Calcium transport in the kidney

Current Opinion in Nephrology and Hypertension

Volumn 8, Issue 5, 1999, Pages 589-595

  Friedman, Peter A ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORIDE CHANNEL; MEGALIN;

BARTTER SYNDROME; CALCIUM TRANSPORT; HUMAN; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; PARATHYROID HORMONE RELEASE; PRIORITY JOURNAL; REVIEW;

ANIMALS; CALCITRIOL; CALCIUM; CALCIUM CHANNELS; CALCIUM-BINDING PROTEIN, VITAMIN D-DEPENDENT; CHLORIDE CHANNELS; HEYMANN NEPHRITIS ANTIGENIC COMPLEX; HUMANS; HYPOKALEMIA; ION TRANSPORT; KIDNEY; KIDNEY CALCULI; MEMBRANE GLYCOPROTEINS; PARATHYROID HORMONE;

EID: 0033432781     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-199909000-00010     Document Type: Review

References (58)

1. 1 Bindels RJM. Calcium handling by the mammalian kidney. J Exp Biol 1993; 184:89-104.
2. 2 Bourdeau JE. Mechanisms and regulation of calcium transport in the nephron. Semin Nephrol 1993; 13:191-201.
3. 3 Friedman PA, Gesek FA. Cellular calcium transport in renal epithelia: measurement, mechanisms, and regulation. Physiol Rev 1995; 75:429-471.
4. 4 Friedman PA. Renal calcium metabolism. In: The kidney: physiology and pathophysiology. Seldin DW, Giebisch G (editors). Philadelphia: Lippincott, Williams & Wilkins; 1999 (in press).
5. 5 Scheinman SJ, Guay-Woodford LM, Thakker RV, Warnock DG. Genetic disorders of renal electrolyte transport. N Engl J Med 1999; 340:1177-1187. This is a lucid, up-to-date review of inherited electrolyte disorders attributable to inactivating or activating mutations of renal ion channels and transporters.
6. 3 1α-hydroxylase and vitamin D synthesis. Science 1997; 277:1827-1830.
7. 7 Haddad JG. Plasma vitamin D-binding protein (Gc-globulin): multiple tasks. J Steroid Biochem Mol Biol 1995; 53:579-582.
8. 8 Haddad JG, Fraser DR, Lawson DE. Vitamin D plasma binding protein. Turnover and fate in the rabbit. J Clin Invest 1981; 67:1550-1560.
9. 3, is mediated to a great extent not by diffusion, but by the megalin receptor.
10. 10 Farquhar MG. The unfolding story of megalin (gp330): now recognized as a drug receptor. J Clin Invest 1995; 96:1184.
11. 2+-sensing protein. J Histochem Cytochem 1997; 45:383-392.
12. 12 Christensen El, Nielsen S, Moestrup SK, Borre C, Maunsbach AB, De Heer E, et al. Segmental distribution of the endocytosis receptor gp330 in renal proximal tubules. Eur J Cell Biol 1995; 66:349-364.
13. 13 Christensen El, Birn H, Verroust P, Moestrup SK. Megalin-mediated endocytosis in renal proximal tubule. Ren Fail 1998; 20:191-199.
14. 14 Cui S, Verroust PJ, Moestrup SK, Christensen El. Megalin/gp330 mediates uptake of albumin in renal proximal tubule. Am J Physiol 1996; 271:F900-F907.
15. 15 Kau ST, Maack T. Transport and catabolism of parathyroid hormone in isolated rat kidney. Am J Physiol 1977; 233:F445-F454.
16. 2-terminal parathyroid hormone by opossum kidney cells. Am J Physiol 1991; 260:E544-E552.
17. 17 Hilpert J, Nykjaer A, Jacobsen C, Wallukat G, Nielsen R, Moestrup SK, et al. Megalin antagonizes activation of the parathyroid hormone receptor. J Biol Chem 1999; 274:5620-5625. This paper describes the finding that megalin not only serves as a PTH clearance receptor in proximal tubules, but does so with remarkable structural specificity.
18. 18 Gardella TJ, Luck MD, Wilson AK, Keutmann HT, Nussbaum SR, Potts JT Jr, et al. Parathyroid hormone (PTH)-PTH-related peptide hybrid peptides reveal functional interactions between the 1-14 and 15-34 domains of the ligand. J Biol Chem 1995; 270:6584-6588.
19. 19 Fisher SE, Van Bakel I, Lloyd SE, Pearce SHS, Thakker RV, Craig IW. Cloning and characterization of CLCN5, the human kidney chloride channel gene implicated in Dent disease (an X-linked hereditary nephrolithiasis). Genomics 1995; 29:598-606.
20. 20 Lloyd SE, Pearce SH, Gunther W, Kawaguchi H, Igarashi T, Jentsch TJ, et al. Idiopathic low molecular weight proteinuria associated with hypercalciuric nephrocalcinosis in Japanese children is due to mutations of the renal chloride channel (CLCN5). J Clin Invest 1997; 99:967-974.
21. 21 Lloyd SE, Günther W, Pearce SHS, Thomson A, Bianchi ML, Bosio M, et al. Characterisation of renal chloride channel, CLCN5, mutations in hypercalciuric nephrolithiasis (kidney stones) disorders. Hum Mol Genet 1997; 6:1233-1239.
22. 22 Lloyd SE, Pearce SH, Fisher SE, Steinmeyer K, Schwappach B, Scheinman SJ, et al. A common molecular basis for three inherited kidney stone diseases. Nature 1996; 379:445-449.
23. 23 Nakazato H, Yoshimuta J, Karashima S, Matsumoto S, Endo F, Matsuda I, et al. Chloride channel CLCN5 mutations in Japanese children with familial idiopathic low molecular weight proteinuria. Kidney Int 1999; 55:63-70.
24. +-ATPase and with internalized proteins early after uptake.
25. 25 Devuyst O, Christie PT, Courtoy PJ, Beauwens R, Thakker RV. Intra-renal and subcellular distribution of the human chloride channel, CLC-5, reveals a pathophysiological basis for Dent's disease. Hum Mol Genet 1999; 8:247-257. This is another important study establishing that CIC-5 colocalizes in proximal tubule cells with Rab4, a marker of recycling early endosomes.
26. 26 Luyckx VA, Goda FO, Mount DB, Nishio T, Hall A, Hebert SC, et al. Intrarenal and subcellular localization of rat CLC5. Am J Physiol 1998; 275:F761-F769.
27. 27 Adachi S, Uchida S, Ito H, Hata M, Hiroe M, Marumo F, et al. Two isoforms of a chloride channel predominantly expressed in thick ascending limb of Henle's loop and collecting ducts of rat kidney. J Biol Chem 1994; 269:17677-17683.
28. 28 Vandewalle A, Cluzeaud F, Bens M, Kieferle S, Steinmeyer K, Jentsch TJ. Localization and induction by dehydration of CIC-K chloride channels in the rat kidney. Am J Physiol 1997; 272:F678-F688.
29. 29 Kieferle S, Fong P, Bens M, Vandewalle A, Jentsch TJ. Two highly homologous members of the CIC chloride channel family in both rat and human kidney. Proc Natl Acad Sci U S A 1994; 91:6943-6947.
30. 30 Gesek FA, Friedman PA. On the mechanism of parathyroid hormone stimulation of calcium uptake by mouse distal convoluted tubule celts. J Clin Invest 1992; 90:749-758.
31. 31 Simon DB, Bindra RS, Mansfield TA, Nelson-Williams C, Mendonca E, Stone R, et al. Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III. Nat Genet 1997; 17:171-178.
32. 32 Simon DB, Karet FE, Hamdan JM, Di Pietro A, Sanjad SA, Lifton RP. Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2CI cotransporter NKCC2. Nat Genet 1996; 13:183-188.
33. + channel, ROMK. Nat Genet 1996; 14:152-156.
34. 34 Yoshikawa M, Uchida S, Yamauchi A, Miyai A, Tanaka Y, Sasaki S, et al. Localization of rat CLC-K2 chloride channel mRNA in the kidney. Am J Physiol Renal Physiol 1999; 276:F552-F558.
35. 2+ channels in renal epithelial cells by parathyroid hormone. Nature 1990; 347:388-391.
36. 2+ channels sensitive to dihydropyridines and activated by hyperpolarizing voltages. Am J Physiol 1994; 267:C157-C165.
37. 37 Barry ELR, Gesek FA, Yu ASL, Lytton J, Friedman PA. Distinct calcium channel isoforms mediate parathyroid hormone and chlorothiazide-stimulated calcium entry in transporting epithelial cells. J Membr Biol 1998; 161:55-64.
38. 3-responsive epithelia. J Biol Chem 1999; 274:8375-8378. This key contribution identifies a nonselective cation channel that is found in distal tubules and may be the apical membrane calcium entry channel.
39. 39 Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997; 389:816-824.
40. 40 Suzuki M, Sato J, Kutsuwada K, Ooki G, Imai M. Cloning of a stretchinhibitable nonselective cation channel. J Biol Chem 1999; 274:6330-6335.
41. 41 Christakos S, Gabrielides C, Rhoten WB. Vitamin D-dependent calcium binding proteins: chemistry, distribution, functional considerations, and molecular biology. Endocr Rev 1989; 10:3-26.
42. 9k and parvalbumin are exclusively located along basolateral membranes in rat distal nephron. J Am Soc Nephrol 1991; 2:1122-1129.
43. 43 Bronner F. Renal calcium transport: mechanisms and regulation - an overview. Am J Physiol 1989; 257:F707-F711.
44. 44 Feher JJ. Facilitated calcium diffusion by intestinal calcium-binding protein. Am J Physiol 1983; 244:C303-C307.
45. 3-dependent calcium binding proteins increase calcium reabsorption by different mechanisms. I. Effect of CaBP 28K. Kidney Int 1994; 45:461-468.
46. 3-dependent calcium binding proteins increase calcium reabsorption by different mechanisms. II. Effect of CaBP 9K. Kidney Int 1994; 45:469-474.
47. 28k knockout mice [Abstract]. J Bone Miner Res 1999 (in press).
48. 48 Hemmingsen C, Staun M, Meibom K, Bang K, Olgaard K. Urinary calcium excretion and renal calbindin-D28k. Kidney Blood Press Res 1997; 20:247-250.
49. 2+-sensing receptor and PTH/PTHrP receptor in rat kidney. Am J Physiol 1996; 271:F951-F956.
50. 2+ polyvalent cation-sensing protein in rat kidney. Am J Physiol Renal Physiol 1998; 274:F611-F622. This careful and well-performed study reveals important cellular and subcellular heterogeneity in the localization of the CaSR.
51. 51 Desfleurs E, Wittner M, Simeone S, Pajaud S, Moine G, Rajerison R, et al. Calcium-sensing receptor: regulation of electrolyte transport in the thick ascending limb of Henle's loop. Kidney Blood Press Res 1998; 21:401-412.
52. 52 Quamme GA. Effect of hypercalcemia on renal tubular handling of calcium and magnesium. Can J Physiol Pharmacol 1982; 60:1275-1280.
53. 2+ decreases chloride reabsorption in rat CTAL by inhibiting cAMP pathway. Am J Physiol Renal Physiol 1998; 275:F198-F203.
54. 2+-sensing receptor in the rabbit cortical thick ascending limb (CTAL) is functionally not coupled to phospholipase C. Pflugers Arch 1999; 437:716-723.
55. 2+-sensing receptor from bovine parathyroid. Nature 1993; 366:575-580.
56. 2+-inhibitable adenylyl cyclases along the renal tubule. Functional consequences for regulation of the cAMP content. J Biol Chem 1996; 271:19264-19271.
57. 2+ inhibits peptide hormone-dependent cAMP production specifically in thick ascending limbs of Henle. Miner Electrolyte Metab 1986; 12:342-346.
58. 2+. J Biol Chem 1998; 273:15192-15202.