Decreased calcium-sensing receptor expression in hyperplastic parathyroid glands of uremic rats: Role of dietary phosphate

Kidney International

Volumn 55, Issue 4, 1999, Pages 1284-1292

  Brown, Alex J ^a,b   Ritter, Cynthia S ^a   Finch, Jane L ^a   Slatopolsky, Eduardo A ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

Calcium homeostasis; Chronic renal failure; Diet; Parathyroid hyperplasia; Receptor; Uremia

Indexed keywords

CALCIUM SENSING RECEPTOR; CELL RECEPTOR; PHOSPHATE; RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FOOD COMPOSITION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; NONHUMAN; ORGAN SIZE; PARATHYROID HYPERPLASIA; PATHOPHYSIOLOGY; PHOSPHATE INTAKE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RECEPTOR DOWN REGULATION; UREMIA;

EID: 0032918925     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1999.00386.x     Document Type: Article

References (33)

1. CHATTOPADHYAY N, MITHAL A, BROWN EM: The calcium-sensing receptor: A window into the physiology and pathophysiology of mineral ion metabolism. Endocr Rev 17:289-307, 1996
2. KHOSLA S, EBELING PR, FIREK AF, BURRITT MM, KAO PC, HEATH H III: Calcium inlusion suggests a "set point" abnormality of parathyroid gland function in familial benign hypercalcemia and more complex disturbances in primary hyperparathyroidism. J Clin Endocrinol Metab 76:715-720, 1993
3. SCHWARZ P, SØRENSEN HA, TRANSBØL I: Inter-relations between the calcium set-points of Parfitt and Brown in primary hyperparathyrojdism: A sequential citrate and calcium clamp study. Eur J Clin Invest 24:553-558, 1994
4. BROWN EM, GARDNER DG, BRENNAN MF, MARX SJ, SPIEGEL AM, ATTIE MF, DOWNS RW JR, DOPPMAN JL, AURBACH GD: Calcium-regulated parathyroid hormone release in primary hyperparathyroidism: Studies in vitro with dispersed parathyroid cells. Am J Med 66:923-931, 1979
5. BROWN EM, WILSON RE, THATCHER JG, MARYNICK SP: Abnormal calcium-related PTH release in normal parathyroid tissue from patients with adenoma. Am J Med 71:565-570, 1981
6. HABENER JF: Responsiveness of neoplastic and hyperplastic parathyroid tissue to calcium in vitro. J Clin Invest 62:436-450, 1978
7. RUDBERG C, AKERSTKOM G, LJUNGHALL S, GRIMELIUS L, JOHANSSON H, PERTOFT H, WIDE L: Regulation of parathyroid hormone release in primary and secondary hyperparathyroidism: Studies in vivo and in vitro. Acta Endocrinol (Copenh) 101:408-413, 1982
8. BROWN EM: Four parameter model of the sigmoidal relationship between PTH release and the extracellular calcium concentration in normal and abnormal parathyroid tissue. J Clin Endocrinol Metab 56:572-581, 1983
9. BROWN EM, WILSON RE, EASTMAN RC, PALLOTTA J, MARYNICK SP: Abnormal regulation of parathyroid hormone release by calcium in secondary hyperparathyroidism due to chronic renal failure. J Clin Endocrinol Metab 54:172-179, 1982
10. WALLFELY CH, LARSSON R, GYLFE E, LJUNGHALL S, RASTAD J, AKERSTROM G: Secretory disturbance in hyperplastic parathyroid nodules of uremic hyperparathyroidism-implication for parathyroid autotransplantation. West J Surg 12:431-438, 1988
11. DELMEZ AJ, TINDIRA C, GROOMS O, DUSSO A, WINDUS DW, SLATOPOLSKY E: Parathyroid hormone suppression by intravenous 1,25-dihydroxyvitamin D: A role for increased sensitivity to calcium. J Clin Invest 83:1349-1355, 1989
12. FELSENFELD AJ, LIACH F: Parathyroid gland function in chronic renal failure. Kidney Int 43:771-789, 1993
13. FELSENFELD AJ, JARA A, PAHL M, BOVER J, RODRIGUEZ M: Differences in the dynamics of parathyroid hormone secretion in hemodialysis patients with marked secondary hyperparathyroidism. J Am Soc Nephrol 6:1371-1378, 1995
14. RAMIREZ JA, GOODMAN WG, GORNBETN J, MENEZES C, MOULTON L, SEGRE GV, SALUSKY IB: Direct in vivo comparison of calcium-regulated parathyroid hormone secretion in normal volunteers and patients with secondary hyperparathyroidism. J Clin Endocrinol Metab 76:1489-1494, 1993
15. MESSA P, VALLONE C, MIONI G, GEATTI O, TURRIN D, PASSONI N, CRUCIATTI A: Direct in vivo assessment of parathyroid hormone-calcium relationship curve in renal patients. Kidney Int 46:1713-1720, 1994
16. INDRIDASON OS, HEATH H III, KHOSLA S, YOHAY DA, QUARLES LD: Non-suppressible parathyroid hormone secretion is related to gland size in uremic secondary hyperparathyroidism. Kidney Int 50:1663-1671, 1996
17. 2+-sensing receptor in primary and uremic secondary hyperparathyroidism. J Clin Endocrinol Metab 81:1598-1606, 1996
18. GOGUSEV J, DUCHAMBON P, HORY B, GIOVANNINI M, GOUREAU Y, SARFATI E, DRUEKE TB: Depressed expression of calcium receptor in parathyroid gland tissue of patients with hyperparathyroidism. Kidney Int 51:328-336, 1997
19. HOLLIS BW: Assay of circulating 1,25-dihydroxyvitamin D metabolites involving a novel single extraction and purification procedure. Clin Chem 32:2060-2063, 1986
20. REINHARDT TA, HORST RL, ORF JW, HOLLIS BW: A microassay for 1,25-dihydroxyvitamin D not requiring high performance liquid chromatography: Application to clinical studies. J Clin Endocrinol Metab 58:91-98, 1984
21. 2+-sensing receptor from bovine parathyroid. Nature 366:575-580, 1993
22. RICCARDI D, PARK J, LEE WE, GAMBA G, BROWN EM, HEBERT SC: Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor. Proc Natl Acad Sci USA 92:131-135, 1995
23. BROWN AJ, ZHONG M, FINCH L, RITTER C, MCCRACKEN R, MORRISSEY J, SLATOPOLSKY E: Rat calcium-sensing receptor is regulated by vitamin D but not by calcium. Am Physiol Soc 270(3 Part 2):F454-F460, 1996
24. MIZE RR: Quantitative image analysis for immunocytochemistry and in situ hybridization. J Neurosci Methods 54:219-237, 1994
25. DENDA M, FINCH J, SLATOPOLSKY E: Phosphorus accelerates the development of parathyroid hyperplasia and secondary hyperparathyroidism in rats with renal failure. Am J Kidney Dis 28:596-602, 1996
26. GARRETT JE, TAMIR H, KIFOR O, SIMIN RT, ROGERS KV, MITHAL A, GAGEL RF, BROWN EM: Calcitonin-secreting cells of the thyroid express an extracellular calcium receptor gene. Endocrinology 136:5202-5211, 1995
27. 2+ receptor is essential for its expression at the cell surface. Endocrinology 138:1916-1922, 1997
28. RAY JM, SQUIRES PE, CURTIS SB, MELOCHE MR, BUCHAN AMJ: Expression of the calcium-sensing receptor on human antral gastrin cells in culture. J Clin Invest 99:2328-2133, 1997
29. ROGERS KV, FOX J, DUNN CK, CONKLIN RL, LOWE SH, PETTY B A: Parathyroid gland calcium receptor mRNA levels are unaffected by chronic renal insufficiency or low dietary calcium in rats. Endocrine 3:769-774, 1995
30. HERNANDEZ A, TORRES A, CONCEPCION MT, SALIDO E: Parathyroid gland calcium receptor gene expression is not regulated by increased dietary phosphate in normal and renal failure rats. Nephrol Dial Transplant 11:S11-S14, 1996
31. BROWN AJ, ZHONG M, RITTER CS, SLATOPOLSKY E: Loss of calcium responsiveness in cultured bovine parathyroid cells is associated with a decrease in calcium receptor expression. Biochem Biophys Res Commun 212:861-867, 1995
32. 2+-sensing receptor messenger ribonucleic acid and protein. Endocrinology 136:3087-3092, 1995
33. NYGREN P, LARSSON R, JOHANSSON H, GYLFE E, RASTAD J, AKERSTROM G: Inhibition of cell growth retains differentiated function of bovine parathyroid cells in monolayer culture. Bone Miner 4:123-132, 1988