Selective loss of gastrointestinal mast cells and impaired immunity in P13K-deficient mice

Nature Immunology

Volumn 3, Issue 3, 2002, Pages 295-304

  Fukao, Taro ^a   Yamada, Taketo ^a   Tanabe, Masanobu ^a   Terauchi, Yasuo ^b   Ota, Takayuki ^a   Takayama, Tetsuro ^a   Asano, Tomoichiro ^b   Takeuchi, Tsutomu ^a   Kadowaki, Takashi ^b   Hata, Jun Ichi ^a   Koyasu, Shigeo ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL KINASE;

ANAPHYLACTIC SHOCK; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; CELL LOSS; CELL MATURATION; CONTROLLED STUDY; DERMIS; ENZYME RECONSTITUTION; ENZYME SUBUNIT; GASTROINTESTINAL TRACT; HELPER CELL; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNITY; INFECTION CONTROL; INFECTION SENSITIVITY; MALE; MAST CELL; MOUSE; NEMATODE; NONHUMAN; PERITONEUM MAST CELL; PERITONITIS; PRIORITY JOURNAL; RAT; SEPSIS; STRONGYLOIDES VENEZUELENSIS; TH2 CELL; WORM INFECTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BACTERIAL INFECTIONS; CYTOKINES; DIGESTIVE SYSTEM; IMMUNITY, NATURAL; LYMPHOCYTES; MAST CELLS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PROTO-ONCOGENE PROTEINS C-KIT; STRONGYLOIDIASIS; TH2 CELLS;

EID: 0036195935     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni768     Document Type: Article

References (59)

1. Mast cells
2. Mast cells and basophils
3. Mast cell and basophil development
4. Critical protective role of mast cells in a model of acute septic peritonitis
5. Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α
6. The diverse roles of mast cells
7. The role of Th2 cytokines in mast cell homeostasis
8. + mast cells and their progenitors to IL-3 and stem cell factor
9. Identification of a committed precursor for the mast cell lineage
10. The kit ligand, stem cell factor
11. v mice and their increase by bone marrow transplantation
12. d mice: Their value for the analysis of the roles of mast cells in biological responses in vivo
13. Cytokine regulation of host defense against parasitic gastrointestinal nematodes: Lessons from studies with rodent models
14. Selective effector mechanisms for the expulsion of intestinal helminths
15. Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases
16. Interleukin 10: A novel stimulatory factor for mast cells and their progenitors
17. Cytokine-mediated regulation of chronic intestinal helminth infection
18. Intestinal mast cell response and mucosal defence against Strongyloides venezuelensis in interleukin-3-hyporesponsive mice
19. Kinetic study of mast-cell growth factor production by lymphocytes during the course of Strongyloides ratti infection in mice
20. IL-13, IL-4Rα, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis
21. Critical role for signal transducer and activator of transcription factor 6 in mediating intestinal muscle hypercontractility and worm expulsion in Trichinella spiralis-infected mice
22. Phosphoinositide kinases
23. The high-affinity IgE receptor (FcεRI): From physiology to pathology
24. Kit signaling through Pl 3-kinase and Src kinase pathways: An essential role for Racl and JNK activation in mast cell proliferation
25. cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of P13-kinase to the PDGFβ-receptor
26. Cloning of P13 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases
27. c-src complexes, and P13-kinase
28. Increased insulin sensitivity and hypoglycemia in mice lacking the p85α subunit of phosphoinositide 3-kinase
29. Xid-like immunodeficiency in mice with disruption of the p85α subunit of phosphoinositide 3-kinase
30. Anaphylaxis
31. Heparin is essential for the storage of specific granule proteases in mast cells
32. Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme
33. Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor α chain gene
34. Anaphylaxis in mast cell-deficient mice
35. Differences in the expression of the cardiopulmonary alterations associated with anti-immunoglobulin E-induced or active anaphylaxis in mast cell-deficient and normal mice. Mast cells are not required for the associated with certain fatal anaphylactic responses
36. Role of mast cells in anaphylaxis. Evidence for the importance of mast cells in the cardiopulmonary alterations and death induced by anti-lgE in mice
37. Impaired kit- but not FcεRI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85α gene products
38. v mice: Evidence that cultured mast cells can give tissue type and mucosal mast cells
39. IL-3-dependent murine mast cells undergo apoptosis on removal of IL-3. Prevention of apoptosis by c-kit ligand
40. Induction of mast cell proliferation, maturation, and heparin synthesis by the rat c-kit ligand, stem cell factor
41. Granulocyte-macrophage colony-stimulating factor, interleukin-3, and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase
42. Hemopoietic growth factors with the exception of interleukin-4 activate the p38 mitogen-activated protein kinase pathway
43. MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells
44. Cellular survival: A play in three Akts
45. Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites
46. Mast cells that reside at different locations in the jejunum of mice infected with Trichinella spiralis exhibit sequential changes in their granule ultrastructure and chymase phenotype
47. Delayed expulsion of the nematode Trichinella spiralis in mice lacking the mucosal mast cell-specific granule chymase, mouse mast cell protease-1
48. Mucosal mast cells and the expulsive mechanisms of mice against Strongyloides venezuelensis
49. Effects of spleen cells and serum on transfer of immunity to Strongyloides venezuelensis infection in hypothymic (nude) mice
50. Transcriptional regulation of the mucosal mast cell-specific protease gene, MMCP-2, by interleukin 10 and interleukin 3
51. IL-10 induces transcription of the gene for mouse mast cell protease-1, a serine protease preferentially expressed in mucosal mast cells of Trichinella spiralis-infected mice
52. Reversible expression of mouse mast cell protease 2 mRNA and protein in cultured mast cells exposed to IL-10
53. v mice by adoptive transfer of bone marrow-derived cultured mast cells and its effects on the protective capacity to Strongyloides ratti-infection
54. Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responses
55. c)- and Jak3-dependent signaling in the proliferation and survival of murine mast cells
56. Intraepithelial infiltration by mast cells with both connective tissue-type and mucosal-type characteristics in gut, trachea, and kidneys of IL-9 transgenic mice
57. Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites
58. IgE enhances mouse mast cell FcεRl expression in vitro and in vivo: Evidence for a novel amplification mechanism in IgE-dependent reactions
59. Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses