Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent Gs signaling during β2-adrenergic stimulation

Circulation Research

Volumn 91, Issue 1, 2002, Pages 46-53

  Jo, Su Hyun ^a   Leblais, Veronique ^a   Wang, Ping H ^a   Crow, Michael T ^a   Xiao, Rui Ping ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

2 adrenoceptor; cAMP signal compartmentation; Cardiac contractility; Phosphatidylinositol 3 kinase; Phospholamban

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY]PROPYL]AMINO]ETHOXY]SALICYLAMIDE; BETA 2 ADRENERGIC RECEPTOR; BETAARK CT; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOLAMBAN; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ARTICLE; BETA ADRENERGIC STIMULATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HEART; HEART CONTRACTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE RELAXATION; INHIBITION KINETICS; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANDROSTADIENES; ANIMALS; CALCIUM; CALCIUM-BINDING PROTEINS; CELL SIZE; CELLS, CULTURED; CHROMONES; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; ETHANOLAMINES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HEART VENTRICLES; HETEROTRIMERIC GTP-BINDING PROTEINS; IMIDAZOLES; INSULIN-LIKE GROWTH FACTOR I; MORPHOLINES; PHOSPHORYLATION; RATS; RECEPTORS, ADRENERGIC, BETA-2; SERINE; SIGNAL TRANSDUCTION;

EID: 0037067463     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000024115.67561.54     Document Type: Article

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