C-reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: Implications for systemic autoimmunity

Journal of Experimental Medicine

Volumn 192, Issue 9, 2000, Pages 1353-1363

  Gershov, Debra ^a   Kim, SunJung ^a   Brot, Nathan ^a   Elkon, Keith B ^a,b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

Apoptosis; Autoimmunity; C reactive protein; Complement; Macrophages

Indexed keywords

C REACTIVE PROTEIN; COMPLEMENT; COMPLEMENT COMPONENT C1Q; COMPLEMENT FACTOR H; TRANSFORMING GROWTH FACTOR BETA;

APOPTOSIS; ARTICLE; AUTOIMMUNITY; COMPLEMENT ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNITY; INFECTION; INFLAMMATION; MACROPHAGE; OPSONIZATION; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN BINDING; T LYMPHOCYTE; TISSUE INJURY;

APOPTOSIS; AUTOIMMUNITY; C-REACTIVE PROTEIN; CALCIUM; COMPLEMENT C1Q; COMPLEMENT C3B; COMPLEMENT FACTOR H; COMPLEMENT MEMBRANE ATTACK COMPLEX; COMPLEMENT PATHWAY, CLASSICAL; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INFLAMMATION; JURKAT CELLS; MACROPHAGES; NECROSIS; OPSONIN PROTEINS; PHAGOCYTOSIS; PROTEIN BINDING; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034613686     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.9.1353     Document Type: Article

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