A calcimimetic agent acutely suppresses parathyroid hormone levels in patients with chronic renal failure

Kidney International

Volumn 53, Issue 1, 1998, Pages 223-227

  Antonsen, John E ^a   Sherrard, Donald J ^a   Andress, Dennis L ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Calcium receptor; Hyperparathyroidism; Parathyroid hormone; Renal osteodystrophy

Indexed keywords

CALCITONIN; CALCITRIOL; CALCITRIOL RECEPTOR; CALCIUM CHANNEL STIMULATING AGENT; CALCIUM ION; N (3 METHOXY ALPHA PHENYLETHYL) 3 (2' CHLOROPHENYL) 1 PROPYLAMINE; N [3 (2 CHLOROPHENYL)PROPYL] 1 (3 METHOXYPHENYL)ETHYLAMINE; PARATHYROID HORMONE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CHRONIC KIDNEY FAILURE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; HEMODIALYSIS; HUMAN; HYPERPARATHYROIDISM; MALE; ORAL DRUG ADMINISTRATION; PARATHYROID CELL; PRIORITY JOURNAL;

EID: 0031888842     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1998.00735.x     Document Type: Article

References (16)

1. ANDRESS DL, SHERRARD DJ: The osteodystrophy of chronic renal failure, in Diseases of the Kidney, edited by SCHRIER RW, GOTTSCHALK CW, Boston, Little, Brown and Company, 1997, pp 2597-2624
2. ANDRESS DL, NORRIS KC, COBURN JW, SLATOPOLSKY EA, SHERRARD DJ: Intravenous calcitriol in the treatment of refractory osteitis fibrosa of chronic renal failure. N Engl J Med 321:274-279, 1989
3. LLACH F, HERVAS J, CEREZO S: The importance of dosing intravenous calcitriol in dialysis patients with severe hyperparathyroidism. Am J Kidney Dis 26:845-851, 1995
4. SILVER J, RUSSEL J, LETTIERI D: Regulation by vitamin D metabolites of messenger ribonucleic acid for preproparathyroid hormone in isolated bovine parathyroid cells. Proc Natl Acad Sci USA 82:4270-4273, 1985
5. COBURN JW, FRAZAO J: Calcitriol in the management of renal osteodystrophy. Semin Dial 9:316-326, 1996
6. FUKUDA N, TANAKA H, TOMINAGA Y, FUKAGAWA M, KUROKAWA K, SEINO Y: Decreased 1,25-dihydroxyvitamin D receptor density is associated with a more severe form of parathyroid hyperplasia in chronic uremic patients. J Clin Invest 92:1436-1443, 1993
7. NEMETH EF, SCARPA A: Rapid mobilization of cellular calcium in bovine parathyroid cells evoked by extracellular divalent cations. Evidence for a cell surface calcium receptor. J Biol Chem 262:5188-5196, 1987
8. BROWN EM, GAMBA G, RICCARDI D, LOMBARDI M, BUTTERS R, KIFOR O, SUN A, HEDIGER MA, LYTTON J, HEBERT SC: Cloning and characterization of an extracellular calcium sensing receptor from bovine parathyroid. Nature 366:575-580, 1993
9. NAVEH-MANY T, FRIEDLANDER MM, MAYER H, SILVER J: Calcium regulates parathyroid hormone messenger ribonucleic acid (mRNA), but not calcitonin mRNA in vivo in the rat. Dominant role of 1,25-dihydroxyvitamin D. Endocrinology 125:275-280, 1989
10. TORRES A, RODRIGUEZ M, FELSENFELD A, MARTIN-MALO A, LLACH F: Sigmoidal relationship between calcitonin and calcium: Studies in normal, parathyroidectomized, and azotemic rats. Kidney Int 40:700-704, 1991
11. MCSHEEHY PMJ, CHAMBERS TJ: Osteoblastic cells mediate osteoclastic responsiveness to parathyroid hormone. Endocrinology 118:824-828, 1986
12. MALGAROLI AJ, MELDOLESI A, ZAMBONIN-ZALLONE A, TETI A: Control of cytosolic free calcium in rat and chicken osteoclasts. The role of extracellular calcium and calcitonin. J Biol Chem 264:14342-14347, 1989
13. NICHOLSON GC, MOSELEY JM, SEXTON PM, MENDELSOHN FAO, MARTIN TJ: Abundant calcitonin receptors in isolated rat osteoclasts. J Clin Invest 78:355-361, 1986
14. HEYNEN G, KANIS JA, OLIVER D, LEDINGHAM JGG, RUSSELL RGG: Evidence that endogenous calcitonin protects against renal bone disease. Lancet 2:1322-1326, 1976
15. KANIS JA, EARNSHAW M, HEYNEN G, LEDINGHAM JGG, OLIVER DO, RUSSELL RGG, WOODS CG, FRANCHIMONT P, GASPAR S: Changes in histologic and biochemical indexes of bone turnover after bilateral nephrectomy in patients on hemodialysis. N Engl J Med 296:1073-1079, 1977
16. GOGUSEV J, DUCHAMBON P, HORY B, GIOVANNINI M, GOUREAU Y, SARFATI E, DRUEKE TB: Depressed expression of calcium receptor in parathyroid gland tissue of patients with hyperparathyroidism. Kidney Int 51:328-336, 1997