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Volumn 63, Issue 85, 2003, Pages

Calcimimetic agents: Review and perspectives

Author keywords

Calcimimetics; Calcium sensing receptor; Hypocalcemia; Parathyroid hormone; Renal osteodystrophy; Review; Secondary hyperparathyroidism

Indexed keywords

ALUMINUM; BARIUM; CADMIUM; CALCIUM; CALCIUM CHANNEL STIMULATING AGENT; CALCIUM PHOSPHATE; CALCIUM SENSING RECEPTOR; CATION; CINACALCET; COBALT; GADOLINIUM; GENTAMICIN; HEXACYCLINE; IRON; KANAMYCIN B; KRN 568; LANTHANUM; LEAD; MAGNESIUM; N [3 (2 CHLOROPHENYL)PROPYL] 1 (3 METHOXYPHENYL)ETHYLAMINE; NEOMYCIN; NICKEL; NPS R567; NPS S567; NPS S568; PARATHYROID HORMONE; PHOSPHORUS; POLYAMINE; STREPTOMYCIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 0037512520     PISSN: 00986577     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.63.s85.22.x     Document Type: Conference Paper
Times cited : (47)

References (31)
  • 1
    • 0031756899 scopus 로고    scopus 로고
    • New concepts in renal osteodystrophy
    • HRUSKA K: New concepts in renal osteodystrophy. Nephrol Dial Transplant 13:2755-2760, 1998
    • (1998) Nephrol Dial Transplant , vol.13 , pp. 2755-2760
    • Hruska, K.1
  • 2
    • 0027485515 scopus 로고
    • Aplastic osteodystrophy without aluminum: The role of "suppressed" parathyroid function
    • HERCZ G, PEI Y, GREENWOOD C, et al: Aplastic osteodystrophy without aluminum: The role of "suppressed" parathyroid function. Kidney Int 44:860-866, 1993
    • (1993) Kidney Int , vol.44 , pp. 860-866
    • Hercz, G.1    Pei, Y.2    Greenwood, C.3
  • 4
    • 0026936519 scopus 로고
    • Short and long-term efficacy of total parathyroidectomy with immediate autografting compared with subtotal parathyroidectomy in hemodialysis patients
    • GAGNÉ ER, UREÑA P, LEITE-SILVA S, et al: Short and long-term efficacy of total parathyroidectomy with immediate autografting compared with subtotal parathyroidectomy in hemodialysis patients. J Am Soc Nephrol 3:1008-1017, 1992
    • (1992) J Am Soc Nephrol , vol.3 , pp. 1008-1017
    • Gagné, E.R.1    Ureña, P.2    Leite-Silva, S.3
  • 5
    • 0034682247 scopus 로고    scopus 로고
    • Coronary artery calcification in young adults with end-stage renal disease who are undergoing dialysis
    • GOODMAN W, GOLDIN J, KUIZON B, et al: Coronary artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med 342:1478-1483, 2000
    • (2000) N Engl J Med , vol.342 , pp. 1478-1483
    • Goodman, W.1    Goldin, J.2    Kuizon, B.3
  • 6
    • 0031920748 scopus 로고    scopus 로고
    • Association of serum phosphorus and calcium x phosphorus product with mortality risk in chronic hemodialysis patients: A national study
    • BLOCK G, HULBERT-SHEARON T, LEVIN N, PORT F: Association of serum phosphorus and calcium x phosphorus product with mortality risk in chronic hemodialysis patients: A national study. Am J Kidney Dis 31:607-617, 1998
    • (1998) Am J Kidney Dis , vol.31 , pp. 607-617
    • Block, G.1    Hulbert-Shearon, T.2    Levin, N.3    Port, F.4
  • 7
    • 0036109562 scopus 로고    scopus 로고
    • Calciphylaxis is usually non-ulcerating: Risk factors, outcome and therapy
    • FINE A, ZACHARIAS J: Calciphylaxis is usually non-ulcerating: Risk factors, outcome and therapy. Kidney Int 61:2210-2217, 2002
    • (2002) Kidney Int , vol.61 , pp. 2210-2217
    • Fine, A.1    Zacharias, J.2
  • 8
    • 0027765508 scopus 로고
    • Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid
    • BROWN E, GAMBA G, RICCARDI D, et al: Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid. Nature 366:575-580, 1993
    • (1993) Nature , vol.366 , pp. 575-580
    • Brown, E.1    Gamba, G.2    Riccardi, D.3
  • 9
    • 0029051541 scopus 로고
    • Calcium-ion-sensing cell-surface receptors
    • BROWN E, POLLAK M, SEIDMAN C, et al: Calcium-ion-sensing cell-surface receptors. N Engl J Med 333:234-240, 1995
    • (1995) N Engl J Med , vol.333 , pp. 234-240
    • Brown, E.1    Pollak, M.2    Seidman, C.3
  • 10
    • 0033029793 scopus 로고    scopus 로고
    • Calcimimetic compounds: A direct approach to controlling plasma levels of parathyroid hormone in hyperparathyroidism
    • NEMETH E, FOX J: Calcimimetic compounds: A direct approach to controlling plasma levels of parathyroid hormone in hyperparathyroidism. Trends Endocrinol Metab 10:66-71, 1999
    • (1999) Trends Endocrinol Metab , vol.10 , pp. 66-71
    • Nemeth, E.1    Fox, J.2
  • 11
    • 0032808078 scopus 로고    scopus 로고
    • NPS R-568 A type II calcimimetic compound that acts on parathyroid cell calcium receptor of rats to reduce plasma levels of parathyroid hormone and calcium
    • FOX J, LOWE S, PETTY B, NEMETH E: NPS R-568: A type II calcimimetic compound that acts on parathyroid cell calcium receptor of rats to reduce plasma levels of parathyroid hormone and calcium. J Pharmacol Exp Ther 290:473-479, 1999
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 473-479
    • Fox, J.1    Lowe, S.2    Petty, B.3    Nemeth, E.4
  • 12
    • 0033175760 scopus 로고    scopus 로고
    • Structure and function of the extracellular calcium-sensing receptors
    • BAI M: Structure and function of the extracellular calcium-sensing receptors (review). Int J Mol Med 4:115-125, 1999
    • (1999) Int J Mol Med , vol.4 , pp. 115-125
    • Bai, M.1
  • 13
    • 0031978982 scopus 로고    scopus 로고
    • The extracellular calcium-sensing cell-surface receptor: Its role in health and disease
    • BROWN E, POLLAK M, HEBERT S: The extracellular calcium-sensing cell-surface receptor: Its role in health and disease. Annu Rev Med 49:15-29, 1998
    • (1998) Annu Rev Med , vol.49 , pp. 15-29
    • Brown, E.1    Pollak, M.2    Hebert, S.3
  • 14
    • 0032987986 scopus 로고    scopus 로고
    • Extracellular "calcistat" in health and disease
    • PEARCE S: Extracellular "calcistat" in health and disease. Lancet 353:82-83, 1999
    • (1999) Lancet , vol.353 , pp. 82-83
    • Pearce, S.1
  • 15
    • 0035958057 scopus 로고    scopus 로고
    • The Ca2+-sensing receptor activates cytosolic phospholipase A(2) via a G(Q) alpha-dependent ERK-independent pathway
    • HANDLOGTEN M, HUANG C, SHIRAISHI N, et al: The Ca2+-sensing receptor activates cytosolic phospholipase A(2) via a G(Q) alpha-dependent ERK-independent pathway. J Biol Chem 276:13941-13948, 2001
    • (2001) J Biol Chem , vol.276 , pp. 13941-13948
    • Handlogten, M.1    Huang, C.2    Shiraishi, N.3
  • 16
    • 0033935152 scopus 로고    scopus 로고
    • A calcimimetic agent lowers plasma parathyroid hormone levels in patients with secondary hyperparathyroidism
    • GOODMAN W, FRAZAO JM, GOODKIN D, et al: A calcimimetic agent lowers plasma parathyroid hormone levels in patients with secondary hyperparathyroidism. Kidney Int 58:436-445, 2000
    • (2000) Kidney Int , vol.58 , pp. 436-445
    • Goodman, W.1    Frazao, J.M.2    Goodkin, D.3
  • 17
    • 0032584086 scopus 로고    scopus 로고
    • Calcimimetics with potent and selective activity on the parathyroid calcium receptor
    • NEMETH E, STEFFEY M, HAMMERLAND L, et al: Calcimimetics with potent and selective activity on the parathyroid calcium receptor. Proc Nat Acad Sci 95:4040-4045, 1998
    • (1998) Proc Nat Acad Sci , vol.95 , pp. 4040-4045
    • Nemeth, E.1    Steffey, M.2    Hammerland, L.3
  • 18
    • 0037166287 scopus 로고    scopus 로고
    • Evidence for distinct cation and calcimimetic compound (NPS 568) recognition domains in the transmembrane regions of the human calcium receptor
    • RAY K, NORTHUP J: Evidence for distinct cation and calcimimetic compound (NPS 568) recognition domains in the transmembrane regions of the human calcium receptor. J Biol Chem 277:18908-18913, 2002
    • (2002) J Biol Chem , vol.277 , pp. 18908-18913
    • Ray, K.1    Northup, J.2
  • 19
    • 0032985183 scopus 로고    scopus 로고
    • The calcimimetic NPS R- 568 decreases plasma PTH in rats with mild and severe renal or dietary secondary hyperparathyroidism
    • FOX J, LOWE S, CONKLIN R, NEMETH E: The calcimimetic NPS R-568 decreases plasma PTH in rats with mild and severe renal or dietary secondary hyperparathyroidism. Endocrine 10:97-103, 1999
    • (1999) Endocrine , vol.10 , pp. 97-103
    • Fox, J.1    Lowe, S.2    Conklin, R.3    Nemeth, E.4
  • 20
    • 0032763887 scopus 로고    scopus 로고
    • Calcimimetic compound NPS R-568 stimulates calcitonin secretion but selectively targets parathyroid gland Ca(2+) receptor in rats
    • FOX J, LOWE S, CONKLIN R, et al: Calcimimetic compound NPS R-568 stimulates calcitonin secretion but selectively targets parathyroid gland Ca(2+) receptor in rats. J Pharmacol Exp Ther 290:480-486, 1999
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 480-486
    • Fox, J.1    Lowe, S.2    Conklin, R.3
  • 21
    • 0031466527 scopus 로고    scopus 로고
    • The calcimimetic compound NPS R- 568 suppresses parathyroid cell proliferation in rats with renal insufficiency
    • WADA M, FURUYA Y, SAKIYAMA J, et al: The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. J Clin Invest 100:2977-2983, 1997
    • (1997) J Clin Invest , vol.100 , pp. 2977-2983
    • Wada, M.1    Furuya, Y.2    Sakiyama, J.3
  • 22
    • 0033998869 scopus 로고    scopus 로고
    • Calcimimetic NPS R- 568 prevents parathyroid hyperplasia in rats with severe secondary hyperparathyroidism
    • WADA M, NAGANO N, FURUYA Y, et al: Calcimimetic NPS R-568 prevents parathyroid hyperplasia in rats with severe secondary hyperparathyroidism. Kidney Int 57:50-58, 2000
    • (2000) Kidney Int , vol.57 , pp. 50-58
    • Wada, M.1    Nagano, N.2    Furuya, Y.3
  • 23
    • 0034012178 scopus 로고    scopus 로고
    • Activation of the calcium receptor by a calcimimetic compound halts the progression of secondary hyperparathyroidism in uremic rats
    • CHIN J, MILLER S, WADA M, et al: Activation of the calcium receptor by a calcimimetic compound halts the progression of secondary hyperparathyroidism in uremic rats. J Am Soc Nephrol 11:903-911, 2000
    • (2000) J Am Soc Nephrol , vol.11 , pp. 903-911
    • Chin, J.1    Miller, S.2    Wada, M.3
  • 24
    • 0031885412 scopus 로고    scopus 로고
    • NPS R- 568 halts or reverses osteitis fibrosa in uremic rats
    • WADA M, ISHII H, FURUYA Y, et al: NPS R-568 halts or reverses osteitis fibrosa in uremic rats. Kidney Int 53:448-453, 1998
    • (1998) Kidney Int , vol.53 , pp. 448-453
    • Wada, M.1    Ishii, H.2    Furuya, Y.3
  • 25
    • 0033962371 scopus 로고    scopus 로고
    • Daily intermittent decreases in serum levels of parathyroid hormone have an anabolic-like action on the bones of uremic rats with low-turnover bone and osteomalacia
    • ISHII H, WADA M, FURUYA Y, et al: Daily intermittent decreases in serum levels of parathyroid hormone have an anabolic-like action on the bones of uremic rats with low-turnover bone and osteomalacia. Bone 26:175-182, 2000
    • (2000) Bone , vol.26 , pp. 175-182
    • Ishii, H.1    Wada, M.2    Furuya, Y.3
  • 26
    • 0034053977 scopus 로고    scopus 로고
    • Calcimimetic agents and the calcium-sensing receptor
    • COBURN J, MAUNG H: Calcimimetic agents and the calcium-sensing receptor. Curr Opin Nephrol Hypertens 9:123-132, 2000
    • (2000) Curr Opin Nephrol Hypertens , vol.9 , pp. 123-132
    • Coburn, J.1    Maung, H.2
  • 27
    • 0032892011 scopus 로고    scopus 로고
    • Mixed-effects modeling of the pharmaco-dynamic response to the calcimimetic agent R- 568
    • LALONDE RL, GAUDREAULT J, KARHU DA, MARRIOTT TB: Mixed-effects modeling of the pharmaco-dynamic response to the calcimimetic agent R-568. Clin Pharmacol Ther 65:40-49, 1999
    • (1999) Clin Pharmacol Ther , vol.65 , pp. 40-49
    • Lalonde, R.L.1    Gaudreault, J.2    Karhu, D.A.3    Marriott, T.B.4
  • 28
    • 0030667380 scopus 로고    scopus 로고
    • Short-term inhibition of parathyroid hormone secretion by a calcium receptor agonist in primary hyperparathyroidism
    • SILVERBERG SI, BONE H, MARRIOT T, et al: Short-term inhibition of parathyroid hormone secretion by a calcium receptor agonist in primary hyperparathyroidism. N Engl J Med 337:1506-1510, 1997
    • (1997) N Engl J Med , vol.337 , pp. 1506-1510
    • Silverberg, S.I.1    Bone, H.2    Marriot, T.3
  • 29
    • 0031763613 scopus 로고    scopus 로고
    • Treatment of hypercalcemia secondary to parathyroid carcinoma with a novel calcimimetic agent
    • COLLINS MT, SKARULIS MC, BILEZIKIAN JP, et al: Treatment of hypercalcemia secondary to parathyroid carcinoma with a novel calcimimetic agent. J Clin Endocrinol Metab 83:1083-1088, 1998
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 1083-1088
    • Collins, M.T.1    Skarulis, M.C.2    Bilezikian, J.P.3
  • 30
    • 0031888842 scopus 로고    scopus 로고
    • A calcimimetic agent acutely suppresses parathyroid hormone levels in patients with chronic renal failure
    • ANTONSEN J, SHERRARD D, ANDRESS D: A calcimimetic agent acutely suppresses parathyroid hormone levels in patients with chronic renal failure. Kidney Int 53:223-227, 1998
    • (1998) Kidney Int , vol.53 , pp. 223-227
    • Antonsen, J.1    Sherrard, D.2    Andress, D.3
  • 31
    • 0036208986 scopus 로고    scopus 로고
    • The calcimimetic agent AMG 073 lowers plasma parathyroid hormone levels in hemodialysis patients with secondary hyperparathyroidism
    • GOODMAN W, HLADIK GA, TURNER SA, et al: The calcimimetic agent AMG 073 lowers plasma parathyroid hormone levels in hemodialysis patients with secondary hyperparathyroidism. J Am Soc Nephrol 13:1017-1024, 2002
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1017-1024
    • Goodman, W.1    Hladik, G.A.2    Turner, S.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.