Signal transduction pathways involved in the regulation of protein synthesis by insulin in L6 myoblasts

American Journal of Physiology - Cell Physiology

Volumn 274, Issue 1 43-1, 1998, Pages

  Kimball, Scot R ^a   Horetsky, Rick L ^a   Jefferson, Leonard S ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Eukaryotic initiation factor 4E; Eukaryotic initiation factor 4E binding protein; Eukaryotic initiation factor 4G; Translation initiation

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; INITIATION FACTOR 4E; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; RAPAMYCIN; WORTMANNIN;

ANIMAL CELL; ARTICLE; DEPHOSPHORYLATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HORMONAL REGULATION; MYOBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS REGULATION; RAT; SIGNAL TRANSDUCTION; TRANSLATION INITIATION;

ANIMALIA; EUKARYOTA;

EID: 0031951444     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1998.274.1.c221     Document Type: Article

References (43)

1. Azpiaza, I., A. R. Saltiel, A. A. DePaoli-Roach, and J. C. Lawrence. Regulation of both glycogen synthase and PHAS-I by insulin in rat skeletal muscle involves MAP kinase-independent and rapamycin-sensitive pathways. J. Biol. Chem. 271: 5033-5039, 1996.
2. Beretta, L., A.-C. Gingras, Y. V. Svitkin, M. N. Hall, and N. Sonenberg. Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. EMBO J. 15: 658-664, 1996.
3. Chipkin, S. R., K. L. Kelly, and N. B. Ruderman. Hormone-fuel interrelationships: fed state, starvation, and diabetes mellitus. In: Joslin's Diabetes Mellitus (13th ed.), edited by C. R. Kahn and G. C. Weir. Malvern, PA: Lea and Febiger, 1994, p. 97-115.
4. Chung, J., T. C. Grammer, K. P. Lemon, A. Kazlauskas, and J. Blenis. PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase. Nature 370: 71-75, 1994.
5. Cobb, M. H., and E. J. Goldsmith. How MAP kinases are regulated. J. Biol. Chem. 270: 14843-14846, 1995.
6. Cross, D. A., D. R. Alessi, J. R. Vandenheede, H. E. McDowell, H. S. Hundal, and P. Cohen. The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf. Biochem. J. 303: 21-26, 1994.
7. Flynn, A., and C. G. Proud. Insulin-stimulated phosphorylation of initiation factor 4E is mediated by the MAP kinase pathway. FEBS Lett. 389: 162-166, 1996.
8. Flynn, A., and C. G. Proud. The role of eIF-4 in cell proliferation. Cancer Surv. 27: 293-310, 1996.
9. Graves, L. M., K. E. Bornfeldt, G. M. Argast, E. G. Krebs, X. Kong, T. A. Lin, and J. C. Lawrence. cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells. Proc. Natl. Acad. Sci. USA 92: 7222-7226, 1995.
10. Haghighat, A., S. Mader, A. Pause, and N. Sonenberg. Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E. EMBO J. 14: 5701-5709, 1995.
11. Haystead, T. A. J., C. M. M. Haystead, C. Hu, T.-A. Lin, and J. C. Lawrence. Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes. J. Biol. Chem. 269: 23185-23191, 1994.
12. Jeffrey, I. W., F. J. Kelly, R. Duncan, J. W. B. Hershey, and V. M. Pain. Effect of starvation and diabetes on the activity of the eukaryotic initiation factor eIF-2 in rat skeletal muscle. Biochimie 72: 751-757, 1990.
13. Joshi, B., R. Yan, and R. E. Rhoads. In vitro synthesis of human protein synthesis initiation factor-4γ and its localization on 43 and 48 S initiation complexes. J. Biol. Chem. 269: 2048-2055, 1994.
14. Karinch, A. M., S. R. Kimball, T. C. Vary, and L. S. Jefferson. Regulation of eukaryotic initiation factor 2B activity in muscle of diabetic rats. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E101-E108, 1993.
15. Kelly, F. J., and L. S. Jefferson. Control of peptide-chain initiation in rat skeletal muscle. Development of methods for preparation of native ribosomal subunits and analysis of the effect of insulin on formation of 40 S initiation complexes. J. Biol. Chem. 260: 6677-6683, 1985.
16. Kimball, S. R., K. E. Flaim, D. E. Peavy, and L. S. Jefferson. Protein metabolism. In: Ellenberg and Rifkin's Diabetes Mellitus: Theory and Practice, edited by H. Rifkin and D. J. Porte. New York: Elsevier, 1990, p. 41-50.
17. Kimball, S. R., and L. S. Jefferson. Effect of diabetes on guanine nucleotide exchange factor activity in skeletal muscle and heart. Biochem. Biophys. Res. Commun. 156: 706-711, 1988.
18. Kimball, S. R., and L. S. Jefferson. Mechanism of inhibition of protein synthesis by vasopressin in rat liver. J. Biol. Chem. 265: 16794-16798, 1990.
19. Kimball, S. R., L. S. Jefferson, P. Fadden, T. A. J. Haystead, and J. C. Lawrence, Jr. Insulin and diabetes cause reciprocal changes in the association of eIF-4E and PHAS-I in rat skeletal muscle. Am. J. Physiol. 270 (Cell Physiol. 39): C705-C709, 1996.
20. Kimball, S. R., C. V. Jurasinski, J. C. Lawrence, Jr., and L. S. Jefferson. Insulin stimulates protein synthesis in skeletal muscle by enhancing the association of eIF-4E and eIF-4G. Am. J. Physiol. 272 (Cell Physiol. 41): C754-C759, 1997.
21. Kimball, S. R., A. M. Karinch, R. C. Feldhoff, H. Mellor, and L. S. Jefferson. Purification and characterization of eukaryotic initiation factor eIF-2B from liver. Biochim. Biophys. Acta 1201: 473-481, 1994.
22. Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
23. Lamphear, B. J., R. Kirchweger, T. Skern, and R. E. Rhoads. Mapping of functional domains in eukaryotic protein synthesis initiation factor 4G (eIF-4G) with picronaviral proteases. Implications for cap-dependent and cap-independent translational initiation. J. Biol. Chem. 270: 21975-21983, 1995.
24. Lin, T.-A., X. Kong, T. A. J. Haystead, A. Pause, G. Belsham, N. Sonenberg, and J. C. Lawrence. PHAS-I as a link between mitogen-activated protein kinase and translation initiation. Science 266: 653-656, 1994.
25. Lin, T.-A., X. Kong, A. R. Saltiel, P. J. Blackshear, and J. C. Lawrence. Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway. J. Biol. Chem. 270: 18531-18538, 1995.
26. Mader, S., H. Lee, A. Pause, and N. Sonenberg. The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4gamma and the translational repressers 4E-binding proteins. Mol. Cell. Biol. 15: 4990-4997, 1995.
27. Manzella, J. M., W. Rychlik, R. E. Rhoads, J. W. B. Hershey, and P. J. Blackshear. Insulin induction of ornithine decarboxylase. Importance of mRNA secondary structure and phosphorylation of eucaryotic initiation factors eIF-4B and eIF-4E. J. Biol. Chem. 266: 2382-2389, 1991.
28. Mendez, R., M. G. Myers, Jr., M. F. White, and R. E. Rhoads. Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase. Mol. Cell. Biol. 16: 2857-2864, 1996.
29. Morley, S. J., and J. A. Traugh. Differential stimulation of phosphorylation of initiation factors eIF-4F, eIF-4B, eIF-3, and ribosomal protein S6 by insulin and phorbol esters. J. Biol. Chem. 265: 10611-10616, 1990.
30. Morley, S. J., and J. A. Traugh. Stimulation of translation in 3T3-L1 cells in response to insulin and phorbol ester is directly correlated with increased phosphate labelling of initiation factor (eIF-) 4F and ribosomal protein S6. Biochimie 75: 985-989, 1993.
31. Pain, V. M. Initiation of protein synthesis in eukaryotic cells. Eur. J. Biochem. 236: 747-771, 1996.
32. Palmer, R. M., and P. A. Bain. Indomethacin inhibits the insulin-induced increases in RNA and protein synthesis in L6 skeletal muscle myoblasts. Prostaglandins 37: 193-203, 1989.
33. Pause, A., G. J. Belsham, A.-C. Gingras, O. Donze, T.-A. Lin, J. C. Lawrence, and N. Sonenberg. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function. Nature 371: 762-767, 1994.
34. Redpath, N. T., and C. G. Proud. Molecular mechanisms in the control of translation by hormones and growth factors. Biochim. Biophys. Acta 1220: 147-162, 1994.
35. Rinker-Schaeffer, C. W., V. Austin, S. Zimmer, and R. E. Rhoads. Ras transformation of cloned rat embryo fibroblasts results in increased rates of protein synthesis and phosphorylation of eukaryotic initiation factor 4E. J. Biol. Chem. 267: 10659-10664, 1992.
36. Roeder, R. A., S. D. Thorpe, F. M. Byers, G. T. Schelling, and J. M. Gunn. Influence of anabolic agents on protein synthesis and degradation in muscle cells grown in culture. Growth 50: 485-495, 1986.
37. Rychlik, W., J. S. Rush, R. E. Rhoads, and C. J. Waechter. Increased rate of phosphorylation-dephosphorylation of the translational initiation factor eIF-4E correlates with the induction of protein and glycoprotein biosynthesis in activated B lymphocytes. J. Biol. Chem. 265: 19467-19471, 1990.
38. Servant, M. J., E. Giasson, and S. Meloche. Inhibition of growth factor-induced protein synthesis by a selective MEK inhibitor in aortic smooth muscle cells. J. Biol. Chem. 271: 16047-16052, 1996.
39. Thompson, M. G., S. C. Mackie, A. Thom, D. G. Hazlerigg, K. S. Morrison, and R. M. Palmer. Cyclic AMP stimulates protein synthesis in L6 myoblasts and its effects are additive to those of insulin, vasopressin, and 12-O-tetradecanoylphorbol-13-acetate. Possible involvement of mitogen activated protein kinase. Biochim. Biophys. Acta 1311: 37-44, 1996.
40. Thompson, M. G., M. Pascal, S. C. Mackie, A. Thom, K. S. Morrison, F. R. C. Backwell, and R. M. Palmer. Evidence that protein kinase C and mitogen activated protein kinase are not involved in the mechanism by which insulin stimulates translation in L6 myoblasts. Biosci. Rep. 15: 37-46, 1995.
41. Von Manteuffel, S. R., A.-C. Gingras, X.-F. Ming, N. Sonenberg, and G. Thomas. 4E-BP1 phosphorylation is mediated by FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase. Proc. Natl. Acad. Sci. USA 93: 4076-4080, 1996.
42. Welsh, G. I., and C. G. Proud. Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B. Biochem. J. 294: 625-629, 1993.
43. Weng, Q.-P., K. Andrabi, M. T. Kozlowski, J. R. Grove, and J. Avruch. Multiple independent inputs are required for activation of the p70 S6 kinase. Mol. Cell. Biol. 15: 2333-2340, 1995.