Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 46, 2006, Pages 17456-17461

  Johnson, P T ^a   Betts, K E ^a   Radeke, M J ^a   Hageman, G S ^b   Anderson, D H ^a   Johnson, L V ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Alternative pathway; Eye; Retinal pigmented epithelium (RPE)

Indexed keywords

C REACTIVE PROTEIN; COMPLEMENT FACTOR H; HISTIDINE; TYROSINE;

ADULT; AGED; ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; BRUCH MEMBRANE; CFH GENE; CHOROID; CHRONIC INFLAMMATION; CLINICAL ARTICLE; COMPLEMENT INHIBITION; CONTROLLED STUDY; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOTYPE; HIGH RISK POPULATION; HOMOZYGOTE; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOREACTIVITY; MALE; PATHOGENESIS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RETINA MACULA AGE RELATED DEGENERATION; SINGLE NUCLEOTIDE POLYMORPHISM;

AGE DISTRIBUTION; AGED; AGED, 80 AND OVER; C-REACTIVE PROTEIN; CHOROID; COMPLEMENT FACTOR H; COMPLEMENT MEMBRANE ATTACK COMPLEX; FEMALE; HOMOZYGOTE; HUMANS; MACULAR DEGENERATION; MALE; MIDDLE AGED; PIGMENT EPITHELIUM OF EYE; RISK FACTORS; TRANSCRIPTION, GENETIC; VARIATION (GENETICS);

EID: 33751243644     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0606234103     Document Type: Article

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