Maximal lengthening contractions increase p70 S6 kinase phosphorylation in human skeletal muscle in the absence of nutritional supply

American Journal of Physiology - Endocrinology and Metabolism

Volumn 291, Issue 6, 2006, Pages

  Eliasson, Jörgen ^a,b   Elfegoun, Thibault ^a,b   Nilsson, Johnny ^a   Köhnke, Rickard ^a   Ekblom, Björn ^a,b   Blomstrand, Eva ^a,b  

^a SWEDISH SCHOOL OF SPORT AND HEALTH SCIENCES   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Mode of contraction; Protein synthesis; Translation initiation

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; PROTEIN S6; S6 KINASE;

ARTICLE; CONCENTRIC MUSCLE CONTRACTION; CONTROLLED STUDY; EXERCISE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; MUSCLE BIOPSY; MUSCLE CONTRACTION; NORMAL HUMAN; NUTRITION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SKELETAL MUSCLE; VASTUS LATERALIS MUSCLE;

ADULT; BLOOD GLUCOSE; BLOTTING, WESTERN; ELECTROMYOGRAPHY; EXERCISE; HUMANS; LACTIC ACID; LEG; MALE; MUSCLE CONTRACTION; MUSCLE, SKELETAL; NUTRITION PHYSIOLOGY; PHOSPHORYLATION; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION;

EID: 33750371417     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00141.2006     Document Type: Article

References (36)

1. Astrand PO and Rodahl K. Textbook of Work Physiology. New York: McGraw Hill, 1986, p. 43-45, 358, 428-434.
2. Atherton PJ, Babraj JA, Smith K, Singh J, Rennie MJ, and Wackerhage H. Selective activation of AMPK-PGC-1α or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation. FASEB J 19: 786-788, 2005.
3. S6k correlates with increased skeletal muscle mass following resistance exercise. Am J Physiol Cell Physiol 276: C120-C127, 1999.
4. Bergmeyer HU. Methods of Enzymatic Analysis. New York: Academic, 1974.
5. Bodine SC, Stitt TN, Gonzalez M, Kline WO, Stover GL, Bauerlein R, Zlotchenko E, Scrimgeour A, Lawrence JC, Glass DJ, and Yancopoulos GD. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol 3: 1014-1019, 2001.
6. Bolster DR, Kubica N, Crozier SJ, Williamson DL, Farrell PA, Kimball SR, and Jefferson LS. Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle. J Physiol 553: 213-220, 2003.
7. Chiang GG and Abraham RT. Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase. J Biol Chem 280: 25485-25490, 2005.
8. Coffey VG, Zhong Z, Shield A, Canny BJ, Chibalin AV, Zierath JR, and Hawley JA. Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans. FASEB J 20: 190-192, 2006.
9. Creer A, Gallagher P, Slivka D, Jemiolo B, Fink W, and Trappe S. Influence of muscle glycogen availability on ERK1/2 and Akt signaling after resistance exercise in human skeletal muscle. J Appl Physiol 99: 950-956, 2005.
10. Cuthbertson DJ, Babraj J, Smith K, Wilkes E, Fedele MJ, Esser K, and Rennie M. Anabolic signaling and protein synthesis in human skeletal muscle after dynamic shortening or lengthening exercise. Am J Physiol Endocrinol Metab 290: E731-E738, 2006.
11. Cuthbertson D, Smith K, Babraj J, Leese G, Waddell T, Atherton P, Wackerhage H, Taylor PM, and Rennie MJ. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB J 19: 422-424, 2005.
12. Deshmukh A, Coffey VG, Zhong Z, Chibalin AV, Hawley JA, and Zierath JR. Exercise-induced phosphorylation of the novel Akt substrates AS 160 and filamin A in human skeletal muscle. Diabetes 55: 1776-1782, 2006.
13. Gibala MJ, Interisano SA, Tarnopolsky MA, Roy BD, MacDonald JR, Yarasheski KE, and MacDougall JD. Myofibrillar disruption following acute concentric and eccentric resistance exercise in strength-trained men. Can J Physiol Pharmacol 78: 656-661, 2000.
14. Goldspink G, Williams P, and Simpson H. Gene expression in response to muscle stretch. Clin Orthop Relat Res 403: S146-S152, 2002.
15. Guillet C, Prod'homme M, Balage M, Gachon P, Giraudet C, Morin L, Grizard J, and Boirie Y. Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans. FASEB J 18: 1586-1587, 2004.
16. Hather BM, Tesch PA, Buchanan P, and Dudley GA. Influence of eccentric actions on skeletal muscle adaptations to resistance training. Acta Physiol Scand 143: 177-185, 1991.
17. Henriksson KG. "Semi-open" muscle biopsy technique. A simple outpatient procedure. Acta Neurol Scand 59: 317-323, 1979.
18. Higbie EJ, Cureton KJ, Warren GL III, and Prior BM. Effects of concentric and eccentric training on muscle strength, cross-sectional area, and neural activation. J Appl Physiol 81: 2173-2181, 1996.
19. Holz MK and Blenis J. Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J Biol Chem 280: 26089-26093, 2005.
20. Hornberger TA, Stuppard R, Conley KE, Fedele MJ, Fiorotto ML, Chin ER, and Esser KA. Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism. Biochem J 380: 795-804, 2004.
21. Hortobágyi T, Dempsey L, Fraser D, Zheng D, Hamilton G, Lambert J, and Dohm L. Changes in muscle strength, muscle fibre size and myofibrillar gene expression after immobilization and retraining in humans. J Physiol 524: 293-304, 2000.
22. Hortobagyi T, Hill JP, Houmard JA, Fraser DD, Lambert NJ, and Israel RG. Adaptive responses to muscle lengthening and shortening in humans. J Appl Physiol 80: 765-772, 1996.
23. s6k. EMBO J 16: 3693-3704, 1997.
24. Jessen N and Goodyear LJ. Contraction signaling to glucose transport in skeletal muscle. J Appl Physiol 99: 330-337, 2005.
25. Jones DA and Rutherford OM. Human muscle strength training: the effects of three different regimens and the nature of the resultant changes. J Physiol 391: 1-11, 1987.
26. S6k phosphorylation in human skeletal muscle after resistance exercise. Am J Physiol Endocrinol Metab 287: E1-E7, 2004.
27. Moore DR, Phillips SM, Babraj JA, Smith K, and Rennie MJ. Myofibrillar and collagen protein synthesis in human skeletal muscle in young men after maximal shortening and lengthening contractions. Am J Physiol Endocrinol Metab 288: E1153-E1159, 2005.
28. Nader GA and Esser KA. Intracellular signaling specificity in skeletal muscle in response to different modes of exercise. J Appl Physiol 90: 1936-1942, 2001.
29. Ohanna M, Sobering AK, Lapointe T, Lorenzo L, Praud C, Petroulakis E, Sonenberg N, Kelly PA, Sotiropoulos A, and Pende M. Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control. Nat Cell Biol 7: 286-294, 2005.
30. Parkington JD, Siebert AP, LeBrasseur NK, and Fielding RA. Differential activation of mTOR signaling by contractile activity in skeletal muscle. Am J Physiol Regul Integr Comp Physiol 285: R1086-R1090, 2003.
31. Phillips SM, Tipton KD, Aarsland A, Wolf SE, and Wolfe RR. Mixed muscle protein synthesis and breakdown after resistance exercise in humans. Am J Physiol Endocrinol Metab 273: E99-E107, 1997.
32. s6k by PDK1. Science 279: 707-710, 1998.
33. Seger JY, Arvidsson B, and Thorstensson A. Specific effects of eccentric and concentric training on muscle strength and morphology in humans. Eur J Appl Physiol Occup Physiol 79: 49-57, 1998.
34. Tesch PA. Skeletal muscle adaptations consequent to long-term heavy resistance exercise. Med Sci Sports Exerc 20: S132-S134, 1988.
35. Trappe TA, White F, Lambert CP, Cesar D, Hellerstein M, and Evans WJ. Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis. Am J Physiol Endocrinol Metab 282: E551-E556, 2002.
36. Yang Y, Creer A, Jemiolo B, and Trappe S. Time course of myogenic and metabolic gene expression in response to acute exercise in human skeletal muscle. J Appl Physiol 98: 1745-1752, 2005.