The Calcium-Sensing Receptor

Seldin and Giebisch's The Kidney

Volumn , Issue , 2008, Pages 1785-1802

  Hebert, Steven C ^a   Riccardi, Daniela ^a   Geibel, John P ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 67650119128     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012088488-9.50066-8     Document Type: Chapter

References (312)

1. Abdullah H.I., Pedraza P.L., Hao S., Rodland K.D., McGiff J.C., Ferreri N.R. NFAT regulates calcium-sensing receptor-mediated TNF production. Am J Physiol Renal Physiol 2006, 290:F1110-F1117.
2. Adams G.B., Chabner K.T., Alley I.R., Olson D.P., Szczepiorkowski Z.M., Poznansky M.C., Kos C.H., Pollak M.R., Brown E.M., Scadden D.T. Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature 2006, 439:599-603.
3. Amann K., Neususs R., Ritz E., Irzyniec T., Wiest G., Mall G. Changes of vascular architecture independent of blood pressure in experimental uremia. Am J Hypertens 1995, 8:409-417.
4. Amann K., Tornig J., Flechtenmacher C., Nabokov A., Mall G., Ritz E. Blood-pressureindependent wall thickening of intramyocardial arterioles in experimental uraemia: evidence for a permissive action of PTH. Nephrol Dial Transplant 1995, 10:2043-2048.
5. - cotransport in medullary thick ascending limb: control by PKA, PKC, and 20-HETE. Am J Physiol Cell Physiol 1997, 271:C455-C463.
6. Antonsen J.E., Sherrard D.J., Andress D.L. A calcimimetic agent acutely suppresses parathyroid hormone levels in patients with chronic renal failure. Kidney Int 1998, 53:223-227..
7. Arthur J.M., Collinsworth G.P., Gettys T.W., Quarles L.D., Raymond J.R. Specific coupling of cation-sensing receptor to G protein α-subunits in MDCK cells. Am J Physiol 1997, 273:F129-F135.
8. Deleted in proof.
9. Arthur J.M., Lawrence M.S., Payne C.R., Rane M.J., McLeish K.R. The calcium-sensing receptor stimulates JNK in MDCK cells. Biochem Biophys Res Commun 2000, 275:538-541.
10. Deleted in proof.
11. Awata H., Huang C., Handlogten M.E., Miller R.T. Interaction of the calcium-sensing receptor and filamin, a potential scaffolding protein. J Biol Chem 2001, 276:34871-34879.
12. Ba J., Friedman P.A. Calcium-sensing receptor regulation of renal mineral ion transport. Cell Calcium 2004, 35:229-237.
13. o-sensing receptor. J Biol Chem 1996, 271:19537-19545.
14. Bai M., Trivedi S., Brown E.M. Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 cells. J Biol Chem 1998, 273:23605-23610.
15. Bai M., Trivedi S., Kifor O., Quinn S.J., Brown E.M. Intermolecular interactions between dimeric calcium-sensing receptor monomers are important for its normal function. Proc Natl Acad Sci U S A 1999, 96:2834-2839.
16. Bailly C. Transducing pathways involved in the control of NaCl reabsorption in the thick ascending limb of Henle's loop. Kidney Int Suppl 1998, 65:S29-S35.
17. 2+ uptake in mouse distal convoluted tubule cells. Am J Physiol 1998, 275:F353-F360.
18. 2+-sensing in mouse distal convoluted tubule cells. Kidney Int 1998, 53:583-592.
19. 3, calcium and phosphorus. Mol Cell Endocrinol 1990, 72:23-31.
20. Bas S., guilera-Tejero E., Bas A., Estepa J.C., Lopez I., Madueno J.A., Rodriguez M. The influence of the progression of secondary hyperparathyroidism on the set point of the parathyroid hormone-calcium curve. J Endocrinol 2005, 184:241-247.
21. Biner H.L., Arpin-Bott M.P., Loffing J., Wang X., Knepper M., Hebert S.C., Kaissling B. Human cortical distal nephron: distribution of electrolyte and water transport pathways. J Am Soc Nephrol 2002, 13:836-847.
22. Blacher J., Guerin A.P., Pannier B., Marchais S.J., London G.M. Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease. Hypertension 2001, 38:938-942.
23. Blankenship K.A., Williams J.J., Lawrence M.S., McLeish K.R., Dean W.L., Arthur J.M. The calcium-sensing receptor regulates calcium absorption in MDCK cells by inhibition of PMCA. Am J Physiol Renal Physiol 2001, 280:F815-F822.
24. Block G.A. The impact of calcimimetics on mineral metabolism and secondary hyperparathyroidism in end-stage renal disease. Kidney Int 2003, S131-S136. (Suppl).
25. Block G.A., Hulbert-Shearon T.E., Levin N.W., Port F.K. Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: a national study. Am J Kidney Dis 1998, 31:607-617.
26. Block G.A., Martin K.J., de Francisco A.L., Turner S.A., Avram M.M., Suranyi M.G., Hercz G., Cunningham J., bu-Alfa A.K., Messa P., Coyne D.W., Locatelli F., Cohen R.M., Evenepoel P., Moe S.M., Fournier A., Braun J., McCary L.C., Zani V.J., Olson K.A., Drueke T.B., Goodman W.G. Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis. N Engl J Med 2004, 350:1516-1525.
27. Bogin E., Levi J., Harary I., Massry S.G. Effects of parathyroid hormone on oxidative phosphorylation of heart mitochondria. Miner Electrolyte Metab 1982, 7:151-156.
28. Bogin E., Massry S.G., Harary I. Effect of parathyroid hormone on rat heart cells. J Clin Invest 1981, 67:1215-1227.
29. Bourdeau J.E., Burg M.B. Voltage dependence of calcium transport in the thick ascending limb of Henle's loop. Am J Physiol (Renal Fluid Electrolyte Physiol) 1979, 236:F357-F364.
30. Brauner-Osborne H., Jensen A.A., Sheppard P.O., O'Hara P., Krogsgaard-Larsen P. The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain. J Biol Chem 1999, 274:18382-18386.
31. Breitwieser G.E., Gama L. Calcium-sensing receptor activation induces intracellular calcium oscillations. Am J Physiol Cell Physiol 2001, 280:C1412-C1421.
32. Brown A.J., Ritter C.S., Finch J.L., Slatopolsky E.A. Decreased calcium-sensing receptor expression in hyperplastic parathyroid glands of uremic rats: role of dietary phosphate. Kidney Int 1999, 55:1284-1292.
33. Brown A.J., Zhong M., Finch J., Ritter C., McCracken R., Morrissey J., Slatopolsky E. Rat calcium-sensing receptor is regulated by vitamin D but not by calcium. Am J Physiol 1996, 270:F454-F460.
34. 2+ and other ions as extracellular (first) messengers. Physiol Rev 1991, 71:371-411.
35. Brown E.M., Butters R., Katz C., Kifor O. Neomycin mimics the effects of high extracellular calcium concentrations on parathyroid function in dispersed bovine parathyroid cells. Endocrinology 1991, 128:3047-3054.
36. 2+ to function as a versatile extracellular first messenger. Rec Progr Hormone Res 1998, 53:257-280.
37. Brown E.M., Chattopadhyay N., Yano S. Calcium-sensing receptors in bone cells. J Musculoskelet Neuronal Interact 2004, 4:412-413.
38. 2+-sensing receptor from bovine parathyroid. Nature 1993, 366:575-580.
39. Brown E.M., Katz C., Butters R., Kifor O. Polyarginine, polylysine, and protamine mimic the effects of high extracellular calcium concentrations on dispersed bovine parathyroid cells. J Bone Min Res 1991, 6:1217-1225.
40. Brown E.M., MacLeod R.J. Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev 2001, 81:239-297.
41. Brown E.M., Pollak M., Seidman C.E., Seidman J.G., Chou Y.-H.W., Riccardi D., Hebert S.C. Calcium-sensing cell-surface receptors. New Engl J Med 1995, 333:234-240.
42. Brown E.M., Vassilev P.M., Hebert S.C. Calcium ions as extracellular messengers. Cell 1995, 83:679-682.
43. Brunette M.G., Mailloux J., Lajeunesse D. Calcium transport through the luminal membrane of the distal tubult, I: interrelationship with sodium. Kidney Int 1992, 41:281-288.
44. Burg M.B., Green N. Function of the thick ascending limb of Henle's loop. Am J Physiol 1973, 224:659-668.
45. Canadillas S., Canalejo A., Santamaria R., Rodriguez M.E., Estepa J.C., Martin-Malo A., Bravo J., Ramos B., guilera-Tejero E., Rodriguez M., Almaden Y. Calcium-sensing receptor expression and parathyroid hormone secretion in hyperplastic parathyroid glands from humans. J Am Soc Nephrol 2005, 16:2190-2197.
46. Canaff L., Hendy G.N. Human calcium-sensing receptor gene. Vitamin D response elements in promoters P1 and P2 confer transcriptional responsiveness to 1,25-dihydroxyvitamin D. J Biol Chem 2002, 277:30337-30350.
47. 2+-inhibitable adenylyl cyclases along the renal tubule. Functional consequences for regulation of the cAMP content. J Biol Chem 1996, 271:19264-19271.
48. 2+ increase in the inhibition of intracellular cAMP conten. Cell Signal 1999, 11:651-663.
49. 2+ receptor RaKCaR. J Membr Biol 1997, 156:117-129.
50. 2+-sensing receptor mediate efficient cell-surface expression and phospholipase C activatio. J Biol Chem 2001, 276:44129-44136.
51. Deleted in proof.
52. Chattopadhyay N. Biochemistry, physiology and pathophysiology of the extracellular calcium-sensing receptor. Int J Biochem Cell Biol 2000, 32:789-804.
53. Chattopadhyay N., Baum M., Bai M., Riccardi D., Hebert S.C., Harris H.W., Brown E.M. Ontogeny of the extracellular calcium-sensing receptor in rat kidney. Am J Physiol Renal Fluid Electrolyte Physiol 1996, 40:F736-F743.
54. Chen C.J., Barnett J.V., Congo D.A., Brown E.M. Divalent cations suppress 3',5'-adenosine monophosphate accumulation by stimulating a pertussis toxin-sensitive guanine nucleotidebinding protei in cultured bovine parathyroid cells. Endocrinology 1989, 124:233-239.
55. Christiansen B., Wellendorph P., Brauner-Osborne H. Known regulators of nitric oxide synthase and arginase are agonists at the human G-protein-coupled receptor GPRC6A. Br J Pharmacol 2006, 147:855-863.
56. Deleted in proof.
57. Coburn J.W., Elangovan L., Goodman W.G., Frazao J.M. Calcium-sensing receptor and calcimimetic agents. Kidney Int 1999, 73:S52-S58. (Suppl).
58. Coburn J.W., Maung H.M. Calcimimetic agents and the calcium-sensing receptor. Curr Opin Nephrol Hypertens 2000, 9:123-132.
59. Cohen A., Silverberg S.J. Calcimimetics: therapeutic potential in hyperparathyroidism. Curr Opin Pharmacol 2002, 2:734-739.
60. Cole D.E., Vieth R., Trang H.M., Wong B.Y., Hendy G.N., Rubin L.A. Association between total serum calcium and the A986S polymorphism of the calcium-sensing receptor gene. Mol Genet Metab 2001, 72:168-174.
61. Cole D.E.C., Peltekova V.D., Rubin L.A., Hawker G.A., Vieth R., Liew C.C., Hwang D.M., Evrovski J., Hendy G.N. A986S polymorphism of the calcium-sensing receptor and circulating calcium concentrations. Lancet 1999, 353:112-115.
62. Collins M.T., Skarulis M.C., Bilezikian J.P., Silverberg S.J., Spiegel A.M., Marx S.J. Treatment of hypercalcemia secondary to parathyroid carcinoma with a novel calcimimetic agent. J Clin Endocrinol Metab 1998, 83:1083-1088.
63. Colloton M., Shatzen E., Miller G., Stehman-Breen C., Wada M., Lacey D., Martin D. Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism. Kidney Int 2005, 67:467-476.
64. Conigrave A.D., Franks A.H., Brown E.M., Quinn S.J. L-amino acid sensing by the calciumsensing receptor: a general mechanism for coupling protein and calcium metabolism?. Eur J Clin Nutr 2002, 56:1072-1080.
65. 2+-sensing receptor. Proc Natl Acad Sci U S A 2000, 97:4814-4819.
66. Corbetta S., Lania A., Filopanti M., Vicentini L., Ballare E., Spada A. Mitogen-activated protein kinase cascade in human normal and tumoral parathyroid cells. J Clin Endocrinol Metab 2002, 87:2201-2205.
67. Costanzo L.S., Windhager E.E. Calcium and sodium transport by the distal convoluted tubule of the rat. Am J Physiol Renal Fluid Electrolyte Physiol 1978, 235:F492-F506.
68. - absorption in single mouse medullary thick ascending limbs of Henle. J Clin Invest 1983, 71:1588-1601.
69. Cunningham J., Danese M., Olson K., Klassen P., Chertow G.M. Effects of the calcimimetic cinacalcet HCl on cardiovascular disease, fracture, and health-related quality of life in secondary hyperparathyroidism. Kidney Int 2005, 68:1793-1800.
70. De Rouffignac C. Multihormonal regulation of nephron epithelia: achieved through combinational mode?. Am J Physiol 1995, 269:R739-R748.
71. De Rouffignac C., Di Stefano A., Wittner M., Roinel N., Elalouf J.M. Consequences of differential effects of ADH and other peptide hormones on thick ascending limb of mammalian kidney. Am J Physiol Regulatory Integrative Comp Physiol 1991, 260:R1023-R1035.
72. De Rouffignac C., Quamme G. Renal magnesium handling and its hormonal control. Physiol Rev 1994, 74:305-322.
73. Degenhardt S., Toell A., Weidemann W., Dotzenrath C., Spindler K.D., Grabensee B. Point mutations of the human parathyroid calcium receptor gene are not responsible for nonsuppressible renal hyperparathyroidism. Kidney Int 1998, 53:556-561.
74. 2+- sensing receptor in the rabbit cortical thick ascending limb (CTAL) is functionally not coupled to phospholipase C. Pflugers Arch 1999, 437:716-723..
75. Desfleurs E., Wittner M., Simeone S., Pajaud S., Moine G., Rajerison R., Di Stefano A. Calcium-sensing receptor: regulation of electrolyte transport in the thick ascending limb of Henle's loop. Kidney Blood Press Res 1998, 21:401-412.
76. 2+ transport in the cortical thick ascending limb of henle's loop of the mouse is a voltage-dependent process. Renal Physiol Biochem 1993, 16:157-166.
77. 2+ sensor in the thick ascending limb of the loop of Henle. Kidney Blood Press Res 1997, 20:190-193.
78. Drueke T.B. Cell biology of parathyroid gland hyperplasia in chronic renal failure. J Am Soc Nephrol 2000, 11:1141-1152.
79. Drueke T.B. Modulation and action of the calcium-sensing receptor. Nephrol Dial Transplant 2004, 19(Suppl 5):V20-V26.
80. 2+ as an extracellular signal in bone. Cell Calcium 2004, 35:249-255.
81. el-Hajj F., Seifter J., Scott J., Brown EM. Calcium-regulated renal calcium handling in healthy men: relationship to sodium handling. J Clin Endocrinol Metab 1998, 83:2366-2372.
82. Enomoto H., Hendy G.N., Andrews G.K., Clemens T.L. Regulation of avian calbindin-D28K gene expression in primary chick kidney cells: importance of posttranscriptional mechanisms and calcium ion concentration. Endocrinology 1992, 130:3467-3474.
83. Escalante B., Erlij D., Falck J.R., McGiff J.C. Effect of cytochrome P450 arachidonate metabolites on ion transport in rabbit kidney loop of Henle. Science 1991, 251:799-802.
84. Escalante B., Erlij D., Falck J.R., McGiff J.C. Ion transport inhibition in the medullary thick ascending limb of Henle's loop by cytochrome P450-arachidonic acid metabolites. Adv Prostagl Thrombox Leukotr Res 1991, 21:209-212.
85. Farnebo F., Enberg U., Grimelius L., Bäckdahl M., Schalling M., Larsson C., Farnebo L.-O. Tumor-specific decreased expression of calcium sensing receptor messenger ribonucleic acid in sporadic primary hyperparathyroidism. J Clin Endocrinol Metab 1997, 82:3481-3486.
86. Favus M.J., Langman C.B. Evidence for calcium-dependent control of 1,25-dihydroxyvitamin D3 production by rat kidney proximal tubules. J Biol Chem 1986, 261:11224-11229.
87. Ferreri N.R., An S.J., McGiff J.C. Cyclooxygenase-2 expression and function in the medullary thick ascending limb. Am J Physiol 1999, 277:F360-F368.
88. Ferreri N.R., McGiff J.C., Carroll M.A., Quilley J. Renal COX-2, cytokines and 20-HETE: tubular and vascular mechanisms. Curr Pharm Des 2004, 10:613-626.
89. Ferreri N.R., McGiff J.C., Vio C.P., Carroll M.A. TNFα regulates renal COX-2 in the rat thick ascending limb (TAL). Thromb Res 2003, 110:277-280.
90. Firsov D., Aarab L., Mandon B., Siaume-Perez S., De Rouffignac C., Chabardes D. Arachidonic acid inhibits hormone-stimulated cAMP accumulation in the medullary thick ascending limb of the rat kidney by a mechanism sensitive to pertussis t. Pflugers Arch 1995, 429:636-646.
91. Fox J., Lowe S.H., Conklin R.L., Petty B.A., Nemeth E.F. Calcimimetic compound NPS R-568 stimulates calcitonin secretion but selectively targets parathyroid gland Ca(2+) receptor in rats. J Pharmacol Exp Ther 1999, 290:480-486.
92. Fox J., Lowe S.H., Petty B.A., Nemeth E.F. NPS R-568: a type II calcimimetic compound that acts on parathyroid cell calcium receptor of rats to reduce plasma levels of parathyroid hormone and calcium. J Pharmacol Exp Ther 1999, 290:473-479.
93. Franceschini N., Joy M.S., Kshirsagar A. Cinacalcet HCl: a calcimimetic agent for the management of primary and secondary hyperparathyroidism. Expert Opin Investig Drugs 2003, 12:1413-1421.
94. Fraser W.D., Ahmad A.M., Vora J.P. The physiology of the circadian rhythm of parathyroid hormone and its potential as a treatment for osteoporosis. Curr Opin Nephrol Hypertens 2004, 13:437-444.
95. Fray J.C., Lush D.J., Park C.S. Interrelationship of blood flow, juxtaglomerular cells, and hypertension: role of physical equilibrium and Ca. Am J Physiol 1986, 251:R643-R662.
96. Fray J.C.S., Park C.S., Valentine N.D. Calcium and the control of renin secretion. Endocr Res 1987, 8:53-93.
97. Frazao J.M., Martins P., Coburn J.W. The calcimimetic agents: perspectives for treatment. Kidney Int 2002, 149-154. (Suppl).
98. Friedman P.A. Codependence of renal calcium and sodium transport. Annu Rev Physiol 1998, 60:179-197.
99. Friedman P.A. Calcium transport in the kidney. Curr Opin Nephrol Hypertens 1999, 8:589-595.
100. Friedman P.A., Gesek F.A. Cellular calcium transport in renal epithelia: measurement, mechanisms, and regulation. Physiol Rev 1995, 75:429-471.
101. Fushimi K., Sasaki S., Marumo F. Phosphorylation of serine 256 is required for cAMPdependent regulatory exocytosis of the Aquaporin-2 water channel. J Biol Chem 1997, 272:14800-14804.
102. Geibel J., Sritharan K., Geibel R., Geibel P., Persing J.S., Seeger A., Roepke T.K., Deichstetter M., Prinz C., Cheng S.X., Martin D., Hebert S.C. Calcium-sensing receptor abrogates secretagogue- induced increases in intestinal net fluid secretion by enhancing cyclic nucleotide destruction. Proc Natl Acad Sci U S A 2006, 103:9390-9397.
103. Deleted in proof.
104. 2+ oscillations. J Cell Biol 2005, 171:303-312.
105. Deleted in proof.
106. Giachelli C.M., Jono S., Shioi A., Nishizawa Y., Mori K., Morii H. Vascular calcification and inorganic phosphate. Am J Kidney Dis 2001, 38:S34-S37.
107. Gogusev J., Duchambon P., Hory B., Giovannini M., Goureau Y., Sarfati E., Drueke T.B. Depressed expression of calcium receptor in parathyroid gland tissue of patients with hyperparathyroidism. Kidney Int 1997, 51:328-336.
108. Goldsmith P.K., Fan G.F., Ray K., Shiloach J., McPhie P., Rogers K.V., Spiegel A.M. Expression, purification, and biochemical characterization of the amino- terminal extracellular domain of the human calcium receptor. J Biol Chem 1999, 274:11303-11309.
109. + by rat medullary thick ascending limb: inhibition by potassium. Am J Physiol (Renal Fluid Electrolyte Physiol) 1988, 255:F78-F87. 1988.
110. Good D.W. Ammonium transport by the thick ascending limb of Henle's loop. Annu Rev Physiol 1994, 56:623-647.
111. - absorption via a cytochrome P-450- dependent pathway in MTAL. Am J Physiol 1999, 276:F726-F736.
112. Goodman W.G. Calcimimetic agents for the treatment of hyperparathyroidism. Curr Opin Nephrol Hypertens 2001, 10:575-580.
113. Goodman W.G. Calcimimetic agents and secondary hyperparathyroidism: treatment and prevention. Nephrol Dial Transplant 2002, 17:204-207.
114. Goodman W.G. Calcimimetic agents and secondary hyperparathyroidism: rationale for use and results from clinical trials. Pediatr Nephrol 2003, 18:1206-1210.
115. Goodman W.G., Frazao J.M., Goodkin D.A., Turner S.A., Liu W., Coburn J.W. A calcimimetic agent lowers plasma parathyroid hormone levels in patients with secondary hyperparathyroidism. Kidney Int 2000, 58:436-445.
116. Goodman W.G., Hladik G.A., Turner S.A., Blaisdell P.W., Goodkin D.A., Liu W., Barri Y.M., Cohen R.M., Coburn J.W. The Calcimimetic agent AMG 073 lowers plasma parathyroid hormone levels in hemodialysis patients with secondary hyperparathyroidism. J Am Soc Nephrol 2002, 13:1017-1024.
117. Goodman W.G., London G., Amann K., Block G.A., Giachelli C., Hruska K.A., Ketteler M., Levin A., Massy Z., McCarron D.A., Raggi P., Shanahan C.M., Yorioka N. Vascular calcification in chronic kidney disease. Am J Kidney Dis 2004, 43:572-579.
118. Greger R., Schlatter E., Bleich M., Hirsch J. Regulation of tubular transport via ion channels. Clin Investig 1993, 71:849-851.
119. Grider J.S., Falcone J.C., Kilpatrick E.L., Ott C.E., Jackson B.A. P450 arachidonate metabolites mediate bradykinin-dependent inhibition of NaCl transport in the rat thick ascending limb. Can J Physiol Pharmacol 1997, 75:91-96.
120. Griffith L.E., Guyatt G.H., Cook R.J., Bucher H.C., Cook D.J. The influence of dietary and nondietary calcium supplementation on blood pressure: an updated metaanalysis of randomized controlled trials. Am J Hypertens 1999, 12:84-92.
121. Gu R.M., Wei Y., Jiang H., Balazy M., Wang W.H. The role of 20-HETE in mediating the effect of dietary K intake on the apical K channels in the mTAL. Am J Physiol Renal Physiol 2001, 280:F223-F230.
122. 2+-induced inhibition of the apical K channels in the mTAL of rat kidney. J Gen Physiol 2002, 119:33-44.
123. Gunn I.R., Gaffney D. Clinical and laboratory features of calcium-sensing receptor disorders: a systematic review. Ann Clin Biochem 2004, 41:441-458.
124. 2+ receptor expressed in Xenopus laevis oocytes by NPS 467 or NPS 568. Mol Pharmacol 1998, 53:1083-1088.
125. 2+ receptors. Mol Pharmacol 1999, 55:642-648.
126. 2+ sensing in guard cells. Nature 2003, 425:196-200.
127. 2+-sensing receptor activates cytosolic phospholipase A2 via a Gqα-dependent ERK-independent pathway. J Biol Chem 2001, 276:13941-13948.
128. 2+ receptor/metabotropic glutamate chimeric receptors. Endocrinology 2000, 141:4156-4163.
129. Haven C.J., van P.M., Karperien M., Fleuren G.J., Morreau H. Differential expression of the calcium sensing receptor and combined loss of chromosomes 1q and 11q in parathyroid carcinoma. J Pathol 2004, 202:86-94.
130. Hebert S.C. Extracellular calcium-sensing receptor: Implications for calcium and magnesium handling in the kidney. Kidney Int 1996, 50:2129-2139.
131. Hebert S.C. Bartter syndrome. Curr Opin Nephrol Hypertens 2003, 12:527-532.
132. Hebert S.C. Calcium and salinity sensing by the thick ascending limb: a journey from mammals to fish and back again. Kidney Int 2004, S28-S33. (Suppl).
133. Hebert S.C., Andreoli T.E. Control of NaCl transport in the thick ascending limb. Am J Physiol Renal Fluid Electrolyte Physiol 1984, 246:F745-F756. 1984.
134. 2+-sensing receptors in divalent mineral ion homeostasis. J Exp Biol 1997, 200:295-302.
135. 2+-sensing receptor in the gastrointestinal tract. Cell Calcium 2004, 35:239-247.
136. Hebert S.C., Desir G., Giebisch G., Wang W. Molecular diversity and regulation of renal potassium channels. Physiol Rev 2005, 85:319-371.
137. Helies-Toussaint C., Aarab L., Gasc J.M., Verbavatz J.M., Chabardes D. Cellular localization of type 5 and type 6 ACs in collecting duct and regulation of cAMP synthesis. Am J Physiol Renal Physiol 2000, 279:F185-F194.
138. Hjalm G., MacLeod R.J., Kifor O., Chattopadhyay N., Brown E.M. Filamin-A binds to the carboxyl-terminal tail of the calcium-sensing receptor, an interaction that participates in CaR-mediated activation of mitogen-activated protein kinase. J Biol Chem 2001, 276:34880-34887.
139. Ho C., Conner D.A., Pollak M.R., Ladd D.J., Kifor O., Warren H.B., Brown E.M., Seidman J.G., Seidman C.E. A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Nat Genet 1995, 11:389-394.
140. Hodsman A.B., Bauer D.C., Dempster D., Dian L., Hanley D.A., Harris S.T., Kendler D., McClung M.R., Miller P.D., Olszynski W.P., Orwoll E., Yuen C.K. Parathyroid hormone and terparatide for the treatment of osteoporosis: a review of the evidence and suggested guidelines for its use. Endocr Rev 2005, 26:688-703.
141. Hofer A.M., Brown E.M. Extracellular calcium sensing and signalling. Nat Rev Mol Cell Biol 2003, 4:530-538.
142. Hofer A.M., Curci S., Doble M.A., Brown E.M., Soybel D.I. Intercellular communication mediated by the extracellular calcium-sensing receptor. Nat Cell Biol 2000, 2:392-398.
143. 2+-sensing receptor gene in human parathyroid tumors. J Clin Endocrinol Metab 1995, 80:3107-3110.
144. Hough T.A., Bogani D., Cheeseman M.T., Favor J., Nesbit M.A., Thakker R.V., Lyon M.F. Activating calcium-sensing receptor mutation in the mouse is associated with cataracts and ectopic calcification. Proc Natl Acad Sci U S A 2004, 101:13566-13571.
145. 2+ receptor cysteine-rich domain. Analysis of function of mutant and chimeric receptors. J Biol Chem 2000, 275:16382-16389.
146. 2+. J Biol Chem 2005, 280:5113-5120.
147. 2+ and a positive allosteric modulator. J Biol Chem 2003, 277:46622-46631.
148. 2+-sensing receptor couples to Gα12/13 to activate phospholipase D in Madin-Darby canine kidney cells. Am J Physiol Cell Physiol 2004, 286:C22-C30.
149. 2+-sensing receptor signaling. FEBS Lett 2006, 580:1795-1800.
150. Ishii H., Wada M., Furuya Y., Nagano N., Nemeth E.F., Fox J. Daily intermittent decreases in serum levels of parathyroid hormone have an anabolic-like action on the bones of uremic rats with low-turnover bone and osteomalacia. Bone 2000, 26:175-182.
151. Jensen A.A., Hansen J.L., Sheikh S.P., Brauner-Osborne H. Probing intermolecular proteinprotein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET). Eur J Biochem 2002, 269:5076-5087.
152. 2+ decreases chloride reabsorption in rat CTAL by inhibiting cAMP pathway. Am J Physiol 1998, 275:F198-F203.
153. 2+. J Biol Chem 1998, 273:15192-15202.
154. Jingami H., Nakanishi S., Morikawa K. Structure of the metabotropic glutamate receptor. Curr Opin Neurobiol 2003, 13:271-278.
155. Joy M.S., Kshirsagar A.V., Franceschini N. Calcimimetics and the treatment of primary and secondary hyperparathyroidism. Ann Pharmacother 2004, 38:1871-1880.
156. 2+ uptake in mouse distal convoluted tubule cells. Can J Physiol Pharmacol 2000, 78:595-602.
157. Katsura T., Gustafson C.E., Ausiello D.A., Brown D. Protein kinase A phorphorylation is involved in regulated exocytosis of aquaporin-2 in transfected LLC-PK1 cells. Am J Physiol Renal Physiol 1997, 272:F817-F822.
158. Khwaja A., Downward J. Lack of correlation between activation of Jun-NH2-terminal kinase and induction of apoptosis after detachment of epithelial cells. J Cell Biol 1997, 139:1017-1023.
159. Kifor O., MacLeod R.J., Diaz R., Bai M., Yamaguchi T., Yao T., Kifor I., Brown E.M. Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells. Am J Physiol Renal Physiol 2001, 280:F291-F302.
160. Kifor O., McElduff A., LeBoff M.S., Moore F.D., Butters R., Gao P., Cantor T.L., Kifor I., Brown E.M. Activating antibodies to the calcium-sensing receptor in two patients with autoimmune hypoparathyroidism. J Clin Endocrinol Metab 2004, 89:548-556.
161. Kifor O., Moore F.D., Delaney M., Garber J., Hendy G.N., Butters R., Gao P., Cantor T.L., Kifor I., Brown E.M., Wysolmerski J. A syndrome of hypocalciuric hypercalcemia caused by autoantibodies directed at the calcium-sensing receptor. J Clin Endocrinol Metab 2003, 88:60-72.
162. 2+-sensing receptor in primary and uremic secondary hyperparathyroidism. J Clin Endocrinol Metab 1996, 81:1598-1606.
163. 3. Nature 1989, 339:478-480.
164. + transport pathways in mouse medullary thick limb of Henle: regulation by intracellular pH. J Gen Physiol 1992, 99:435-461.
165. Knepper M.A., Packer R., Good D.W. Ammonium transport in the kidney. Physiol Rev 1989, 69:179-249.
166. Kos C.H., Karaplis A.C., Peng J.B., Hediger M.A., Goltzman D., Mohammad K.S., Guise T.A., Pollak M.R. The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone. J Clin Invest 2003, 111:1021-1028.
167. Krebs L.J. Calcimimetics and hyperparathyroidism. Curr Opin Investig Drugs 2004, 5:1080-1085.
168. Kuang D., Yao Y., Lam J., Tsushima R.G., Hampson D.R. Cloning and characterization of a family C orphan G-protein coupled receptor. J Neurochem 2005, 93:383-391.
169. Kumar G.N., Sproul C., Poppe L., Turner S., Gohdes M., Ghoborah H., Padhi D., Roskos L. Metabolism and disposition of calcimimetic agent cinacalcet HCl in humans and animal models. Drug Metab Dispos 2004, 32:1491-1500.
170. Kunishima N., Shimada Y., Tsuji Y., Sato T., Yamamoto M., Kumasaka T., Nakanishi S., Jingami H., Morikawa K. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature 2000, 407:971-977.
171. Kurokawa K. Nephrology forum: Calcium-regulating hormones and the kidney. Kidney Int 1987, 32:760-771.
172. Kurokawa K. The kidney and calcium homeostasis. Kidney Int 1994, 44:S97-S105.
173. 2+ handling. Kidney Int 2006, 69:650-654.
174. Lewin E., Garfia B., Recio F.L., Rodriguez M., Olgaard K. Persistent downregulation of calcium-sensing receptor mRNA in rat parathyroids when severe secondary hyperparathyroidism is reversed by an isogenic kidney transplantation. J Am Soc Nephrol 2002, 13:2110-2116.
175. Lindberg J.S., Culleton B., Wong G., Borah M.F., Clark R.V., Shapiro W.B., Roger S.D., Husserl F.E., Klassen P.S., Guo M.D., Albizem M.B., Coburn J.W. Cinacalcet HCl, an oral calcimimetic agent for the treatment of secondary hyperparathyroidism in hemodialysis and peritoneal dialysis: a randomized, double-blind, multicenter study. J Am Soc Nephrol 2005, 16:800-807.
176. Lindberg J.S., Moe S.M., Goodman W.G., Coburn J.W., Sprague S.M., Liu W., Blaisdell P.W., Brenner R.M., Turner S.A., Martin K.J. The calcimimetic AMG 073 reduces parathyroid hormone and calcium x phosphorus in secondary hyperparathyroidism. Kidney Int 2003, 63:248-254.
177. Liu H.J., Wei Y., Ferreri N., Nasjletti A., Wang W.H. Vasopressin and PGE2 regulate the apical 70 pS K channel in the thick ascending limb of rat kidney. Am J Phyiol Cell Physiology 2000, C905-C913.
178. Loffing J., Loffing-Cueni D., Valderrabano V., Klausli L., Hebert S.C., Rossier B.C., Hoenderop J.G., Bindels R.J., Kaissling B. Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron. Am J Physiol Renal Physiol 2001, 281:F1021-F1027.
179. Lopez I., guilera-Tejero E., Mendoza F.J, Almaden Y., Perez J., Martin D., Rodriguez M. Calcimimetic R-568 decreases extraosseous calcifications in uremic rats treated with calcitriol. J Am Soc Nephrol 2006, 17:795-804.
180. + channel in the thick ascending limb of the rat kidney. J Gen Physiol 1996, 108:537-547.
181. + channel, ROMK1. Am J Physiol Renal Fluid Electrolyte Physiol 1996, 40:F588-F594.
182. Macica C.M., Yang Y., Lerea K., Hebert S.C., Wang W. Role of the NH2 terminus of the cloned renal K+ channel, ROMK1, in arachidonic acid-mediated inhibition. Am J Physiol Renal Physiol 1997, 274:F175-F181.
183. 2+ exchanger expression in distal convoluted tubule cells. Am J Physiol Renal Physiol 2002, 283:F29-F40.
184. + transport in the cortical and medullary thick ascending limb of the rat nephron: influence of transepithelial voltage. Pflugers Arch 1993, 424:558-560.
185. 2 and prostaglandin H synthase-2 in rats. Role of angiotensin II AT1 receptors. J Clin Invest 1997, 100:1941-1950.
186. Massry S.G., Goldstein D.A. The search for uremic toxin(s) "X" "X" = PTH. Clin Nephrol 1979, 11:181-189.
187. Massry S.G., Smogorzewski M. Mechanisms through which parathyroid hormone mediates its deleterious effects on organ function in uremia. Semin Nephrol 1994, 14:219-231.
188. Mathias R.S., Brown E.M. Divalent cations modulate PTH-dependent 3' 5'-cyclic adenosine monophosphate production in renal proximal tubule cells. Endocrinology 1991, 128:3005-3012.
189. 3-1 α-hydroxylase to PTH in rats. Am J Physiol 1987, 253:E503-E507.
190. May L.T., Avlani V.A., Sexton P.M., Christopoulos A. Allosteric modulation of G proteincoupled receptors. Curr Pharm Des 2004, 10:2003-2013.
191. McCarron D.A. Diet and blood pressure-the paradigm shift. Science 1998, 281:933-934.
192. McGiff J.C., Ferreri N.R., Carroll M.A. The eicosanoid factor: a determinant of individuality of nephron segments. J Physiol Pharmacol 2002, 53:525-532.
193. McGiff J.C., Quilley J. 20-HETE and the kidney: resolution of old problems and new beginnings. Am J Physiol 1999, 277:R607-R623.
194. McKinney T.D., Myers P. Effect of calcium and phosphate on bicarbonate and fluid transport by proximal tubules in vitro. Kidney Int 1982, 21:433-438.
195. McLarnon S., Holden D., Ward D., Jones M., Elliott A., Riccardi D. Aminoglycoside antibiotics induce pH-sensitive activation of the calcium-sensing receptor. Biochem Biophys Res Commun 2002, 297:71-77.
196. McNeil S.E., Hobson S.A., Nipper V., Rodland K.D. Functional calcium-sensing receptors in rat fibroblasts are required for activation of SRC kinase and mitogen-activated protein kinase in response to extracellular calcium. J Biol Chem 1998, 273:1114-1120.
197. Mentaverri R., Yano S., Chattopadhyay N., Petit L., Kifor O., Kamel S., Terwilliger E.F, Brazier M., Brown E.M. The calcium sensing receptor is directly involved in both osteoclast differentiation and apoptosis. FASEB J 2006.
198. Miller M.A., Fox J. Daily transient decreases in plasma parathyroid hormone levels induced by the calcimimetic NPS R-568 slows the rate of bone loss but does not increase bone mass in ovariectomized rats. Bone 2000, 27:511-519.
199. 2+-sensing receptor messenger ribonucleic acid and protein. Endocrinology 1995, 136:3087-3092.
200. Mizobuchi M., Hatamura I., Ogata H., Saji F., Uda S., Shiizaki K., Sakaguchi T., Negi S., Kinugasa E., Koshikawa S., Akizawa T. Calcimimetic compound upregulates decreased calcium-sensing receptor expression level in parathyroid glands of rats with chronic renal insufficiency. J Am Soc Nephrol 2004, 15:2579-2587.
201. Moe S.M., Chen N.X. Pathophysiology of vascular calcification in chronic kidney disease. Circ Res 2004, 95:560-567.
202. Morel F. Sites of hormone action in the mammalian nephron. Am J Physiol Renal Fluid Electrolyte Physiol 1981, 240:F159-F164.
203. Morel F., Imbert-Teboul M., Chabardes D. Receptors to vasopressin and other hormones in the mammalian kidney. Kidney Int 1987, 31:512-520.
204. Motoyama H.I., Friedman P.A. Calcium-sensing receptor regulation of PTH-dependent calcium absorption by mouse cortical ascending limbs. Am J Physiol Renal Physiol 2002, 283:F399-F406.
205. 2+-sensing receptor's venus flytrap domain that selectively disables L-amino acid sensing. J Biol Chem 2005, 280:29067-29072.
206. 2+ -sensing receptor is required for L-amino acid sensing. J Biol Chem 2004, 279:51739-51744.
207. Nearing J., Betka M., Quinn S., Hentschel H., Elger M., Baum M., Bai M., Chattopadyhay N., Brown E.M., Hebert S.C., Harris H.W. Polyvalent cation receptor proteins (CaRs) are salinity sensors in fish. Proc Natl Acad Sci U S A 2002, 99:9231-9236.
208. Nemeth E.F. Pharmacological regulation of parathyroid hormone secretion. Curr Pharm Des 2002, 8:2077-2087.
209. Nemeth E.F. Calcimimetic and calcilytic drugs: just for parathyroid cells?. Cell Calcium 2004, 35:283-289.
210. Nemeth E.F., Bennett S.A. Tricking the parathyroid gland with novel calcimimetic agents. Nephrol Dial Transplant 1998, 13:1923-1925.
211. Nemeth E.F., Fox J. Calcimimetic compounds: a direct approach to controlling plasma levels of parathyroid hormone in hyperparathyroidism. Trends Endocrinol Metab 1999, 10:66-71.
212. Nemeth E.F., Heaton W.H., Miller M., Fox J., Balandrin M.F., Van Wagenen B.C., Colloton M., Karbon W., Scherrer J., Shatzen E., Rishton G., Scully S., Qi M., Harris R., Lacey D., Martin D. Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl. J Pharmacol Exp Ther 2004, 308:627-635.
213. Nemeth E.F., Steffey M.E., Hammerland L.G., Hung B.C., Van Wagenen B.C., DelMar E.G., Balandrin M.F. Calcimimetics with potent and selective activity on the parathyroid calcium receptor. Proc Natl Acad Sci U S A 1998, 95:4040-4045.
214. Nielsen S., Frokiaer J., Marples D., Kwon T.H., Agre P., Knepper M.A. Aquaporins in the kidney: from molecules to medicine. Physiol Rev 2002, 82:205-244.
215. Odenwald T., Nakagawa K., Hadtstein C., Roesch F., Gohlke P., Ritz E., Schaefer F., Schmitt C.P. Acute blood pressure effects and chronic hypotensive action of calcimimetics in uremic rats. J Am Soc Nephrol 2006, 17:655-662.
216. Ogata H., Ritz E., Odoni G., Amann K., Orth S.R. Beneficial effects of calcimimetics on progression of renal failure and cardiovascular risk factors. J Am Soc Nephrol 2003, 14:959-967.
217. Ohanian J., Gatfield K.M., Ward D.T., Ohanian V. Evidence for a functional calcium-sensing receptor that modulates myogenic tone in rat subcutaneous small arteries. Am J Physiol Heart Circ Physiol 2005, 288:H1756-H1762.
218. Ohashi N., Uematsu T., Nagashima S., Kanamaru M., Togawa A., Hishida A., Uchida E., Akizawa T., Koshikawa S. The calcimimetic agent KRN 1493 lowers plasma parathyroid hormone and ionized calcium concentrations in patients with chronic renal failure on haemodialysis both on the day of haemodialysis and on the day without haemodialysis. Br J Clin Pharmacol 2004, 57:726-734.
219. Pallais J.C., Kifor O., Chen Y.B., Slovik D., Brown E.M. Acquired hypocalciuric hypercalcemia due to autoantibodies against the calcium-sensing receptor. N Engl J Med 2004, 351:362-369.
220. i resulting in enhanced spatial interactions with calbindin-D28k protein. Int J Mol Med 2004, 13:3-11.
221. Parkash J., Chaudhry M.A., Rhoten W.B. Calbindin-D28k and calcium sensing receptor cooperate in MCF-7 human breast cancer cells. Int J Oncol 2004, 24:1111-1119.
222. 2+/polyvalent cation sensor in the mouse thick ascending limb. Am J Physiol 1996, 271:F1052-F1060.
223. Peacock M., Bilezikian J.P., Klassen P.S., Guo M.D., Turner S.A., Shoback D. Cinacalcet hydrochloride maintains long-term normocalcemia in patients with primary hyperparathyroidism. J Clin Endocrinol Metab 2005, 90:135-141.
224. Peterson L.N., McKay A.J., Borzecki J.S. Endogenous prostaglandin E2 mediates inhibition of rat thick ascending limb Cl reabsorption in chronic hypercalcemia. J Clin Invest 1993, 91:2399-2407.
225. 2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane. J Biol Chem 2004, 279:18990-18997.
226. Pi M., Faber P., Ekema G., Jackson P.D., Ting A., Wang N., Fontilla-Poole M., Mays R.W., Brunden K.R., Harrington J.J., Quarles L.D. Identification of a novel extracellular cationsensing G-protein-coupled receptor. J Biol Chem 2005, 280:40201-40209.
227. Pi M., Spurney R.F., Tu Q., Hinson T., Quarles L.D. Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor. Endocrinology 2002, 143:3830-3838.
228. Pidasheva S., Grant M., Canaff L., Ercan O., Kumar U., Hendy G.N. Calcium-sensing receptor dimerizes in the endoplasmic reticulum: biochemical and biophysical characterization of CASR mutants retained intracellularly. Hum Mol Genet 2006, 15:2200-2209.
229. Pin J.P., Kniazeff J., Liu J., Binet V., Goudet C., Rondard P., Prezeau L. Allosteric functioning of dimeric class C G-protein-coupled receptors. FEBS J 2005, 272:2947-2955.
230. 2+-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Cell 1993, 75:1297-1303.
231. 2+-sensing receptor gene mutation. Nat Genet 1994, 8:303-307.
232. Procino G., Carmosino M., Tamma G., Gouraud S., Laera A., Riccardi D., Svelto M., Valenti G. Extracellular calcium antagonizes forskolin-induced aquaporin 2 trafficking in collecting duct cells. Kidney Int 2004, 66:2245-2255.
233. Quamme G.A., de R.C. Epithelial magnesium transport and regulation by the kidney. Front Biosci 2000, 5:D694-D711.
234. Quarles L.D., Sherrard D.J., Adler S., Rosansky S.J., McCary L.C., Liu W., Turner S.A., Bushinsky D.A. The calcimimetic AMG 073 as a potential treatment for secondary hyperparathyroidism of end-stage renal disease. J Am Soc Nephrol 2003, 14:575-583.
235. Quinn S.J., Bai M., Brown E.M. pH Sensing by the calcium-sensing receptor. J Biol Chem 2004, 279:37241-37249.
236. Quinn S.J., Kifor O., Trivedi S., Diaz R., Vassilev P., Brown E. Sodium and ionic strength sensing by the calcium receptor. J Biol Chem 1998, 273:19579-19586.
237. 2+-sensing receptor: a target for polyamines. Am J Physiol 1997, 273:C1315-C1323.
238. Ray K. Structure-function relationships of the family 3 G-protein-coupled receptors. Int Arch Biosci 2001, 1027-1035.
239. Ray K., Fan G.-F., Goldsmith P.K., Spiegel A.M. The carboxyl terminus of the human calcium receptor. Requirements for cell-surface expression and signal transduction. J Biol Chem 1997, 272:31355-31361.
240. 2+ receptor. J Biol Chem 1999, 274:27642-27650.
241. Ray K., Northup J. Evidence for distinct cation and calcimimetic compound (NPS 568) recognition domains in the transmembrane regions of the human Ca2+ receptor. J Biol Chem 2002, 277:18908-18913.
242. Reinalter S.C., Jeck N., Peters M., Seyberth H.W. Pharmacotyping of hypokalaemic salt-losing tubular disorders. Acta Physiol Scand 2004, 181:513-521.
243. 2+ receptor extracellular domain. Analysis of function of lobe I loop deletion mutants. J Biol Chem 2001, 276:32145-32151.
244. 2+(polyvalent) cation-sensing receptor in kidney. Am J Physiol Renal Physiol 1998, 274:F611-F622.
245. 2+-sensing receptor and PTH/PTHrP receptor in rat kidney. Am J Physiol 1996, 271:F951-F956.
246. 2+. Am J Physiol Renal Physiol 2001, 280:F868-F878.
247. 2+. Am J Physiol Renal Physiol 2001, 280:F868-F878.
248. Ritter C.S., Finch J.L., Slatopolsky E.A., Brown A.J. Parathyroid hyperplasia in uremic rats precedes down-regulation of the calcium receptor. Kidney Int 2001, 60:1737-1744.
249. Ritter C.S., Martin D.R., Lu Y., Slatopolsky E., Brown A.J. Reversal of secondary hyperparathyroidism by phosphate restriction restores parathyroid calcium-sensing receptor expression and function. J Bone Miner Res 2002, 17:2206-2213.
250. Ritz E. Calcimimetics: fooling the calcium receptor. Pediatr Nephrol 2005, 20:15-18.
251. Rodriguez M., Nemeth E., Martin D. The calcium-sensing receptor: a key factor in the pathogenesis of secondary hyperparathyroidism. Am J Physiol Renal Physiol 2005, 288:F253-F264.
252. 3. Endocrinology 1995, 136:499-504.
253. Roussanne M.C., Lieberherr M., Souberbielle J.C., Sarfati E., Drueke T., Bourdeau A. Human parathyroid cell proliferation in response to calcium, NPS R-467, calcitriol and phosphate. Eur J Clin Invest 2001, 31:610-616.
254. 2+-sensing receptor expression in functionally active, long-term human parathyroid cell cultures. J Bone Min Res 1998, 13:354-362.
255. Rubin M.R., Bilezikian J.P. The anabolic effects of parathyroid hormone therapy. Clin Geriatr Med 2003, 19:415-432.
256. Sands J.M., Flores F.X., Kato A., Baum M.A., Brown E.M., Ward D.T., Hebert S.C., Harris H.W. Vasopressin-elicited water and urea permeabilities are altered in IMCD in hypercalcemic rats. Am J Physiol Renal Physiol 1998, 274:F978-F985.
257. Sands J.M., Naruse M., Baum M., Jo I., Hebert S.C., Brown E.M., Harris H.W. Apical extracellular calcium/polyvalent cation-sensing receptor regulates vasopressin-elicited water permeability in rat kidney inner medullary collecting duct. J Clin Invest 1997, 99:1399-1405.
258. Schmitt C.P., Homme M., Schaefer F. Structural organization and biological relevance of oscillatory parathyroid hormone secretion. Pediatr Nephrol 2005, 20:346-351.
259. Schwartz T.W., Holst B. Ago-allosteric modulation and other types of allostery in dimeric 7TM receptors. J Recept Signal Transduct Res 1906, 26:107-128.
260. +)ATPase. Nature 1985, 314:620-622.
261. Scillitani A., Guarnieri V., De G.S., Muscarella L.A., Battista C., D'Agruma L., Bertoldo F., Florio C., Minisola S., Hendy G.N., Cole D.E. Blood ionized calcium is associated with clustered polymorphisms in the carboxyl-terminal tail of the calcium-sensing receptor. J Clin Endocrinol Metab 2004, 89:5634-5638.
262. Shalhoub V., Grisanti M., Padagas J., Scully S., Rattan A., Qi M., Varnum B., Vezina C., Lacey D., Martin D. In vitro studies with the calcimimetic, cinacalcet HCl, on normal human adult osteoblastic and osteoclastic cells. Crit Rev Eukaryot Gene Expr 2003, 13:89-106.
263. Shoback D.M., Bilezikian J.P., Turner S.A., McCary L.C., Guo M.D., Peacock M. The calcimimetic cinacalcet normalizes serum calcium in subjects with primary hyperparathyroidism. J Clin Endocrinol Metab 2003, 88:5644-5649.
264. Silver J., Levi R. Cellular and molecular mechanisms of secondary hyperparathyroidism. Clin Nephrol 2005, 63:119-126.
265. Silverberg S.J., Bone H.G., Marriott T.B., Locker F.G., Thys-Jacobs S., Dziem G., Kaatz S., Sanguinetti E.L., Bilezikian J.P. Short-term inhibition of parathyroid hormone secretion by a calcium-receptor agonist in patients with primary hyperparathyroidism. N Engl J Med 1997, 337:1506-1510.
266. Slama M., Susic D., Frohlich E.D. Prevention of hypertension. Curr Opin Cardiol 2002, 17:531-536.
267. 3 in the kidney. Curr Opin Nephrol Hypertens 2000, 9:341-347.
268. Spurlino J.C., Lu G.Y., Quiocho F.A. The 2.3-Å resolution structure of the maltose- or maltodextrin-binding protein, a primary receptor of bacterial active transport and chemotaxis. J Biol Chem 1991, 266:5202-5219.
269. Szczech L.A. The impact of calcimimetic agents on the use of different classes of phosphate binders: results of recent clinical trials. Kidney Int 2004, S46-S48. (Suppl).
270. 2+ inhibits peptide hormone-dependent cAMP production specifically in thick ascending limbs of Henle. Mineral Electrolyte Metab 1986, 12:342-346.
271. 2+ inhibits AVP-dependent cAMP production in thick ascending limbs of Henle. Am J Physiol Renal Fluid Electrolyte Physiol 1986, 250:F770-F776.
272. Tfelt-Hansen J., Brown E.M. The calcium-sensing receptor in normal physiology and pathophysiology: a review. Crit Rev Clin Lab Sci 2005, 42:35-70.
273. Thakker R.V. Diseases associated with the extracellular calcium-sensing receptor. Cell Calcium 2004, 35:275-282.
274. Thakker R.V. Genetics of endocrine and metabolic disorders: parathyroid. Rev Endocr Metab Disord 2004, 5:37-51.
275. 3+. Proc Natl Acad Sci U S A 1902, 99:2660-2665.
276. Tu Q., Pi M., Karsenty G., Simpson L., Liu S., Quarles L.D. Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null background. J Clin Invest 2003, 111:1029-1037.
277. Urena P. Use of calcimimetics in uremic patients with secondary hyperparathyroidism: review. Artif Organs 2003, 27:759-764.
278. Urena P., Frazao J.M. Calcimimetic agents: review and perspectives. Kidney Int 2002, S91-S96. (Suppl).
279. Valimaki S., Farnebo F., Forsberg L., Larsson C., Farnebo L.O. Heterogeneous expression of receptor mRNAs in parathyroid glands of secondary hyperparathyroidism. Kidney Int 2001, 60:1666-1675.
280. Vargas-Poussou R., Huang C., Hulin P., Houillier P., Jeunemaitre X., Paillard M., Planelles G., Dechaux M., Miller R.T., Antignac C. Functional characterization of a calcium-sensing receptor mutation in severe autosomal dominant hypocalcemia with a Bartter-like syndrome. J Am Soc Nephrol 2002, 13:2259-2266.
281. Wada M., Furuya Y., Sakiyama J., Kobayashi N., Miyata S., Ishii H., Nagano N. The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency: control of parathyroid cell growth via a calcium receptor. J Clin Invest 1997, 100:2977-2983.
282. Wada M, Ishii H, Furuya Y, Fox J, Nemeth EF, Nagano N. NPS R-586 halts or reverses osteitis fibrosa in uremic rats. Kidney Int 53: 448-453.
283. Wada M., Nagano N. Control of parathyroid cell growth by calcimimetics. Nephrol Dial Transplant 2003, 18(Suppl 3):iii13-iii17.
284. Wada M., Nagano N., Furuya Y., Chin J., Nemeth E.F., Fox J. Calcimimetic NPS R-568 prevents parathyroid hyperplasia in rats with severe secondary hyperparathyroidism. Kidney Int 2000, 57:50-58.
285. Wada M., Nagano N., Nemeth E.F. The calcium receptor and calcimimetics. Curr Opin Nephrol Hypertens 1999, 8:429-433.
286. Wang D., An S.J., Wang W.H., McGiff J.C., Ferreri N.R. CaR-mediated COX-2 expression in primary cultured mTAL cells. Am J Physiol Renal Physiol 2001, 281:F658-F664.
287. Wang D., McGiff J.C., Ferreri N.R. Regulation of cyclooxygenase isoforms in the renal thick ascending limb: effects of extracellular calcium. J Physiol Pharmacol 2000, 51:587-595.
288. Wang D., Pedraza P.L., Abdullah H.I., McGiff J.C., Ferreri N.R. Calcium-sensing receptormediated TNF production in medullary thick ascending limb cells. Am J Physiol Renal Physiol 2002, 283:F963-F970.
289. Wang N.N., Wang X.Y., Peng T., Wu H.F., Hu J.M., Zhao W.H., Yu X.B. Expression of the calcium receptor CaR in the parathyroid of secondary hyperparathyroidism patients. Chin Med J (Engl) 2004, 117:1408-1410.
290. + channel in the thick ascending limb of the rat kidney. J Gen Physiol 1995, 106:727-743.
291. + channels in rat TAL. Am J Physiol 1997, 273:F421-F429.
292. + channels in the TAL. Am J Physiol 1996, 271:C103-C111.
293. Ward D.T. Calcium receptor-mediated intracellular signalling. Cell Calcium 2004, 35:217-228.
294. Deleted in proof.
295. Ward D.T., Brown E.M., Harris H.W. Disulfide bonds in the extracellular calcium-polyvalent cation-sensing receptor correlate with dimer formation and its response to divalent cations in vitro. J Biol Chem 1998, 273:14476-14483.
296. Ward D.T., Maldonado-Perez D., Hollins L., Riccardi D. Aminoglycosides induce acute cell signaling and chronic cell death in renal cells that express the calcium-sensing receptor. J Am Soc Nephrol 2005, 16:1236-1244.
297. Watanabe S., Fukumoto S., Chang H., Takeuchi Y., Hasegawa Y., Okazaki R., Chikatsu N., Fujita T. Association between activating mutations of calcium-sensing receptor and Bartter's syndrome. Lancet 2002, 360:692-694.
298. Weigel R.J. Nonoperative management of hyperparathyroidism: present and future. Curr Opin Oncol 2001, 13:33-38.
299. Wellendorph P., Brauner-Osborne H. Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor. Gene 2004, 335:37-46.
300. Wellendorph P., Hansen K.B., Balsgaard A., Greenwood J.R., Egebjerg J., Brauner-Osborne H. Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. Mol Pharmacol 2005, 67:589-597.
301. Weston A.H., Absi M., Ward D.T., Ohanian J., Dodd R.H., Dauban P., Petrel C., Ruat M., Edwards G. Evidence in favor of a calcium-sensing receptor in arterial endothelial cells: studies with calindol and Calhex 231. Circ Res 2005, 97:391-398.
302. 2+ transport in the cortical thick ascending limb of henle's loop of the mouse: evidence for a change in the paracellular pathway permeability. Pflugers Arch 1993, 423:387-396.
303. 2+-sensing receptor-induced apoptosis. J Lipid Res 2005, 46:1396-1404.
304. Deleted in proof.
305. Yang H., Curinga G., Giachelli C.M. Elevated extracellular calcium levels induce smooth muscle cell matrix mineralization in vitro. Kidney Int 2004, 66:2293-2299.
306. Yano S., Sugimoto T., Tsukamoto T., Chihara K., Kobayashi A., Kitazawa S., Maeda S., Kitazawa R. Association of decreased calcium-sensing receptor expression with proliferation of parathyroid cells in secondary hyperparathyroidism. Kidney Int 2000, 58:1980-1986.
307. Yano S., Sugimoto T., Tsukamoto T., Chihara K., Kobayashi A., Kitazawa S., Maeda S., Kitazawa R. Decrease in vitamin D receptor and calcium-sensing receptor in highly proliferative parathyroid adenomas. Eur J Endocrinol 2003, 148:403-411.
308. 2+-sensing receptor. Am J Physiol Cell Physiol 2002, 282:C1414-C1422.
309. 2+-sensing receptor require negative feedback by protein kinase C. J Biol Chem 2002, 277:46871-46876.
310. Zhang Z., Jiang Y., Quinn S.J., Krapcho K., Nemeth E.F., Bai M. L-phenylalanine and NPS R-467 synergistically potentiate the function of the extracellular calcium-sensing receptor through distinct sites. J Biol Chem 2002, 277:33736-33741.
311. Zhang Z., Sun S., Quinn S.J., Brown E.M., Bai M. The extracellular calcium-sensing receptor dimerizes through multiple types of intermolecular interactions. J Biol Chem 2001, 276:5316-5322.
312. Zou A.P., Drummond H.A., Roman R.J. Role of 20-HETE in elevating loop chloride reabsorption in Dahl SS/Jr rats. Hypertension 1996, 27:631-635.