Dynamic regulation of MEK/Erks and Akt/GSK-3β in human end-stage heart failure after left ventricular mechanical support: Myocardial mechanotransduction-sensitivity as a possible molecular mechanism

Cardiovascular Research

Volumn 59, Issue 2, 2003, Pages 390-399

  Baba, Hideo A ^a,c   Stypmann, Jörg ^c   Grabellus, Florian ^a,c   Kirchhof, Paulus ^c   Sokoll, Andrea ^c   Schäfers, Michael ^c   Takeda, Atsushi ^b   Wilhelm, Markus J ^c   Scheld, Hans H ^c   Takeda, Nobuakira ^b   Breithardt, Günter ^c   Levkau, Bodo ^c  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Apoptosis; Heart failure; Mechanotransduction; Protein kinases; Remodeling; Stretch

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; PROTEIN P70; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

ADULT; ANIMAL CELL; ANIMAL MODEL; ANTIBODY SPECIFICITY; ARTICLE; CELL SIZE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; HEART ASSIST DEVICE; HEART FAILURE; HEART LEFT VENTRICLE; HEART MUSCLE CELL; HEART MUSCLE PERFUSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MOLECULAR DYNAMICS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SAMPLING; TENSILE STRENGTH; WESTERN BLOTTING;

ADOLESCENT; ADULT; ANIMALS; BLOTTING, WESTERN; FEMALE; GLYCOGEN SYNTHASE KINASE 3; HEART FAILURE, CONGESTIVE; HEART-ASSIST DEVICES; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MECHANOTRANSDUCTION, CELLULAR; MICE; MICE, INBRED STRAINS; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCARDIUM; MYOCYTES, CARDIAC; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; STRESS, MECHANICAL;

EID: 10744230103     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(03)00393-6     Document Type: Article

References (35)

1. Müller J., Wallukat G., Weng Y.G., et al. Weaning from mechanical cardiac support in patients with idiopathic dilated cardiomyopathy. Circulation. 96:1997;542-549.
2. Hetzer R., Muller J.H., Weng Y., Meyer R., Dandel M. Bridging-to-recovery. Ann Thorac Surg. 71:2001;S109-S113.
3. Zafeiridis A., Jeevanandam V., Houser S.R., et al. Regression of cellular hypertrophy after left ventricular assist device support. Circulation. 98:1998;656-662.
4. Altemose G.T., Gritsus V., Jeevanandam V., et al. Altered myocardial phenotype after mechanical support in human beings with advanced cardiomyopathy. J Heart Lung Transplant. 16:1997;765-773.
5. Plenz G., Baba H.A., Erren M., et al. Reversal of myocardial interleukin-6-mRNA expression following long-term left ventricular assist device support for myocarditis-associated low output syndrome. J Heart Lung Transplant. 18:1999;923-924.
6. Torre-Amione G., Stetson S.J., Youker K.A., et al. Decreased expression of tumor necrosis factor-alpha in failing human myocardium after mechanical circulatory support: a potential mechanism for cardiac recovery. Circulation. 100:1999;1189-1193.
7. Bartling B., Milting H., Schumann H., et al. Myocardial gene expression of regulators of myocyte apoptosis and myocyte calcium homeostasis during hemodynamic unloading by ventricular assist devices in patients with end-stage heart failure. Circulation. 100:1999;II216-II223.
8. Grabellus F., Levkau B., Sokoll A., et al. Reversible activation of Nuclear Factor-κB in human end-stage heart failure after left ventricular mechanical support. Cardiovasc Res. 53:2002;124-130.
9. Michel M.C., Li Y., Heusch G. Mitogen-activated protein kinases in the heart. Naunyn Schmiedebergs Arch Pharmacol. 363:2001;245-266.
10. Frey N., McKinsey T.A., Olson E.N. Decoding calcium signals involved in cardiac growth and function. Nat Med. 6:2000;1221-1227.
11. Shioi T., McMullen J.R., Kang P.M., et al. Akt/protein kinase B promotes organ growth in transgenic mice. Mol Cell Biol. 22:2002;2799-2809.
12. Hardt S.E., Sadoshima J. Glycogen synthase kinase-3beta: a novel regulator of cardiac hypertrophy and development. Circ Res. 90:2002;1055-1063.
13. Haq S., Choukroun G., Lim H., et al. Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure. Circulation. 103:2001;670-677.
14. Takeishi Y., Huang Q., Abe J., et al. Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy. Cardiovasc Res. 53:2002;131-137.
15. Sugden P.H., Clerk A. 'Stress-responsive' mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium. Circ Res. 83:1998;345-352.
16. Kozma S.C., Thomas G. Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K. Bioessays. 24:2002;65-71.
17. Datta S.R., Brunet A., Greenberg M.E. Cellular survival: a play in three Akts. Genes Dev. 13:1999;2905-2927.
18. Matsui T., Li L., del Monte F., Fukui Y., Franke T.F., Hajjar R.J., Rosenzweig A. Adenoviral gene transfer of activated phosphatidylinositol 3′-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation. 100:1999;2373-2379.
19. Hardt S.E., Sadoshima J. Glycogen synthase kinase-3beta: a novel regulator of cardiac hypertrophy and development. Circ Res. 90:2002;1055-1063.
20. Senbonmatsu T., Ichihara S., Price E.J., Gaffney F.A., Inagami T., Evidence for angiotensin I.I. type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload. J Clin Invest. 106:2000;R25-R29.
21. Baba H.A., Iwai T., Bauer M., Irlbeck M., Schmid K.W., Zimmer H.G. Differential effects of angiotensin II receptor blockade on pressure-induced left ventricular hypertrophy and fibrosis in rats. J Mol Cell Cardiol. 31:1999;445-455.
22. Baba H.A., Schmid K.W., Schmid C., et al. Possible relation between heat shock protein 70, cardiac hemodynamics, and survival in the early period after heart transplantation. Transplantation. 65:1998;799-804.
23. Fabritz C.L., Kirchhof P., Franz M.R., et al. Prolonged action potential durations, increased dispersion of repolarization, and polymorphic ventricular tachycardia in a mouse model of proarrhythmia. Basic Res Cardiol. 98:2003;25-32.
24. Pullen N., Thomas G. The modular phosphorylation and activation of p70s6k. FEBS Lett. 410:1997;78-82.
25. Flesch M., Margulies K.B., Mochmann H.C., Engel D., Sivasubramanian N., Mann D.L. Differential regulation of mitogen-activated protein kinases in the failing human heart in response to mechanical unloading. Circulation. 104:2001;2273-2276.
26. Shima H., Pende M., Chen Y., Fumagalli S., Thomas G., Kozma S.C. Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J. 17:1998;6649-6659.
27. Chen W.S., Xu P.Z., Gottlob K., et al. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev. 15:2001;2203-2208.
28. Baba H.A., Grabellus F., August C., et al. Reversal of metallothionein expression is different throughout the human myocardium after prolonged left ventricular mechanical support. J Heart Lung Transplant. 19:2000;668-674.
29. Grabellus F., Schmid C., Levkau B., et al. Reduction of hypoxia-inducible heme oxygenase-1 in the myocardium after left ventricular mechanical support. J Pathol. 197:2002;230-237.
30. Sadoshima J., Izumo S. The cellular and molecular response of cardiac myocytes to mechanical stress. Annu Rev Physiol. 59:1997;551-571.
31. Ruwhof C., van der Laarse A. Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways. Cardiovasc Res. 47:2000;23-37.
32. Sugden P.H. Mechanotransduction in cardiomyocyte hypertrophy. Circulation. 103:2001;1375-1377.
33. Seko Y., Takahashi N., Tobe K., Kadowaki T., Yazaki Y. Pulsatile stretch activates mitogen-activated protein kinase (MAPK) family members and focal adhesion kinase (p125(FAK)) in cultured rat cardiac myocytes. Biochem Biophys Res Commun. 259:1999;8-14.
34. Pimentel D.R., Amin J.K., Xiao L., et al. Reactive oxygen species mediate amplitude-dependent hypertrophic and apoptotic responses to mechanical stretch in cardiac myocytes. Circ Res. 89:2001;453-460.
35. Yamamoto K., Dang Q.N., Maeda Y., Huang H., Kelly R.A., Lee R.T. Regulation of cardiomyocyte mechanotransduction by the cardiac cycle. Circulation. 103:2001;1459-1464.