Impact of resistance loading on myostatin expression and cell cycle regulation in young and older men and women

American Journal of Physiology - Endocrinology and Metabolism

Volumn 288, Issue 6 51-6, 2005, Pages

  Kim, Jeong Su ^a,b   Cross, James M ^c   Bamman, Marcas M ^a,b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b BIRMINGHAM VA MEDICAL CENTER   (United States)

^c Kentucky   (United States)

Author keywords

Aging; Mechano growth factor; p27kip; Resistance exercise; Sarcopenia

Indexed keywords

CYCLIN B1; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; GROWTH FACTOR; MECHANO GROWTH FACTOR; MESSENGER RNA; MYOSTATIN; UNCLASSIFIED DRUG;

ADULT; AGE; AGED; ANALYSIS OF VARIANCE; ARTICLE; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FATIGUE; FEMALE; GENETIC TRANSCRIPTION; HUMAN; HUMAN EXPERIMENT; KNEE FUNCTION; MALE; MUSCLE ATROPHY; MUSCLE BIOPSY; MUSCLE HYPERTROPHY; MYOBLAST; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX DIFFERENCE; VASTUS LATERALIS MUSCLE;

ADULT; AGE FACTORS; AGED; BIOPSY; CELL CYCLE; CELL CYCLE PROTEINS; CYCLIN B; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; EXERCISE; FEMALE; HUMANS; MALE; MIDDLE AGED; MUSCLE, SKELETAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEX FACTORS; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEINS;

EID: 19444370186     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00464.2004     Document Type: Article

References (45)

1. Adams GR, Caiozzo VJ, Haddad F, and Baldwin KM. Cellular and molecular responses to increased skeletal muscle loading after irradiation. Am J Physiol Cell Physiol 283: C1182-C1195, 2002.
2. Adams GR, Haddad F, and Baldwin KM. Time course of changes in markers of myogenesis in overloaded rat skeletal muscles. J Appl Physiol 87: 1705-1712, 1999.
3. Bamman MM, Hill VJ, Adams GR, Haddad F, Wetzstein CJ, Gower BA, Ahmed A, and Hunter GR. Gender differences in resistance-training-induced myofiber hypertrophy among older adults. J Gerontol A Biol Sci Med Sci 58: 108-116, 2003.
4. Bamman MM, Ragan RC, Kim JS, Cross JM, Hill VJ, Tuggle SC, and Allman RM. Myogenic protein expression before and after resistance loading in 26- and 64-yr-old men and women. J Appl Physiol 97: 1329-1337, 2004.
5. Bickel CS, Slade JM, Haddad F, Adams GR, and Dudley GA. Acute molecular responses of skeletal muscle to resistance exercise in able-bodied and spinal cord-injured subjects. J Appl Physiol 94: 2255-2262, 2003.
6. Carlson CJ, Booth FW, and Gordon SE. Skeletal muscle myostatin mRNA expression is fiber-type specific and increases during hindlimb unloading. Am J Physiol Regul Integr Comp Physiol 277: R601-R606, 1999.
7. Chomczynski P and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
8. Coats S, Whyte P, Fero ML, Lacy S, Chung G, Randel E, Firpo E, and Roberts JM. A new pathway for mitogen-dependent cdk2 regulation uncovered in p27(Kip1)-deficient cells. Curr Biol 9: 163-173, 1999.
9. Evans W, Phinney S, and Young V. Suction applied to a muscle biopsy maximizes sample size. Med Sci Sports Exerc 14: 101-102, 1982.
10. Figueroa A, Going SB, Milliken LA, Blew RM, Sharp S, Teixeira PJ, and Lohman TG. Effects of exercise training and hormone replacement therapy on lean and fat mass in postmenopausal women. J Gerontol A Biol Sci Med Sci 58: 266-270, 2003.
11. Gonzalez-Cadavid NF, Taylor WE, Yarasheski K, Sinha-Hikim I, Ma K, Ezzat S, Shen R, Lalani R, Asa S, Mamita M, Nair G, Arver S, and Bhasin S. Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting. Proc Natl Acad Sci USA 95: 14938-14943, 1998.
12. Haddad F and Adams GR. Selected contribution: acute cellular and molecular responses to resistance exercise. J Appl Physiol 93: 394-403, 2002.
13. Hameed M, Lange KH, Andersen JL, Schjerling P, Kjaer M, Harridge SD, and Goldspink G. The effect of recombinant human growth hormone and resistance training on IGF-I mRNA expression in the muscles of elderly men. J Physiol 555: 231-240, 2004.
14. Hameed M, Orrell RW, Cobbold M, Goldspink G, and Harridge SD. Expression of IGF-I splice variants in young and old human skeletal muscle after high-resistance exercise. J Physiol 547: 247-254, 2003.
15. Hill M and Goldspink G. Expression and splicing of the insulin-like growth factor gene in rodent muscle is associated with muscle satellite (stem) cell activation following local tissue damage. J Physiol 549: 409-418, 2003.
16. Hunter GR, McCarthy JP, and Bamman MM. Effects of resistance training on older adults. Sports Med 34: 329-348, 2004.
17. Ivey FM, Roth SM, Ferrell RE, Tracy BL, Lemmer JT, Hurlbut DE, Martel GF, Siegel EL, Fozard JL, Jeffrey Metter E, Fleg JL, and Hurley BF. Effects of age, gender, and myostatin genotype on the hypertrophic response to heavy resistance strength training. J Gerontol A Biol Sci Med Sci 55: M641-M648, 2000.
18. Ivey FM, Tracy BL, Lemmer JT, NessAiver M, Metter EJ, Fozard JL, and Hurley BF. Effects of strength training and detraining on muscle quality: age and gender comparisons. J Gerontol A Biol Sci Med Sci 55: B152-B157; discussion B158-B159, 2000.
19. Kawada S, Tachi C, and Ishii N. Content and localization of myostatin in mouse skeletal muscles during aging, mechanical unloading and reloading. J Muscle Res Cell Motil 22: 627-633, 2001.
20. Lalani R, Bhasin S, Byhower F, Tarnuzzer R, Grant M, Shen R, Asa S, Ezzat S, and Gonzalez-Cadavid NF. Myostatin and insulin-like growth factor-I and -II expression in the muscle of rats exposed to the microgravity environment of the NeuroLab space shuttle flight. J Endocrinol 167: 417-428, 2000.
21. Langley B, Thomas M, Bishop A, Sharma M, Gilmour S, and Kambadur R. Myostatin inhibits myoblast differentiation by downregulating MyoD expression. J Biol Chem 277: 49831-49840, 2002.
22. Lin J, Della-Fera MA, Li C, Page K, Ho Choi Y, Hartzell DL, and Baile CA. P27 knockout mice: reduced myostatin in muscle and altered adipogenesis. Biochem Biophys Res Commun 300: 938-942, 2003.
23. Marcell TJ. Sarcopenia: causes, consequences, and preventions. J Gerontol A Biol Sci Med Sci 58: M911-M916, 2003.
24. McCroskery S, Thomas M, Maxwell L, Sharma M, and Kambadur R. Myostatin negatively regulates satellite cell activation and self-renewal. J Cell Biol 162: 1135-1147, 2003.
25. McPherron AC, Lawler AM, and Lee SJ. Regulation of skeletal muscle mass in mice by a new TGF-β superfamily member. Nature 387: 83-90, 1997.
26. McPherron AC and Lee SJ. Double muscling in cattle due to mutations in the myostatin gene. Proc Natl Acad Sci USA 94: 12457-12461, 1997.
27. Petrella JK, Kim JS, Tuggle SC, Hall SR, and Bamman MM. Age differences in knee extension power, contractile velocity, and fatigability. J Appl Physiol 98: 211-220, 2005.
28. Psilander N, Damsgaard R, and Pilegaard H. Resistance exercise alters MRF and IGF-I mRNA content in human skeletal muscle. J Appl Physiol 95: 1038-1044, 2003.
29. Reardon KA, Davis J, Kapsa RM, Choong P, and Byrne E. Myostatin, insulin-like growth factor-1, and leukemia inhibitory factor mRNAs are upregulated in chronic human disuse muscle atrophy. Muscle Nerve 24: 893-899, 2001.
30. Rios R, Carneiro I, Arce VM, and Devesa J. Myostatin is an inhibitor of myogenic differentiation. Am J Physiol Cell Physiol 282: C993-C999, 2002.
31. Roth SM, Martel GF, Ferrell RE, Metter EJ, Hurley BF, and Rogers MA. Myostatin gene expression is reduced in humans with heavy-resistance strength training: a brief communication. Exp Biol Med (Maywood) 228: 706-709, 2003.
32. Schuelke M, Wagner KR, Stolz LE, Hubner C, Riebel T, Komen W, Braun T, Tobin JF, and Lee SJ. Myostatin mutation associated with gross muscle hypertrophy in a child. N Engl J Med 350: 2682-2688, 2004.
33. Schulte JN and Yarasheski KE. Effects of resistance training on the rate of muscle protein synthesis in frail elderly people. Int J Sport Nutr Exerc Metab 11, Suppl: S111-S118, 2001.
34. Seibert MJ, Xue QL, Fried LP, and Walston JD. Polymorphic variation in the human myostatin (GDF-8) gene and association with strength measures in the Women's Health and Aging Study II cohort. J Am Geriatr Soc 49: 1093-1096, 2001.
35. Spangenburg EE, Chakravarthy MV, and Booth FW. p27Kip1: a key regulator of skeletal muscle satellite cell proliferation. Clin Orthop Relat Res 403: S221-S227, 2002.
36. Taylor WE, Bhasin S, Artaza J, Byhower F, Azam M, Willard DH Jr, Kull FC Jr, and Gonzalez-Cadavid N. Myostatin inhibits cell proliferation and protein synthesis in C2C12 muscle cells. Am J Physiol Endocrinol Metab 280: E221-E228, 2001.
37. Thomas M, Langley B, Berry C, Sharma M, Kirk S, Bass J, and Kambadur R. Myostatin, a negative regulator of muscle growth, functions by inhibiting myoblast proliferation. J Biol Chem 275: 40235-40243, 2000.
38. Wehling M, Cai B, and Tidball JG. Modulation of myostatin expression during modified muscle use. FASEB J 14: 103-110, 2000.
39. Welle S, Bhatt K, Shah B, and Thornton C. Insulin-like growth factor-1 and myostatin mRNA expression in muscle: comparison between 62-77 and 21-31 yr old men. Exp Gerontol 37: 833-839, 2002.
40. Widrick JJ, Maddalozzo GF, Lewis D, Valentine BA, Garner DP, Stelzer JE, Shoepe TC, and Snow CM. Morphological and functional characteristics of skeletal muscle fibers from hormone-replaced and non-replaced postmenopausal women. J Gerontol A Biol Sci Med Sci 58: 3-10, 2003.
41. Willoughby DS. Effects of heavy resistance training on myostatin mRNA and protein expression. Med Sci Sports Exerc 36: 574-582, 2004.
42. Willoughby DS and Nelson MJ. Myosin heavy-chain mRNA expression after a single session of heavy-resistance exercise. Med Sci Sports Exerc 34: 1262-1269, 2002.
43. Yang SY and Goldspink G. Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation. FEBS Lett 522: 156-160, 2002.
44. Yarasheski KE, Bhasin S, Sinha-Hikim I, Pak-Loduca J, and Gonzalez-Cadavid NF. Serum myostatin-immunoreactive protein is increased in 60-92 year old women and men with muscle wasting. J Nutr Health Aging 6: 343-348, 2002.
45. Zimmers TA, Davies MV, Koniaris LG, Haynes P, Esquela AF, Tomkinson KN, McPherron AC, Wolfman NM, and Lee SJ. Induction of cachexia in mice by systemically administered myostatin. Science 296: 1486-1488, 2002.