Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation

Molecular and Cellular Biology

Volumn 27, Issue 21, 2007, Pages 7405-7413

  Wang, Xuerong ^a   Yue, Ping ^a   Chan, Chi Bun ^a   Ye, Keqiang ^a   Ueda, Takeshi ^b   Watanabe Fukunaga, Rie ^b   Fukunaga, Rikiro ^b   Fu, Haian ^a   Khuri, Fadlo R ^a   Sun, Shi Yong ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; INITIATION FACTOR 4E; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN MNK; PROTEIN MNK1; PROTEIN MNK2; PROTEIN P70; RAPAMYCIN; S6 KINASE; SERINE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL CYCLE PROGRESSION; CELL SURVIVAL; CELL TRANSFORMATION; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RNA TRANSLATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL LINE, TUMOR; ENZYME ACTIVATION; ENZYME INDUCTION; EUKARYOTIC INITIATION FACTOR-4E; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MODELS, BIOLOGICAL; NEOPLASMS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, IGF TYPE 1; SIROLIMUS;

EUKARYOTA; MAMMALIA; RAPTORES;

EID: 35648962915     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00760-07     Document Type: Article

References (25)

1. Ahn, J. Y., R. Rong, X. Liu, and K. Ye. 2004. PIKE/nuclear PI 3-kinase signaling mediates the antiapoptotic actions of NGF in the nucleus. EMBO J. 23:3995-4006.
2. Bjornsti, M. A., and P. J. Houghton. 2004. Lost in translation: dysregulation of cap-dependent translation and cancer. Cancer Cell 5:519-523.
3. Bjornsti, M. A., and P. J. Houghton. 2004. The TOR pathway: a target for cancer therapy. Nat. Rev. Cancer 4:335-348.
4. De Benedetti, A., and A. L. Harris. 1999. eIF4E expression in tumors: its possible role in progression of malignancies. Int. J. Biochem. Cell. Biol. 31:59-72.
5. Franch, H. A., X. Wang, S. Sooparb, N. S. Brown, and J. Du. 2002. Phosphatidylinositol 3-kinase activity is required for epidermal growth factor to suppress proteolysis. J. Am. Soc. Nephrol. 13:903-909.
6. Harrington, L. S., G. M. Findlay, and R. F. Lamb. 2005. Restraining PI3K: mTOR signalling goes back to the membrane. Trends Biochem. Sci. 30: 35-42.
7. Herbert, T. P., G. R. Kilhams, I. H. Batty, and C. G. Proud. 2000. Distinct signalling pathways mediate insulin and phorbol ester-stimulated eukaryotic initiation factor 4F assembly and protein synthesis in HEK 293 cells. J. Biol. Chem. 275:11249-11256.
8. Knauf, U., C. Tschopp, and H. Gram. 2001. Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. Mol. Cell. Biol. 21:5500-5511.
9. Lachance, P. E., M. Miron, B. Raught, N. Sonenberg, and P. Lasko. 2002. Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth. Mol. Cell. Biol. 22:1656-1663.
10. Mahalingam, M., and J. A. Cooper. 2001. Phosphorylation of mammalian eIF4E by Mnk1 and Mnk2: tantalizing prospects for a role in translation. Prog. Mol. Subcell. Biol. 27:132-142.
11. Mamane, Y., E. Petroulakis, L. Rong, K. Yoshida, L. W. Ler, and N. Sonenberg. 2004. eIF4E - from translation to transformation. Oncogene 23:3172-3179.
12. Manning, B. D. 2004. Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis. J. Cell Biol. 167:399-403.
13. Morley, S. J., and S. Naegele. 2002. Phosphorylation of eukaryotic initiation factor (eIF) 4E is not required for de novo protein synthesis following recovery from hypertonic stress in human kidney cells. J. Biol. Chem. 277: 32855-32859.
14. O'Reilly, K. E., F. Rojo, Q. B. She, D. Solit, G. B. Mills, D. Smith, H. Lane, F. Hofmann, D. J. Hicklin, D. L. Ludwig, J. Baselga, and N. Rosen. 2006. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res. 66:1500-1508.
15. Pyronnet, S. 2000. Phosphorylation of the cap-binding protein eIF4E by the MAPK-activated protein kinase Mnk1. Biochem. Pharmacol. 60:1237-1243.
16. Raught, B., and A. C. Gingras. 1999. eIF4E activity is regulated at multiple levels. Int. J. Biochem. Cell. Biol. 31:43-57.
17. Richter, J. D., and N. Sonenberg. 2005. Regulation of cap-dependent translation by eIF4E inhibitory proteins. Nature 433:477-480.
18. Sarbassov, D. D., D. A. Guertin, S. M. Ali, and D. M. Sabatini. 2005. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307:1098-1101.
19. Sarbassov, D. D., S. M. Ali, S. Sengupta, J. H. Sheen, P. P. Hsu, A. F. Bagley, A. L. Markhard, and D. M. Sabatini. 2006. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol. Cell 22:159-168.
20. Sun, S. Y., L. M. Rosenberg, X. Wang, Z. Zhou, P. Yue, H. Fu, and F. R. Khuri. 2005. Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res 65:7052-7058.
21. Sun, S. Y., P. Yue, G. S. Wu, W. S. El-Deiry, B. Shroot, W. K. Hong, and R. Lotan. 1999. Mechanisms of apoptosis induced by the synthetic retinoid CD437 in human non-small cell lung carcinoma cells. Oncogene 18:2357-2365.
22. Ueda, T., R. Watanabe-Fukunaga, H. Fukuyama, S. Nagata, and R. Fukunaga. 2004. Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development. Mol. Cell. Biol. 24:6539-6549.
23. von der Haar, T., J. D. Gross, G. Wagner, and J. E. McCarthy. 2004. The mRNA cap-binding protein eIF4E in post-transcriptional gene expression. Nat. Struct. Mol. Biol. 11:503-511.
24. Wan, X., B. Harkavy, N. Shen, P. Grohar, and L. J. Helman. 2006. Rapamycin induces feedback activation of Akt signaling through an IGF-IR-dependent mechanism. Oncogene 26:1932-1940.
25. Winnay, J. N., J. C. Bruning, D. J. Burks, and C. R. Kahn. 2000. Gab-1-mediated IGF-1 signaling in IRS-1-deficient 3T3 fibroblasts. J. Biol. Chem. 275:10545-10550.