메뉴 건너뛰기




Volumn 172, Issue 1, 2004, Pages 449-456

Modulation of the Phosphoinositide 3-Kinase Pathway Alters Innate Resistance to Polymicrobial Sepsis

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOMODULATING AGENT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; PHOSPHATIDYLINOSITOL 3 KINASE; TUMOR NECROSIS FACTOR ALPHA; WORTMANNIN;

EID: 0346103719     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.1.449     Document Type: Article
Times cited : (153)

References (41)
  • 1
    • 0035434019 scopus 로고    scopus 로고
    • Sepsis syndromes: Understanding the role of innate and acquired immunity
    • Oberholzer, A., C. Oberholzer, and L. L. Moldawer. 2001. Sepsis syndromes: understanding the role of innate and acquired immunity. Shock 16:83.
    • (2001) Shock , vol.16 , pp. 83
    • Oberholzer, A.1    Oberholzer, C.2    Moldawer, L.L.3
  • 2
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
    • Angus, D. C., W. T. Linde-Zwirble, J. Lidicker, G. Clermont, J. Carcillo, and M. R. Pinsky. 2001. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit. Care Med. 29:1303.
    • (2001) Crit. Care Med. , vol.29 , pp. 1303
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 3
    • 0036199607 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase in immunological systems
    • Fruman, D. A., and L. C. Cantley. 2002. Phosphoinositide 3-kinase in immunological systems. Semin. Immunol. 14:7.
    • (2002) Semin. Immunol. , vol.14 , pp. 7
    • Fruman, D.A.1    Cantley, L.C.2
  • 4
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley, L. C. 2002. The phosphoinositide 3-kinase pathway. Science 296:1655.
    • (2002) Science , vol.296 , pp. 1655
    • Cantley, L.C.1
  • 5
    • 0037199972 scopus 로고    scopus 로고
    • The PI3K-Akt pathway limits LPS activation of signaling pathways and expression of inflammatory mediators in human monocytic cells
    • Guha, M., and N. Mackman. 2002. The PI3K-Akt pathway limits LPS activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J. Biol. Chem. 277:32124.
    • (2002) J. Biol. Chem. , vol.277 , pp. 32124
    • Guha, M.1    Mackman, N.2
  • 6
    • 0037629646 scopus 로고    scopus 로고
    • PI3K and negative regulation of TLR signaling
    • Fukao, T., and S. Koyasu. 2003. PI3K and negative regulation of TLR signaling. Trends Immunol. 24:358.
    • (2003) Trends Immunol. , vol.24 , pp. 358
    • Fukao, T.1    Koyasu, S.2
  • 7
    • 0033504127 scopus 로고    scopus 로고
    • Early activation of hepatic NFκB and NF-IL6 in polymicrobial sepsis correlates with bacteremia, cytokine expression and mortality
    • Williams, D. L., T. Ha, C. Li, J. H. Kalbfleisch, and D. A. Ferguson, Jr. 1999. Early activation of hepatic NFκB and NF-IL6 in polymicrobial sepsis correlates with bacteremia, cytokine expression and mortality. Ann. Surg. 230:95.
    • (1999) Ann. Surg. , vol.230 , pp. 95
    • Williams, D.L.1    Ha, T.2    Li, C.3    Kalbfleisch, J.H.4    Ferguson Jr., D.A.5
  • 9
    • 0032779231 scopus 로고    scopus 로고
    • Inhibiting early activation of tissue nuclear factor-κB and nuclear factor interleukin 6 with (1→3)-β-D-glucan increases long-term survival in polymicrobial sepsis
    • Williams, D. L., T. Ha, C. Li, J. H. Kalbfleisch, J. J. Laffan, and D. A. Ferguson. 1999. Inhibiting early activation of tissue nuclear factor-κB and nuclear factor interleukin 6 with (1→3)-β-D-glucan increases long-term survival in polymicrobial sepsis. Surgery 126:54.
    • (1999) Surgery , vol.126 , pp. 54
    • Williams, D.L.1    Ha, T.2    Li, C.3    Kalbfleisch, J.H.4    Laffan, J.J.5    Ferguson, D.A.6
  • 10
    • 0034203996 scopus 로고    scopus 로고
    • Inhibition of LPS induced NFκB activation by a glucan ligand involves down regulation of 1KKβ kinase activity and altered phosphorylation and degradation of IκBα
    • Williams, D. L., T. Ha, C. Li, J. Laffan, J. Kalbfleisch, and W. Browder. 2000. Inhibition of LPS induced NFκB activation by a glucan ligand involves down regulation of 1KKβ kinase activity and altered phosphorylation and degradation of IκBα. Shock 13:446.
    • (2000) Shock , vol.13 , pp. 446
    • Williams, D.L.1    Ha, T.2    Li, C.3    Laffan, J.4    Kalbfleisch, J.5    Browder, W.6
  • 11
    • 0038047587 scopus 로고    scopus 로고
    • Modulation of tissue Toll-like receptor 2 and 4 during the early phases of polymicrobial sepsis correlates with mortality
    • Williams, D. L., T. Ha, C. Li, J. H. Kalbfleisch, J. Schweitzer, W. Vogt, and I. W. Browder. 2003. Modulation of tissue Toll-like receptor 2 and 4 during the early phases of polymicrobial sepsis correlates with mortality. Crit. Care Med. 31:1808.
    • (2003) Crit. Care Med. , vol.31 , pp. 1808
    • Williams, D.L.1    Ha, T.2    Li, C.3    Kalbfleisch, J.H.4    Schweitzer, J.5    Vogt, W.6    Browder, I.W.7
  • 14
    • 0028955385 scopus 로고
    • Comparison of the carbohydrate biological response modifiers Krestin, schizophyllan and glucan phosphate by aqueous size exclusion chromatography with in-line argon-ion multi-angle laser light scattering photometry and differential viscometry detectors
    • Mueller, A., H. Pretus, R. McNamee, E. Jones, I. Browder, and D. Williams. 1995. Comparison of the carbohydrate biological response modifiers Krestin, schizophyllan and glucan phosphate by aqueous size exclusion chromatography with in-line argon-ion multi-angle laser light scattering photometry and differential viscometry detectors. J. Chromatogr. 666:283.
    • (1995) J. Chromatogr. , vol.666 , pp. 283
    • Mueller, A.1    Pretus, H.2    McNamee, R.3    Jones, E.4    Browder, I.5    Williams, D.6
  • 15
    • 0028691066 scopus 로고
    • Lipid content of macroparticulate (1→3)-β-D-glucan isolated from Saccharomyces cerevisiae
    • Mueller, A., W. Mayberry, R. Acuff, S. Thedford, W. Browder, and D. Williams. 1994. Lipid content of macroparticulate (1→3)-β-D-glucan isolated from Saccharomyces cerevisiae. Microbios 79:253.
    • (1994) Microbios , vol.79 , pp. 253
    • Mueller, A.1    Mayberry, W.2    Acuff, R.3    Thedford, S.4    Browder, W.5    Williams, D.6
  • 16
    • 0031824297 scopus 로고    scopus 로고
    • Identification of phosphate substitution sites by NMR spectroscopy in a water-soluble phosphorylated (1→3)-β-D-glucan
    • Lowman, D., H. Ensley, and D. Williams. 1998. Identification of phosphate substitution sites by NMR spectroscopy in a water-soluble phosphorylated (1→3)-β-D-glucan. Carbohyd. Res. 306:559.
    • (1998) Carbohyd. Res. , vol.306 , pp. 559
    • Lowman, D.1    Ensley, H.2    Williams, D.3
  • 18
    • 0028991081 scopus 로고
    • (1→3)-β-D-glucan in culture fluid of fungi activates factor G, a limulus coagulation factor
    • Miyazaki, T., S. Kohno, K. Mitsutake, S. Maesaki, K. Tanaka, and K. Hara. 1995. (1→3)-β-D-glucan in culture fluid of fungi activates factor G, a limulus coagulation factor. J. Clin. Lab. Anal. 9:334.
    • (1995) J. Clin. Lab. Anal. , vol.9 , pp. 334
    • Miyazaki, T.1    Kohno, S.2    Mitsutake, K.3    Maesaki, S.4    Tanaka, K.5    Hara, K.6
  • 19
    • 0020520054 scopus 로고
    • Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model
    • Baker, C. C., I. H. Chaudry, H. O. Gaines, and A. E. Baue. 1983. Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model. Surgery 94:331.
    • (1983) Surgery , vol.94 , pp. 331
    • Baker, C.C.1    Chaudry, I.H.2    Gaines, H.O.3    Baue, A.E.4
  • 20
    • 0036356846 scopus 로고    scopus 로고
    • Differential alterations in cardiovascular responses during the progression of polymicrobial sepsis in the mouse
    • Yang, S., C. S. Chung, A. Ayala, I. H. Chaudry, and P. Wang. 2002. Differential alterations in cardiovascular responses during the progression of polymicrobial sepsis in the mouse. Shock 17:55.
    • (2002) Shock , vol.17 , pp. 55
    • Yang, S.1    Chung, C.S.2    Ayala, A.3    Chaudry, I.H.4    Wang, P.5
  • 22
    • 0033856462 scopus 로고    scopus 로고
    • PI3-kinase inhibition: A target for drug development?
    • Stein, R. C., and M. D. Waterfield. 2000. PI3-kinase inhibition: a target for drug development? Mol. Med. Today 6:347.
    • (2000) Mol. Med. Today , vol.6 , pp. 347
    • Stein, R.C.1    Waterfield, M.D.2
  • 23
    • 0034794639 scopus 로고    scopus 로고
    • Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment
    • Stein, R. C. 2001. Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment. Endocrine-Related Cancer 8:237.
    • (2001) Endocrine-Related Cancer , vol.8 , pp. 237
    • Stein, R.C.1
  • 24
    • 0033767872 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling is important for smooth muscle cell replication after arterial injury
    • Shigematsu, K., H. Koyama, N. E. Olson, A. Cho, and M. A. Reidy. 2000. Phosphatidylinositol 3-kinase signaling is important for smooth muscle cell replication after arterial injury. Arterioscler. Thromb. Vasc. Biol. 20:2373.
    • (2000) Arterioscler. Thromb. Vasc. Biol. , vol.20 , pp. 2373
    • Shigematsu, K.1    Koyama, H.2    Olson, N.E.3    Cho, A.4    Reidy, M.A.5
  • 26
    • 0035115257 scopus 로고    scopus 로고
    • Growth factor-stimulated phosphorylation of Akt and p70(S6K) is differentially inhibited by LY294002 and wortmannin
    • Adi, S., N. Y. Wu, and S. M. Rosenthal. 2001. Growth factor-stimulated phosphorylation of Akt and p70(S6K) is differentially inhibited by LY294002 and wortmannin. Endocrinology 142:498.
    • (2001) Endocrinology , vol.142 , pp. 498
    • Adi, S.1    Wu, N.Y.2    Rosenthal, S.M.3
  • 28
    • 0029977686 scopus 로고    scopus 로고
    • Glucan-based macrophage stimulators: A review of their anti-infective potential
    • Williams, D. L., A. Mueller, and W. Browder. 1996. Glucan-based macrophage stimulators: a review of their anti-infective potential. Clin. Immunother. 5:392.
    • (1996) Clin. Immunother. , vol.5 , pp. 392
    • Williams, D.L.1    Mueller, A.2    Browder, W.3
  • 29
    • 0032477308 scopus 로고    scopus 로고
    • Enhanced clearance of a multiple antibiotic resistant Staphylococcus aureus in rats treated with PGG-glucan is associated with increased leukocyte counts and increased neutrophil oxidative burst activity
    • Liang, J., D. Melican, L. Cafro, G. Palace, L. Fisette, R. Armstrong, and M. L. Patchen. 1998. Enhanced clearance of a multiple antibiotic resistant Staphylococcus aureus in rats treated with PGG-glucan is associated with increased leukocyte counts and increased neutrophil oxidative burst activity. Int. J. Immunopharm. 20:595.
    • (1998) Int. J. Immunopharm. , vol.20 , pp. 595
    • Liang, J.1    Melican, D.2    Cafro, L.3    Palace, G.4    Fisette, L.5    Armstrong, R.6    Patchen, M.L.7
  • 30
    • 0031438660 scopus 로고    scopus 로고
    • Overview of (1→3)-β-D-glucan immunobiology
    • Williams, D. L. 1997. Overview of (1→3)-β-D-glucan immunobiology. Mediat. Inflamm. 6:247.
    • (1997) Mediat. Inflamm. , vol.6 , pp. 247
    • Williams, D.L.1
  • 31
    • 0031471317 scopus 로고    scopus 로고
    • PGG-Glucan activates NF-κB-like and NF-IL-6-like transcription factor complexes in a murine monocytic cell line
    • Adams, D. S., S. C. Pero, J. B. Petro, R. Nathans, W. M. Mackin, and E. Wakshull. 1997. PGG-Glucan activates NF-κB-like and NF-IL-6-like transcription factor complexes in a murine monocytic cell line. J. Leukocyte Biol. 62:865.
    • (1997) J. Leukocyte Biol. , vol.62 , pp. 865
    • Adams, D.S.1    Pero, S.C.2    Petro, J.B.3    Nathans, R.4    Mackin, W.M.5    Wakshull, E.6
  • 33
    • 0029118603 scopus 로고
    • Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase
    • Ui, M., T. Okada, K. Hazeki, and O. Hazeki. 1995. Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase. TIBS 20:303.
    • (1995) TIBS , vol.20 , pp. 303
    • Ui, M.1    Okada, T.2    Hazeki, K.3    Hazeki, O.4
  • 35
    • 0029348036 scopus 로고
    • Blockade of tumor necrosis factor reduces lipopolysaccharide lethality, but not the lethality of cecal ligation and puncture
    • Remick, D., P. Manohar, G. Bolgos, J. Rodriguez, L. Moldawer, and G. Wollenburg. 1995. Blockade of tumor necrosis factor reduces lipopolysaccharide lethality, but not the lethality of cecal ligation and puncture. Shock 4:89.
    • (1995) Shock , vol.4 , pp. 89
    • Remick, D.1    Manohar, P.2    Bolgos, G.3    Rodriguez, J.4    Moldawer, L.5    Wollenburg, G.6
  • 36
    • 0032919556 scopus 로고    scopus 로고
    • Modulation of endotoxin- and enterotoxin-induced cytokine release by in vivo treatment with β-(1,6)-branched β-(1,3)-glucan
    • Soltys, J., and M. T. Quinn. 1999. Modulation of endotoxin- and enterotoxin-induced cytokine release by in vivo treatment with β-(1,6)-branched β-(1,3)-glucan. Infect. Immun. 67:244.
    • (1999) Infect. Immun. , vol.67 , pp. 244
    • Soltys, J.1    Quinn, M.T.2
  • 37
    • 0028783362 scopus 로고
    • Structure-activity relationship of (1→3)-β-glucans in the induction of cytokine production from macrophages in vitro
    • Okazaki, M., Y. Adachi, N. Ohno, and T. Yadomae. 1995. Structure-activity relationship of (1→3)-β-glucans in the induction of cytokine production from macrophages in vitro. Biol. Pharm. Bull. 18:1320.
    • (1995) Biol. Pharm. Bull. , vol.18 , pp. 1320
    • Okazaki, M.1    Adachi, Y.2    Ohno, N.3    Yadomae, T.4
  • 41
    • 0029903114 scopus 로고    scopus 로고
    • Sir Isaac Newton, sepsis, S1RS, and CARS
    • Bone, R. C. 1996. Sir Isaac Newton, sepsis, S1RS, and CARS. Crit. Care Med. 24:1125.
    • (1996) Crit. Care Med. , vol.24 , pp. 1125
    • Bone, R.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.