Disease-associated sequence variations congregate in a polyanion recognition patch on human factor H revealed in three-dimensional structure

Journal of Biological Chemistry

Volumn 281, Issue 24, 2006, Pages 16512-16520

  Herbert, Andrew P ^a,b   Uhrín, Dusan ^a   Lyon, Malcolm ^c   Pangburn, Michael K ^b   Barlow, Paul N ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; DISEASES; MUTAGENESIS; PLASMAS; PROTEINS; SACCHARIFICATION; THREE DIMENSIONAL;

155-KDA PLASMA GLYCOPROTEIN; ATYPICAL HEMOLYTIC UREMIC SYNDROME (AHUS); POLYANION RECOGNITION; POLYMORPHISMS;

MOLECULAR BIOLOGY;

COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C3D; COMPLEMENT FACTOR H; HEPARIN DERIVATIVE; POLYANION;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; DISEASE ASSOCIATION; HEMOLYTIC UREMIC SYNDROME; KIDNEY; MICROVASCULATURE; MISSENSE MUTATION; PRIORITY JOURNAL; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE;

AMINO ACID SEQUENCE; ANIONS; COMPLEMENT C3D; COMPLEMENT FACTOR H; HEPARIN; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; PICHIA; POLYMORPHISM, GENETIC; PROTEIN CONFORMATION; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 33745202838     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M513611200     Document Type: Article

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