Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cells

FASEB Journal

Volumn 13, Issue 3, 1999, Pages 477-484

  Hageman, Gregory S ^a   Mullins, Robert F ^a   Russell, Stephen R ^a   Johnson, Lincoln V ^b   Anderson, Don H ^b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Age related macular degeneration; Extracellular matrix; Heparan sulfate proteoglycan; Retinal pigment epithelium

Indexed keywords

MESSENGER RNA; VITRONECTIN;

ARTICLE; DRUSEN; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; PATHOGENESIS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA MACULA DEGENERATION;

EID: 0032967793     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.13.3.477     Document Type: Article

References (54)

1. Hyman, L. (1992) Epidemiology of AMD. In Age-related macular degeneration: principles and practice (Hampton, G., and Nelsen, P., eds) pp. 1-36, Raven Press, New York
2. Klein, R., Rowland, M., and Harris, M. (1995) Racial/ethnic differences in age-related maculopathy. Third National Health and Nutrition Examination Survey. Ophthalmology 102, 371-381
3. Heiba, I., Elston, R., Klein, B., and Klein, R. (1994) Sibling correlations and segregation analysis of age-related maculopathy: the Beaver Dam Eye Study. Genetic Epidemiology 11, 51-67
4. Stone, E., and Sheffield, V. (1993) Molecular Genetics of Inherited Eye Disorders (Wright, A., and Harwood, B., eds) Academic Publishers, Chur, Switzerland
5. Klein, M., Mauldin, W., and Stoumbos, V. (1994) Heredity and age-related macular degeneration. Observations in monozygotic twins. Arch. Ophthalmol. 112, 932-937
6. Sarks, S. (1976) Aging and degeneration in the macular region: a clinico-pathologic study. Br. J. Ophthalmol. 60, 324-341
7. Sarks, J., Sarks, S., and Killingsworth, M. (1988) Evolution of geographic atrophy of the retinal pigment epithelium. Eye 2, 552-577
8. Bird, A. (1992) Bruch's membrane change with age. Br. J. Ophthalmol. 763, 166-168
9. van der Schaft, T., Mooy, C., de Bruijn, W., Oron, F., Mulder, P., and de Jong, P. (1992) Histological features of age-related macular degeneration. A statistical analysis. Ophthalmology 99, 278-286
10. Green, W., and Enger, C. (1993) Age-related macular degeneration histopathologic studies. Ophthalmology 100, 1519-1535
11. Feeney-Burns, L., and Ellersieck, M. (1985) Age-related changes in the ultrastructure of Bruch's membrane. Am. J. Ophthalmol. 100, 686-697
12. Young, R. (1987) Pathophysiology of age-related macular degeneration. Surv. Ophthalmol. 31, 291-306
13. Kincaid, M. (1992) Pathology of AMD. In: Age-related Macular Degeneration: Principles and Practice (Hampton, G., and Nelsen, P., eds) Raven Press, New York
14. Bressler, S., Maguire, G., Bressler, N., and Fine, S. (1990) Relationship of drusen and abnormalities of the retinal pigment epithelium to the prognosis of neovascular macular degeneration. Arch. Ophthalmol. 108, 1442-1447
15. Pauleikhoff, D., Barondes, M., Minassian, D., Chisholm, I., and Bird, A. (1990) Drusen as risk factors in age-related macular disease. Am. J Ophthalmol. 109, 38-43
16. Vinding, T. (1990) Occurrence of drusen, pigmentary changes and exudative changes in the macula with reference to age-related macular degeneration. An epidemiological study of 1000 aged individuals. Acta Opthalmologica 68, 410-414
17. Bressler, N., Silva, J., Bressler, S., Fine, S., and Green, W. (1994) Clinicopathologic correlation of drusen and retinal pigment epithelial abnormalities in age-related macular degeneration. Retina 14, 130-142
18. Lewis, H., Straatsma, B., and Foos, R. (1980) Chorioretinal juncture: multiple extramacular drusen. Ophthalmology 93, 1098-1112
19. Sarks, S., and Sarks, J. (1989) Age-related macular degeneration: atrophic form. In: The Retina (Ryan, S., ed) Vol. 2, CV Mosby, St. Louis
20. Klein, R., Davis, M., Magli, Y. Segal, P., Klein, B., and Hubbard, L. (1991) The Wisconsin age-related maculopathy grading system. Ophthalmology 98, 1128-1134
21. Farkas, T., Sylvester, V., and Archer, D. (1971) The ultrastructure of drusen. Am. J. Ophthalmol. 71, 1196-1205
22. Sarks, S., Van Driel, D., Maxwell, L., and Killings-worth. M. (1980) Softening of drusen and subretinal neovascularization. Trans. Ophthalmol. Soc. U.K. 100, 414-422
23. Burns, R., and Feeney Burns, L. (1980) Clinico-morphologic correlations of drusen of Bruch's membrane. Trans. Am. Ophthalmol. Soc. 78, 206-225
24. Green, W., McDonnell, P., and Yeo, J. (1985) Pathologic features of senile macular degeneration. Ophthalmology 92. 615-27
25. van der Schaft, T., Mooy, C., de Bruijn, W., and de Jong, P. (1993) Early stages of age-related macular degeneration: an immunofluorescence and electron microscopy study. Br. J. Ophthalmol. 77, 657-661
26. Hogasen, K., Eirik-Mollnes, T., and Harboe, M. (1992) Heparin-binding properties of vitronectin are linked to complex formation as illustrated by in vitro polymerization and binding to the terminal complement complex. J. Biol. Chem. 267, 23076-23082
27. Bittorf, S. V., Williams, E. C., and Mosher, D. F. (1993) Alteration of vitronectin: characterization of changes induced by treatment with urea. J. Biol. Chem. 268, 24838-24846
28. Volker, W., Hess, S., Vischer, P., and Preissner, K. (1993) Binding and processing of multimeric vitronectin by vascular endothelial cells. J. Histochem. Cytochem. 41, 1823-1832
29. Mullins, R., Johnson, L., Anderson, D., and Hageman, G. (1997) Characterization of drusen-associated glycoconjugates. Ophthalmology 104, 288-294
30. Johnson, L., and Blanks, J. (1984) Application of acrylamide as an embedding medium in studies in lectin and antibody binding in the vertebrate retina. Curr. Eye Res. 3, 909-974
31. Hale, I., and Matsumoto, B. (1993) Resolution of subcellular detail in thick tissue sections: immunohistochemical preparation and fluorescence confocal microscopy. Methods Cell Biol. 38, 289-324
32. Chirgwin, J., Przbyla, A., MacDonald, R., and Rutter, W. (1979) Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18, 5294-5299
33. Preissner, K. (1991) Structure and biological role of vitronectin. Annu. Rev. Cell Biol. 7, 275-310
34. Hayman, E., Pierschbacher, M., Ohgren, Y., and Ruoslahti, E. (1983) Serum spreading factor (vitronectin) is present at the cell surface and in tissues. Proc. Natl. Acad. Sci. USA 80, 4003-4007
35. Stockman, A., Hess, S., Declerck, P., Timpl, R.. and Preissner, K. (1993) Multimeric vitronectin. Identification and characterization of conformation-dependent self-association of the adhesive protein. J. Biol. Chem. 268, 22874-2282
36. Newsome, D., Hewitt, A., Huh, W., Robey, P., and Hassell, J. (1987) Detection of specific extracellular matrix molecules in drusen, Bruch's membrane, and ciliary body. Am. J. Ophthalmol. 104, 373-381
37. Pauleikhoff, D., Zuels, S., Sheraidah, G., Marshall, J., Wessing, A., and Bird, A. (1992) Correlation between biochemical composition and fluorescein binding of deposits in Bruch's membrane. Ophthalmology 99, 1548-1553
38. van der Schaft, T., Mooy, C., de Bruijn, W., Bosman, F., and de Jong, P. (1994) Immunohistochemical light and electron microscopy of basal laminar deposit. Graefe's Arch. Clin. Exp. Ophthalmol. 232, 40-46
39. Kliffen, M., Mooy, C., Luider, T., Huijnums, J., Kerkvliet, S., and de Jong, P. (1996) Identification of glycosaminoglycans in age-related macular deposits. Arch. Ophthalmol. 114, 1009-1014
40. Paulcikhoff, D., Sheraidah, G., Marshall, J., Bird, A., and Wessing, A. (1994) Biochemical and histochemical analysis of age related lipid deposits in Bruch's membrane. Ophthalmologe 91, 730-734
41. Feeney-Burns, L., Gao, C., and Berman, E. (1988) The fate of immunoreactive opsin following phagocytosis by pigment epithelium in human and monkey retinas. Invest. Ophthalmol. Vis. Sci. 29, 708-719
42. Tomasini, B., and Mosher, D. (1991) Vitronectin. Prog. Hemostasis Thromb. 10, 269-305
43. Stiffert, D., Crain, K., Wagner, N., and Loskutoff, D. (1994) Vitronectin gene expression in vivo: evidence for extrahepatic synthesis and acute phase regulation. J. Biol. Chem. 269, 19836-19842
44. Yasumitsu, H., Seo, N., Misugi, H., Miyazaki, K., and Umeda, M. (1993) Vitronectin secretion by hepatic and non-hepatic human cancer cells. In vitro Cell Dev. Biol. 29A, 403-407
45. Solem, M., Heimlich, A., Collodi, P., and Barnes, D. (1991) Human and mouse S-protein mRNA detected in northern blot experiments and evidence for the gene encoding S-protein in mammals by Southern blot analysis. Mol. Cell Biochem. 100, 141-149
46. Ishibashi, T., Patterson, R., Ohnishi, Y., Inomata, H., and Ryan, S. (1986) Formation of drusen in the human eye. Am. J. Ophthalmol. 101, 342-353
47. Fine, B. (1981) Lipoidal degeneration of the retinal pigment epithelium. Am. J. Ophthalmol. 91, 469-473
48. Niculescu, F., Rus, H., Porutiu, D., Ghiurca, V., and R. V. (1989) Immunoelectron-microscopic localization of S-protein/vitro-nectin in human atherosclerotic wall. Atherosclerosis 78, 197-203.
49. Dahlback, K., Lofberg, H., and Dahlback, B. (1988) Immunohistochemical studies on vitronectin in elastic tissue disorders, cutaneous amyloidosis, Lichen ruberplanus and porphyria. Acta Dermato-Venereol. 68, 107-115
50. Jansen, J., Hogasen, K., and Mollnes, T. (1993) Extensive complement activation in hereditary porcine membranoproliferative glomerulonephritis type II (porcine dense deposit disease). Am. J. Pathol. 143, 1356-1365
51. Dahlback, K., Wulf, H., and Dahlback, B. (1993) Vitronectin in mouse skin:immunohistochemical demonstration of its association with cutaneous amyloid. Invest. Dermatol. 100, 166-170
52. Akiyama, H., Kawamata, T., Dedhar, S., and McGreer, P. (1991) Immunohistochemical localization of vitronectin, its receptor, and beta-3 integrin in Alzheimer brain tissue. J. Neuroimmunol. 32, 19-28
53. Vingerling, J., Dielemans, I., Bots, M., Hofman, A., Grobbee, D., and de Jong, P. (1995) Age-related macular degeneration is associated with atherosclerosis. The Rotterdam Study. Am. J. Epidemiol. 142, 404-409
54. Blumenkranz, M., Russell, S., Robey, M., Kott-Blumenkranz, R., and Penneys, N. (1986) Risk factors in age-related maculopathy complicated by choroidal neovascularization. Ophthalmology 93, 552-558