The factor H variant associated with age-related macular degeneration (His-384) and the non-disease-associated form bind differentially to C-reactive protein, fibromodulin, DNA, and necrotic cells

Journal of Biological Chemistry

Volumn 282, Issue 15, 2007, Pages 10894-10900

  Sjöberg, Andreas P ^a   Trouw, Leendert A ^a   Clark, Simon J ^b   Sjölander, Jonatan ^a   Heinegård, Dick ^c   Sim, Robert B ^b   Day, Anthony J ^b,d   Blom, Anna M ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c LUND UNIVERSITY   (Sweden)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MACULAR DEGENERATION; NECROTIC CELLS; PHOSPHORYLCHOLINE; PROTEIN FIBROMODULIN;

BINDING SITES; CELLS; DISEASES; POLYMORPHISM; PROTEINS;

GENE EXPRESSION;

C REACTIVE PROTEIN; COMPLEMENT COMPONENT C1Q; COMPLEMENT CONTROL PROTEIN 6; COMPLEMENT CONTROL PROTEIN 7; COMPLEMENT CONTROL PROTEIN 8; COMPLEMENT FACTOR H; DNA; FIBROMODULIN; GENE PRODUCT; GLYCOSAMINOGLYCAN; HISTIDINE; PHOSPHORYLCHOLINE; POLYPEPTIDE; TYROSINE; UNCLASSIFIED DRUG; PROTEOGLYCAN; SCLEROPROTEIN;

ALLELE; ARTICLE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE ACTIVATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; INFLAMMATION; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN MODIFICATION; RETINA MACULA AGE RELATED DEGENERATION; RISK FACTOR; ALTERNATIVE RNA SPLICING; CELL LINE; GENETICS; METABOLISM; NECROSIS; PATHOLOGY; RETINA MACULA DEGENERATION; SURFACE PLASMON RESONANCE;

ALTERNATIVE SPLICING; C-REACTIVE PROTEIN; CELL LINE; COMPLEMENT FACTOR H; DNA; EXTRACELLULAR MATRIX PROTEINS; HISTIDINE; HUMANS; MACULAR DEGENERATION; NECROSIS; PROTEIN BINDING; PROTEOGLYCANS; SURFACE PLASMON RESONANCE; TYROSINE;

EID: 34249740145     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M610256200     Document Type: Article

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