Daily transient decreases in plasma parathyroid hormone levels induced by the calcimimetic NPS R-568 slows the rate of bone loss but does not increase bone mass in ovariectomized rats

Bone

Volumn 27, Issue 4, 2000, Pages 511-519

  Miller, M A ^a   Fox, J ^a  

^a NPS Pharmaceutical Inc   (United States)

Author keywords

Bone; Ca 2+ receptor; Calcimimetics; Osteoblasts; Osteoclasts; Osteoporosis

Indexed keywords

CALCITONIN; N [3 (2 CHLOROPHENYL)PROPYL] 1 (3 METHOXYPHENYL)ETHYLAMINE; PARATHYROID HORMONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE ATROPHY; BONE MINERAL; CANCELLOUS BONE; CONTROLLED STUDY; FEMALE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOPOROSIS; OVARIECTOMY; RAT;

ANILINE COMPOUNDS; ANIMALS; BODY WEIGHT; BONE DENSITY; BONE DISEASES, METABOLIC; CALCIUM; OSTEOCALCIN; OVARIECTOMY; PARATHYROID HORMONE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0033807482     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(00)00350-1     Document Type: Article

References (34)

1. Anabolic actions of parathyroid hormone on bone
2. The calcimimetic NPS R-568 decreases plasma PTH in rats with mild and severe renal or dietary secondary hyperparathyroidism
3. 2+ receptor in rats
4. NPS R-568; A type II calcimimetic compound that acts on parathyroid cell calcium receptor of rats to reduce plasma levels of parathyroid hormone and calcium
5. The calcimimetic NPS R-568 prevents the development of secondary hyperparathyroidism and elevated bone formation in rats with mild chronic renal insufficiency [abstract]
6. Plasma levels of parathyroid hormone that induce anabolic effects in bone of ovariectomized rats can be achieved by stimulation of endogenous hormone secretion
7. Pairwise multiple comparison procedures with unequal n's and/or variances; A Monte Carlo study
8. Calcitonin-secreting cells of the thyroid express an extracellular calcium receptor gene
9. A randomized controlled trial to compare the efficacy of cyclical parathyroid hormone versus cyclical parathyroid hormone and sequential calcitonin to improve bone mass in postmenopausal women with osteoporosis
10. Expression of an extracellular calcium-sensing receptor in human and mouse bone marrow cells
11. Daily intermittent decreases in serum levels of parathyroid hormone have an anabolic-like action on the bones of uremic rats with low-turnover bone and osteomalacia
12. Skeletal responsiveness to parathyroid hormone in healthy females; Relationship to menopause and oestrogen replacement
13. The effect of recombinant human (1-84) or synthetic human (1-34) parathyroid hormone on the skeleton of adult osteopenic ovariectomized rats
14. Mixed-effects modeling of the pharmacodynamic response to the calcimimetic agent R-568
15. Stimulation of calcitonin secretion by calcium receptor activators; Evaluation using a new, highly-sensitive homologous immunoradiometric assay for rat calcitonin
16. Randomized controlled study of effect ofparathyroid hormone on vertebral-bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis
17. Disparate effects of mild, moderate, and severe secondary hyperparathyroidism on cancellous and cortical bone in rats with chronic renal insufficiency
18. The anabolic effects of human parathyroid hormone (hPTH) on rat vertebral body mass are also reflected in the quality of bone, assessed by biomechanical testing; A comparison study between hPTH-(1-34) and hPTH-(1-84)
19. Stimulation of parathyroid hormone secretion by a small molecule antagonist of the calcium receptor [abstract]
20. Calcimimetics with potent and selective activity on the parathyroid calcium receptor
21. Bone histomorphometry; Standardization of nomenclature, symbols, and units
22. Parathyroid hormone 1-34 (hPTH 1-34) and estrogen produce dramatic bone density increases in postmenopausal osteoporosis-Results from a placebo-controlled randomized trial [abstract]
23. Parathyroidectomy does not prevent bone loss in the oophoectomized rat
24. Extracellular calcium-sensing receptors on osteoclasts and parathyroid cells are pharmacologically distinct
25. Bone responsiveness to parathyroid hormone in normal and postmenopausal osteoporotic women
26. NPS R-568 halts or reverses osteitis fibrosa in uremic rats
27. Restoration of severely depleted femoral trabecular bone in ovariectomized rats by parathyroid hormone-(1-34)
28. 2+)-sensing receptor in clonal osteoblast-like cell lines, UMR-106 and SaOS-2
29. Emerging insights into the role of calcium ions in osteoclast regulation