An oral essential amino acid-carbohydrate supplement enhances muscle protein anabolism after resistance exercise

Journal of Applied Physiology

Volumn 88, Issue 2, 2000, Pages 386-392

  Rasmussen, Blake B ^a   Tipton, Kevin D ^a   Miller, Sharon L ^a   Wolf, Steven E ^a   Wolfe, Robert R ^a  

^a SHRINERS HOSPITALS FOR CHILDREN   (United States)

Author keywords

Muscle protein synthesis; Nutritional supplementation; Stable isotopes

Indexed keywords

ASPARTAME; CARBOHYDRATE; DEUTERIUM; ESSENTIAL AMINO ACID; NITROGEN 15; PHENYLALANINE; PLACEBO; SUCROSE; UREA;

ADULT; ARTICLE; BLOOD SAMPLING; CARBOHYDRATE INTAKE; COMPARTMENT MODEL; DIET SUPPLEMENTATION; EXERCISE; FEMALE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; ISOTOPE LABELING; LEG MUSCLE; MALE; MUSCLE BIOPSY; MUSCLE METABOLISM; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN INTAKE; PROTEIN SYNTHESIS;

EID: 0033954379     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2000.88.2.386     Document Type: Article

References (19)

1. Biolo, G., D. Chinkes, X. J. Zhang, and R. R. Wolfe. Harry M. Vars Research Award. A new model to determine in vivo the relationship between amino acid transmembrane transport and protein kinetics in muscle, J. Parenter. Enterai. Nutr. 16: 305-315, 1992.
2. Biolo, G., R. Y. Declan Fleming, and R. R. Wolfe. Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle. J. Clin. Invest. 95: 811-819, 1995.
3. Biolo, G., R. Y. Fleming, S. P. Maggi, and R. R. Wolfe. Transmembrane transport and intracellular kinetics of amino acids in human skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 268: E75-E84, 1995.
4. Biolo, G., S. P. Maggi, B. D. Williams, K. D. Tipton, and R. R. Wolfe. Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans. Am. J. Physiol. Endocrinol. Metab. 268: E514-E520, 1995.
5. Biolo, G., K. D. Tipton, S. Klein, and R. R. Wolfe. An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein. Am. J. Physiol. Endocrinol. Metab. 273: E122-E129, 1997.
6. Biolo, G., X. J. Zhang, and R. R. Wolfe. Role of membrane transport in interorgan amino acid flow between muscle and small intestine. Metabolism 44: 719-724, 1995.
7. Fox, H. L., P. T. Pham, S. R. Kimball, L. S. Jefferson, and C. J. Lynch. Amino acid effects on translational repressor 4E-BP1 are mediated primarily by L-leucine in isolated adipocytes. Am. J. Physiol. Cell Physiol. 275: C1232-C1238, 1998.
8. Gautsch, T. A., J. C. Anthony, S. R. Kimball, G. L. Paul, D. K. Layman, and L. S. Jefferson. Availability of eIF4E regulates skeletal muscle protein synthesis during recovery from exercise. Am. J. Physiol. Cell Physiol. 274: C406-C414, 1998.
9. Jorfeldt, L., and J. Wahren. Leg blood flow during exercise in man. Clin. Sci. 41: 459-473, 1971.
10. Lundholm, K., K. Bennegard, H. Zachrisson, F. Lundgren, E. Eden, and A. C. Moller-Loswick. Transport kinetics of amino acids across the resting human leg. J. Clin. Invest. 80: 763-771, 1987.
11. Phillips, S. M., K. D. Tipton, A. Aarsland, S. E. Wolf, and R. R. Wolfe. Mixed muscle protein synthesis and breakdown after resistance exercise in humans. Am. J. Physiol. Endocrinol. Metab. 273: E99-E107, 1997.
12. Roy, B. D., M. A. Tarnopolsky, J. D. MacDougall, J. Fowles, and K. E. Yarasheski. The effect of glucose supplement timing on protein metabolism following resistance training. J. Appl. Physiol. 82: 1882-1888, 1997.
13. Smith, K., N. Reynolds, S. Downie, A. Patel, and M. J. Rennie. Effects of flooding amino acids on incorporation of labeled amino acids into human muscle protein. Am. J. Physiol. Endocrinol. Metab. 275: E73-E78, 1998.
14. Tipton, K. D., A. A. Ferrando, S. M. Phillips, D. Doyle, and R. R. Wolfe. Postexercise net protein synthesis in human muscle from orally administered amino acids. Am. J. Physiol. Endocrinol. Metab. 276: E628-E634, 1999.
15. Tipton, K. D., B. E. Gurkin, S. Matin, and R. R. Wolfe. Nonessential amino acids are not necessary to stimulate net muscle protein synthesis in healthy volunteers. J. Nutr. Biochem. 10: 89-95, 1999.
16. Volpi, E., B. Mittendorfer, S. E. Wolf, and R. R. Wolfe. Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first pass splanchnic extraction. Am. J. Physiol. Endocrinol. Metab. 277: E513-E520, 1999.
17. Wolfe, R. R. Radioactive and Stable Isotope Tracers in Biomedicine. New York: Wiley-Liss, 1992.
18. Wolfe, R. R., and E. Volpi. Insulin and protein metabolism. In: Handbook of Physiology: The Endocrine Pancreas and Regulation of Metabolism, edited by L. S. Jefferson and A. D Cherrington. New York: Oxford University. In press.
19. Yoshizawa, F., S. R. Kimball, T. C. Vary, and L. S. Jefferson. Effect of dietary protein on translation initiation in rat skeletal muscle and liver. Am. J. Physiol. Endocrinol. Metab. 275: E814-E820, 1998.