Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism

Journal of Biological Chemistry

Volumn 282, Issue 26, 2007, Pages 18960-18968

  Herbert, Andrew P ^a   Deakin, Jon A ^b   Schmidt, Christoph Q ^a   Blaum, Bärbel S ^a   Egan, Claire ^a   Ferreira, Viviana P ^c   Pangburn, Michael K ^c   Lyon, Malcolm ^b   Uhrín, Dusan ^a   Barlow, Paul N ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; GENE EXPRESSION; INTERFACES (MATERIALS); MOLECULAR STRUCTURE; NUCLEOTIDES; PROTEINS;

COMPLEMENT CONTROL PROTEIN (CCP) MODULES; GENE PREDISPOSES; NUCLEOTIDE POLYMORPHISM; PROTEIN RECOGNITION SITES;

POLYSACCHARIDES;

C REACTIVE PROTEIN; COMPLEMENT FACTOR H; GLYCOSAMINOGLYCAN; HEPARIN; HISTIDINE; OLIGOSACCHARIDE; TETRASACCHARIDE; TYROSINE;

APOPTOSIS; ARTICLE; BINDING AFFINITY; GEL MOBILITY SHIFT ASSAY; HUMAN; MEASUREMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; RETINA MACULA AGE RELATED DEGENERATION; RETINA MACULA LUTEA; SINGLE NUCLEOTIDE POLYMORPHISM; SURFACE PLASMON RESONANCE;

AGING; ANTICOAGULANTS; APOPTOSIS; BINDING SITES; COMPLEMENT FACTOR H; GLYCOSAMINOGLYCANS; HEPARIN; HISTIDINE; HUMANS; MACULAR DEGENERATION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; SURFACE PLASMON RESONANCE; TYROSINE;

EID: 34547102526     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M609636200     Document Type: Article

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