellows, M. Tyers, Curr. Opin. Chem. Biol. 8, 81 (2004).
30. P. E. Blower et al., Pharmacogenomics J. 2, 259 (2002).
31. We thank J. Rine, C. Boone, K. Kuchler, E. Ericson, and members of the Giaever and Nislow labs for comments. Supported by grants from the National Human Genome Research Institute (to R.W.D, C.N., and G.G.), the NSF (to M.E.H. and D.K.), the Canadian Institute for Health Research (no. 81340 to G.G. and C.N.), and the Canadian Research Chair in Genomics (to G.G.).