The C-terminus of complement regulator Factor H mediates target recognition: Evidence for a compact conformation of the native protein

Clinical and Experimental Immunology

Volumn 144, Issue 2, 2006, Pages 342-352

  Oppermann, M ^a   Manuelian, T ^b   Jozsi M ^b   Brandt, E ^a   Jokiranta, T S ^c   Heinen, S ^b   Meri, S ^c   Skerka, C ^b   Gotze O ^a   Zipfel, P F ^b,d  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b HANS KNÖLL INSTITUTE   (Germany)

^c UNIVERSITY OF HELSINKI   (Finland)

^d FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Complement Factor H; Conformational change; Haemolytic uraemic syndrome; Host recognition; Steric effect

Indexed keywords

COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C3D; COMPLEMENT FACTOR H; HEPARIN; LIGAND; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY C 14; MONOCLONAL ANTIBODY C 18; UNCLASSIFIED DRUG; ZYMOSAN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; ASSAY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT FACTOR; COMPLEMENT INHIBITION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE CONSTRUCT; GENE DELETION; GENE MUTATION; HEMOLYTIC UREMIC SYNDROME; HUMAN; HUMAN CELL; MODEL; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; REGULATORY MECHANISM; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION REGULATION;

ANTIBODIES, MONOCLONAL; BINDING SITES, ANTIBODY; COMPLEMENT C3B; COMPLEMENT C3D; COMPLEMENT FACTOR H; COMPLEMENT PATHWAY, ALTERNATIVE; ENDOTHELIAL CELLS; EPITOPES; HEPARIN; HUMANS; LIGANDS; MODELS, BIOLOGICAL; MUTATION; PROTEIN CONFORMATION; ZYMOSAN;

EID: 33645851021     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2006.03071.x     Document Type: Article

References (41)

1. Janeway CA Jr. Medzhitov R. Innate immune recognition Annu Rev Immunol 2002 20 197 216
2. Walport MJ. Complement N Engl J Med 2001 344 1140 4
3. Morgan BP Harris CL. Complement regulatory proteins 1999 San Diego Academic Press.
4. Zipfel PF Jokiranta ST Hellwage J Koistinen V Meri S. The factor H-protein family Immunopharmacology 1999 42 53 60
5. Kühn S Skerka C Zipfel PF. Mapping of the complement regulatory domains in the human factor H-like protein 1 and in factor H J Immunol 1995 155 5663 70
6. Sharma AK Pangburn MK. Identification of three physically and functionally distinct binding sites for C3b in human complement factor H by deletion mutagenesis Proc Natl Acad Sci USA 1996 93 10996 1001
7. Gordon DL Kaufman RM Blackmore TK Kwong J Lublin D. Identification of complement regulatory domains in human factor H J Immunol 1995 155 348 6
8. Kühn S Zipfel PF. Mapping of the domains required for co-factor activity of complement factor H Eur J Immunol 1996 6 2383 7
9. Hellwage J S. Kühn PF. Zipfel The human complement regulatory factor H-like protein 1, which represents a truncated form of factor H displays cell spreading activity Biochem J 1997 326 321 7
10. Jokiranta TS Hellwage J Koistinen V Zipfel PF Meri S. Each of the three binding sites on complement factor H interacts with a distinct site on C3b J Biol Chem 2000 275 27657 62
11. Blackmore TK Sadlon TA Ward HM Lublin DM Gordon DL. Identification of a heparin binding domain in the seventh short consensus repeat of complement factor H J Immunol 1996 157 5422 7
12. Pangburn MK Atkinson MA Meri S. Localization of the heparin-binding site on complement factor H J Biol Chem 1991 266 16847 53
13. Blackmore TK Hellwage J Sadlon TA et al. Identification of the second heparin-binding domain in human complement factor H J Immunol 1998 160 3342 8
14. Hellwage J Jokiranta TS Friese MA et al. Complement C3b/C3d and cell surface polyanions are recognized by overlapping binding sites on the most carboxyl-terminal domain of complement factor H J Immunol 2002 169 6935 44
15. Pangburn MK. Localization of the host recognition functions of complement factor H at the carboxyl-terminal: implications for hemolytic uremic syndrome J Immunol 2002 169 4702 6
16. Peters JH Baumgarten H. Monoclonal antibodies Berlin Springer Verlag 1992
17. Würzner R Oppermann M Zierz R Baumgarten H Gotze O. Determination of the epitope specificities of monoclonal antibodies using unprocessed supernatants of hybridoma cultures J Immunol Meth 1990 126 231 7
18. Kühn S Zipfel PF. The baculovirus expression vector pBSV-8His directs secretion of histidine-tagged proteins Gene 1995 162 225 9
19. Skerka C Hellwage J Weber W et al. The human factor H related protein 4: a novel short consensus repeat-containing protein is associated with human triglyceride-rich lipoproteins J Biol Chem 1997 272 5627 34
20. Manuelian T Hellwage J Meri S et al. Factor H gene mutations in hemolytic uremic syndrome: single amino acid exchanges reduce binding affinity to C3b, heparin and surface attachment to endothelial cells J Clin Invest 2003 111 1181 90
21. Wieland GD Nehmann N Muller D et al. Early growth response proteins EGR-4 and EGR-3 interact with immune inflammatory mediators NF-kappaB p50 and p65 J Cell Sci 2005 118 3203 12
22. Zipfel PF Heinen S Jozsi M Skerka C. Complement and diseases: defective alternative pathway control results in kidney and eye diseases Mol Immunol 2006 43 97 106
23. DiScipio RG. Ultrastructures and interactions of complement factors H and I J Immunol 1992 149 2592 9
24. Prodinger W Hellwage J Spruth M Dierich MP Zipfel PF. The C-terminus of factor H: monoclonal antibodies inhibit heparin binding and identify epitopes common to factor H and factor H-related proteins Biochem J 1998 331 41 7
25. Jokiranta ST Zipfel PF Hakulinen J et al. Analysis of the recognition mechanism of the alternative pathway of complement by monoclonal anti-factor H antibodies: evidence for multiple interactions between H and surface bound C3b FEBS Lett 1996 393 297 302
26. Jokiranta TS Cheng ZZ Seeberger H et al Binding of complement Factor H to endothelial cells is mediated by the carboxy terminal gylcosaminglycan binding site Am J Pathol 2005 167 1173 81
27. Ripoche J Erdei A Gilbert D Al Salihi A Sim RB Fontaine M. Two populations of complement factor H differ in their ability to bind to cell surfaces Biochem J 1988 53 475 80
28. Ripoche J Al Salihi A Rousseaux J Fontaine M. Isolation of two molecular populations of human complement factor H Biochem J 1984 221 89 96
29. Ohtsuka H Imamura T Matsushita M et al. Thrombin generates monocyte chemotactic activity from complement factor H enerates monocyte chemotactic activity from complement factor H Immunology 1993 80 140 5
30. Imamura T Ohtsuka H Matsushita M Tsuruta J Okada H Kambara T. A new biological activity of the complement factor H. Identification of the precursor of the major macrophage-chemotactic factor in delayed hypersensitivity reaction sites of guinea pigs Biochem Biophys Res Commun 1992 185 505 9
31. Perkins SJ Gilbert HE Aslam M Hannan J Holers VM Goodship THJ. Solution structures of complement components by X-ray and neutron scatter and analytical ultracentrifugation Biochem Soc Trans 2002 30 996 1001
32. Koistinen V. Effect of complement-protein-C3b density on the binding of complement factor H to surface-bound C3b Biochem J 1991 280 255 9
33. Józsi M Manuelian T Heinen S Oppermann M Zipfel PF. Attachment of the soluble complement regulator factor H to cell and tissue surfaces: relevance for pathology Histol Histopathol 2004 19 251 8
34. Taylor CM. Complement factor H and the haemolytic uraemic syndrome Lancet 2001 358 1200- 2
35. Zipfel PF. Hemolytic uremic syndrome: how do factor H mutants mediate endothelial damage? Trends Immunol 2001 22 345 8
36. Caprioli J Bettinaglio P Zipfel PF et al. The molecular basis of familial hemolytic uremic syndrome. mutation analysis of factor H gene reveals a hot spot in short consensus repeat 20 J Am Soc Nephrol 2001 12 297 307
37. Richards A Buddles MR Donne RL et al. Factor H mutations in hemolytic uremic syndrome cluster in exons 18-20, a domain important for host cell recognition Am J Hum Genet 2001 68 485 90
38. Perez-Caballero D Gonzalez-Rubio C Gallardo ME et al. Clustering of missense mutations in the C-terminal region of factor H in atypical hemolytic uremic syndrome Am J Hum Genet 2001 68 478 84
39. Neumann HPH Bohnert-Iwan B Manuelian T et al. Frequency of factor H gene mutations in hemolytic uremic syndrome J Med Genet 2003 40 676 81
40. Perkins SJ Goodship TH. Molecular modeling of the C-terminal domains of factor H of human complement: a correlation between haemolytic uraemic syndrome and a predicted heparin binding site J Mol Biol 2003 2316 217 24
41. Sanchez-Corral P Perez-Caballero D Huarte O et al. Structural and functional characterization of factor H mutations associated with atypical hemolytic uremic syndrome Am J Hum Genet 2002 71 1285 95