메뉴 건너뛰기




Volumn 20, Issue 7, 2006, Pages 772-783

Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures

Author keywords

ATR; BRCA1; Checkpoint control; Claspin; Xenopus egg extract

Indexed keywords

ATR PROTEIN; BRCA1 PROTEIN; DOUBLE STRANDED DNA; EGG PROTEIN; PROTEIN CLASPIN; UNCLASSIFIED DRUG;

EID: 33645516584     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1398806     Document Type: Article
Times cited : (50)

References (38)
  • 1
    • 0035449355 scopus 로고    scopus 로고
    • Cell cycle checkpoint signaling through the ATM and ATR kinases
    • Abraham, R.T. 2001. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes & Dev. 15: 2177-2196.
    • (2001) Genes & Dev. , vol.15 , pp. 2177-2196
    • Abraham, R.T.1
  • 2
    • 3142534591 scopus 로고    scopus 로고
    • Initiating cellular stress responses
    • Bakkenist, C.J. and Kastan, M.B. 2004. Initiating cellular stress responses. Cell 118: 9-17.
    • (2004) Cell , vol.118 , pp. 9-17
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 4
    • 0043032435 scopus 로고    scopus 로고
    • Human Claspin is required for replication checkpoint control
    • Chini, C.C. and Chen, J. 2003. Human Claspin is required for replication checkpoint control. J. Biol. Chem. 278: 30057-30062.
    • (2003) J. Biol. Chem. , vol.278 , pp. 30057-30062
    • Chini, C.C.1    Chen, J.2
  • 5
    • 0033636737 scopus 로고    scopus 로고
    • Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage
    • Costanzo, V., Robertson, K., Ying, C.Y., Kim, E., Avvedimento, E., Gottesman, M., Grieco, D., and Gautier, J. 2000. Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage. Mol. Cell 6: 649-659.
    • (2000) Mol. Cell , vol.6 , pp. 649-659
    • Costanzo, V.1    Robertson, K.2    Ying, C.Y.3    Kim, E.4    Avvedimento, E.5    Gottesman, M.6    Grieco, D.7    Gautier, J.8
  • 6
    • 0037245862 scopus 로고    scopus 로고
    • An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication
    • Costanzo, V., Shechter, D., Lupardus, P.J., Cimprich, K.A., Gottesman, M., and Gautier, J. 2003. An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol. Cell 11: 203-213.
    • (2003) Mol. Cell , vol.11 , pp. 203-213
    • Costanzo, V.1    Shechter, D.2    Lupardus, P.J.3    Cimprich, K.A.4    Gottesman, M.5    Gautier, J.6
  • 7
    • 0025284348 scopus 로고
    • Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: Studies in Xenopus
    • Dasso, M. and Newport, J.W. 1990. Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: Studies in Xenopus. Cell 61: 811-823.
    • (1990) Cell , vol.61 , pp. 811-823
    • Dasso, M.1    Newport, J.W.2
  • 8
    • 0343294336 scopus 로고    scopus 로고
    • Response of Xenopus Cds1 in cell-free extracts to DNA templates with double-stranded ends
    • Guo, Z. and Dunphy, W.G. 2000. Response of Xenopus Cds1 in cell-free extracts to DNA templates with double-stranded ends. Mol. Biol. Cell 11: 1535-1546.
    • (2000) Mol. Biol. Cell , vol.11 , pp. 1535-1546
    • Guo, Z.1    Dunphy, W.G.2
  • 9
    • 0034312277 scopus 로고    scopus 로고
    • Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
    • Guo, Z., Kumagai, A., Wang, S.X., and Dunphy, W.G. 2000. Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. Genes & Dev. 14: 2745-2756.
    • (2000) Genes & Dev. , vol.14 , pp. 2745-2756
    • Guo, Z.1    Kumagai, A.2    Wang, S.X.3    Dunphy, W.G.4
  • 10
    • 0034649590 scopus 로고    scopus 로고
    • Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint
    • Hekmat-Nejad, M., You, Z., Yee, M., Newport, J.W., and Cimprich, K.A. 2000. Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint. Curr. Biol. 10: 1565-1573.
    • (2000) Curr. Biol. , vol.10 , pp. 1565-1573
    • Hekmat-Nejad, M.1    You, Z.2    Yee, M.3    Newport, J.W.4    Cimprich, K.A.5
  • 11
    • 0344443718 scopus 로고    scopus 로고
    • Phosphorylated Claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation
    • Jeong, S.-Y., Kumagai, A., Lee, J., and Dunphy, W.G. 2003. Phosphorylated Claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation. J. Biol. Chem. 278: 46782-46788.
    • (2003) J. Biol. Chem. , vol.278 , pp. 46782-46788
    • Jeong, S.-Y.1    Kumagai, A.2    Lee, J.3    Dunphy, W.G.4
  • 12
    • 0035833994 scopus 로고    scopus 로고
    • Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development
    • Joukov, V., Chen, J., Fox, E.A., Green, J.B., and Livingston, D.M. 2001. Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development. Proc. Natl. Acad. Sci. 98: 12078-12083.
    • (2001) Proc. Natl. Acad. Sci. , vol.98 , pp. 12078-12083
    • Joukov, V.1    Chen, J.2    Fox, E.A.3    Green, J.B.4    Livingston, D.M.5
  • 14
    • 0036676302 scopus 로고    scopus 로고
    • Focus-formation of replication protein A, activation of checkpoint system and DNA repair synthesis induced by DNA double-strand breaks in Xenopus egg extract
    • Kobayashi, T., Tada, S., Tsuyama, T., Murofushi, H., Seki, M., and Enomoto, T. 2002. Focus-formation of replication protein A, activation of checkpoint system and DNA repair synthesis induced by DNA double-strand breaks in Xenopus egg extract. J. Cell Sci. 115: 3159-3169.
    • (2002) J. Cell Sci. , vol.115 , pp. 3159-3169
    • Kobayashi, T.1    Tada, S.2    Tsuyama, T.3    Murofushi, H.4    Seki, M.5    Enomoto, T.6
  • 15
    • 0033634679 scopus 로고    scopus 로고
    • Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
    • Kumagai, A. and Dunphy, W.G. 2000. Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol. Cell 6: 839-849.
    • (2000) Mol. Cell , vol.6 , pp. 839-849
    • Kumagai, A.1    Dunphy, W.G.2
  • 16
    • 0037289840 scopus 로고    scopus 로고
    • Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1
    • _. 2003. Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1. Nat. Cell Biol. 5: 161-165.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 161-165
  • 17
    • 0032555924 scopus 로고    scopus 로고
    • The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts
    • Kumagai, A., Guo, Z., Emami, K.H., Wang, S.X., and Dunphy, W.G. 1998a. The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts. J. Cell Biol. 142: 1559-1569.
    • (1998) J. Cell Biol. , vol.142 , pp. 1559-1569
    • Kumagai, A.1    Guo, Z.2    Emami, K.H.3    Wang, S.X.4    Dunphy, W.G.5
  • 18
    • 0031906844 scopus 로고    scopus 로고
    • 14-3-3 proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts
    • Kumagai, A., Yakowec, P.S., and Dunphy, W.G. 1998b. 14-3-3 proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts. Mol. Biol. Cell 9: 345-354.
    • (1998) Mol. Biol. Cell , vol.9 , pp. 345-354
    • Kumagai, A.1    Yakowec, P.S.2    Dunphy, W.G.3
  • 19
    • 9644275421 scopus 로고    scopus 로고
    • Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1
    • Kumagai, A., Kim, S.-M., and Dunphy, W.G. 2004. Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1. J. Biol. Chem. 279: 49599-49608.
    • (2004) J. Biol. Chem. , vol.279 , pp. 49599-49608
    • Kumagai, A.1    Kim, S.-M.2    Dunphy, W.G.3
  • 20
    • 0037291130 scopus 로고    scopus 로고
    • Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17
    • Lee, J., Kumagai, A., and Dunphy, W.G. 2003. Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17. Mol. Cell 11: 329-340.
    • (2003) Mol. Cell , vol.11 , pp. 329-340
    • Lee, J.1    Kumagai, A.2    Dunphy, W.G.3
  • 21
    • 27644514672 scopus 로고    scopus 로고
    • Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response
    • Lee, J., Gold, D.A., Shevchenko, A., Shevchenko, A., and Dunphy, W.G. 2005. Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response. Mol. Biol. Cell 16: 5269-5282.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 5269-5282
    • Lee, J.1    Gold, D.A.2    Shevchenko, A.3    Shevchenko, A.4    Dunphy, W.G.5
  • 22
    • 3042597013 scopus 로고    scopus 로고
    • Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases
    • Li, W., Kim, S.M., Lee, J., and Dunphy, W.G. 2004. Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases. J. Cell Biol. 165: 801-812.
    • (2004) J. Cell Biol. , vol.165 , pp. 801-812
    • Li, W.1    Kim, S.M.2    Lee, J.3    Dunphy, W.G.4
  • 23
    • 2342628449 scopus 로고    scopus 로고
    • Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation
    • Lin, S.Y., Li, K., Stewart, G.S., and Elledge, S.J. 2004. Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation. Proc. Natl. Acad. Sci. 101: 6484-6489.
    • (2004) Proc. Natl. Acad. Sci. , vol.101 , pp. 6484-6489
    • Lin, S.Y.1    Li, K.2    Stewart, G.S.3    Elledge, S.J.4
  • 25
    • 0037106186 scopus 로고    scopus 로고
    • A requirement for replication in activation of the ATR-dependent DNA damage checkpoint
    • Lupardus, P.J., Byun, T., Yee, M.C., Hekmat-Nejad, M., and Cimprich, K.A. 2002. A requirement for replication in activation of the ATR-dependent DNA damage checkpoint. Genes & Dev. 16: 2327-2332.
    • (2002) Genes & Dev. , vol.16 , pp. 2327-2332
    • Lupardus, P.J.1    Byun, T.2    Yee, M.C.3    Hekmat-Nejad, M.4    Cimprich, K.A.5
  • 26
    • 0031022391 scopus 로고    scopus 로고
    • Cell cycle regulation of the replication licensing system: Involvement of a Cdk-dependent inhibitor
    • Mahbubani, H.M., Chong, J.P., Chevalier, S., Thommes, P., and Blow, J.J. 1997. Cell cycle regulation of the replication licensing system: Involvement of a Cdk-dependent inhibitor. J. Cell Biol. 136: 125-135.
    • (1997) J. Cell Biol. , vol.136 , pp. 125-135
    • Mahbubani, H.M.1    Chong, J.P.2    Chevalier, S.3    Thommes, P.4    Blow, J.J.5
  • 27
    • 0032511148 scopus 로고    scopus 로고
    • Geminin, an inhibitor of DNA replication, is degraded during mitosis
    • McGarry, T.J. and Kirschner, M.W. 1998. Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 93: 1043-1053.
    • (1998) Cell , vol.93 , pp. 1043-1053
    • McGarry, T.J.1    Kirschner, M.W.2
  • 28
    • 0036948433 scopus 로고    scopus 로고
    • Toward maintaining the genome: DNA damage and replication checkpoints
    • Nyberg, K.A., Michelson, R.J., Putnam, C.W., and Weinert, T.A. 2002. Toward maintaining the genome: DNA damage and replication checkpoints. Annu. Rev. Genet. 36: 617-656.
    • (2002) Annu. Rev. Genet. , vol.36 , pp. 617-656
    • Nyberg, K.A.1    Michelson, R.J.2    Putnam, C.W.3    Weinert, T.A.4
  • 29
    • 0038506000 scopus 로고    scopus 로고
    • Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53
    • Osborn, A.J. and Elledge, S.J. 2003. Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. Genes & Dev. 17: 1755-1767.
    • (2003) Genes & Dev. , vol.17 , pp. 1755-1767
    • Osborn, A.J.1    Elledge, S.J.2
  • 30
    • 0036849432 scopus 로고    scopus 로고
    • Checking on the fork: The DNA-replication stress-response pathway
    • Osborn, A.J., Elledge, S.J., and Zou, L. 2002. Checking on the fork: The DNA-replication stress-response pathway. Trends Cell Biol. 12: 509-516.
    • (2002) Trends Cell Biol. , vol.12 , pp. 509-516
    • Osborn, A.J.1    Elledge, S.J.2    Zou, L.3
  • 31
    • 3943107573 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    • Sancar, A., Lindsey-Boltz, L.A., Ünsal-Kaçmaz, K., and Linn, S. 2004. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu. Rev. Biochem. 73: 39-85.
    • (2004) Annu. Rev. Biochem. , vol.73 , pp. 39-85
    • Sancar, A.1    Lindsey-Boltz, L.A.2    Ünsal-Kaçmaz, K.3    Linn, S.4
  • 32
    • 0037009006 scopus 로고    scopus 로고
    • DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts
    • Stokes, M.P., Van Hatten, R., Lindsay, H.D., and Michael, W.M. 2002. DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts. J. Cell Biol. 158: 863-872.
    • (2002) J. Cell Biol. , vol.158 , pp. 863-872
    • Stokes, M.P.1    Van Hatten, R.2    Lindsay, H.D.3    Michael, W.M.4
  • 33
    • 28444456705 scopus 로고    scopus 로고
    • The histone code at DNA breaks: A guide to repair?
    • van Attikum, H. and Gasser, S.M. 2005. The histone code at DNA breaks: A guide to repair? Nat. Rev. Mol. Cell Biol. 6: 757-765.
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 757-765
    • Van Attikum, H.1    Gasser, S.M.2
  • 34
    • 0037112212 scopus 로고    scopus 로고
    • 53BP1, a mediator of the DNA damage checkpoint
    • Wang, B., Matsuoka, S., Carpenter, P.B., and Elledge, S.J. 2002. 53BP1, a mediator of the DNA damage checkpoint. Science 298: 1435-1438.
    • (2002) Science , vol.298 , pp. 1435-1438
    • Wang, B.1    Matsuoka, S.2    Carpenter, P.B.3    Elledge, S.J.4
  • 35
    • 0036510163 scopus 로고    scopus 로고
    • BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
    • Yarden, R.I., Pardo-Reoyo, S., Sgagias, M., Cowan, K.H., and Brody, L.C. 2002. BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nat. Genet. 30: 285-289.
    • (2002) Nat. Genet. , vol.30 , pp. 285-289
    • Yarden, R.I.1    Pardo-Reoyo, S.2    Sgagias, M.3    Cowan, K.H.4    Brody, L.C.5
  • 36
    • 2542459341 scopus 로고    scopus 로고
    • Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase
    • Yoo, H.Y., Kumagai, A., Shevchenko, A., Shevchenko, A., and Dunphy, W.G. 2004a. Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase. Cell 117: 575-588.
    • (2004) Cell , vol.117 , pp. 575-588
    • Yoo, H.Y.1    Kumagai, A.2    Shevchenko, A.3    Shevchenko, A.4    Dunphy, W.G.5
  • 37
    • 11144227916 scopus 로고    scopus 로고
    • Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses
    • Yoo, H.Y., Shevchenko, A., Shevchenko, A., and Dunphy, W.G. 2004b. Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses. J. Biol. Chem. 279: 53353-53364.
    • (2004) J. Biol. Chem. , vol.279 , pp. 53353-53364
    • Yoo, H.Y.1    Shevchenko, A.2    Shevchenko, A.3    Dunphy, W.G.4
  • 38
    • 0034967556 scopus 로고    scopus 로고
    • ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
    • Zhao, H. and Piwnica-Worms, H. 2001. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol. Cell. Biol. 21: 4129-4139.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 4129-4139
    • Zhao, H.1    Piwnica-Worms, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.