Negative regulation of interleukin-12 production by a rapamycin-sensitive signaling pathway: A brief communication

Experimental Biology and Medicine

Volumn 228, Issue 9, 2003, Pages 1023-1027

  Uthaisangsook, Suwannee ^a,b   Day, Noorbibi K ^a   Hitchcock, Remi ^a   Lerner, Aaron ^a   James Yarish, Michelle ^a   Good, Robert A ^a   Haraguchi, Soichi ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b NARESUAN UNIVERSITY   (Thailand)

Author keywords

Interleukin 12; Negative regulation; Rapamycin; Signal transduction

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; MESSENGER RNA; PROTEIN P40; PROTEIN P70; RAPAMYCIN;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IMMUNOREGULATION; INFECTION RESISTANCE; INTERFERON PRODUCTION; MONONUCLEAR CELL; NEGATIVE FEEDBACK; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 0141640858     PISSN: 15353702     EISSN: None     Source Type: Journal    
DOI: 10.1177/153537020322800906     Document Type: Article

References (27)

1. D'Andrea A, Rengaraju M, Valiante NM, Chehimi J, Kubin M, Aste M, Chan SH, Kobayashi M, Young D, Nickbarg E, et al. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J Exp Med 176:1387-1398, 1992.
2. Kennedy MK, Picha KS, Fanslow WC, Grabstein KH, Alderson MR, Clifford KN, Chin WA, Mohler KM. CD40/CD40 ligand interactions are required for T cell-dependent production of interleukin-12 by mouse macrophages. Eur J Immunol 26:370-378, 1996.
3. McDyer JF, Wu C-Y, Seder RA. The regulation of IL-12: Its role in infectious, autoimmune, and allergic diseases. J Allergy Clin Immunol 102:11-15, 1998.
4. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 3:133-146, 2003.
5. Altare F, Lammas D, Revy P, Jouanguy E, Döffinger R, Lamhamedi S, Drysdale P, Scheel-Toellner D, Girdlestone J, Darbyshire P, Wadhwa M, Dockrell H. Salmon M, Fischer A, Durandy A, Casanova JL, Kumararatne DS. Inherited interleukin 12 deficiency in a child with Bacille Calmette-Guérin and Salmonella enteritidis disseminated infection. J Clin Invest 102:2035-2040, 1998.
6. Altare F, Durandy A, Lammas D, Emile J-F, Lamhamedi S, Le Deist F, Drysdale P, Jouanguy E, Döffinger R, Bernaudin F, Jeppsson O, Gollob JA, Meinl E, Segal AW, Fischer A, Kumararatne D, Casanova JL. Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency. Science 280:1432-1435, 1998.
7. Haraguchi S, Day NK, Nelson RP Jr, Emmanuel P, Duplantier JE, Christodoulou CS, Good RA. Interleukin 12 deficiency associated with recurrent infections. Proc Natl Acad Sci USA 95:13125-13129, 1998.
8. Ma X, Riemann H, Gri G, Trinchieri G. Positive and negative regulation of interleukin-12 gene expression. Eur Cytokine Netw 9:54-64, 1998.
9. Lee SM, Suen Y, Chang L, Bruner V, Qian J, Indes J, Knoppel E, van de Ven C, Cairo MS. Decreased interleukin-12 (IL-12) from activated cord versus adult peripheral blood mononuclear cells and upregulation of interferon-γ, natural killer, and lymphokine-activated killer activity by IL-12 in cord blood mononuclear cells. Blood 88:945-954, 1996.
10. Lee SM, Suen Y, Qian J, Knoppel E, Cairo MS. The regulation and biological activity of interleukin 12. Leuk Lymphoma 29:427-438, 1998.
11. Aste-Amezaga M, Ma X, Sartori A, Trinchieri G. Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10. J Immunol 160:5936-5944, 1998.
12. Hanada T, Yoshimura A. Regulation of cytokine signaling and inflammation. Cytokine Growth Factor Rev 13:413-421, 2002.
13. Brown EJ, Beal PA, Keith CT, Chen J, Shin TB, Schreiber SL. Control of p70 S6 kinase by kinase activity of FRAP in vivo. Nature 377:441-446, 1995.
14. Price DJ, Grove JR, Calvo V, Avruch J, Bierer BE. Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. Science 257:973-977, 1992.
15. s6k. Proc Natl Acad Sci USA 92:11696-11700, 1995.
16. Wymann MP, Bulgarelli-Leva G, Zvelebil MJ, Pirola L, Vanhaese-broeck B, Waterfield MD, Panayotou G. Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction. Mol Cell Biol 16:1722-1733, 1996.
17. Vlahos CJ, Matter WF. Hui KY, Brown RF. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (Ly294002). J Biol Chem 269:5241-5248, 1994.
18. Wahl LM, Smith PD. Isolation of monocyte/macrophage populations. In: Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W, Eds. Current Protocols in Immunology. New York: John Wiley & Sons, p7.6.1, 1995.
19. Matsue H, Yang C, Matsue K, Edelbaum D, Mummert M, Takashima A. Contrasting impacts of immunosuppressive agents (rapamycin, FK506, cyclosporin A, and dexamethasone) on bidirectional dendritic cell-T cell interaction during antigen presentation. J Immunol 169:3555-3564, 2002.
20. Scheid MP, Charlton L, Pelech SL, Duronio V. Role of p70 S6 kinase in cytokine-regulated hemopoietic cell survival. Biochem Cell Biol 74:595-600, 1996.
21. Salh B, Wagey R, Marotta A, Tao JS, Pelech S. Activation of phosphatidylinositol 3-kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated Raw 264.7 cells: Differential effects of rapamycin, Ly294002, and wortmannin on nitric oxide production. J Immunol 161:6947-6954, 1998.
22. Ettinger SL, Lauener RW, Duronio V. Protein kinase C δ specifically associates with phosphatidylinositol 3-kinase following cytokine stimulation. J Biol Chem 271:14514-14518, 1996.
23. Downward J. Signal transduction: Regulating S6 kinase. Nature 371:378-379, 1994.
24. Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351:95-105, 2000.
25. Fukao T, Tanabe M, Terauchi Y, Ota T, Matsuda S, Asano T, Kadowaki T, Takeuchi T, Koyasu S. P13K-mediated negative feedback regulation of IL-12 production in DCs. Nat Immunol 3:875-881, 2002.
26. Armant M, Avice M-N, Hermann P, Rubio M, Kiniwa M, Delespesse G, Sarfati M. CD47 ligation selectively downregulates human interleukin 12 production. J Exp Med 190:1175-1181, 1999.
27. Feng G-J, Goodridge HS, Harnett MM, Wei X-Q, Nikolaev AV, Higson AP, Liew F-Y. Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase. J Immunol 163:6403-6412, 1999.