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Volumn 632, Issue , 2008, Pages 117-142

Complement factor H: Using atomic resolution structure to illuminate disease mechanisms

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CARBOHYDRATE; COMPLEMENT FACTOR H; ECULIZUMAB; SUGAR; RECOMBINANT PROTEIN;

EID: 58149336975     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-0-387-78952-1_10     Document Type: Review
Times cited : (7)

References (125)
  • 1
    • 33745716919 scopus 로고    scopus 로고
    • Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease)
    • Abrera-Abeleda, M.A., Nishimura, C., Smith, J.L., Sethi, S., McRae, J.L., Murphy, B.F., Silvestri, G., Skerka, C., Jozsi, M., Zipfel, P.F., et al. (2006). Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease). Journal of Medical Genetics 43, 582-589
    • (2006) Journal of Medical Genetics , vol.43 , pp. 582-589
    • Abrera-Abeleda, M.A.1    Nishimura, C.2    Smith, J.L.3    Sethi, S.4    McRae, J.L.5    Murphy, B.F.6    Silvestri, G.7    Skerka, C.8    Jozsi, M.9    Zipfel, P.F.10
  • 2
    • 0021736976 scopus 로고
    • Localization of the complement-component-C3b-binding site and the cofactor activity for factor I in the 38kDa tryptic fragment of factor H
    • Alsenz, J., Lambris, J.D., Schulz, T.F., and Dierich, M.P. (1984). Localization of the complement-component-C3b-binding site and the cofactor activity for factor I in the 38kDa tryptic fragment of factor H. The Biochemical Journal 224, 389-398
    • (1984) The Biochemical Journal , vol.224 , pp. 389-398
    • Alsenz, J.1    Lambris, J.D.2    Schulz, T.F.3    Dierich, M.P.4
  • 3
    • 0022354875 scopus 로고
    • Structural and functional analysis of the complement component factor H with the use of different enzymes and monoclonal antibodies to factor H
    • Alsenz, J., Schulz, T.F., Lambris, J.D., Sim, R.B., and Dierich, M.P. (1985). Structural and functional analysis of the complement component factor H with the use of different enzymes and monoclonal antibodies to factor H. The Biochemical Journal 232, 841- 850
    • (1985) The Biochemical Journal , vol.232 , pp. 841-850
    • Alsenz, J.1    Schulz, T.F.2    Lambris, J.D.3    Sim, R.B.4    Dierich, M.P.5
  • 4
    • 0035008434 scopus 로고    scopus 로고
    • Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: Implications for the process of drusen formation
    • Anderson, D.H., Ozaki, S., Nealon, M., Neitz, J., Mullins, R.F., Hageman, G.S., and Johnson, L.V. (2001). Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: implications for the process of drusen formation. American Journal of Ophthalmology 131, 767-781
    • (2001) American Journal of Ophthalmology , vol.131 , pp. 767-781
    • Anderson, D.H.1    Ozaki, S.2    Nealon, M.3    Neitz, J.4    Mullins, R.F.5    Hageman, G.S.6    Johnson, L.V.7
  • 5
    • 0025126001 scopus 로고
    • Value of C-reactive protein in reflecting the magnitude of complement activation in children undergoing open heart surgery
    • Aronen, M., Leijala, M., and Meri, S. (1990). Value of C-reactive protein in reflecting the magnitude of complement activation in children undergoing open heart surgery. Intensive Care Medicine 16, 128-132
    • (1990) Intensive Care Medicine , vol.16 , pp. 128-132
    • Aronen, M.1    Leijala, M.2    Meri, S.3
  • 6
    • 0035933335 scopus 로고    scopus 로고
    • Folded-back solution structure of monomeric factor H of human complement by synchrotron X-ray and neutron scattering, analytical ultracentrifugation and constrained molecular modelling
    • Aslam, M. and Perkins, S.J. (2001). Folded-back solution structure of monomeric factor H of human complement by synchrotron X-ray and neutron scattering, analytical ultracentrifugation and constrained molecular modelling. Journal of Molecular Biology 309, 1117-1138
    • (2001) Journal of Molecular Biology , vol.309 , pp. 1117-1138
    • Aslam, M.1    Perkins, S.J.2
  • 7
    • 85190658120 scopus 로고    scopus 로고
    • Bao, L., Haas, M., Kraus, D.M., Hack, B.K., Rakstang, J.K., Holers, V.M., and Quigg, R.J. (2003). Administration of a soluble recombinant complement C3 inhibitor protects against renal disease in MRL/lpr mice. Journal of American Society of Nephrology 14, 670-679 134 P.N. Barlow et al.
    • Bao, L., Haas, M., Kraus, D.M., Hack, B.K., Rakstang, J.K., Holers, V.M., and Quigg, R.J. (2003). Administration of a soluble recombinant complement C3 inhibitor protects against renal disease in MRL/lpr mice. Journal of American Society of Nephrology 14, 670-679 134 P.N. Barlow et al.
  • 11
    • 0030589294 scopus 로고    scopus 로고
    • Identification of a heparin binding domain in the seventh short consensus repeat of complement factor H
    • Blackmore, T.K., Sadlon, T.A., Ward, H.M., Lublin, D.M., and Gordon, D.L. (1996). Identification of a heparin binding domain in the seventh short consensus repeat of complement factor H. Journal of Immunology 157, 5422-5427
    • (1996) Journal of Immunology , vol.157 , pp. 5422-5427
    • Blackmore, T.K.1    Sadlon, T.A.2    Ward, H.M.3    Lublin, D.M.4    Gordon, D.L.5
  • 13
    • 0033927532 scopus 로고    scopus 로고
    • Complement factor H gene mutation associated with autosomal recessive atypical hemolytic uremic syndrome
    • Buddles, M.R., Donne, R.L., Richards, A., Goodship, J., and Goodship, T.H. (2000). Complement factor H gene mutation associated with autosomal recessive atypical hemolytic uremic syndrome. American Journal of Human Genetics 66, 1721-1722
    • (2000) American Journal of Human Genetics , vol.66 , pp. 1721-1722
    • Buddles, M.R.1    Donne, R.L.2    Richards, A.3    Goodship, J.4    Goodship, T.H.5
  • 14
    • 33747700932 scopus 로고    scopus 로고
    • His-384 allotypic variant of factor H associated with age-related macular degeneration has different heparin binding properties from the non-disease-associated form
    • Clark, S.J., Higman, V.A., Mulloy, B., Perkins, S.J., Lea, S.M., Sim, R.B., and Day, A.J. (2006). His-384 allotypic variant of factor H associated with age-related macular degeneration has different heparin binding properties from the non-disease-associated form. The Journal of Biological Chemistry 281, 24713-24720
    • (2006) The Journal of Biological Chemistry , vol.281 , pp. 24713-24720
    • Clark, S.J.1    Higman, V.A.2    Mulloy, B.3    Perkins, S.J.4    Lea, S.M.5    Sim, R.B.6    Day, A.J.7
  • 17
    • 36849084660 scopus 로고    scopus 로고
    • Translational mini-review series on complement factor H: Genetics and disease associations of human complement factor H
    • de Cordoba, S.R. and de Jorge, E.G. (2008). Translational mini-review series on complement factor H: genetics and disease associations of human complement factor H. Clinical and Experimental Immunology 151, 1-13
    • (2008) Clinical and Experimental Immunology , vol.151 , pp. 1-13
    • de Cordoba, S.R.1    de Jorge, E.G.2
  • 20
    • 0025822178 scopus 로고
    • Cloning of the 1.4-kb mRNA species of human complement factor H reveals a novel member of the short consensus repeat family related to the carboxy terminal of the classical 150- kDa molecule
    • Estaller, C., Koistinen, V., Schwaeble, W., Dierich, M.P., and Weiss, E.H. (1991). Cloning of the 1.4-kb mRNA species of human complement factor H reveals a novel member of the short consensus repeat family related to the carboxy terminal of the classical 150- kDa molecule. Journal of Immunology 146, 3190-3196
    • (1991) Journal of Immunology , vol.146 , pp. 3190-3196
    • Estaller, C.1    Koistinen, V.2    Schwaeble, W.3    Dierich, M.P.4    Weiss, E.H.5
  • 22
    • 33947593444 scopus 로고    scopus 로고
    • Associative and structural properties of the region of complement factor H encompassing the Tyr402His disease-related polymorphism and its interactions with heparin
    • Fernando, A.N., Furtado, P.B., Clark, S.J., Gilbert, H.E., Day, A.J., Sim, R.B., and Perkins, S.J. (2007). Associative and structural properties of the region of complement factor H encompassing the Tyr402His disease-related polymorphism and its interactions with heparin. Journal of Molecular Biology 368, 564-581
    • (2007) Journal of Molecular Biology , vol.368 , pp. 564-581
    • Fernando, A.N.1    Furtado, P.B.2    Clark, S.J.3    Gilbert, H.E.4    Day, A.J.5    Sim, R.B.6    Perkins, S.J.7
  • 23
    • 33750336175 scopus 로고    scopus 로고
    • Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces
    • Ferreira, V.P., Herbert, A.P., Hocking, H.G., Barlow, P.N., and Pangburn, M.K. (2006). Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces. Journal of Immunology 177, 6308-6316
    • (2006) Journal of Immunology , vol.177 , pp. 6308-6316
    • Ferreira, V.P.1    Herbert, A.P.2    Hocking, H.G.3    Barlow, P.N.4    Pangburn, M.K.5
  • 24
    • 33751103471 scopus 로고    scopus 로고
    • Age-related macular degeneration - emerging pathogenetic and therapeutic concepts
    • Gehrs, K.M., Anderson, D.H., Johnson, L.V., and Hageman, G.S. (2006). Age-related macular degeneration - emerging pathogenetic and therapeutic concepts. Annals of Medicine 38, 450-471
    • (2006) Annals of Medicine , vol.38 , pp. 450-471
    • Gehrs, K.M.1    Anderson, D.H.2    Johnson, L.V.3    Hageman, G.S.4
  • 26
    • 0034613686 scopus 로고    scopus 로고
    • C-Reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: Implications for systemic autoimmunity
    • Gershov, D., Kim, S., Brot, N., and Elkon, K.B. (2000). C-Reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for systemic autoimmunity. The Journal of Experimental Medicine 192, 1353-1364
    • (2000) The Journal of Experimental Medicine , vol.192 , pp. 1353-1364
    • Gershov, D.1    Kim, S.2    Brot, N.3    Elkon, K.B.4
  • 30
    • 0032967793 scopus 로고    scopus 로고
    • Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cells
    • Hageman, G.S., Mullins, R.F., Russell, S.R., Johnson, L.V., and Anderson, D.H. (1999). Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cells. FASEB J 13, 477-484
    • (1999) FASEB J , vol.13 , pp. 477-484
    • Hageman, G.S.1    Mullins, R.F.2    Russell, S.R.3    Johnson, L.V.4    Anderson, D.H.5
  • 31
    • 0034832029 scopus 로고    scopus 로고
    • An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and agerelated macular degeneration
    • Hageman, G.S., Luthert, P.J., Victor Chong, N.H., Johnson, L.V., Anderson, D.H., and Mullins, R.F. (2001). An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and agerelated macular degeneration. Progress in Retinal and Eye Research 20, 705-732
    • (2001) Progress in Retinal and Eye Research , vol.20 , pp. 705-732
    • Hageman, G.S.1    Luthert, P.J.2    Victor Chong, N.H.3    Johnson, L.V.4    Anderson, D.H.5    Mullins, R.F.6
  • 33
    • 33847153137 scopus 로고    scopus 로고
    • Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: Characterization, ethnic distribution and evolutionary implications
    • Hageman, G.S., Hancox, L.S., Taiber, A.J., Gehrs, K.M., Anderson, D.H., Johnson, L.V., Radeke, M.J., Kavanagh, D., Richards, A., Atkinson, J., et al. (2006). Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications. Annals of Medicine 38, 592-604
    • (2006) Annals of Medicine , vol.38 , pp. 592-604
    • Hageman, G.S.1    Hancox, L.S.2    Taiber, A.J.3    Gehrs, K.M.4    Anderson, D.H.5    Johnson, L.V.6    Radeke, M.J.7    Kavanagh, D.8    Richards, A.9    Atkinson, J.10
  • 35
    • 36849043338 scopus 로고    scopus 로고
    • Binding of factor H to C-reactive protein occurs only when the latter has undergone nonphysiologic denaturation
    • Hakobyan, S., Harris, C.L., van den Berg, C., Pepys, M.B., Morgan, B.P. (2007). Binding of factor H to C-reactive protein occurs only when the latter has undergone nonphysiologic denaturation. Molecular Immunology 44, 3983-3984
    • (2007) Molecular Immunology , vol.44 , pp. 3983-3984
    • Hakobyan, S.1    Harris, C.L.2    van den Berg, C.3    Pepys, M.B.4    Morgan, B.P.5
  • 36
    • 36949017977 scopus 로고    scopus 로고
    • Hamilton, G., Proitsi, P., Williams, J., O'Donovan, M., Owen, M., Powell, J., and Lovestone, S. (2007). Complement factor H Y402H polymorphism is not associated with late-onset Alzheimer's disease. Neuromolecular Medicine 9, 331-334
    • Hamilton, G., Proitsi, P., Williams, J., O'Donovan, M., Owen, M., Powell, J., and Lovestone, S. (2007). Complement factor H Y402H polymorphism is not associated with late-onset Alzheimer's disease. Neuromolecular Medicine 9, 331-334
  • 37
    • 0036900126 scopus 로고    scopus 로고
    • The molecular basis for hereditary porcine membranoproliferative glomerulonephritis type II: Point mutations in the factor H coding sequence block protein secretion
    • Hegasy, G.A., Manuelian, T., Hogasen, K., Jansen, J.H., and Zipfel, P.F. (2002). The molecular basis for hereditary porcine membranoproliferative glomerulonephritis type II: point mutations in the factor H coding sequence block protein secretion. The American Journal of Pathology 161, 2027-2034
    • (2002) The American Journal of Pathology , vol.161 , pp. 2027-2034
    • Hegasy, G.A.1    Manuelian, T.2    Hogasen, K.3    Jansen, J.H.4    Zipfel, P.F.5
  • 39
    • 33745202838 scopus 로고    scopus 로고
    • Diseaseassociated sequence variations congregate in a polyanion recognition patch on human factor H revealed in three-dimensional structure
    • Herbert, A.P., Uhrin, D., Lyon, M., Pangburn, M.K., and Barlow, P.N. (2006). Diseaseassociated sequence variations congregate in a polyanion recognition patch on human factor H revealed in three-dimensional structure. The Journal of Biological Chemistry 281, 16512-16520
    • (2006) The Journal of Biological Chemistry , vol.281 , pp. 16512-16520
    • Herbert, A.P.1    Uhrin, D.2    Lyon, M.3    Pangburn, M.K.4    Barlow, P.N.5
  • 40
  • 41
    • 0037527720 scopus 로고    scopus 로고
    • The complement system as a therapeutic target in autoimmunity
    • Orlando, Fla
    • Holers, V.M. (2003). The complement system as a therapeutic target in autoimmunity. Clinical Immunology (Orlando, Fla) 107, 140-151
    • (2003) Clinical Immunology , vol.107 , pp. 140-151
    • Holers, V.M.1
  • 43
    • 33749123246 scopus 로고    scopus 로고
    • A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration
    • Hughes, A.E., Orr, N., Esfandiary, H., Diaz-Torres, M., Goodship, T., and Chakravarthy, U. (2006). A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration. Nature Genetics 38, 1173-1177
    • (2006) Nature Genetics , vol.38 , pp. 1173-1177
    • Hughes, A.E.1    Orr, N.2    Esfandiary, H.3    Diaz-Torres, M.4    Goodship, T.5    Chakravarthy, U.6
  • 45
    • 0031885010 scopus 로고    scopus 로고
    • In situ complement activation in porcine membranoproliferative glomerulonephritis type II
    • Jansen, J.H., Hogasen, K., Harboe, M., and Hovig, T. (1998). In situ complement activation in porcine membranoproliferative glomerulonephritis type II. Kidney International 53, 331-349
    • (1998) Kidney International , vol.53 , pp. 331-349
    • Jansen, J.H.1    Hogasen, K.2    Harboe, M.3    Hovig, T.4
  • 46
    • 0033214998 scopus 로고    scopus 로고
    • Regulation ofcomplement activation by C-reactive protein: Targeting the complement inhibitory activity of factor H by an interaction with short consensus repeat domains 7 and 8-11
    • Jarva, H., Jokiranta, T.S., Hellwage, J., Zipfel, P.F., and Meri, S. (1999). Regulation ofcomplement activation by C-reactive protein: targeting the complement inhibitory activity of factor H by an interaction with short consensus repeat domains 7 and 8-11. Journal of Immunology 163, 3957-3962
    • (1999) Journal of Immunology , vol.163 , pp. 3957-3962
    • Jarva, H.1    Jokiranta, T.S.2    Hellwage, J.3    Zipfel, P.F.4    Meri, S.5
  • 48
    • 0035699547 scopus 로고    scopus 로고
    • Complement activation and inflammatory processes in Drusen formation and age related macular degeneration
    • Johnson, L.V., Leitner, W.P., Staples, M.K., and Anderson, D.H. (2001). Complement activation and inflammatory processes in Drusen formation and age related macular degeneration. Experimental Eye Research 73, 887-896
    • (2001) Experimental Eye Research , vol.73 , pp. 887-896
    • Johnson, L.V.1    Leitner, W.P.2    Staples, M.K.3    Anderson, D.H.4
  • 51
    • 33646164894 scopus 로고    scopus 로고
    • Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome
    • Jokiranta, T.S., Jaakola, V.P., Lehtinen, M.J., Parepalo, M., Meri, S., and Goldman, A. (2006). Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome. The EMBO Journal 25, 1784-1794
    • (2006) The EMBO Journal , vol.25 , pp. 1784-1794
    • Jokiranta, T.S.1    Jaakola, V.P.2    Lehtinen, M.J.3    Parepalo, M.4    Meri, S.5    Goldman, A.6
  • 52
    • 0021690952 scopus 로고
    • Lysine residues, but not carbohydrates, are required for the regulatory function of H on the amplification C3 convertase of complement
    • Jouvin, M.H., Kazatchkine, M.D., Cahour, A., and Bernard, N. (1984). Lysine residues, but not carbohydrates, are required for the regulatory function of H on the amplification C3 convertase of complement. Journal of Immunology 133, 3250-3254
    • (1984) Journal of Immunology , vol.133 , pp. 3250-3254
    • Jouvin, M.H.1    Kazatchkine, M.D.2    Cahour, A.3    Bernard, N.4
  • 55
    • 0025868501 scopus 로고    scopus 로고
    • Kinoshita, T. (1991). Biology of complement: the overture. Immunology today 12, 291-295 Klein, R.J., Zeiss, C., Chew, E.Y., Tsai, J.Y., Sackler, R.S., Haynes, C., Henning, A.K., SanGiovanni, J.P., Mane, S.M., Mayne, S.T., et al. (2005). Complement factor H polymorphism in age-related macular degeneration. Science 308, 385-389
    • Kinoshita, T. (1991). Biology of complement: the overture. Immunology today 12, 291-295 Klein, R.J., Zeiss, C., Chew, E.Y., Tsai, J.Y., Sackler, R.S., Haynes, C., Henning, A.K., SanGiovanni, J.P., Mane, S.M., Mayne, S.T., et al. (2005). Complement factor H polymorphism in age-related macular degeneration. Science 308, 385-389
  • 56
    • 0029850245 scopus 로고    scopus 로고
    • Mapping of the domains required for decay acceleration activity of the human factor H-like protein 1 and factor H
    • Kuhn, S. and Zipfel, P.F. (1996). Mapping of the domains required for decay acceleration activity of the human factor H-like protein 1 and factor H. European Journal of Immunology 26, 2383-2387
    • (1996) European Journal of Immunology , vol.26 , pp. 2383-2387
    • Kuhn, S.1    Zipfel, P.F.2
  • 57
    • 0028875543 scopus 로고
    • Mapping of the complement regulatory domains in the human factor H-like protein 1 and in factor H1
    • Kuhn, S., Skerka, C., and Zipfel, P.F. (1995). Mapping of the complement regulatory domains in the human factor H-like protein 1 and in factor H1. Journal of Immunology 155, 5663-5670
    • (1995) Journal of Immunology , vol.155 , pp. 5663-5670
    • Kuhn, S.1    Skerka, C.2    Zipfel, P.F.3
  • 59
    • 33748325757 scopus 로고    scopus 로고
    • CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration
    • Li, M., Atmaca-Sonmez, P., Othman, M., Branham, K.E., Khanna, R., Wade, M.S., Li, Y., Liang, L., Zareparsi, S., Swaroop, A., et al. (2006). CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration. Nature Genetics 38, 1049-1054
    • (2006) Nature Genetics , vol.38 , pp. 1049-1054
    • Li, M.1    Atmaca-Sonmez, P.2    Othman, M.3    Branham, K.E.4    Khanna, R.5    Wade, M.S.6    Li, Y.7    Liang, L.8    Zareparsi, S.9    Swaroop, A.10
  • 62
    • 0342316481 scopus 로고    scopus 로고
    • Human complement regulators: A major target for pathogenic microorganisms
    • Lindahl, G., Sjobring, U., and Johnsson, E. (2000). Human complement regulators: a major target for pathogenic microorganisms. Current Opinion in Immunology 12, 44-51
    • (2000) Current Opinion in Immunology , vol.12 , pp. 44-51
    • Lindahl, G.1    Sjobring, U.2    Johnsson, E.3
  • 64
    • 0034100951 scopus 로고    scopus 로고
    • Complement factor H: Sequence analysis of 221 kb of human genomic DNA containing the entire fH, fHR-1 and fHR-3 genes
    • Male, D.A., Ormsby, R.J., Ranganathan, S., Giannakis, E., and Gordon, D.L. (2000). Complement factor H: sequence analysis of 221 kb of human genomic DNA containing the entire fH, fHR-1 and fHR-3 genes. Molecular Immunology 37, 41-52
    • (2000) Molecular Immunology , vol.37 , pp. 41-52
    • Male, D.A.1    Ormsby, R.J.2    Ranganathan, S.3    Giannakis, E.4    Gordon, D.L.5
  • 65
    • 34748819371 scopus 로고    scopus 로고
    • Variation in complement factor 3 is associated with risk of age-related macular degeneration
    • Maller, J.B., Fagerness, J.A., Reynolds, R.C., Neale, B.M., Daly, M.J., and Seddon, J.M. (2007). Variation in complement factor 3 is associated with risk of age-related macular degeneration. Nature Genetics 39, 1200-1201
    • (2007) Nature Genetics , vol.39 , pp. 1200-1201
    • Maller, J.B.1    Fagerness, J.A.2    Reynolds, R.C.3    Neale, B.M.4    Daly, M.J.5    Seddon, J.M.6
  • 66
    • 34548849117 scopus 로고    scopus 로고
    • The role of complement in inflammatory diseases from behind the scenes into the spotlight
    • Markiewski, M.M. and Lambris, J.D. (2007). The role of complement in inflammatory diseases from behind the scenes into the spotlight. The American Journal of Pathology 171, 715-727
    • (2007) The American Journal of Pathology , vol.171 , pp. 715-727
    • Markiewski, M.M.1    Lambris, J.D.2
  • 67
    • 35748934824 scopus 로고    scopus 로고
    • Genetic variants of complement factor H gene are not associated with premature coronary heart disease: A family-based study in the Irish population
    • Meng, W., Hughes, A., Patterson, C.C., Belton, C., Kamaruddin, M.S., Horan, P.G., Kee, F., and McKeown, P.P. (2007). Genetic variants of complement factor H gene are not associated with premature coronary heart disease: a family-based study in the Irish population. BMC Medical Genetics 8, 62
    • (2007) BMC Medical Genetics , vol.8 , pp. 62
    • Meng, W.1    Hughes, A.2    Patterson, C.C.3    Belton, C.4    Kamaruddin, M.S.5    Horan, P.G.6    Kee, F.7    McKeown, P.P.8
  • 68
    • 0025314311 scopus 로고
    • Discrimination between activators and nonactivators of the alternative pathway of complement: Regulation via a sialic acid/polyanion binding site on factor H
    • Meri, S. and Pangburn, M.K. (1990). Discrimination between activators and nonactivators of the alternative pathway of complement: regulation via a sialic acid/polyanion binding site on factor H. Proceedings of the National Academy of Sciences of the United States of America 87, 3982-3986
    • (1990) Proceedings of the National Academy of Sciences of the United States of America , vol.87 , pp. 3982-3986
    • Meri, S.1    Pangburn, M.K.2
  • 69
    • 0024440772 scopus 로고
    • Human complement factor H: An additional gene product of 43 kDa isolated from human plasma shows cofactor activity for the cleavage of the third component of complement
    • Misasi, R., Huemer, H.P., Schwaeble, W., Solder, E., Larcher, C., and Dierich, M.P. (1989). Human complement factor H: an additional gene product of 43 kDa isolated from human plasma shows cofactor activity for the cleavage of the third component of complement. European Journal of Immunology 19, 1765-1768
    • (1989) European Journal of Immunology , vol.19 , pp. 1765-1768
    • Misasi, R.1    Huemer, H.P.2    Schwaeble, W.3    Solder, E.4    Larcher, C.5    Dierich, M.P.6
  • 70
    • 35448973312 scopus 로고    scopus 로고
    • Complement Factor H polymorphism Y402H associates with inflammation, visual acuity, and cardiovascular mortality in the elderly population at large
    • Mooijaart, S.P., Koeijvoets, K.M., Sijbrands, E.J., Daha, M.R., and Westendorp, R.G. (2007). Complement Factor H polymorphism Y402H associates with inflammation, visual acuity, and cardiovascular mortality in the elderly population at large. Experimental Gerontology 42, 1116-1122
    • (2007) Experimental Gerontology , vol.42 , pp. 1116-1122
    • Mooijaart, S.P.1    Koeijvoets, K.M.2    Sijbrands, E.J.3    Daha, M.R.4    Westendorp, R.G.5
  • 71
    • 0034012166 scopus 로고    scopus 로고
    • Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease
    • Mullins, R.F., Russell, S.R., Anderson, D.H., and Hageman, G.S. (2000). Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J 14, 835-846
    • (2000) FASEB J 14 , pp. 835-846
    • Mullins, R.F.1    Russell, S.R.2    Anderson, D.H.3    Hageman, G.S.4
  • 72
    • 0034954060 scopus 로고    scopus 로고
    • Mullins, R.F., Aptsiauri, N., and Hageman, G.S. (2001). Structure and composition of drusen associated with glomerulonephritis: implications for the role of complement activation in drusen biogenesis. Eye (London, England) 15, 390-395
    • Mullins, R.F., Aptsiauri, N., and Hageman, G.S. (2001). Structure and composition of drusen associated with glomerulonephritis: implications for the role of complement activation in drusen biogenesis. Eye (London, England) 15, 390-395
  • 73
    • 37349123478 scopus 로고    scopus 로고
    • Implications of the progressive self-association of wild-type human factor H for complement regulation and disease
    • Nan, R., Gor, J., and Perkins, S.J. (2008). Implications of the progressive self-association of wild-type human factor H for complement regulation and disease. Journal of Molecular Biology 375, 891-900
    • (2008) Journal of Molecular Biology , vol.375 , pp. 891-900
    • Nan, R.1    Gor, J.2    Perkins, S.J.3
  • 77
    • 36349016373 scopus 로고    scopus 로고
    • The regulatory SCR-1/5 and cell surface-binding SCR-16/20 fragments of factor H reveal partially folded-back solution structures and different self-associative properties
    • Okemefuna, A.I., Gilbert, H.E., Griggs, K.M., Ormsby, R.J., Gordon, D.L., and Perkins, S.J. (2008). The regulatory SCR-1/5 and cell surface-binding SCR-16/20 fragments of factor H reveal partially folded-back solution structures and different self-associative properties. Journal of Molecular Biology 375, 80-101
    • (2008) Journal of Molecular Biology , vol.375 , pp. 80-101
    • Okemefuna, A.I.1    Gilbert, H.E.2    Griggs, K.M.3    Ormsby, R.J.4    Gordon, D.L.5    Perkins, S.J.6
  • 80
    • 34548425673 scopus 로고    scopus 로고
    • Complement factor H (Y402H) polymorphism and risk of coronary heart disease in US men and women
    • Pai, J.K., Manson, J.E., Rexrode, K.M., Albert, C.M., Hunter, D.J., and Rimm, E.B. (2007). Complement factor H (Y402H) polymorphism and risk of coronary heart disease in US men and women. European Heart Journal 28, 1297-1303
    • (2007) European Heart Journal , vol.28 , pp. 1297-1303
    • Pai, J.K.1    Manson, J.E.2    Rexrode, K.M.3    Albert, C.M.4    Hunter, D.J.5    Rimm, E.B.6
  • 81
    • 0020684529 scopus 로고
    • Kinetic and thermodynamic analysis of the control of C3b by the complement regulatory proteins factors H and I
    • Pangburn, M.K., and Muller-Eberhard, H.J. (1983). Kinetic and thermodynamic analysis of the control of C3b by the complement regulatory proteins factors H and I. Biochemistry 22, 178-185
    • (1983) Biochemistry , vol.22 , pp. 178-185
    • Pangburn, M.K.1    Muller-Eberhard, H.J.2
  • 82
    • 0017704496 scopus 로고
    • Human complement C3b inactivator: Isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution
    • Pangburn, M.K., Schreiber, R.D., and Muller-Eberhard, H.J. (1977). Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution. The Journal of Experimental Medicine 146, 257-270
    • (1977) The Journal of Experimental Medicine , vol.146 , pp. 257-270
    • Pangburn, M.K.1    Schreiber, R.D.2    Muller-Eberhard, H.J.3
  • 85
    • 0025727462 scopus 로고
    • Oligomeric domain structure of human complement factor H by X-ray and neutron solution scattering
    • Perkins, S.J., Nealis, A.S., and Sim, R.B. (1991). Oligomeric domain structure of human complement factor H by X-ray and neutron solution scattering. Biochemistry 30, 2847- 2857
    • (1991) Biochemistry , vol.30 , pp. 2847-2857
    • Perkins, S.J.1    Nealis, A.S.2    Sim, R.B.3
  • 86
    • 0036863301 scopus 로고    scopus 로고
    • Solution structures of complement components by X-ray and neutron scattering and analytical ultracentrifugation
    • Perkins, S.J., Gilbert, H.E., Aslam, M., Hannan, J., Holers, V.M., and Goodship, T.H. (2002). Solution structures of complement components by X-ray and neutron scattering and analytical ultracentrifugation. Biochemical Society Transactions 30, 996-1001
    • (2002) Biochemical Society Transactions , vol.30 , pp. 996-1001
    • Perkins, S.J.1    Gilbert, H.E.2    Aslam, M.3    Hannan, J.4    Holers, V.M.5    Goodship, T.H.6
  • 87
    • 37849022343 scopus 로고    scopus 로고
    • Translational mini-review series on complement factor H: Renal diseases associated with complement factor H: novel insights from humans and animals
    • Pickering, M.C. and Cook, H.T. (2008). Translational mini-review series on complement factor H: renal diseases associated with complement factor H: novel insights from humans and animals. Clinical and Experimental Immunology 151, 210-230
    • (2008) Clinical and Experimental Immunology , vol.151 , pp. 210-230
    • Pickering, M.C.1    Cook, H.T.2
  • 88
    • 0036699540 scopus 로고    scopus 로고
    • Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H
    • Pickering, M.C., Cook, H.T., Warren, J., Bygrave, A.E., Moss, J., Walport, M.J., and Botto, M. (2002). Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H. Nature Genetics 31, 424- 428
    • (2002) Nature Genetics , vol.31 , pp. 424-428
    • Pickering, M.C.1    Cook, H.T.2    Warren, J.3    Bygrave, A.E.4    Moss, J.5    Walport, M.J.6    Botto, M.7
  • 90
    • 34249935563 scopus 로고    scopus 로고
    • Expression, purification, cocrystallization and preliminary crystallographic analysis of sucrose octasulfate/human complement regulator factor H SCRs 6-8
    • Prosser, B.E., Johnson, S., Roversi, P., Clark, S.J., Tarelli, E., Sim, R.B., Day, A.J., and Lea, S.M. (2007a). Expression, purification, cocrystallization and preliminary crystallographic analysis of sucrose octasulfate/human complement regulator factor H SCRs 6-8. Acta Crystallographica 63, 480-483
    • (2007) Acta Crystallographica , vol.63 , pp. 480-483
    • Prosser, B.E.1    Johnson, S.2    Roversi, P.3    Clark, S.J.4    Tarelli, E.5    Sim, R.B.6    Day, A.J.7    Lea, S.M.8
  • 92
  • 94
    • 36048937343 scopus 로고    scopus 로고
    • Complement-targeted therapeutics
    • Ricklin, D. and Lambris, J.D. (2007). Complement-targeted therapeutics. Nature Biotechnology 25, 1265-1275
    • (2007) Nature Biotechnology , vol.25 , pp. 1265-1275
    • Ricklin, D.1    Lambris, J.D.2
  • 95
    • 0022578840 scopus 로고
    • Partial characterization of human complement factor H by protein and cDNA sequencing: Homology with other complement and non-complement proteins
    • 6
    • Ripoche, J., Day, A.J., Willis, A.C., Belt, K.T., Campbell, R.D., and Sim, R.B. (1986). Partial characterization of human complement factor H by protein and cDNA sequencing: homology with other complement and non-complement proteins. Bioscience Reports 6, 65-72
    • (1986) Bioscience Reports , pp. 65-72
    • Ripoche, J.1    Day, A.J.2    Willis, A.C.3    Belt, K.T.4    Campbell, R.D.5    Sim, R.B.6
  • 97
    • 27744462212 scopus 로고    scopus 로고
    • Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk
    • Rivera, A., Fisher, S.A., Fritsche, L.G., Keilhauer, C.N., Lichtner, P., Meitinger, T., and Weber, B.H. (2005). Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk. Human Molecular Genetics 14, 3227-3236
    • (2005) Human Molecular Genetics , vol.14 , pp. 3227-3236
    • Rivera, A.1    Fisher, S.A.2    Fritsche, L.G.3    Keilhauer, C.N.4    Lichtner, P.5    Meitinger, T.6    Weber, B.H.7
  • 99
    • 35948959015 scopus 로고    scopus 로고
    • Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria
    • Rother, R.P., Rollins, S.A., Mojcik, C.F., Brodsky, R.A., and Bell, L. (2007). Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria. Nature Biotechnology 25, 1256-1264
    • (2007) Nature Biotechnology , vol.25 , pp. 1256-1264
    • Rother, R.P.1    Rollins, S.A.2    Mojcik, C.F.3    Brodsky, R.A.4    Bell, L.5
  • 100
    • 0029153651 scopus 로고
    • Complement inhibitory therapeutics and xenotransplantation
    • Ryan, U.S. (1995). Complement inhibitory therapeutics and xenotransplantation. Nature Medicine 1, 967-968
    • (1995) Nature Medicine , vol.1 , pp. 967-968
    • Ryan, U.S.1
  • 101
    • 0033921989 scopus 로고    scopus 로고
    • Complement inhibitors: A resurgent concept in antiinflammatory therapeutics
    • Sahu, A., and Lambris, J.D. (2000). Complement inhibitors: a resurgent concept in antiinflammatory therapeutics. Immunopharmacology 49, 133-148
    • (2000) Immunopharmacology , vol.49 , pp. 133-148
    • Sahu, A.1    Lambris, J.D.2
  • 102
    • 0034868775 scopus 로고    scopus 로고
    • Expression and regulation of complement factors H and I in rat and human cells: Some critical notes
    • Schlaf, G., Demberg, T., Beisel, N., Schieferdecker, H.L., and Gotze, O. (2001). Expression and regulation of complement factors H and I in rat and human cells: some critical notes. Molecular Immunology 38, 231-239
    • (2001) Molecular Immunology , vol.38 , pp. 231-239
    • Schlaf, G.1    Demberg, T.2    Beisel, N.3    Schieferdecker, H.L.4    Gotze, O.5
  • 103
    • 36849044745 scopus 로고    scopus 로고
    • Translational mini-review series on complement factor H: Structural and functional correlations for factor H
    • Schmidt, C.Q., Herbert, A.P., Hocking, H.G., Uhrin, D., and Barlow, P.N. (2008). Translational mini-review series on complement factor H: structural and functional correlations for factor H. Clinical and Experimental Immunology 151, 14-24
    • (2008) Clinical and Experimental Immunology , vol.151 , pp. 14-24
    • Schmidt, C.Q.1    Herbert, A.P.2    Hocking, H.G.3    Uhrin, D.4    Barlow, P.N.5
  • 105
    • 33745673644 scopus 로고    scopus 로고
    • CFH gene variant, Y402H, and smoking, body mass index, environmental associations with advanced age-related macular degeneration
    • Seddon, J.M., George, S., Rosner, B., and Klein, M.L. (2006). CFH gene variant, Y402H, and smoking, body mass index, environmental associations with advanced age-related macular degeneration. Human Heredity 61, 157-165
    • (2006) Human Heredity , vol.61 , pp. 157-165
    • Seddon, J.M.1    George, S.2    Rosner, B.3    Klein, M.L.4
  • 106
    • 0029763437 scopus 로고    scopus 로고
    • Identification of three physically and functionally distinct binding sites for C3b in human complement factor H by deletion mutagenesis
    • Sharma, A.K. and Pangburn, M.K. (1996). Identification of three physically and functionally distinct binding sites for C3b in human complement factor H by deletion mutagenesis. Proceedings of the National Academy of Sciences of the United States of America 93, 10996-11001
    • (1996) Proceedings of the National Academy of Sciences of the United States of America , vol.93 , pp. 10996-11001
    • Sharma, A.K.1    Pangburn, M.K.2
  • 108
    • 34249740145 scopus 로고    scopus 로고
    • The factor H variant associated with age-related macular degeneration (His-384) and the non-disease-associated form bind differentially to Creactive protein, fibromodulin, DNA, and necrotic cells
    • Sjoberg, A.P., Trouw, L.A., Clark, S.J., Sjolander, J., Heinegard, D., Sim, R.B., Day, A.J., and Blom, A.M. (2007). The factor H variant associated with age-related macular degeneration (His-384) and the non-disease-associated form bind differentially to Creactive protein, fibromodulin, DNA, and necrotic cells. The Journal of Biological Chemistry 282, 10894-10900
    • (2007) The Journal of Biological Chemistry 282 , pp. 10894-10900
    • Sjoberg, A.P.1    Trouw, L.A.2    Clark, S.J.3    Sjolander, J.4    Heinegard, D.5    Sim, R.B.6    Day, A.J.7    Blom, A.M.8
  • 111
    • 34547740107 scopus 로고    scopus 로고
    • The common Y402H variant in complement factor H gene is not associated with susceptibility to myocardial infarction and its related risk factors
    • Lond
    • Stark, K., Neureuther, K., Sedlacek, K., Hengstenberg, W., Fischer, M., Baessler, A., Wiedmann, S., Jeron, A., Holmer, S., Erdmann, J., et al. (2007). The common Y402H variant in complement factor H gene is not associated with susceptibility to myocardial infarction and its related risk factors. Clinical Science (Lond) 113, 213-218
    • (2007) Clinical Science , vol.113 , pp. 213-218
    • Stark, K.1    Neureuther, K.2    Sedlacek, K.3    Hengstenberg, W.4    Fischer, M.5    Baessler, A.6    Wiedmann, S.7    Jeron, A.8    Holmer, S.9    Erdmann, J.10
  • 112
    • 0036230235 scopus 로고    scopus 로고
    • Successful treatment of factor H-related haemolytic uraemic syndrome
    • Stratton, J.D., and Warwicker, P. (2002). Successful treatment of factor H-related haemolytic uraemic syndrome. Nephrology Dialysis Transplantation 17, 684-685
    • (2002) Nephrology Dialysis Transplantation , vol.17 , pp. 684-685
    • Stratton, J.D.1    Warwicker, P.2
  • 113
    • 33947108375 scopus 로고    scopus 로고
    • Triggers of inflammation after renal ischemia/reperfusion
    • Orlando, Fla
    • Thurman, J.M. (2007). Triggers of inflammation after renal ischemia/reperfusion. Clinical Immunology (Orlando, Fla) 123, 7-13
    • (2007) Clinical Immunology , vol.123 , pp. 7-13
    • Thurman, J.M.1
  • 114
    • 31144460785 scopus 로고    scopus 로고
    • The central role of the alternative complement pathway in human disease
    • Thurman, J.M., and Holers, V.M. (2006). The central role of the alternative complement pathway in human disease. Journal of Immunology 176, 1305-1310
    • (2006) Journal of Immunology , vol.176 , pp. 1305-1310
    • Thurman, J.M.1    Holers, V.M.2
  • 115
    • 33749018788 scopus 로고    scopus 로고
    • Genetic susceptibility to myocardial infarction and coronary artery disease
    • Topol, E.J., Smith, J., Plow, E.F., and Wang, Q.K. (2006). Genetic susceptibility to myocardial infarction and coronary artery disease. Human Molecular Genetics 15 Spec No 2, R117-R123
    • (2006) Human Molecular Genetics , vol.15 , Issue.SPEC 2
    • Topol, E.J.1    Smith, J.2    Plow, E.F.3    Wang, Q.K.4
  • 116
    • 0035253193 scopus 로고    scopus 로고
    • Heparan sulfate: Decoding a dynamic multifunctional cell regulator
    • Turnbull, J., Powell, A., and Guimond, S. (2001). Heparan sulfate: decoding a dynamic multifunctional cell regulator. Trends in Cell Bbiology 11, 75-82
    • (2001) Trends in Cell Bbiology , vol.11 , pp. 75-82
    • Turnbull, J.1    Powell, A.2    Guimond, S.3
  • 117
    • 0030876651 scopus 로고    scopus 로고
    • Age-related increase in activity of specific lysosomal enzymes in the human retinal pigment epithelium
    • Verdugo, M.E. and Ray, J. (1997). Age-related increase in activity of specific lysosomal enzymes in the human retinal pigment epithelium. Experimental Eye Research 65, 231- 240
    • (1997) Experimental Eye Research , vol.65 , pp. 231-240
    • Verdugo, M.E.1    Ray, J.2
  • 121
    • 34447581121 scopus 로고    scopus 로고
    • Biochemical analysis of a common human polymorphism associated with age-related macular degeneration
    • Yu, J., Wiita, P., Kawaguchi, R., Honda, J., Jorgensen, A., Zhang, K., Fischetti, V.A., and Sun, H. (2007). Biochemical analysis of a common human polymorphism associated with age-related macular degeneration. Biochemistry 46, 8451-8461
    • (2007) Biochemistry , vol.46 , pp. 8451-8461
    • Yu, J.1    Wiita, P.2    Kawaguchi, R.3    Honda, J.4    Jorgensen, A.5    Zhang, K.6    Fischetti, V.A.7    Sun, H.8
  • 122
    • 1842478123 scopus 로고    scopus 로고
    • Current concepts in the pathogenesis of age-related macular degeneration
    • Zarbin, M.A. (2004). Current concepts in the pathogenesis of age-related macular degeneration. Archives of Ophthalmology 122, 598-614
    • (2004) Archives of Ophthalmology , vol.122 , pp. 598-614
    • Zarbin, M.A.1
  • 124
    • 43949161834 scopus 로고
    • Complement factor H and related proteins: An expanding family of complement-regulatory proteins?
    • Zipfel, P.F. and Skerka, C. (1994). Complement factor H and related proteins: an expanding family of complement-regulatory proteins? Immunology Today 15, 121-126
    • (1994) Immunology Today , vol.15 , pp. 121-126
    • Zipfel, P.F.1    Skerka, C.2


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