Regulation of peptide-chain elongation in mammalian cells

European Journal of Biochemistry

Volumn 269, Issue 22, 2002, Pages 5360-5368

  Browne, Gareth J ^a   Proud, Christopher G ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

eEF1; eEF2; Elongation factor; mTOR; Rapamycin; Translation

Indexed keywords

AMINOACYL TRANSFER RNA; CALCIUM ION; CALMODULIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; ELONGATION FACTOR 1ALPHA; ELONGATION FACTOR 1BETA; ELONGATION FACTOR 2; INSULIN; PHOSPHATASE;

ENERGY; ENZYME ACTIVATION; ENZYME ACTIVITY; HORMONAL REGULATION; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; RNA TRANSPORT; SHORT SURVEY; SIGNAL TRANSDUCTION; TRANSLATION REGULATION;

ANIMALS; CELL LINE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HUMANS; INSULIN; MODELS, BIOLOGICAL; MODELS, GENETIC; PEPTIDE ELONGATION FACTOR 1; PEPTIDE ELONGATION FACTOR 2; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEIN STRUCTURE, TERTIARY; RNA, MESSENGER;

EUKARYOTA; MAMMALIA;

EID: 0036438894     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2002.03290.x     Document Type: Short Survey

References (75)

1. Proud, C.G. (2002) Regulation of mammalian translation factors by nutrients. Eur. J. Biochem. 269, 5338-5349.
2. Scheper, G.C. & Proud, C.G. (2002) Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation? Eur. J. Biochem. 269, 5350-5359.
3. Gingras, A.-C., Raught, B. & Sonenberg, N. (2001) Regulation of translation initiation by FRAP/mTOR. Genes Dev. 15, 807-826.
4. Proud, C.G. (2001) Regulation of eukaryotic initiation factor eIF2B. Prog. Mol. Subcell. Biol. 26, 95-114.
5. Macdonald, P. (2001) Diversity in translational regulation. Curr. Opin. Cell. Biol. 13, 326-331.
6. Dever, T.E. (2002) Gene-specific regulation by general translation factors. Cell 108, 545-556.
7. Merrick, W.C. & Nyborg, J. (2000) The protein biosynthesis elongation cycle. In Translational Control of Gene Expression. (Sonenberg, N., Hershey, J.W.B. & Mathews, M.B., eds), pp. 89-125. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
8. Rhoads, R.E. (1999) Signal transduction pathways that regulate eukaryotic protein synthesis. J. Biol. Chem. 274, 30337-30340.
9. Raught, B., Gingras, A.-C. & Sonenberg, N. (2000) Regulation of ribosome recruitment in eukaryotes. In Translational Control of Gene Expression. (Sonenberg, N., Hershey, J.W.B. & Mathews, M.B., eds), pp. 245-293. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
10. Avruch, J., Belham, C., Weng, Q., Hara, K. & Yonezawa, K. (2001) The p70, S6 kinase integrates nutrient and growth signals to control translational capacity. Prog. Mol. Subcell. Biol. 26, 115-154.
11. Carr-Schmid, A., Valente, L., Loik, V.I., Williams, T., Starita, L.M. & Kinzy, T.G. (1999) Mutations in elongation factor 1β, a guanine nucleotide exchange factor, enhance translational fidelity. Mol. Cell. Biol. 19, 5257-5266.
12. Sheu, G.T. & Traugh, J.A. (1997) Recombinant subunits of mammalian elongation factor 1 expressed in Escherichia coli: Subunit interactions, elongation activity, and phosphorylation by protein kinase CKII. J. Biol. Chem. 272, 33290-33297.
13. Traugh, J.A. (2001) Insulin, phorbol ester and serum regulate the elongation phase of protein synthesis. Prog. Mol. Subcell. Biol. 26, 33-48.
14. Sheu, G.T. & Traugh, J.A. (1999) A structural model for elongation factor (EF-1) and phosphorylation by protein kinase CKII. Mol. Cell. Biochem. 191, 181-186.
15. Wang, X., Paulin, F.E.M., Campbell, L.E., Gomez, E., O'Brien, K., Morrice, N. & Proud, C.G. (2001) Eukaryotic initiation factor 2B: Identification of multiple phosphorylation sites in the epsilon subunit and their roles in vivo. EMBO J. 20, 4349-4359.
16. Venema, R.C., Peters, H.I. & Traugh, J.A. (1991) Phosphorylation of elongation factor 1 (EF-1) and valyl-tRNA synthetase by protein kinase C and stimulation of EF-1 activity. J. Biol. Chem. 266, 12574-12580.
17. Venema, R.C., Peters, H.I. & Traugh, J.A. (1991) Phosphorylation of valyl-tRNA synthetase and elongation factor 1 in response to phorbol esters is associated with stimulation of both activities. J. Biol. Chem. 266, 11993-11998.
18. Chang, Y.W. & Traugh, J.A. (1997) Phosphorylation of elongation factor-1 and ribosomal protein S6 by multipotential S6 kinase and insulin stimulation of translational elongation. J. Biol. Chem. 272, 28252-28257.
19. Peters, H.I., Chang, Y.W.E. & Traugh, J.A. (1995) Phosphorylation of elongation factor-1 (EF-1) by protein kinase C stimulates GDP/GTP-exchange activity. Eur. J. Biochem. 234, 550-556.
20. Belle, R., Derancourt, J., Poulhe, R., Capony, J.P., Ozon, R. & Mulner-Lorillon, O. (1989) A purified complex from Xenopus oocytes contains a p47 protein, an in vivo substrate of MPF, and a p30 protein respectively homologous to elongation factors EF-1 gamma and EF-1 beta. FEBS Lett. 255, 101-104.
21. Janssen, G.M., Morales, J., Schipper, A., Labbe, J.C., Mulner-Lorillon, O., Belle, R. & Moller, W. (1991) A major substrate of maturation promoting factor identified as elongation factor 1βγδ in Xenopus laevis. J. Biol. Chem. 266, 14885-14888.
22. Mulner-Lorillon, O., Minella, O., Cormier, P., Capony, J.P., Cavadore, J., Morales, J., Poulhe, R. & Belle, R. (1994) Elongation factor EF-1delta, a new target for maturation- promoting factor in xenopus oocytes. J. Biol. Chem. 269, 20201-20207.
23. Ovchinnikov, L.P., Motuz, L.P., Natapov, P.G., Averbuch, L.J., Wettenhall, R.E., Szyszka, R., Kramer, G. & Hardesty, B. (1990) Three phosphorylation sites in elongation factor 2. FEBS Lett. 275, 209-212.
24. Price, N.T., Redpath, N.T., Severinov, K.V., Campbell, D.G., Russell, J.M. & Proud, C.G. (1991) Identification of the phosphorylation sites in elongation factor-2 from rabbit reticulocytes. FEBS Lett. 282, 253-258.
25. Nygard, O. & Nilsson, L. (1990) Translational dynamics. Interactions between the translational factors, tRNA and ribosomes during eukaryotic protein synthesis. Eur. J. Biochem. 191, 1-17.
26. Ryazanov, A.G. & Davydova, E.K. (1989) Mechanism of elongation factor 2 (EF-2) inactivation upon phosphorylation. Phosphorylated EF-2 is unable to catalyze translocation. FEBS Lett. 251, 187-190.
27. Redpath, N.T., Price, N.T., Severinov, K.V. & Proud, C.G. (1993) Regulation of elongation factor-2 by multisite phosphorylation. Eur. J. Biochem. 213, 689-699.
28. Carlberg, U., Nilsson, A. & Nygard, O. (1990) Functional properties of phosphorylated elongation factor 2. Eur. J. Biochem. 191, 639-645.
29. Redpath, N.T. & Proud, C.G. (1989) The tumour promoter okadaic acid inhibits reticulocytelysate protein synthesis by increasing the net phosphorylation of elongation factor 2. Biochem. J. 262, 69-75.
30. Redpath, N.T. & Proud, C.G. (1990) Activity of protein phosphatases against initiation factor-2 and elongation factor-2. Biochem. J. 272, 175-180.
31. 2+/calmodulin-dependent phosphorylation of elongation factor 2. FEBS Lett. 214, 331-334.
32. r 100,000 substrate for calmodulin-dependent protein kinase III in mammalian cells as elongation factor-2. J. Biol. Chem. 262, 17299-17303.
33. 2+-mediated secretion from rat parotid acini. Biochem. J. 282, 877-882.
34. Mackie, K.P., Nairn, A.C., Hampel, G., Lam, G. & JaKe, E.A. (1989) Thrombin and histamine stimulate the phosphorylation of elongation factor 2 in human umbilical vein endothelial cells. J. Biol. Chem. 264, 1748-1753.
35. Celis, J.E., Madsen, P. & Ryazanov, A.G. (1990) Increased phosphorylation of elongation factor 2 during mitosis in transformed human amnion cells correlates with a decreased rate of protein synthesis. Proc. Natl. Acad. Sci. USA 87, 4231-4235.
36. Mitsui, K., Brady, M., Palfrey, H.C. & Nairn, A.C. (1993) Purification and characterization of calmodulin-dependent protein kinase III from rabbit reticulocytes and rat pancreas. J. Biol. Chem. 268, 13422-13433.
37. Redpath, N.T. & Proud, C.G. (1993) Purification and phosphorylation of elongation factor-2 kinase from rabbit reticulocytes. Eur. J. Biochem. 212, 511-520.
38. Marin, P., Nastiuk, K.L., Daniel, N., Girault, J., Czernik, A.J., Glowinski, J., Nairn, A.C. & Premont, J. (1997) Glutamate dependent phosphorylation of elongation factor 2 and inhibition of protein synthesis in neurons. J. Neurosci. 17, 3445-3454.
39. Redpath, N.T., Price, N.T. & Proud, C.G. (1996) Cloning and expression of cDNA encoding protein synthesis elongation factor-2 kinase. J. Biol. Chem. 271, 17547-17554.
40. Ryazanov, A.G., Ward, M.D., Mendola, C.E., Pavur, K.S., Dorovkov, M.V., Wiedmann, M., Erdjument-Bromage, H., Tempst, P., Parmer, T.G., Prostko, C.R., Germino, F.J. & Hait, W.N. (1997) Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase. Proc. Natl. Acad. Sci. USA 94, 4884-4889.
41. Ryazanov, A.G., Pavur, K.S. & Dorovkov, M.V. (1999) Alpha kinases: A new class of protein kinases with a novel catalytic domain. Curr. Biol. 9, R43-R45.
42. Ryazanov, A.G. (2002) Elongation factor-2 kinase and its newly discovered relatives. FEBS Lett. 514, 26-29.
43. Diggle, T.A., Seehra, C.K., Hase, S. & Redpath, N.T. (1999) Analysis of the domain structure of elongation factor-2 kinase by mutagenesis. FEBS Lett. 457, 189-192.
44. Pavur, K.S., Petrov, A.N. & Ryazanov, A.G. (2000) Mapping the functional domains of elongation factor-2 kinase. Biochemistry 39, 12216-12224.
45. Yamaguchi, H., Matsushita, M., Nairn, A.C. & Kuriyan, J. (2001) Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity. Mol. Cell 7, 1047-1057.
46. Hait, W.N., Ward, M.D., Trakht, I.N. & Ryazanov, A.G. (1996) Elongation factor-2 kinase - Immunological evidence for the existence of tissue-specific isoforms. FEBS Lett. 397, 55-60.
47. McLeod, L.E., Wang, L. & Proud, C.G. (2001) β-Adrenergic agonists increase phosphorylation of elongation factor 2 in car-diomyocytes without eliciting calcium-independent eEF2 kinase activity. FEBS Lett. 489, 225-228.
48. Redpath, N.T. & Proud, C.G. (1993) Cyclic AMP-dependent protein kinase phosphorylates rabbit reticulocyte elongation factor-2 kinase and induces calcium-independent activity. Biochem. J. 293, 31-34.
49. 2+/calmodulin-independent activity. Biochem. J. 353, 621-626.
50. Diggle, T.A., Redpath, N.T., Heesom, K.J. & Denton, R.M. (1998) Regulation of protein synthesis elongation factor-2 kinase by cAMP in adipocytes. Biochem. J. 336, 525-529.
51. 2+/calmodulin-independent elongation factor 2 kinase activity in IPC-81 cells. FEBS Lett. 444, 97-101.
52. Redpath, N.T., Foulstone, E.J. & Proud, C.G. (1996) Regulation of translation elongation factor-2 by insulin via a rapamycin-sensitive signalling pathway. EMBO J. 15, 2291-2297.
53. Wang, L., Wang, X. & Proud, C.G. (2000) Activation of mRNA translation by insulin in rat cardiomyocytes involves multiple rapamycin-sensitive steps. Am. J. Physiol. 278, H1056-H1068.
54. RSK1 and p70, S6 kinase. EMBO J. 20, 4370-4379.
55. Everett, A.D., Stoops, T.D., Nairn, A.C. & Brautigan, D. (2001) Angiotensin II regulates phosphorylation of translation elongation factor-2 in cardiac myocytes. Am. J. Physiol. 281, H161-H167.
56. Wang, L. & Proud, C.G. (2002) Ras/Erk signalling is required for regulation of translation factors linked to mTOR and protein synthesis by hypertrophic agents in cardiomyocytes. Circ. Res. in press.
57. Knebel, A., Morrice, N. & Cohen, P. (2001) A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta. EMBO J. 20, 4360-4369.
58. Patel, J., McLeod, L.E., Vries, R.G., Flynn, A., Wang, X. & Proud, C.G. (2002) Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors. Eur. J. Biochem. 269, 3076-3085.
59. Knebel, A., Haydon, C.E., Morrice, N. & Cohen, P. (2002) Stress-induced regulation of eEF2 kinase by SB203580-sensitive and -insensitive pathways. Biochem. J. 367, 525-532.
60. Althausen, S., Mengesdorf, T., Mies, G., Olah, L., Nairn, A.C., Proud, C.G. & Paschen, W. (2001) Changes in the phosphorylation of initiation factor eIF-2α, elongation factor eEF-2 and p70, S6 kinase after transient focal cerebral ischaemia in mice. J. Neurochem. 78, 779-787.
61. DeGracia, D.J., Neumar, R.W., White, B.C. & Krause, G.S. (1996) Global brain ischemia and reperfusion: Modifications in eukaryotic initiation factors associated with inhibition of translation initiation. J. Neurochem. 67, 2005-2012.
62. Martin de la Vega, C., Burda, J., Nemethova, M., Quevedo, C., Alcazar, A., Martin, M.E., Danielsova, V., Fando, J.L. & Salinas, M. (2001) Possible mechanisms involved in the down-regulation of translation during transient global ischaemia in the rat brain. Biochem. J. 357, 819-826.
63. Horman, S., Browne, G.J., Krause, U., Patel, J.V., Vertommen, D., Bertrand, L., Lavoinne, A., Hue, L., Proud, C.G. & Rider, M.H. (2002) Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis. Curr. Biol. 12, 1419-1423.
64. Dennis, P.B., Jaeschke, A., Saitoh, M., Fowler, B., Kozma, S.C. & Thomas, G. (2001) Mammalian TOR: A homeostatic ATP sensor. Science 294, 1102-1105.
65. Hardie, D.G., Carling, D. & Carlson, M. (1998) The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell? Annu. Rev. Biochem. 67, 821-855.
66. Di Como, C.J. & Arndt, K.T. (1996) Nutrients, via the TOR proteins, stimulate the association of Tap42 with Type phosphatases. Genes Dev. 10, 1904-1916.
67. Barbet, N.C., Schneider, U., Helliwell, S.B., Stansfield, I. & Tuite, M.F. (1996) TOR controls translation initiation and early G1 progression in yeast. Mol. Biol. Cell 7, 25-42.
68. Jiang, Y. & Broach, J.R. (1999) Tor proteins and protein phosphatase 2A reciprocally regulate Tap42p in controlling cell growth in yeast. EMBO J. 18, 2782-2792.
69. Chen, J., Peterson, R.T. & Schreiber, S.L. (1998) Alpha-4 associates with protein phosphatases 2A, 4 and 6. Biochem. Biophys. Res. Commun. 247, 827-832.
70. Chung, H., Nairn, A.C., Murata, K. & Brautigan, D.L. (1999) Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favours association with the alpha4 subunit which promotes dephosphorylation of elongation factor-2. Biochemistry 10, 10371-10376.
71. Peterson, R.T., Desai, B.N., Hardwick, J.S. & Schreiber, S.L. (1999) Protein phosphatase 2A interacts with the 70 kDa S6 kinase and is activated by inhibition of FKBP-12-rapamycin-associated protein. Proc. Natl. Acad. Sci. USA 96, 4438-4442.
72. Oldfield, S. & Proud, C.G. (1993) Phosphorylation of elongation factor-2 from the lepidopteran insect, Spodoptera frugiperda. FEBS Lett. 327, 71-74.
73. Morrison, D.K., Murakami, M.S. & Cleghon, V. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell. Biol. 150, F57-F62.
74. Donovan, M.G. & Bodley, J.W. (1991) Saccharomyces cerevisiae elongation factor 2 is phosphorylated by an endogenous kinase. FEBS Lett. 291, 303-306.
75. Gingras, A.-C., Raught, B., Gygi, S.P., Niedzwieka, A., Miron, M., Burley, S.K., Polakiewicz, R.D., Wyslouch-Cieczyska, A., Aebersold, R. & Sonenberg, N. (2001) Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev. 15, 2852-2864.