High level expression of differentially localized BAG-1 isoforms in some oestrogen receptor-positive human breast cancers

British Journal of Cancer

Volumn 81, Issue 6, 1999, Pages 1042-1051

  Brimmell, M ^a   Burns, J S ^b   Munson, P ^c   McDonald, L ^a,e   O'Hare, M J ^b   Lakhani, S R ^c   Packham, G ^a,d  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^d St Mary s Campus   (United Kingdom)

^e ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

BAG 1; BCL 2; Breast cancer; Oestrogen receptor

Indexed keywords

ESTROGEN RECEPTOR;

ADULT; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL CULTURE; CLINICAL ARTICLE; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL;

EID: 0032749421     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690805     Document Type: Article

References (40)

1. Adachi M, Masuo S, Torigoe T, Takayama S, Reed JC, Miyazaki T, Minami Y, Taniguchi T and Imai K (1996) Interleukin-2 (IL-2) upregulates Bag-1 gene expression through serine-rich region within IL-2 receptor βc chain. Blood 88: 4118-4123
2. Bardelli A, Longati P, Albero D, Goruppi S, Schneider A, Ponzetta C and Comoglio PM (1996) HGF receptor associates with the anti-apoptotic protein Bag-1 and prevents cell death. EMBO J 15: 6205-6212
3. Bardon S, Vignon F, Montcourrier P and Rochefort H (1987) Steroid receptor-mediated cytotoxicity of an antiestrogen and an antiprogestin in breast cancer cells. Cancer Res 47: 1441-1448
4. Beveglia L, Matsumoto K. Lin CS, Ziober BL and Kramer RH (1997) Expression of the c-Met/HGF receptor in human breast carcinoma; correlation with tumor progression. Int J Cancer 74: 301-309
5. Bhargava V, Kell DL, van de Rijn M and Warnke RA (1994) Bcl-2 immunoreactivity in breast carcinoma correlates with hormonc receptor positivity. Am J Pathol 145: 535-540
6. Chalbos D, Vignon F, Keydar I and Rochefort H (1982) Estrogens stimulate cell proliferation and induce secretory proteins in a human breast cancer cell line (T47D). J Clin Endocrinol Metab 55: 270-283
7. Clarke C, Titley J, Davies S and O'Hare MJ (1994) An immunomagnetic separation method using supermagnetic (MACS) beads for large-scale purificiation of human mammary luminal and myoepithelial cells. Epithelial Cell Biol 3: 38-46
8. Clevenger CV, Thickman K, Ngo W, Chang W-P, Takayama S and Reed JC (1997) Role of Bag-1 in the survival and proliferation of the cytokine-dependent lymphocyte lines, Ba/F3 and Nb2. Mol Endocrinol 11: 608-618
9. Coradini D, Cappelletti V, Granta G and di Fonzo G (1991) Activity of tamoxifen and its metabolites on endocrine-dependent and endocrine-independent breast cancer cells. Tumour Biol 12: 149-158
10. Engel LW, Young NA, Tralka TS, Lippman ME, O'Brien SJ and Joyce MJ (1978) Establishment and characterisation of three new continuous cell lines derived from human breast carcinomas. Cancer Res 38: 3352-3364
11. Fredersdorf S, Milne AW, Hall PA and Lu X (1996) Characterisation of a panel of novel anti-p21 wafl/cipl monoclonal antibodies and immunochemical analysis of p21 wafl/cipl expression in normal human tissues. Am J Pathol 148: 825-835
12. Froesch BA, Takayama S and Reed JC (1998) Bag-1L protein enhances androgen receptor function. J Biol Chem 273: 11660-11666
13. Gioanni J, Le FD, Zanghellini E, Mazeau C, Ettore F, Lambert JC, Schneider M and Dutrillaux B (1990) Establishment and characterisation of a new tumorigenic cell line with a normal karyotype derived from a human breast adenocarcinoma. Br J Cancer 62: 8-13
14. Hohfeld J and Jentsch S (1997) GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein Bag 1 EMBO J 16: 6209-6216
15. Huang Y, Ray S, Reed JC, Ibrado AM, Tang C, Nawabi A and Bhalla K (1997) Estrogen increases intracellular p26Bcl-2 to p21 Bax ratios and inhibits taxol induced apoptosis of human breast cancer MCF-7 cells. Breast Cancer Res Treat 42: 73-81
16. Hurst J, Maniar N, Tombarkiewicz J, Lucas F, Roberson C, Steplewski Z, James W and Perras J (1993) A novel model of a metastatic human breast tumour xenograft line. Br J Cancer 6: 274-276
17. Kullmann M, Schneikert J, Moll J, Heck S, Zeiner M, Gehring U and Cato ACB (1998) Rap46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis. J Biol Chem 273: 14620-14625
18. Kyprianou N, English HF, Davidson NE and Isaacs JT (1991) Programmed cell death during regression of the MCF-7 human breast cancer following estrogen ablation. Cancer Res 51: 162-166
19. Landel CC, Kushner PJ and Greene GL (1994) The interaction of human estrogen receptor with DNA is modulated by receptor associated proteins. Mol Endocrinol 8: 1407-1419
20. Leek RD, Kaklamanis L, Pezzella F, Gatter KC and Harris AL (1994) Bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer. Br J Cancer 69: 135-139
21. Lippman ME and Dickson RB (1989) Mechanisms of growth control in normal and malignant breast epithelium. Recent Prog 45: 383-440
22. Lippman ME, Bolan G and Huff K (1976) The effects of estrogens and antiestrogens on hormone-responsive human breast cancer in long term tissue culture. Cancer Res 36: 4595-4601
23. Liu R, Takayama S, Zheng Y, Froesch B, Chen G-Q, Zhang X, Reed JC and Zhang X K (1998) Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells. J Biol Chem 273: 16985-16992
24. Matsuzawa S-I, Takayama S, Froesch BA, Zapata JM and Reed JC (1998) p53-inducible human homologue of drosophila seven in absentia (siah) inhibits cell growth: suppression by Bag-1. EMBO J 17: 2736-2747
25. Packham G, Brimmell M and Cleveland JL (1997) Mammaltan cells express two differently localized BAG-1 isoforms generated by alternate translation. Biochem J 328: 807-813
26. Reed JC (1997) Double identity for proteins of the Bel-2 family, Nature 387: 773-776
27. Schulz JB, Bremen D, Reed JC, Lommatzsch J, Takayama S, Wullner U, Loschmann PA, Klockgether T and Weller M (1907) Cooperative interception of neuronal apoptosis by bel-2 and bag-1 expression: prevention of caspase activation and reduced production of reactive oxygen species. J Neurochem 69: 2075-2086
28. Silvestrini R, Vencroni S, Daidone MG, Benini E, Boracchi P, Mezzetti M, di Fronzo G, Rilke F and Veronesi U (1994) The Bel-2 protein: a prognostic indicator strongly related to p53 protein in lymph node-negative breast cancer patients. J Natl Cancer Inst 86: 499-504
29. Takayama S, Sato T, Krajewski S, Kochel K, Irie S, Millan JA and Reed JC (1995) Cloning and functional analysis of Bag-1; a novel Bel-2-binding protein with anti-cell death activity. Cell 80: 279-284
30. Takayama S, Kochel K, Iric S, Inazawa J, Abe T, Sato T, Druck T, Huebner K and Reed JC (1996) Cloning of cDNAs encoding the human BAG1 protein and localisation of the human BAG1 gene to chromosome 9p12. Genomics 35: 494-498
31. Takayama S, Bimston DN, Matsuzawa S, Freeman BC, Aime-Sempe C, Xie Z, Morimoto RJ and Reed JC (1907) Bag-1 modulates the chaperone activity of hsp70/hsc70. EMBO J 16: 4887-4896
32. Takayama S, Krajewski S, Krajewski M, Kitada S, Zapata JM, Kochel K, Knee D, Scudicro D, Tudor G, Miller GJ, Miyashita T, Yamada M and Reed JC (1998) Expression and location of HSP70/HSC-binding anti-apoptotic protein BAG I and its variants in normal tissues and tumor cell lines. Cancer Res 58: 3116-3131
33. Teixeira C, Reed JC and Pratt MAC (1995) Estrogen promotes chemotherapeutic drug resistance by a machanism involving bel-2 proto-oncogene expression in human breast cancer cells. Cancer Res 55: 3902-3907
34. Tuck AB, Park M, Sterns EE, Boag A and Elliott BE (1996) Coexpression of hepatocyte growth factor and receptor (met) in human breast carcinoma. Am J Pathol 148: 225-232
35. Wakeling AE, Dukes M and Bowler J (1991) A potent specific pure antiestrogen with clinical potential. Cancer Res 51: 3867-3873
36. Wang HG, Takayama S. Rapp UR and Reed JC (1996) Bel-2 interacting protein, Bag-1, binds to and activates the kinase Raf-1. Proc Natl Acad Sci USA 93: 7063-7068
37. Wilson JW, Wakeling AE, Morris ID, Hickman JA and Dive C (1995) MCF-7 human mammary adenocarcinoma cell death in vitro in response to hormone. withdrawal and DNA damage. Int J Cancer 61: 502-508
38. Zapata JM, Krajewska M, Krajewska S, Huang R-P, Takayama S, Wang H-G, Adamson E and Reed JC (1998) Expression of multiple apoptosis-regulatory genes in human breast cancer cell lines and primary tumours. Breast Cancer Res Treat 47: 129-140
39. Ziener M and Gehring U (1995) A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning. Proc Natl Acad Sci USA 92: 11465-11469
40. Zeiner M, Gebauer M and Gehring U (1997) Mammalian protein RAP46: an interaction partner and modulator of 70 kDa heat shock proteins. EMBO J 167: 5483-5490