Calcimimetics with potent and selective activity on the parathyroid calcium receptor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 7, 1998, Pages 4040-4045

  Nemeth, Edward F ^a   Steffey, Michael E ^a   Hammerland, Lance G ^a   Hung, Benjamin C P ^a   Van Wagenen, Bradford C ^a   DelMar, Eric G ^a   Balandrin, Manuel F ^a  

^a NPS Pharmaceutical Inc   (United States)

Author keywords

Cytoplasmic Ca2+; Hyperparathyroidism; NPS R 467; NPS R 568; Parathyroid cells

Indexed keywords

1 (3 METHOXYPHENYL) N (3 PHENYLPROPYL)ETHYLAMINE; CALCIUM; CALCIUM CHANNEL STIMULATING AGENT; CELL RECEPTOR; N [3 (2 CHLOROPHENYL)PROPYL] 1 (3 METHOXYPHENYL)ETHYLAMINE; PARATHYROID HORMONE; PHENYLALKYLAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CATTLE; CONCENTRATION RESPONSE; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENANTIOMER; EXTRACELLULAR CALCIUM; HUMAN; HUMAN CELL; NONHUMAN; PARATHYROID HORMONE RELEASE; PRIMARY HYPERPARATHYROIDISM; PRIORITY JOURNAL; STEREOCHEMISTRY; XENOPUS;

ANILINE COMPOUNDS; ANIMALS; CALCIUM; CATTLE; GTP-BINDING PROTEINS; HUMANS; PARATHYROID GLANDS; PARATHYROID HORMONE; RECEPTORS, CALCIUM-SENSING; RECEPTORS, CELL SURFACE;

EID: 0032584086     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.7.4040     Document Type: Article

References (19)

1. Nemeth, E. F. & Scarpa, A. (1986) FEBS Lett. 203, 15-19.
2. Nemeth, E. F. & Scarpa, A. (1987) J. Biol. Chem. 262, 5188-5196.
3. Brown, E. M. (1991) Physiol. Rev. 71, 371-411.
4. Brown, E. M., Gamba, G., Riccardi, D., Lombardi, M., Butters, R., Kifor, O., Sun, A., Hediger, M. A., Lytton, J. & Hebert, S. C. (1993) Nature (London) 366, 575-580.
5. Garrett, J. E., Capuano, I. V., Hammerland, L. G., Hung, B. C. P., Brown, E. M., Hebert, S. C., Nemeth, E. F. & Fuller, F. H. (1995) J. Biol. Chem. 270, 12919-12925.
6. Shoback, D. M., Membreno, L. A. & McGhee, J. G. (1988) Endocrinology 123, 382-389.
7. Brown, E. M., Butters, R., Katz, C. & Kifor, O. (1991) Endocrinology 128, 3047-3054.
8. Nemeth, E. F. (1987) in Calcium-Binding Proteins in Health and Disease, eds. Norman, A. W., Vanaman, T. C. & Means, A. R. (Academic, San Diego), pp. 36-38.
9. Brown, E. M., Fuleihan, G.e.-H., Chen, C. J. & Kifor, O. (1990) Endocrinology 127, 1064-1071.
10. Brown, E. M., Katz, C., Butters, R. & Kifor, O. (1991) J. Bone Miner. Res. 6, 1217-1225.
11. Racke, F. K. & Nemeth, E. F. (1993) J. Physiol. 468, 141-162.
12. Racke, F. K. & Nemeth, E. F. (1993) J. Physiol. 468, 163-176.
13. Saugstad, J. A., Segerson, T. P. & Westbrook, G. L. (1996) J. Neurosci. 16, 5979-5985.
14. Muff, R., Nemeth, E. F., Haller-Brem, S. & Fischer, J. A. (1988) Arch. Biochem. Biophys. 265, 128-135.
15. Nemeth, E. F. & Kosz, L. M. (1989) Am. J. Physiol. 257, E505-E513.
16. Knöpfel, T. & Gasparini, F. (1996) DDT 1, 103-108.
17. Chen, C. J., Barnett, J. V., Congo, D. A. & Brown, E. M. (1989) Endocrinology 124, 233-239.
18. Nemeth, E. F. (1996) in Principles of Bone Biology (Academic, San Diego), pp. 1019-1035.
19. Silverberg, S. J., Bone, H. G., III, Marriott, T. B., Locker, F. G., Thys-Jacobs, S., Dziem, G., Kaatz, S., Sanguinetti, E. L. & Bilezkian, J. P. (1997) N. Engl. J. Med. 337, 1506-1510.