Reduced Immunostaining for the Extracellular Ca2+-Sensing Receptor in Primary and Uremic Secondary Hyperparathyroidism

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 4, 1996, Pages 1598-1606

  Kifor, Olga ^a   Moore Jr , Francis D ^a   Wang, Peter ^a   Goldstein, Meryl ^a   Vassilev, Peter ^a   Kifor, Imre ^a   Hebert, Steven C ^a   Brown, Edward M ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BOVINAE;

CALCIUM;

ARTICLE; DIAGNOSTIC ACCURACY; EXTRACELLULAR CALCIUM; HUMAN; HUMAN TISSUE; HYPERCALCEMIA; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; PARATHYROID ADENOMA; PARATHYROIDECTOMY; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; RECEPTOR AFFINITY; SECONDARY HYPERPARATHYROIDISM;

ADENOMA; ANIMALS; ANTIBODIES; BIOPSY; CALCIUM-BINDING PROTEINS; CATTLE; HUMANS; HYPERPARATHYROIDISM; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; MICE; PARATHYROID GLANDS; PARATHYROID NEOPLASMS; RATS; REFERENCE VALUES; UREMIA;

EID: 0029873489     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.81.4.8636374     Document Type: Article

References (49)

1. Brown EM, Broadus AE, Brennan MF, et al. 1979 Direct comparison in vivo and in vitro of suppressibility of parathyroid function by calcium in primary hyperparathyroidism. J Clin Endocrinol Metab. 48:604-610.
2. Khosla S, Ebeling PR, Firek AF, Burritt MM, Kao PC, Heath III H. 1993 Calcium infusion suggests a "set point" abnormality of parathyroid gland function in familial benign hypercalcemia and more complex disturbances in primary hyperparathyroidism. J Clin Endocrinol Metab. 76:715-720.
3. D'Amour P, Weisnagel, Rousseau L, Brossard JH, Ste-Marie L-G, Lepage R. 1994 The parathyroid function in vivo in primary hyperparathyroidism. Comparison with normals [Abstract]. J Bone Miner Res. 9:S337.
4. Habener JF. 1978 Responsiveness of neoplastic and hyperplastic parathyroid tissue to calcium in vitro. J Clin Invest. 62:436-450.
5. Birnbaumer ME, Schneider AB, Palmer D, Hanley DA, Sherwood LM. 1977 Secretion of parathyroid hormone by abnormal parathyroid glands in vitro. J Clin Endocrinol Metab. 45:105-113.
6. Brown EM. 1983 Four parameter model of the sigmoidal relationship between PTH release and the extracellular calcium concentration in normal and abnormal parathyroid tissue. J Clin Endocrinol Metab. 56:572-581.
7. Rudberg C, Akerstrom G, Ljunghall S, et al. 1982 Regulation of parathyroid hormone secretion in primary and secondary hyperparathyroidism: studies in vivo and in vitro. Acta Endocrinol (Copenh). 101:408-413.
8. Brown EM, Wilson RE, Thatcher JC, Marynick SP. 1981 Abnormal calcium-regulated PTH release in normal parathyroid tissue from patients with an adenoma. Am J Med. 71:565-570.
9. Brent GA, LeBoff MS, Seely EW, Conlin PR, Brown EM. 1988 Relationship between the concentration and rate of change of calcium and serum intact parathyroid hormone levels in normal humans. J Clin Endocrinol Metab. 67:944-950.
10. Brown EM, Wilson RE, Eastman RC, Marynick SP. 1982 Abnormal regulation of PTH release by calcium in secondary hyperparathyroidism due to chronic renal failure. J Clin Endocrinol Metab. 54:172-179.
11. Delmez AJ, Tindira C, Grooms O, Dusso A, Windus DW, Slatopolsky E. 1989 Parathyroid hormone suppression by intravenous 1,25-dihydroxyvitamin D: a role for increased sensitivity to calcium. J Clin Invest. 83:1349-1355.
12. Wallfelt CH, Larsson R, Gylfe E, Ljunghall S, Rastad J, Akerstrom. 1988 Secretory disturbance in hyperplastic parathyroid nodules of uremic hyperparathyroidism-implication for parathyroid autotransplantation. West J Surg. 12:431-438.
13. Brown EM, LeBoff MS, Oetting M, Posillico JT, Chen C. 1987 Secretory control in normal and abnormal parathyroid tissue. Recent Prog Horm Res. 43:337-382.
14. LeBoff MS, Shoback DM, Brown EM, et al. 1985 Regulation of parathyroid hormone release and cytosolic calcium by extracellular calcium in dispersed and cultured bovine and pathological human parathyroid cells. J Clin Invest. 75:49-57.
15. 2+-sensing function of parathyroid cells in vitro and in hyperparathyroidism. Biochim Biophys Acta. 968:253-260.
16. 2+-sensing receptor from bovine parathyroid. Nature. 366: 575-580.
17. 2+-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Cell. 75:1297-1303.
18. Marx, SJ, Lasker R, Brown E, et al. 1986 Secretory dysfunction in parathyroid cells from a neonate with severe primary hyperparathyroidism. J Clin Endocrinol Metab. 62:445-448.
19. Cooper L, Wertheimer J, Levey R, et al. 1986 Severe primary hyperparathyroidism in a neonate with two hypercalcemic parents: management with parathyroidectomy and heterotopic autotransplantation. Pediatrics. 78:263-268.
20. 2+-sensing receptor gene in human parathyroid adenomas. J Clin Endocrinol Metab 80:3107-3110.
21. 2+ -sensing receptor mRNA and protein. Endocrinology. 136:3087-3092.
22. Garrett, J, Capuano IV, Hammerland LG, et al. Molecular cloning and characterization of a human parathyroid calcium receptor. J Biol Chem. In press.
23. Erickson PA, Lewis GP, Fisher SK. 1993 Postembedding immunocytochemical techniques for light and electron microscopy. In: Asai DJ, ed. Antibodies in cell biology. New York: Academic Press; 306.
24. Johnson A, Thorpe R. 1987 Immunocytochemistry and immunohistochemistry. In: Johnson A, Thorpe R, eds. Immunochemistry in practice. London: Blackwell; 283.
25. a-biotinylated neuropeptide Y analogs. In: Conn PM, ed. Receptors: molecular biology, receptor subclasses, localization and ligand design. New York: Academic Press; 373.
26. Hale IL, Matsumoto B. 1993 Resolution of subcellular detail in thick tissue sections: immunohistochemical preparation and fluorescence confocal microscopy. In: Matsumoto B, ed. Cell biological applications of confocal microscopy. New York: Academic Press.
27. Chiou C-Y, Williams GH, Kifor I. 1995 Study of the renin-angiotensin system of the rat adrenal gland at a cellular level. J Clin Invest. 96:1375-1381.
28. Treadway JL, Pessin JE. 1990 Receptor characterization. In: Siddle K, Hutton JC, eds. Peptide hormone action. IRL Press; 43.
29. Laemmli UK. 1970 Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature. 227:680-685.
30. Gittes RF, Radde IC. 1966 Experimental model for hyperparathyroidism: effect of excessive numbers of transplanted isologous parathyroid glands. J Urol. 95:595-603.
31. Parfitt AM. 1969 A theoretical model of the relationship between parathyroid cell mass and plasma calcium concentration in normal and uremic subjects: an analysis of the concept of autonomy and speculations on the mechanism of parathyroid hyperplasia. Arch Intern Med. 124:269-273.
32. Motokura T, Bloom T, Kim HG, et al. 1991 A novel cyclin encoded by a bell-linked candidate oncogene. Nature. 350:512-515.
33. Friedman E, Sakaguchi K, Bale AE, et al. 1989 Clonality of parathyroid tumors in familial multiple endocrine neoplasia type 1. N Engl J Med. 321:213-218.
34. Cryns VL, Thor A, Xu H-J, et al. 1994 Loss of retinoblastoma tumor-suppressor gene in parathyroid carcinoma. N Engl J Med. 330:757-761.
35. Pearce SHS, Trump D, Wooding C, et al. 1994 Four novel mutations in the calcium-sensing receptor gene associated with familial benign (hypocalciuric) hypercalcemia [Abstract]. J Bone Miner Res. 9(Suppl 1):S145.
36. Heath III H, Odelberg S, Brown D, et al. 1994 Sequence analysis of the parathyroid cell calcium receptor (CaR) gene in familial benign hypercalcemia (FBH): a multiplicity of mutation [Abstract]? J Bone Miner Res. 9(Suppl 1):S414.
37. Pollak M, Chou Y-HW, Marx SJ, et al. 1994 Familial hypocalciuric hypercalcemia and neonatal severe hypercalcemia: the effects of mutant gene dosage on phenotype. J Clin Invest. 93:1108-1112.
38. 3. Endocrinology. 136:499-504.
39. Nygren P, Larsson R, Gylfe E, et al. 1987 Development of abnormal parathyroid cell function during monolayer culture and its relation to cellular hypertrophy and proliferation. Acta Pathol Microbiol Scand [A]. 95:207-214.
40. Brown EM, Gardner DG, Brennan MF, et al. 1979 Calcium-regulated parathyroid hormone release in primary hyperparathyroidism: studies, in vitro with dispersed parathyroid cells. Am J Med. 66:923-931.
41. Roth SI, Raisz LG. 1966 Time course and reversibility of calcium effect on the ultrastructure of the rat parathyroid glands in organ culture. Lab Invest. 15:1187-1211.
42. Arnold A, Staunton CE, Kim HG, Gaz RD, Kronenberg HM. 1988 Monoclonality and abnormal parathyroid hormone genes in parathyroid adenomas. N Engl J Med. 318:658-662.
43. Arnold A, Brown MF, Urena P, Sarfati E, Drueke T. 1995 Monoclonality of parathyroid tumors in chronic renal failure and in primary parathyroid hyperplasia. J Clin Invest. 95:2047-2053.
44. Cloutier M, Gascon-Barre M, D'Amour P. 1992 Chronic adaption of dog parathyroid function to low-calcium-high sodium-vitamin D-deficient diet. J Bone Miner Res. 7:1021-1028.
45. Felsenfeld AJ, Llach F. 1993 Parathyroid gland function in chronic renal failure. Kidney Int. 43:771-789.
46. Sanchez C, Goodman WG, Ramirez J, et al. 1994 Dynamic assessment of parathyroid function in dialysis patients with either osteitis fibrosa or adynamic renal osteodystrophy [Abstract]. J Bone Miner Res. 9:S347.
47. Juhlin C, Klareskog L, Nygren P, et al. 1988 Hyperparathyroidism is associated with reduced expression of a parathyroid calcium receptor mechanism defined by monoclonal antiparathyroid antibodies. Endocrinology. 122:2999-3001.'
48. Lundgren S, Hjalm G, Hellman P, et al. 1994 A protein involved in calcium sensing of the human parathyroid and placental cytotrophoblast cells belongs to the LDL-receptor protein superfamily. Exp Cell Res. 212:344-350.
49. Saito A, Pietromonaco S, Kwor-Chieh Loo A, Farquhar MG. 1994 Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family. Proc Natl Acad Sci USA. 91: 9725-9729.