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Volumn 106, Issue 4, 2009, Pages 1374-1384

Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling

Author keywords

Contraction; Essential amino acids; Leucine; Translation initiation

Indexed keywords

ESSENTIAL AMINO ACID; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MUSCLE PROTEIN; UNCLASSIFIED DRUG; MTORC1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

EID: 66149097065     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.91397.2008     Document Type: Review
Times cited : (240)

References (113)
  • 1
    • 0033980371 scopus 로고    scopus 로고
    • Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation
    • Anthony JC, Anthony TG, Kimball SR, Vary TC, Jefferson LS. Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation. J Nutr 130: 139-145, 2000.
    • (2000) J Nutr , vol.130 , pp. 139-145
    • Anthony, J.C.1    Anthony, T.G.2    Kimball, S.R.3    Vary, T.C.4    Jefferson, L.S.5
  • 2
    • 0033808169 scopus 로고    scopus 로고
    • Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway
    • Anthony JC, Yoshizawa F, Anthony TG, Vary TC, Jefferson LS, Kimball SR. Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. J Nutr 130: 2413-2419, 2000.
    • (2000) J Nutr , vol.130 , pp. 2413-2419
    • Anthony, J.C.1    Yoshizawa, F.2    Anthony, T.G.3    Vary, T.C.4    Jefferson, L.S.5    Kimball, S.R.6
  • 3
    • 0032948278 scopus 로고    scopus 로고
    • Phosphorylation of p70(S6k) correlates with increased skeletal muscle mass following resistance exercise
    • Baar K, Esser K. Phosphorylation of p70S6k correlates with increased skeletal muscle mass following resistance exercise. Am J Physiol Cell Physiol 276: C120-C127, 1999. (Pubitemid 29063574)
    • (1999) American Journal of Physiology - Cell Physiology , vol.276 , Issue.1
    • Baar, K.1    Esser, K.2
  • 4
    • 39749141485 scopus 로고    scopus 로고
    • The regulation and function of Class III PI3Ks: Novel roles for Vps34
    • Backer JM. The regulation and function of Class III PI3Ks: novel roles for Vps34. Biochem J 410: 1-17, 2008.
    • (2008) Biochem J , vol.410 , pp. 1-17
    • Backer, J.M.1
  • 6
    • 0024567234 scopus 로고
    • 13C]leucine
    • Bennet WM, Connacher AA, Scrimgeour CM, Smith K, Rennie MJ. Increase in anterior tibialis muscle protein synthesis in healthy man during mixed amino acid infusion: studies of incorporation of [1-13C]leucine. Clin Sci (Lond) 76: 447-454, 1989. (Pubitemid 19104300)
    • (1989) Clinical Science , vol.76 , Issue.4 , pp. 447-454
    • Bennet, W.M.1    Connacher, A.A.2    Scrimgeour, C.M.3    Smith, K.4    Rennie, M.J.5
  • 7
    • 0028837394 scopus 로고
    • Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle
    • Biolo G, Declan Fleming RY, Wolfe RR. Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle. J Clin Invest 95: 811-819, 1995.
    • (1995) J Clin Invest , vol.95 , pp. 811-819
    • Biolo, G.1    Declan Fleming, R.Y.2    Wolfe, R.R.3
  • 8
    • 0028914883 scopus 로고
    • Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans
    • Biolo G, Maggi SP, Williams BD, Tipton KD, Wolfe RR. Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans. Am J Physiol Endocrinol Metab 268: E514-E520, 1995.
    • (1995) Am J Physiol Endocrinol Metab , vol.268
    • Biolo, G.1    Maggi, S.P.2    Williams, B.D.3    Tipton, K.D.4    Wolfe, R.R.5
  • 10
    • 0032932849 scopus 로고    scopus 로고
    • Insulin action on muscle protein kinetics and amino acid transport during recovery after resistance exercise
    • DOI 10.2337/diabetes.48.5.949
    • Biolo G, Williams BD, Fleming RY, Wolfe RR. Insulin action on muscle protein kinetics and amino acid transport during recovery after resistance exercise. Diabetes 48: 949-957, 1999. (Pubitemid 29226339)
    • (1999) Diabetes , vol.48 , Issue.5 , pp. 949-957
    • Biolo, G.1    Williams, B.D.2    Fleming, R.Y.D.3    Wolfe, R.R.4
  • 12
    • 0344033820 scopus 로고    scopus 로고
    • Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle
    • DOI 10.1113/jphysiol.2003.047019
    • Bolster DR, Kubica N, Crozier SJ, Williamson DL, Farrell PA, Kimball SR, Jefferson LS. Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle. J Physiol 553: 213-220, 2003. (Pubitemid 37483929)
    • (2003) Journal of Physiology , vol.553 , Issue.1 , pp. 213-220
    • Bolster, D.R.1    Kubica, N.2    Crozier, S.J.3    Williamson, D.L.4    Farrell, P.A.5    Kimball, S.R.6    Jefferson, L.S.7
  • 13
    • 3042701690 scopus 로고    scopus 로고
    • Leucine regulates translation initiation in rat skeletal muscle via enhanced eIF4G phosphorylation
    • Bolster DR, Vary TC, Kimball SR, Jefferson LS. Leucine regulates translation initiation in rat skeletal muscle via enhanced eIF4G phosphorylation. J Nutr 134: 1704-1710, 2004.
    • (2004) J Nutr , vol.134 , pp. 1704-1710
    • Bolster, D.R.1    Vary, T.C.2    Kimball, S.R.3    Jefferson, L.S.4
  • 16
    • 0036438894 scopus 로고    scopus 로고
    • Regulation of peptide-chain elongation in mammalian cells
    • Browne GJ, Proud CG. Regulation of peptide-chain elongation in mammalian cells. Eur J Biochem 269: 5360-5368, 2002.
    • (2002) Eur J Biochem , vol.269 , pp. 5360-5368
    • Browne, G.J.1    Proud, C.G.2
  • 17
    • 25444457577 scopus 로고    scopus 로고
    • hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
    • Byfield MP, Murray JT, Backer JM. hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J Biol Chem 280: 33076-33082, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 33076-33082
    • Byfield, M.P.1    Murray, J.T.2    Backer, J.M.3
  • 20
    • 1942469564 scopus 로고    scopus 로고
    • 2446 Is a Novel Mammalian Target of Rapamycin (mTOR) Phosphorylation Site Regulated by Nutrient Status
    • DOI 10.1074/jbc.C300534200
    • Cheng SW, Fryer LG, Carling D, Shepherd PR. Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status. J Biol Chem 279: 15719-15722, 2004. (Pubitemid 38509255)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.16 , pp. 15719-15722
    • Cheng, S.W.Y.1    Fryer, L.G.D.2    Carling, D.3    Shepherd, P.R.4
  • 22
    • 33749249371 scopus 로고    scopus 로고
    • Mechanism of insulin's anabolic effect on muscle: Measurements of muscle protein synthesis and breakdown using aminoacyl-tRNA and other surrogate measures
    • DOI 10.1152/ajpendo.00003.2006
    • Chow LS, Albright RC, Bigelow ML, Toffolo G, Cobelli C, Nair KS. Mechanism of insulin's anabolic effect on muscle: measurements of muscle protein synthesis and breakdown using aminoacyl-tRNA and other surrogate measures. Am J Physiol Endocrinol Metab 291: E729-E736, 2006. (Pubitemid 44484914)
    • (2006) American Journal of Physiology - Endocrinology and Metabolism , vol.291 , Issue.4
    • Chow, L.S.1    Albright, R.C.2    Bigelow, M.L.3    Toffolo, G.4    Cobelli, C.5    Nair, K.S.6
  • 23
    • 15444362044 scopus 로고    scopus 로고
    • The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway
    • DOI 10.1074/jbc.C400557200
    • Corradetti MN, Inoki K, Guan KL. The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. J Biol Chem 280: 9769-9772, 2005. (Pubitemid 40395821)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.11 , pp. 9769-9772
    • Corradetti, M.N.1    Inoki, K.2    Guan, K.-L.3
  • 24
    • 24044466141 scopus 로고    scopus 로고
    • Influence of muscle glycogen availability on ERK1/2 and Akt signaling after resistance exercise in human skeletal muscle
    • DOI 10.1152/japplphysiol.00110.2005
    • Creer A, Gallagher P, Slivka D, Jemiolo B, Fink W, Trappe S. Influence of muscle glycogen availability on ERK1/2 and Akt signaling after resistance exercise in human skeletal muscle. J Appl Physiol 99: 950-956, 2005. (Pubitemid 41214508)
    • (2005) Journal of Applied Physiology , vol.99 , Issue.3 , pp. 950-956
    • Creer, A.1    Gallagher, P.2    Slivka, D.3    Jemiolo, B.4    Fink, W.5    Trappe, S.6
  • 27
    • 38949116663 scopus 로고    scopus 로고
    • Effects of resistance exercise with and without creatine supplementation on gene expression and cell signaling in human skeletal muscle
    • Deldicque L, Atherton P, Patel R, Theisen D, Nielens H, Rennie MJ, Francaux M. Effects of resistance exercise with and without creatine supplementation on gene expression and cell signaling in human skeletal muscle. J Appl Physiol 104: 371-378, 2008.
    • (2008) J Appl Physiol , vol.104 , pp. 371-378
    • Deldicque, L.1    Atherton, P.2    Patel, R.3    Theisen, D.4    Nielens, H.5    Rennie, M.J.6    Francaux, M.7
  • 28
    • 40149092526 scopus 로고    scopus 로고
    • Aging alters gene expression of growth and remodeling factors in human skeletal muscle both at rest and in response to acute resistance exercise
    • Dennis RA, Przybyla B, Gurley C, Kortebein PM, Simpson P, Sullivan DH, Peterson CA. Aging alters gene expression of growth and remodeling factors in human skeletal muscle both at rest and in response to acute resistance exercise. Physiol Genomics 32: 393-400, 2008.
    • (2008) Physiol Genomics , vol.32 , pp. 393-400
    • Dennis, R.A.1    Przybyla, B.2    Gurley, C.3    Kortebein, P.M.4    Simpson, P.5    Sullivan, D.H.6    Peterson, C.A.7
  • 29
    • 38349056675 scopus 로고    scopus 로고
    • Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14 -3-3 shuttling
    • DeYoung MP, Horak P, Sofer A, Sgroi D, Ellisen LW. Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14 -3-3 shuttling. Genes Dev 22: 239-251, 2008.
    • (2008) Genes Dev , vol.22 , pp. 239-251
    • DeYoung, M.P.1    Horak, P.2    Sofer, A.3    Sgroi, D.4    Ellisen, L.W.5
  • 30
    • 33749351995 scopus 로고    scopus 로고
    • Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle
    • DOI 10.1113/jphysiol.2006.113175
    • Dreyer HC, Fujita S, Cadenas JG, Chinkes DL, Volpi E, Rasmussen BB. Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle. J Physiol 576: 613-624, 2006. (Pubitemid 44490149)
    • (2006) Journal of Physiology , vol.576 , Issue.2 , pp. 613-624
    • Dreyer, H.C.1    Fujita, S.2    Cadenas, J.G.3    Chinkes, D.L.4    Volpi, E.5    Rasmussen, B.B.6
  • 35
    • 41849128507 scopus 로고    scopus 로고
    • Gene and protein expression associated with protein synthesis and breakdown in paraplegic skeletal muscle
    • Drummond MJ, Glynn EL, Lujan HL, Dicarlo SE, Rasmussen BB. Gene and protein expression associated with protein synthesis and breakdown in paraplegic skeletal muscle. Muscle Nerve 37: 505-513, 2008.
    • (2008) Muscle Nerve , vol.37 , pp. 505-513
    • Drummond, M.J.1    Glynn, E.L.2    Lujan, H.L.3    Dicarlo, S.E.4    Rasmussen, B.B.5
  • 36
    • 66149116366 scopus 로고    scopus 로고
    • Expression of growth-related genes in young and old human skeletal muscle following an acute stimulation of protein synthesis
    • September 11, doi:10.1152/japplphysiol.90842.2008
    • Drummond MJ, Miyazaki M, Dreyer HC, Pennings B, Dhanani S, Volpi E, Esser KA, Rasmussen BB. Expression of growth-related genes in young and old human skeletal muscle following an acute stimulation of protein synthesis. J Appl Physiol (September 11, 2008); doi:10.1152/japplphysiol.90842.2008.
    • (2008) J Appl Physiol
    • Drummond, M.J.1    Miyazaki, M.2    Dreyer, H.C.3    Pennings, B.4    Dhanani, S.5    Volpi, E.6    Esser, K.A.7    Rasmussen, B.B.8
  • 37
    • 33750371417 scopus 로고    scopus 로고
    • Maximal lengthening contractions increase p70 S6 kinase phosphorylation in human skeletal muscle in the absence of nutritional supply
    • Eliasson J, Elfegoun T, Nilsson J, Kohnke R, Ekblom B, Blomstrand E. Maximal lengthening contractions increase p70 S6 kinase phosphorylation in human skeletal muscle in the absence of nutritional supply. Am J Physiol Endocrinol Metab 291: E1197-E1205, 2006.
    • (2006) Am J Physiol Endocrinol Metab , vol.291
    • Eliasson, J.1    Elfegoun, T.2    Nilsson, J.3    Kohnke, R.4    Ekblom, B.5    Blomstrand, E.6
  • 38
    • 34147141941 scopus 로고    scopus 로고
    • A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling
    • DOI 10.1042/BJ20061881
    • Findlay GM, Yan L, Procter J, Mieulet V, Lamb RF. A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling. Biochem J 403: 13-20, 2007. (Pubitemid 46569862)
    • (2007) Biochemical Journal , vol.403 , Issue.1 , pp. 13-20
    • Findlay, G.M.1    Yan, L.2    Procter, J.3    Mieulet, V.4    Lamb, R.F.5
  • 41
    • 0028807373 scopus 로고
    • Insulin and insulin-like growth factor-I enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms
    • Fryburg DA, Jahn LA, Hill SA, Oliveras DM, Barrett EJ. Insulin and insulin-like growth factor-I enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms. J Clin Invest 96: 1722-1729, 1995.
    • (1995) J Clin Invest , vol.96 , pp. 1722-1729
    • Fryburg, D.A.1    Jahn, L.A.2    Hill, S.A.3    Oliveras, D.M.4    Barrett, E.J.5
  • 43
    • 58149287209 scopus 로고    scopus 로고
    • Essential amino acid and carbohydrate ingestion prior to resistance exercise does not enhance postexercise muscle protein synthesis
    • Fujita S, Dreyer HC, Drummond MJ, Glynn EL, Volpi E, Rasmussen BB. Essential amino acid and carbohydrate ingestion prior to resistance exercise does not enhance postexercise muscle protein synthesis. J Appl Physiol, 2008.
    • (2008) J Appl Physiol
    • Fujita, S.1    Dreyer, H.C.2    Drummond, M.J.3    Glynn, E.L.4    Volpi, E.5    Rasmussen, B.B.6
  • 45
    • 33646566510 scopus 로고    scopus 로고
    • Functional genomics identifies TOR-regulated genes that control growth and division
    • Guertin DA, Guntur KV, Bell GW, Thoreen CC, Sabatini DM. Functional genomics identifies TOR-regulated genes that control growth and division. Curr Biol 16: 958-970, 2006.
    • (2006) Curr Biol , vol.16 , pp. 958-970
    • Guertin, D.A.1    Guntur, K.V.2    Bell, G.W.3    Thoreen, C.C.4    Sabatini, D.M.5
  • 46
    • 9444290436 scopus 로고    scopus 로고
    • Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans
    • Guillet C, Prod'homme M, Balage M, Gachon P, Giraudet C, Morin L, Grizard J, Boirie Y. Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans. FASEB J 18: 1586-1587, 2004.
    • (2004) FASEB J , vol.18 , pp. 1586-1587
    • Guillet, C.1    Prod'homme, M.2    Balage, M.3    Gachon, P.4    Giraudet, C.5    Morin, L.6    Grizard, J.7    Boirie, Y.8
  • 48
    • 0347363479 scopus 로고    scopus 로고
    • Inhibition of MAP/ERK kinase prevents IGF-I-induced hypertrophy in rat muscles
    • DOI 10.1152/japplphysiol.00856.2003
    • Haddad F, Adams GR. Inhibition of MAP/ERK kinase prevents IGF-I-induced hypertrophy in rat muscles. J Appl Physiol 96: 203-210, 2004. (Pubitemid 38032002)
    • (2004) Journal of Applied Physiology , vol.96 , Issue.1 , pp. 203-210
    • Haddad, F.1    Adams, G.R.2
  • 49
    • 33644943620 scopus 로고    scopus 로고
    • AMPK: A key sensor of fuel and energy status in skeletal muscle
    • Hardie DG, Sakamoto K. AMPK: a key sensor of fuel and energy status in skeletal muscle. Physiology (Bethesda) 21: 48-60, 2006.
    • (2006) Physiology (Bethesda) , vol.21 , pp. 48-60
    • Hardie, D.G.1    Sakamoto, K.2
  • 50
    • 3042820402 scopus 로고    scopus 로고
    • Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- And growth factor-independent mechanism
    • DOI 10.1042/BJ20040274
    • Hornberger TA, Stuppard R, Conley KE, Fedele MJ, Fiorotto ML, Chin ER, Esser KA. Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism. Biochem J 380: 795-804, 2004. (Pubitemid 38850521)
    • (2004) Biochemical Journal , vol.380 , Issue.3 , pp. 795-804
    • Hornberger, T.A.1    Stuppard, R.2    Conley, K.E.3    Fedele, M.J.4    Fiorotto, M.L.5    Chin, E.R.6    Esser, K.A.7
  • 51
    • 33645659052 scopus 로고    scopus 로고
    • Mechanical stimuli and nutrients regulate rapamycin-sensitive signaling through distinct mechanisms in skeletal muscle
    • Hornberger TA, Chien S. Mechanical stimuli and nutrients regulate rapamycin-sensitive signaling through distinct mechanisms in skeletal muscle. J Cell Biochem 97: 1207-1216, 2006.
    • (2006) J Cell Biochem , vol.97 , pp. 1207-1216
    • Hornberger, T.A.1    Chien, S.2
  • 52
    • 33645241260 scopus 로고    scopus 로고
    • The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle
    • Hornberger TA, Chu WK, Mak YW, Hsiung JW, Huang SA, Chien S. The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle. Proc Natl Acad Sci USA 103: 4741-4746, 2006.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 4741-4746
    • Hornberger, T.A.1    Chu, W.K.2    Mak, Y.W.3    Hsiung, J.W.4    Huang, S.A.5    Chien, S.6
  • 53
    • 33847174115 scopus 로고    scopus 로고
    • Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase
    • DOI 10.1038/nature05528, PII NATURE05528
    • Hsu YC, Chern JJ, Cai Y, Liu M, Choi KW. Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase. Nature 445: 785-788, 2007. (Pubitemid 46279709)
    • (2007) Nature , vol.445 , Issue.7129 , pp. 785-788
    • Hsu, Y.-C.1    Chern, J.J.2    Cai, Y.3    Liu, M.4    Choi, K.-W.5
  • 54
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4: 648-657, 2002.
    • (2002) Nat Cell Biol , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 55
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
    • DOI 10.1016/S0092-8674(03)00929-2
    • Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 115: 577-590, 2003. (Pubitemid 37506046)
    • (2003) Cell , vol.115 , Issue.5 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.-L.3
  • 58
    • 31544482447 scopus 로고    scopus 로고
    • Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids
    • Katsanos CS, Kobayashi H, Sheffield-Moore M, Aarsland A, Wolfe RR. Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. Am J Clin Nutr 82: 1065-1073, 2005. (Pubitemid 43779766)
    • (2005) American Journal of Clinical Nutrition , vol.82 , Issue.5 , pp. 1065-1073
    • Katsanos, C.S.1    Kobayashi, H.2    Sheffield-Moore, M.3    Aarsland, A.4    Wolfe, R.R.5
  • 60
    • 19444370186 scopus 로고    scopus 로고
    • Impact of resistance loading on myostatin expression and cell cycle regulation in young and older men and women
    • Kim JS, Cross JM, Bamman MM. Impact of resistance loading on myostatin expression and cell cycle regulation in young and older men and women. Am J Physiol Endocrinol Metab 288: E1110-E1119, 2005.
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Kim, J.S.1    Cross, J.M.2    Bamman, M.M.3
  • 61
    • 0031951444 scopus 로고    scopus 로고
    • Signal transduction pathways involved in the regulation of protein synthesis by insulin in L6 myoblasts
    • Kimball SR, Horetsky RL, Jefferson LS. Signal transduction pathways involved in the regulation of protein synthesis by insulin in L6 myoblasts. Am J Physiol Cell Physiol 274: C221-C228, 1998.
    • (1998) Am J Physiol Cell Physiol , vol.274
    • Kimball, S.R.1    Horetsky, R.L.2    Jefferson, L.S.3
  • 62
    • 41249094257 scopus 로고    scopus 로고
    • Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis
    • Kimball SR, Do AN, Kutzler L, Cavener DR, Jefferson LS. Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis. J Biol Chem 283: 3465-3475, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 3465-3475
    • Kimball, S.R.1    Do, A.N.2    Kutzler, L.3    Cavener, D.R.4    Jefferson, L.S.5
  • 67
    • 17444431201 scopus 로고    scopus 로고
    • Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
    • DOI 10.1016/j.cell.2005.02.031
    • Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 121: 179-193, 2005. (Pubitemid 40546387)
    • (2005) Cell , vol.121 , Issue.2 , pp. 179-193
    • Ma, L.1    Chen, Z.2    Erdjument-Bromage, H.3    Tempst, P.4    Pandolfi, P.P.5
  • 70
    • 57749196164 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM
    • Maeurer C, Holland S, Pierre S, Potstada W, Scholich K. Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM. Cell Signal 21: 293-300, 2009.
    • (2009) Cell Signal , vol.21 , pp. 293-300
    • Maeurer, C.1    Holland, S.2    Pierre, S.3    Potstada, W.4    Scholich, K.5
  • 71
    • 0036342294 scopus 로고    scopus 로고
    • Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
    • Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell 10: 151-162, 2002.
    • (2002) Mol Cell , vol.10 , pp. 151-162
    • Manning, B.D.1    Tee, A.R.2    Logsdon, M.N.3    Blenis, J.4    Cantley, L.C.5
  • 73
    • 0002446937 scopus 로고    scopus 로고
    • Proteins and amino acids
    • edited by Shils ME, Olson JA, Shike M, and Ross AC. Baltimore, MD: Williams & Wilkins
    • Matthews DE. Proteins and amino acids. In: Modern Nutrition and Health and Disease (9th ed.), edited by Shils ME, Olson JA, Shike M, and Ross AC. Baltimore, MD: Williams & Wilkins, 1999, p. 11- 48.
    • (1999) Modern Nutrition and Health and Disease (9th Ed.) , pp. 11-48
    • Matthews, D.E.1
  • 75
  • 76
    • 0033429554 scopus 로고    scopus 로고
    • Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
    • Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR. Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem J 344: 427-431, 1999.
    • (1999) Biochem J , vol.344 , pp. 427-431
    • Nave, B.T.1    Ouwens, M.2    Withers, D.J.3    Alessi, D.R.4    Shepherd, P.R.5
  • 79
    • 58149133630 scopus 로고    scopus 로고
    • Dietary protein recommendations and the prevention of sarcopenia
    • Paddon-Jones D, Rasmussen BB. Dietary protein recommendations and the prevention of sarcopenia. Curr Opin Clin Nutr Metab Care 12: 86-90, 2009.
    • (2009) Curr Opin Clin Nutr Metab Care , vol.12 , pp. 86-90
    • Paddon-Jones, D.1    Rasmussen, B.B.2
  • 82
    • 0030740005 scopus 로고    scopus 로고
    • The modular phosphorylation and activation of p70(s6k)
    • DOI 10.1016/S0014-5793(97)00323-2, PII S0014579397003232
    • Pullen N, Thomas G. The modular phosphorylation and activation of p70s6k. FEBS Lett 410: 78-82, 1997. (Pubitemid 27283388)
    • (1997) FEBS Letters , vol.410 , Issue.1 , pp. 78-82
    • Pullen, N.1    Thomas, G.2
  • 83
    • 0033954379 scopus 로고    scopus 로고
    • An oral essential amino acid-carbohydrate supplement enhances muscle protein anabolism after resistance exercise
    • Rasmussen BB, Tipton KD, Miller SL, Wolf SE, Wolfe RR. An oral essential amino acid-carbohydrate supplement enhances muscle protein anabolism after resistance exercise. J Appl Physiol 88: 386-392, 2000.
    • (2000) J Appl Physiol , vol.88 , pp. 386-392
    • Rasmussen, B.B.1    Tipton, K.D.2    Miller, S.L.3    Wolf, S.E.4    Wolfe, R.R.5
  • 85
    • 0019822897 scopus 로고
    • Effect of exercise on protein turnover in man
    • Rennie MJ, Edwards RH, Krywawych S, Davies CT, Halliday D, Waterlow JC, Millward DJ. Effect of exercise on protein turnover in man. Clin Sci (Lond) 61: 627-639, 1981. (Pubitemid 12226762)
    • (1981) Clinical Science , vol.61 , Issue.5 , pp. 627-639
    • Rennie, M.J.1    Edwards, R.H.T.2    Krywawych, S.3
  • 86
    • 0020464729 scopus 로고
    • Muscle protein synthesis measured by stable isotope techniques in man: The effects of feeding and fasting
    • Rennie MJ, Edwards RH, Halliday D, Matthews DE, Wolman SL, Millward DJ. Muscle protein synthesis measured by stable isotope techniques in man: the effects of feeding and fasting. Clin Sci (Lond) 63: 519-523, 1982. (Pubitemid 13213942)
    • (1982) Clinical Science , vol.63 , Issue.6 , pp. 519-523
    • Rennie, M.J.1    Edwards, R.H.T.2    Halliday, D.3
  • 87
    • 33746876019 scopus 로고    scopus 로고
    • Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia
    • DOI 10.1113/jphysiol.2006.110742
    • Rieu I, Balage M, Sornet C, Giraudet C, Pujos E, Grizard J, Mosoni L, Dardevet D. Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia. J Physiol 575: 305-315, 2006. (Pubitemid 44182713)
    • (2006) Journal of Physiology , vol.575 , Issue.1 , pp. 305-315
    • Rieu, I.1    Balage, M.2    Sornet, C.3    Giraudet, C.4    Pujos, E.5    Grizard, J.6    Mosoni, L.7    Dardevet, D.8
  • 88
    • 21744446249 scopus 로고    scopus 로고
    • Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)
    • DOI 10.1042/BJ20041888
    • Rolfe M, McLeod LE, Pratt PF, Proud CG. Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2). Biochem J 388: 973-984, 2005. (Pubitemid 40941586)
    • (2005) Biochemical Journal , vol.388 , Issue.3 , pp. 973-984
    • Rolfe, M.1    McLeod, L.E.2    Pratt, P.F.3    Proud, C.G.4
  • 89
    • 34347242470 scopus 로고    scopus 로고
    • RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation
    • DOI 10.1074/jbc.M700906200
    • Roux PP, Shahbazian D, Vu H, Holz MK, Cohen MS, Taunton J, Sonenberg N, Blenis J. RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. J Biol Chem 282: 14056-14064, 2007. (Pubitemid 47100467)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.19 , pp. 14056-14064
    • Roux, P.P.1    Shahbazian, D.2    Vu, H.3    Holz, M.K.4    Cohen, M.S.5    Taunton, J.6    Sonenberg, N.7    Blenis, J.8
  • 92
    • 33745150462 scopus 로고    scopus 로고
    • Ribosomal protein S6 phosphorylation: From protein synthesis to cell size
    • DOI 10.1016/j.tibs.2006.04.003, PII S0968000406001137
    • Ruvinsky I, Meyuhas O. Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. Trends Biochem Sci 31: 342-348, 2006. (Pubitemid 43903237)
    • (2006) Trends in Biochemical Sciences , vol.31 , Issue.6 , pp. 342-348
    • Ruvinsky, I.1    Meyuhas, O.2
  • 96
    • 66149154339 scopus 로고    scopus 로고
    • Maximal lengthening contractions induce different signaling response in the type I and type II fibers of human skeletal muscle
    • December 26, doi:10.1152/japplphysiol.91243.2008
    • Tannerstedt J, Apro W, Blomstrand E. Maximal lengthening contractions induce different signaling response in the type I and type II fibers of human skeletal muscle. J Appl Physiol ( December 26, 2008); doi:10.1152/japplphysiol. 91243.2008.
    • (2008) J Appl Physiol
    • Tannerstedt, J.1    Apro, W.2    Blomstrand, E.3
  • 97
    • 37449029143 scopus 로고    scopus 로고
    • Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila
    • Teleman AA, Hietakangas V, Sayadian AC, Cohen SM. Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila. Cell Metab 7: 21-32, 2008.
    • (2008) Cell Metab , vol.7 , pp. 21-32
    • Teleman, A.A.1    Hietakangas, V.2    Sayadian, A.C.3    Cohen, S.M.4
  • 102
    • 0032080924 scopus 로고    scopus 로고
    • Exogenous amino acids stimulate net muscle protein synthesis in the elderly
    • Volpi E, Ferrando AA, Yeckel CW, Tipton KD, Wolfe RR. Exogenous amino acids stimulate net muscle protein synthesis in the elderly. J Clin Invest 101: 2000-2007, 1998.
    • (1998) J Clin Invest , vol.101 , pp. 2000-2007
    • Volpi, E.1    Ferrando, A.A.2    Yeckel, C.W.3    Tipton, K.D.4    Wolfe, R.R.5
  • 104
    • 0042068305 scopus 로고    scopus 로고
    • Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults
    • Volpi E, Kobayashi H, Sheffield-Moore M, Mittendorfer B, Wolfe RR. Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. Am J Clin Nutr 78: 250-258, 2003. (Pubitemid 39655228)
    • (2003) American Journal of Clinical Nutrition , vol.78 , Issue.2 , pp. 250-258
    • Volpi, E.1    Kobayashi, H.2    Sheffield-Moore, M.3    Mittendorfer, B.4    Wolfe, R.R.5
  • 106
    • 34547099855 scopus 로고    scopus 로고
    • PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding
    • DOI 10.1074/jbc.M702376200
    • Wang L, Harris TE, Roth RA, Lawrence JC Jr. PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding. J Biol Chem 282: 20036-20044, 2007. (Pubitemid 47100127)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.27 , pp. 20036-20044
    • Wang, L.1    Harris, T.E.2    Roth, R.A.3    Lawrence Jr., J.C.4
  • 107
    • 47049127002 scopus 로고    scopus 로고
    • Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation
    • Wang L, Harris TE, Lawrence JC Jr. Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation. J Biol Chem 283: 15619-15627, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 15619-15627
    • Wang, L.1    Harris, T.E.2    Lawrence Jr., J.C.3
  • 108
    • 0035881470 scopus 로고    scopus 로고
    • RSK1 and p70 S6 kinase
    • DOI 10.1093/emboj/20.16.4370
    • Wang X, Li W, Williams M, Terada N, Alessi DR, Proud CG. Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. EMBO J 20: 4370-4379, 2001. (Pubitemid 32772031)
    • (2001) EMBO Journal , vol.20 , Issue.16 , pp. 4370-4379
    • Wang, X.1    Li, W.2    Williams, M.3    Terada, N.4    Alessi, D.R.5    Proud, C.G.6
  • 109
    • 33749431713 scopus 로고    scopus 로고
    • The mTOR pathway in the control of protein synthesis
    • Wang X, Proud CG. The mTOR pathway in the control of protein synthesis. Physiology (Bethesda) 21: 362-369, 2006.
    • (2006) Physiology (Bethesda) , vol.21 , pp. 362-369
    • Wang, X.1    Proud, C.G.2
  • 110
    • 35648962915 scopus 로고    scopus 로고
    • Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation
    • DOI 10.1128/MCB.00760-07
    • Wang X, Yue P, Chan CB, Ye K, Ueda T, Watanabe-Fukunaga R, Fukunaga R, Fu H, Khuri FR, Sun SY. Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation. Mol Cell Biol 27: 7405-7413, 2007. (Pubitemid 350033648)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.21 , pp. 7405-7413
    • Wang, X.1    Yue, P.2    Chan, C.-B.3    Ye, K.4    Ueda, T.5    Watanabe-Fukunaga, R.6    Fukunaga, R.7    Fu, H.8    Khuri, F.R.9    Sun, S.-Y.10
  • 111
    • 0028045582 scopus 로고
    • Postprandial myofibrillar and whole body protein synthesis in young and old human subjects
    • Welle S, Thornton C, Statt M, McHenry B. Postprandial myofibrillar and whole body protein synthesis in young and old human subjects. Am J Physiol Endocrinol Metab 267: E599-E604, 1994. (Pubitemid 2159108)
    • (1994) AM.J.PHYSIOL. , vol.267 , Issue.4 PART 1
    • Welle, S.1    Thornton, C.2    Statt, M.3    McHenry, B.4
  • 112
    • 0037444470 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase (MAPK) pathway activation: Effects of age and acute exercise on human skeletal muscle
    • DOI 10.1113/jphysiol.2002.036673
    • Williamson D, Gallagher P, Harber M, Hollon C, Trappe S. Mitogen-activated protein kinase (MAPK) pathway activation: effects of age and acute exercise on human skeletal muscle. J Physiol 547: 977-987, 2003. (Pubitemid 36367378)
    • (2003) Journal of Physiology , vol.547 , Issue.3 , pp. 977-987
    • Williamson, D.1    Gallagher, P.2    Harber, M.3    Hollon, C.4    Trappe, S.5
  • 113
    • 0027202154 scopus 로고
    • Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly men and women
    • Yarasheski KE, Zachwieja JJ, Bier DM. Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly men and women. Am J Physiol Endocrinol Metab 265: E210-E214, 1993.
    • (1993) Am J Physiol Endocrinol Metab , vol.265
    • Yarasheski, K.E.1    Zachwieja, J.J.2    Bier, D.M.3


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