Hypoxia-inducible factor-2α: Effect on radiation sensitivity and differential regulation by an mTOR inhibitor

BJU International

Volumn 102, Issue 3, 2008, Pages 358-363

  Bhatt, Rupal S ^b   Landis, Daniel M ^b,d   Zimmer, Michael ^b,c   Torregrossa, Joelle ^b   Chen, Shaoyong ^b   Sukhatme, Vikas P ^b   Iliopoulos, Othon ^b,c   Balk, Steve ^b   Bubley, Glenn J ^a,b  

^a HARVARD INSTITUTES OF MEDICINE   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d SWEDISH MEDICAL CENTER   (United States)

Author keywords

Hypoxia; Hypoxia inducible factor; Radiation; Renal cancer

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; RAPAMYCIN; SHORT HAIRPIN RNA;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DRUG ACTIVITY; DRUG MECHANISM; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IONIZING RADIATION; KIDNEY CARCINOMA; PRIORITY JOURNAL; RADIATION DOSE; RADIOSENSITIVITY; REPORTER GENE; STATISTICAL SIGNIFICANCE;

ANTIBIOTICS, ANTINEOPLASTIC; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BLOTTING, WESTERN; CARCINOMA, RENAL CELL; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; FLOW CYTOMETRY; G2 PHASE; GENES, REPORTER; HUMANS; KIDNEY NEOPLASMS; LUCIFERASES; PROTEIN KINASES; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; SIROLIMUS;

EID: 47649094400     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2008.07558.x     Document Type: Article

References (20)

1. Turner KJ, Moore JW, Jones A et al. Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation. Cancer Res 2002 62 : 2957 61
2. Kaelin WG Jr. The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing. Biochem Biophys Res Commun 2005 338 : 627 38
3. Ryan HE, Lo J, Johnson RS. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J 1998 17 : 3005 15
4. Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin WG Jr. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 2002 1 : 237 46
5. Zimmer M, Doucette D, Siddiqui N, Iliopoulos O. Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors. Mol Cancer Res 2004 2 : 89 95
6. Krieg M, Haas R, Brauch H, Acker T, Flamme I, Plate KH. Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function. Oncogene 2000 19 : 5435 43
7. Harrison LB, Chadha M, Hill RJ, Hu K, Shasha D. Impact of tumor hypoxia and anemia on radiation therapy outcomes. Oncologist 2002 7 : 492 508
8. Ishikawa H, Sakurai H, Hasegawa M et al. Expression of hypoxic-inducible factor 1α predicts metastasis-free survival after radiation therapy alone in stage IIIB cervical squamous cell carcinoma. Int J Radiat Oncol Biol Phys 2004 60 : 513 21
9. Koukourakis MI, Giatromanolaki A, Sivridis E et al. Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer. Int J Radiat Oncol Biol Phys 2002 53 : 1192 202
10. Zhang X, Kon T, Wang H et al. Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1α. Cancer Res 2004 64 : 8139 42
11. Moeller BJ, Dreher MR, Rabbani ZN et al. Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Cancer Cell 2005 8 : 99 110
12. Cordes N, van Beuningen D. Arrest of human lung fibroblasts in G2 phase after irradiation is regulated by converging phospatidyinositol-3 kinase and β1-integrin signaling in vitro. Int J Radiat Oncol Biol Phys 2004 58 : 453 62
13. Majumder PK, Febbo PG, Bikoff R et al. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med 2004 10 : 594 601
14. Hudson CC, Liu M, Chiang GG et al. Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin. Mol Cell Biol 2002 22 : 7004 14
15. Maranchie JK, Zhan Y. Nox4 is critical for hypoxia-inducible factor 2α transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma. Cancer Res 2005 65 : 9190 3
16. Palayoor ST, Burgos MA, Shoaibi A, Tofilon PJ, Coleman CN. Effect of radiation and ibuprofen on normoxic renal carcinoma cells overexpressing hypoxia-inducible factors by loss of von Hippel-Lindau tumor suppressor gene function. Clin Cancer Res 2004 10 : 4158 64
17. Nakamura E, Abreu-e-Lima P, Awakura Y et al. Clusterin is a secreted marker for a hypoxia-inducible factor-independent function of the von Hippel-Lindau tumor suppressor protein. Am J Pathol 2006 168 : 574 84
18. Covello KL, Simon MC, Keith B. Targeted replacement of hypoxia-inducible factor-1α by a hypoxia-inducible factor-2α knock-in allele promotes tumor growth. Cancer Res 2005 65 : 2277 86
19. Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC. Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation. Mol Cell Biol 2003 23 : 9361 74
20. Blancher C, Moore JW, Robertson N, Harris AL. Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1α, HIF-2α, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3′-kinase/Akt signaling pathway. Cancer Res 2001 61 : 7349 55