Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

EMBO Journal

Volumn 22, Issue 18, 2003, Pages 4666-4676

  Mora, Alfonso ^a   Davies, Anthony M ^a   Bertrand, Luc ^d   Sharif, Isam ^b   Budas, Grant R ^a   Jovanović, Sofija ^a   Mouton, Véronique ^d   Kahn, C Ronald ^c   Lucocq, John M ^a   Gray, Gillian A ^b   Jovanović, Aleksandar ^a   Alessi, Dario R ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c HARVARD MEDICAL SCHOOL   (United States)

^d NONE

Author keywords

Akt; Cardiac muscle; Heart failure; Hypoxia; PDK1; PI 3 kinase; PKB

Indexed keywords

3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; 6 PHOSPHOFRUCTO 2 KINASE; FRUCTOSE 2,6 BISPHOSPHATE; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; S6 KINASE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ASSAY; CELL COUNT; CELL VIABILITY; CELL VOLUME; ECHOCARDIOGRAPHY; HEART ATRIUM ENLARGEMENT; HEART FAILURE; HEART MUSCLE; HEART MUSCLE CELL; HEART RIGHT VENTRICLE HYPERTROPHY; HEART VENTRICLE WALL; HYPOXIA; MOUSE; MUSCLE MASS; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL HYPOXIA; ECHOCARDIOGRAPHY; ENZYME ACTIVATION; HEART; HEART FAILURE, CONGESTIVE; INSULIN; KINETICS; MICE; MICE, KNOCKOUT; MUSCLE CELLS; MYOCARDIUM; PHOSPHOFRUCTOKINASE-2; PROTEIN-SERINE-THREONINE KINASES;

ANIMALIA;

EID: 0141737071     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg469     Document Type: Article

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