메뉴 건너뛰기




Volumn 82, Issue 4, 2007, Pages 381-388

Rapamycin: Something old, something new, sometimes borrowed and now renewed

Author keywords

[No Author keywords available]

Indexed keywords

AP 23573; CARBAMAZEPINE; CYCLOSPORIN; CYTOCHROME P450 3A; DEXAMETHASONE; DRUG BINDING PROTEIN; ERYTHROMYCIN; EVEROLIMUS; FK 506 BINDING PROTEIN; GLYCOPROTEIN P; KETOCONAZOLE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PHENOBARBITAL; PHENYTOIN; RAPAMYCIN; RIFAMPICIN; RITONAVIR; SIGNAL PEPTIDE; TEMSIROLIMUS;

EID: 34548700597     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/sj.clpt.6100317     Document Type: Review
Times cited : (209)

References (104)
  • 1
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger, S., Loewith, R. & Hall, M.N. TOR signaling in growth and metabolism. Cell 124, 471-484 (2006).
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 4
    • 8344281974 scopus 로고    scopus 로고
    • Targeting the molecular target of rapamycin (mTOR)
    • Rowinsky, E.K. Targeting the molecular target of rapamycin (mTOR). Curr. Opin. Oncol. 16, 564-575 (2004).
    • (2004) Curr. Opin. Oncol , vol.16 , pp. 564-575
    • Rowinsky, E.K.1
  • 5
    • 20844435467 scopus 로고    scopus 로고
    • The NF1 tumor suppressor critically regulates TSC2 and mTOR
    • Johannessen, C.M. et al. The NF1 tumor suppressor critically regulates TSC2 and mTOR. Proc. Natl. Acad. Sci. USA 102, 8573-8578 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 8573-8578
    • Johannessen, C.M.1
  • 6
    • 33746637660 scopus 로고    scopus 로고
    • Current development of mTOR inhibitors as anticancer agents
    • Faivre, S., Kroemer, G. & Raymond, E. Current development of mTOR inhibitors as anticancer agents. Nat. Rev. Drug Discov. 5, 671-688 (2006).
    • (2006) Nat. Rev. Drug Discov , vol.5 , pp. 671-688
    • Faivre, S.1    Kroemer, G.2    Raymond, E.3
  • 7
    • 11144356304 scopus 로고    scopus 로고
    • S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway
    • Pende, M. et al. S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol. Cell. Biol. 24, 3112-3124 (2004).
    • (2004) Mol. Cell. Biol , vol.24 , pp. 3112-3124
    • Pende, M.1
  • 9
    • 33750211376 scopus 로고    scopus 로고
    • Predicted mechanisms of resistance to mTOR inhibitors
    • Kurmasheva, R.T., Huang, S. & Houghton, P.J. Predicted mechanisms of resistance to mTOR inhibitors. Br. J. Cancer 95, 955-960 (2006).
    • (2006) Br. J. Cancer , vol.95 , pp. 955-960
    • Kurmasheva, R.T.1    Huang, S.2    Houghton, P.J.3
  • 10
    • 0346362997 scopus 로고    scopus 로고
    • Rapamycins: Mechanism of action and cellular resistance
    • Huang, S., Bjornsti, M.A. & Houghton, P.J. Rapamycins: mechanism of action and cellular resistance. Cancer Biol. Ther. 2, 222-232 (2003).
    • (2003) Cancer Biol. Ther , vol.2 , pp. 222-232
    • Huang, S.1    Bjornsti, M.A.2    Houghton, P.J.3
  • 11
    • 0016713286 scopus 로고
    • Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization
    • Sehgal, S.N., Baker, H. & Vezina, C. Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. J. Antibiot. (Tokyo) 28, 727-732 (1975).
    • (1975) J. Antibiot. (Tokyo) , vol.28 , pp. 727-732
    • Sehgal, S.N.1    Baker, H.2    Vezina, C.3
  • 12
    • 0017362502 scopus 로고
    • Inhibition of the immune response by rapamycin, a new antifungal antibiotic
    • Martel, R.R., Klicius, J. & Galet, S. Inhibition of the immune response by rapamycin, a new antifungal antibiotic. Can. J. Physiol. Pharmacol. 55, 48-51 (1977).
    • (1977) Can. J. Physiol. Pharmacol , vol.55 , pp. 48-51
    • Martel, R.R.1    Klicius, J.2    Galet, S.3
  • 13
    • 0024976525 scopus 로고
    • Rapamycin for immunosuppression in organ allografting
    • Calne, R.Y. et al. Rapamycin for immunosuppression in organ allografting. Lancet 2, 227 (1989).
    • (1989) Lancet , vol.2 , pp. 227
    • Calne, R.Y.1
  • 14
    • 0025902276 scopus 로고
    • Preclinical evaluation of a new potent immunosuppressive agent, rapamycin
    • Kahan, B.D., Chang, J.Y. & Sehgal, S.N. Preclinical evaluation of a new potent immunosuppressive agent, rapamycin. Transplantation 52, 185-191 (1991).
    • (1991) Transplantation , vol.52 , pp. 185-191
    • Kahan, B.D.1    Chang, J.Y.2    Sehgal, S.N.3
  • 15
    • 0032823635 scopus 로고    scopus 로고
    • Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action
    • Cardenas, M.E. et al. Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action. Clin. Microbiol. Rev. 12, 583-611 (1999).
    • (1999) Clin. Microbiol. Rev , vol.12 , pp. 583-611
    • Cardenas, M.E.1
  • 16
    • 1842473009 scopus 로고    scopus 로고
    • Antifungal attributes of immunosuppressive agents: New paradigms in management and elucidating the pathophysiologic basis of opportunistic mycoses in organ transplant recipients
    • Singh, N. & Heitman, J. Antifungal attributes of immunosuppressive agents: new paradigms in management and elucidating the pathophysiologic basis of opportunistic mycoses in organ transplant recipients. Transplantation 77, 795-800 (2004).
    • (2004) Transplantation , vol.77 , pp. 795-800
    • Singh, N.1    Heitman, J.2
  • 17
    • 15844391440 scopus 로고    scopus 로고
    • Mechanism of action of the immunosuppressant rapamycin
    • Dumont, F.J. & Su, Q. Mechanism of action of the immunosuppressant rapamycin. Life Sci. 58, 373-395 (1996).
    • (1996) Life Sci , vol.58 , pp. 373-395
    • Dumont, F.J.1    Su, Q.2
  • 18
    • 0018606537 scopus 로고
    • Rapamycin (AY-22,989), a new antifungal antibiotic. IV. Mechanism of action
    • Singh, K., Sun, S. & Vezina, C. Rapamycin (AY-22,989), a new antifungal antibiotic. IV. Mechanism of action. J. Antibiot. (Tokyo) 32, 630-645 (1979).
    • (1979) J. Antibiot. (Tokyo) , vol.32 , pp. 630-645
    • Singh, K.1    Sun, S.2    Vezina, C.3
  • 19
    • 0033376927 scopus 로고    scopus 로고
    • Conversion from liquid to solid rapamycin formulations in stable renal allograft transplant recipients
    • Kelly, P.A., Napoli, K. & Kahan, B.D. Conversion from liquid to solid rapamycin formulations in stable renal allograft transplant recipients. Biopharm. Drug Dispos. 20, 249-253 (1999).
    • (1999) Biopharm. Drug Dispos , vol.20 , pp. 249-253
    • Kelly, P.A.1    Napoli, K.2    Kahan, B.D.3
  • 20
    • 0034804744 scopus 로고    scopus 로고
    • From beach to bedside: History of the development of sirolimus
    • Napoli, K.L. & Taylor, P.J. From beach to bedside: history of the development of sirolimus. Ther. Drug Monit. 23, 559-586 (2001).
    • (2001) Ther. Drug Monit , vol.23 , pp. 559-586
    • Napoli, K.L.1    Taylor, P.J.2
  • 21
    • 0034870203 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of sirolimus
    • Mahalati, K. & Kahan, B.D. Clinical pharmacokinetics of sirolimus. Clin. Pharmacokinet. 40, 573-585 (2001).
    • (2001) Clin. Pharmacokinet , vol.40 , pp. 573-585
    • Mahalati, K.1    Kahan, B.D.2
  • 22
    • 13144256680 scopus 로고    scopus 로고
    • The effects of relative timing of sirolimus and cyclosporine microemulsion formulation coadministration on the pharmacokinetics of each agent
    • Kaplan, B., Meier-Kriesche, H.U., Napoli, K.L. & Kahan, B.D. The effects of relative timing of sirolimus and cyclosporine microemulsion formulation coadministration on the pharmacokinetics of each agent. Clin. Pharmacol. Ther. 63, 48-53 (1998).
    • (1998) Clin. Pharmacol. Ther , vol.63 , pp. 48-53
    • Kaplan, B.1    Meier-Kriesche, H.U.2    Napoli, K.L.3    Kahan, B.D.4
  • 23
    • 0033346578 scopus 로고    scopus 로고
    • The effect of a high-fat meal on the oral bioavailability of the immunosuppressant sirolimus (rapamycin)
    • Zimmerman, J.J., Ferron, G.M., Lim, H.K. & Parker, V. The effect of a high-fat meal on the oral bioavailability of the immunosuppressant sirolimus (rapamycin). J. Clin. Pharmacol. 39, 1155-1161 (1999).
    • (1999) J. Clin. Pharmacol , vol.39 , pp. 1155-1161
    • Zimmerman, J.J.1    Ferron, G.M.2    Lim, H.K.3    Parker, V.4
  • 25
    • 27844596265 scopus 로고    scopus 로고
    • Pharmacokinetics of sirolimus (rapamycin) in subjects with mild to moderate hepatic impairment
    • Zimmerman, J.J. et al. Pharmacokinetics of sirolimus (rapamycin) in subjects with mild to moderate hepatic impairment. J. Clin. Pharmacol. 45, 1368-1372 (2005).
    • (2005) J. Clin. Pharmacol , vol.45 , pp. 1368-1372
    • Zimmerman, J.J.1
  • 26
    • 0032128447 scopus 로고    scopus 로고
    • Rapamycin: Distribution, pharmacokinetics and therapeutic range investigations: an update
    • Trepanier, D.J., Gallant, H., Legatt, D.F. & Yatscoff, R.W. Rapamycin: distribution, pharmacokinetics and therapeutic range investigations: an update. Clin. Biochem. 31, 345-351 (1998).
    • (1998) Clin. Biochem , vol.31 , pp. 345-351
    • Trepanier, D.J.1    Gallant, H.2    Legatt, D.F.3    Yatscoff, R.W.4
  • 27
    • 0034075822 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of sirolimus: Correlations with efficacy and toxicity
    • Kahan, B.D. et al. Therapeutic drug monitoring of sirolimus: correlations with efficacy and toxicity. Clin. Transplant. 14, 97-109 (2000).
    • (2000) Clin. Transplant , vol.14 , pp. 97-109
    • Kahan, B.D.1
  • 28
    • 23744467925 scopus 로고    scopus 로고
    • Sirolimus: The evidence for clinical pharmacokinetic monitoring
    • Stenton, S.B., Partovi, N. & Ensom, M.H. Sirolimus: the evidence for clinical pharmacokinetic monitoring. Clin. Pharmacokinet. 44, 769-786 (2005).
    • (2005) Clin. Pharmacokinet , vol.44 , pp. 769-786
    • Stenton, S.B.1    Partovi, N.2    Ensom, M.H.3
  • 29
    • 2342518773 scopus 로고    scopus 로고
    • Everolimus
    • discussion 864-873
    • Chapman, T.M. & Perry, C.M. Everolimus. Drugs 64, 861-872 (2004); discussion 864-873.
    • (2004) Drugs , vol.64 , pp. 861-872
    • Chapman, T.M.1    Perry, C.M.2
  • 30
    • 0030832514 scopus 로고    scopus 로고
    • SDZ RAD, a new rapamycin derivative: Pharmacological properties in vitro and in vivo
    • Schuler, W. et al. SDZ RAD, a new rapamycin derivative: pharmacological properties in vitro and in vivo. Transplantation 64, 36-42 (1997).
    • (1997) Transplantation , vol.64 , pp. 36-42
    • Schuler, W.1
  • 31
    • 0034901515 scopus 로고    scopus 로고
    • Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition
    • Dudkin, L. et al. Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition. Clin. Cancer Res. 7, 1758-1764 (2001).
    • (2001) Clin. Cancer Res , vol.7 , pp. 1758-1764
    • Dudkin, L.1
  • 32
    • 23944453425 scopus 로고    scopus 로고
    • Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: A North Central Cancer Treatment Group Study
    • Galanis, E. et al. Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study. J. Clin. Oncol. 23, 5294-5304 (2005).
    • (2005) J. Clin. Oncol , vol.23 , pp. 5294-5304
    • Galanis, E.1
  • 33
    • 33749002279 scopus 로고    scopus 로고
    • Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies
    • Yee, K.W. et al. Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies. Clin. Cancer Res. 12, 5165-5173 (2006).
    • (2006) Clin. Cancer Res , vol.12 , pp. 5165-5173
    • Yee, K.W.1
  • 34
    • 17044411266 scopus 로고    scopus 로고
    • Phase I, pharmacokinetic (PK), and pharmacodynamic (PD) study of AP23573, an mTOR inhibitor, administered IV daily X 5 every other week in patients (pts) with refractory or advanced malignancies
    • Mita, M.M. et al. Phase I, pharmacokinetic (PK), and pharmacodynamic (PD) study of AP23573, an mTOR inhibitor, administered IV daily X 5 every other week in patients (pts) with refractory or advanced malignancies. J. Clin. Oncol. (Meeting Abstracts) 22, 3076 (2004).
    • (2004) J. Clin. Oncol. (Meeting Abstracts) , vol.22 , pp. 3076
    • Mita, M.M.1
  • 36
    • 0034746371 scopus 로고    scopus 로고
    • Longitudinal assessment of everolimus in de novo renal transplant recipients over the first post-transplant year: Pharmacokinetics, exposure-response relationships, and influence on cyclosporine
    • Kovarik, J.M. et al. Longitudinal assessment of everolimus in de novo renal transplant recipients over the first post-transplant year: pharmacokinetics, exposure-response relationships, and influence on cyclosporine. Clin. Pharmacol. Ther. 69, 48-56 (2001).
    • (2001) Clin. Pharmacol. Ther , vol.69 , pp. 48-56
    • Kovarik, J.M.1
  • 37
    • 33646946644 scopus 로고    scopus 로고
    • Development of a pharmacokinetic (PK) model and assessment of patient (pt) covariate effects on dose-dependent PK following different dosing schedules in two phase I trials of AP23573 (AP), a mTOR inhibitor
    • Desai, A.A. et al. Development of a pharmacokinetic (PK) model and assessment of patient (pt) covariate effects on dose-dependent PK following different dosing schedules in two phase I trials of AP23573 (AP), a mTOR inhibitor. J. Clin. Oncol. (Meeting Abstracts) 23, 3043 (2005).
    • (2005) J. Clin. Oncol. (Meeting Abstracts) , vol.23 , pp. 3043
    • Desai, A.A.1
  • 38
    • 34548076410 scopus 로고    scopus 로고
    • In Vitro Metabolic Study Of Temsirolimus: Preparation, Isolation, And Identification Of The Metabolites
    • Cai, P., Tsao, R. & Ruppen, M.E. In Vitro Metabolic Study Of Temsirolimus: Preparation, Isolation, And Identification Of The Metabolites. Drug Metab Dispos 35, 1554-1563 (2007).
    • (2007) Drug Metab Dispos , vol.35 , pp. 1554-1563
    • Cai, P.1    Tsao, R.2    Ruppen, M.E.3
  • 39
    • 0035082180 scopus 로고    scopus 로고
    • Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD
    • Jacobsen, W. et al. Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD. Transplant. Proc. 33, 514-515 (2001).
    • (2001) Transplant. Proc , vol.33 , pp. 514-515
    • Jacobsen, W.1
  • 40
    • 0035215119 scopus 로고    scopus 로고
    • Influence of hepatic impairment on everolimus pharmacokinetics: Implications for dose adjustment
    • Kovarik, J.M. et al. Influence of hepatic impairment on everolimus pharmacokinetics: implications for dose adjustment. Clin. Pharmacol. Ther. 70, 425-430 (2001).
    • (2001) Clin. Pharmacol. Ther , vol.70 , pp. 425-430
    • Kovarik, J.M.1
  • 41
    • 0032736334 scopus 로고    scopus 로고
    • Entry-into-human study with the novel immunosuppressant SDZ RAD in stable renal transplant recipients
    • Neumayer, H.H. et al. Entry-into-human study with the novel immunosuppressant SDZ RAD in stable renal transplant recipients. Br. J. Clin. Pharmacol. 48, 694-703 (1999).
    • (1999) Br. J. Clin. Pharmacol , vol.48 , pp. 694-703
    • Neumayer, H.H.1
  • 42
    • 33750321673 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of temsirolimus (CCI-779) administered intravenously daily for 5 days every 2 weeks to patients with advanced cancer
    • Hidalgo, M. et al. A phase I and pharmacokinetic study of temsirolimus (CCI-779) administered intravenously daily for 5 days every 2 weeks to patients with advanced cancer. Clin. Cancer Res. 12, 5755-5763 (2006).
    • (2006) Clin. Cancer Res , vol.12 , pp. 5755-5763
    • Hidalgo, M.1
  • 43
    • 2942735384 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
    • Raymond, E. et al. Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. J. Clin. Oncol. 22, 2336-2347 (2004).
    • (2004) J. Clin. Oncol , vol.22 , pp. 2336-2347
    • Raymond, E.1
  • 44
    • 34147146014 scopus 로고    scopus 로고
    • Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
    • Zeng, Z. et al. Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML. Blood 109, 3509-3512 (2007).
    • (2007) Blood , vol.109 , pp. 3509-3512
    • Zeng, Z.1
  • 45
    • 33745242315 scopus 로고    scopus 로고
    • Antiangiogenic potential of the mammalian target of rapamycin inhibitor temsirolimus
    • Del Bufalo, D. et al. Antiangiogenic potential of the mammalian target of rapamycin inhibitor temsirolimus. Cancer Res. 66, 5549-5554 (2006).
    • (2006) Cancer Res , vol.66 , pp. 5549-5554
    • Del Bufalo, D.1
  • 46
    • 33750238350 scopus 로고    scopus 로고
    • Updated results of a phase II trial of AP23573, a novel mTOR inhibitor, in patients (pts) with advanced soft tissue or bone sarcomas
    • Chawla, S.P. et al. Updated results of a phase II trial of AP23573, a novel mTOR inhibitor, in patients (pts) with advanced soft tissue or bone sarcomas. J. Clin. Oncol. (Meeting Abstracts) 24, 9505 (2006).
    • (2006) J. Clin. Oncol. (Meeting Abstracts) , vol.24 , pp. 9505
    • Chawla, S.P.1
  • 47
    • 33749834063 scopus 로고    scopus 로고
    • Sirolimus - challenging current perspectives
    • Buhaescu, I., Izzedine, H. & Covic, A. Sirolimus - challenging current perspectives. Ther. Drug Monit. 28, 577-584 (2006).
    • (2006) Ther. Drug Monit , vol.28 , pp. 577-584
    • Buhaescu, I.1    Izzedine, H.2    Covic, A.3
  • 48
    • 33645833623 scopus 로고    scopus 로고
    • Brief communication: Sirolimus-associated pneumonitis: 24 cases in renal transplant recipients
    • Champion, L. et al. Brief communication: sirolimus-associated pneumonitis: 24 cases in renal transplant recipients. Ann. Intern. Med. 144, 505-509 (2006).
    • (2006) Ann. Intern. Med , vol.144 , pp. 505-509
    • Champion, L.1
  • 49
    • 33746617583 scopus 로고    scopus 로고
    • Characterisation of the lung toxicity of the cell cycle inhibitor temsirolimus
    • Duran, I. et al. Characterisation of the lung toxicity of the cell cycle inhibitor temsirolimus. Eur. J. Cancer 42, 1875-1880 (2006).
    • (2006) Eur. J. Cancer , vol.42 , pp. 1875-1880
    • Duran, I.1
  • 51
    • 33746058731 scopus 로고    scopus 로고
    • Safety, tolerability, and efficacy of everolimus in de novo liver transplant recipients: 12- and 36-month results
    • Levy, G. et al. Safety, tolerability, and efficacy of everolimus in de novo liver transplant recipients: 12- and 36-month results. Liver Transpl. 12, 1640-1648 (2006).
    • (2006) Liver Transpl , vol.12 , pp. 1640-1648
    • Levy, G.1
  • 52
    • 33644856861 scopus 로고    scopus 로고
    • Everolimus versus azathioprine in maintenance lung transplant recipients: An international, randomized, double-blind clinical trial
    • Snell, G.I. et al. Everolimus versus azathioprine in maintenance lung transplant recipients: an international, randomized, double-blind clinical trial. Am. J. Transplant. 6, 169-177 (2006).
    • (2006) Am. J. Transplant , vol.6 , pp. 169-177
    • Snell, G.I.1
  • 53
    • 20844461132 scopus 로고    scopus 로고
    • Sirolimus in de novo heart transplant recipients reduces acute rejection and prevents coronary artery disease at 2 years: A randomized clinical trial
    • Keogh, A. et al. Sirolimus in de novo heart transplant recipients reduces acute rejection and prevents coronary artery disease at 2 years: a randomized clinical trial. Circulation 110, 2694-2700 (2004).
    • (2004) Circulation , vol.110 , pp. 2694-2700
    • Keogh, A.1
  • 54
    • 17644398757 scopus 로고    scopus 로고
    • Rapamycin successfully treats post-transplant autoimmune hepatitis
    • Kerkar, N. et al. Rapamycin successfully treats post-transplant autoimmune hepatitis. Am. J. Transplant. 5, 1085-1089 (2005).
    • (2005) Am. J. Transplant , vol.5 , pp. 1085-1089
    • Kerkar, N.1
  • 55
    • 4644262759 scopus 로고    scopus 로고
    • Sirolimus for GVHD prophylaxis in allogeneic stem cell transplantation
    • Cutler, C. & Antin, J.H. Sirolimus for GVHD prophylaxis in allogeneic stem cell transplantation. Bone Marrow Transplant. 34, 471-476 (2004).
    • (2004) Bone Marrow Transplant , vol.34 , pp. 471-476
    • Cutler, C.1    Antin, J.H.2
  • 56
    • 0035660613 scopus 로고    scopus 로고
    • Sirolimus (rapamycin) for the treatment of steroid-refractory acute graft-versus-host disease
    • Benito, A.I. et al. Sirolimus (rapamycin) for the treatment of steroid-refractory acute graft-versus-host disease. Transplantation 72, 1924-1929 (2001).
    • (2001) Transplantation , vol.72 , pp. 1924-1929
    • Benito, A.I.1
  • 57
    • 24944570255 scopus 로고    scopus 로고
    • Sirolimus in combination with tacrolimus and corticosteroids for the treatment of resistant chronic graft-versus-host disease
    • Couriel, D.R. et al. Sirolimus in combination with tacrolimus and corticosteroids for the treatment of resistant chronic graft-versus-host disease. Br. J. Haematol. 130, 409-417 (2005).
    • (2005) Br. J. Haematol , vol.130 , pp. 409-417
    • Couriel, D.R.1
  • 58
    • 33749345289 scopus 로고    scopus 로고
    • Rapamycin reduces disease activity and normalizes T cell activation-induced calcium fluxing in patients with systemic lupus erythematosus
    • Fernandez, D., Bonilla, E., Mirza, N., Niland, B. & Perl, A. Rapamycin reduces disease activity and normalizes T cell activation-induced calcium fluxing in patients with systemic lupus erythematosus. Arthritis Rheum. 54, 2983-2988 (2006).
    • (2006) Arthritis Rheum , vol.54 , pp. 2983-2988
    • Fernandez, D.1    Bonilla, E.2    Mirza, N.3    Niland, B.4    Perl, A.5
  • 59
    • 12844270561 scopus 로고    scopus 로고
    • Rapamycin (sirolimus) as a steroid-sparing agent in dermatomyositis
    • Nadiminti, U. & Arbiser, J.L. Rapamycin (sirolimus) as a steroid-sparing agent in dermatomyositis. J. Am. Acad. Dermatol. 52, 17-19 (2005).
    • (2005) J. Am. Acad. Dermatol , vol.52 , pp. 17-19
    • Nadiminti, U.1    Arbiser, J.L.2
  • 60
    • 33646235411 scopus 로고    scopus 로고
    • Sirolimus rescue for tacrolimus-associated post-transplant autoimmune hemolytic anemia
    • Valentini, R.P. et al. Sirolimus rescue for tacrolimus-associated post-transplant autoimmune hemolytic anemia. Pediatr. Transplant. 10, 358-361 (2006).
    • (2006) Pediatr. Transplant , vol.10 , pp. 358-361
    • Valentini, R.P.1
  • 61
    • 20844444336 scopus 로고    scopus 로고
    • Efficacy of rapamycin in patient with juvenile rheumatoid arthritis
    • Foroncewicz, B., Mucha, K., Paczek, L., Chmura, A. & Rowinski, W. Efficacy of rapamycin in patient with juvenile rheumatoid arthritis. Transpl. Int. 18, 366-368 (2005).
    • (2005) Transpl. Int , vol.18 , pp. 366-368
    • Foroncewicz, B.1    Mucha, K.2    Paczek, L.3    Chmura, A.4    Rowinski, W.5
  • 62
    • 0034636055 scopus 로고    scopus 로고
    • The immunosuppressive macrolide RAD inhibits growth of human Epstein-Barr virus-transformed B lymphocytes in vitro and in vivo: A potential approach to prevention and treatment of posttransplant lymphoproliferative disorders
    • Majewski, M. et al. The immunosuppressive macrolide RAD inhibits growth of human Epstein-Barr virus-transformed B lymphocytes in vitro and in vivo: a potential approach to prevention and treatment of posttransplant lymphoproliferative disorders. Proc. Natl. Acad. Sci. USA 97, 4285-4290 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 4285-4290
    • Majewski, M.1
  • 63
    • 0026636411 scopus 로고
    • Rapamycin prevents the onset of insulin-dependent diabetes mellitus (IDDM) in NOD mice
    • Baeder, W.L., Sredy, J., Sehgal, S.N., Chang, J.Y. & Adams, L.M. Rapamycin prevents the onset of insulin-dependent diabetes mellitus (IDDM) in NOD mice. Clin. Exp. Immunol. 89, 174-178 (1992).
    • (1992) Clin. Exp. Immunol , vol.89 , pp. 174-178
    • Baeder, W.L.1    Sredy, J.2    Sehgal, S.N.3    Chang, J.Y.4    Adams, L.M.5
  • 64
    • 0031423936 scopus 로고    scopus 로고
    • Tacrolimus-rapamycin combination therapy for experimental autoimmune uveoretinitis
    • Ikeda, E., Hikita, N., Eto, K. & Mochizuki, M. Tacrolimus-rapamycin combination therapy for experimental autoimmune uveoretinitis. Jpn. J. Ophthalmol. 41, 396-402 (1997).
    • (1997) Jpn. J. Ophthalmol , vol.41 , pp. 396-402
    • Ikeda, E.1    Hikita, N.2    Eto, K.3    Mochizuki, M.4
  • 65
    • 0028858836 scopus 로고
    • Synergistic effect of rapamycin and cyclosporin A in the treatment of experimental autoimmune uveoretinitis
    • Martin, D.F., DeBarge, L.R., Nussenblatt, R.B., Chan, C.C. & Roberge, F.G. Synergistic effect of rapamycin and cyclosporin A in the treatment of experimental autoimmune uveoretinitis. J. Immunol. 154, 922-927 (1995).
    • (1995) J. Immunol , vol.154 , pp. 922-927
    • Martin, D.F.1    DeBarge, L.R.2    Nussenblatt, R.B.3    Chan, C.C.4    Roberge, F.G.5
  • 66
    • 33748681906 scopus 로고    scopus 로고
    • Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)
    • Teachey, D.T. et al. Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS). Blood 108, 1965-1971 (2006).
    • (2006) Blood , vol.108 , pp. 1965-1971
    • Teachey, D.T.1
  • 67
    • 0345166113 scopus 로고    scopus 로고
    • Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling
    • Brown, V.I. et al. Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling. Proc. Natl. Acad. Sci. USA 100, 15113-15118 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 15113-15118
    • Brown, V.I.1
  • 68
    • 0028289245 scopus 로고
    • The effect of dexamethasone, cyclosporine, and rapamycin on T-lymphocyte proliferation in vitro: Comparison of cells from patients with glucocorticoid-sensitive and glucocorticoid-resistant chronic asthma
    • Haczku, A. et al. The effect of dexamethasone, cyclosporine, and rapamycin on T-lymphocyte proliferation in vitro: comparison of cells from patients with glucocorticoid-sensitive and glucocorticoid-resistant chronic asthma. J. Allergy Clin. Immunol. 93, 510-519 (1994).
    • (1994) J. Allergy Clin. Immunol , vol.93 , pp. 510-519
    • Haczku, A.1
  • 69
    • 33745861719 scopus 로고    scopus 로고
    • Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4+ T cells
    • Valmori, D. et al. Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4+ T cells. J. Immunol. 177, 944-949 (2006).
    • (2006) J. Immunol , vol.177 , pp. 944-949
    • Valmori, D.1
  • 70
    • 34247503135 scopus 로고    scopus 로고
    • Rapamycin enhances the number of alloantigen-induced human CD103+CD8+ regulatory T cells in vitro
    • Uss, E., Yong, S.L., Hooibrink, B., van Lier, R.A. & ten Berge, I.J. Rapamycin enhances the number of alloantigen-induced human CD103+CD8+ regulatory T cells in vitro. Transplantation 83, 1098-1106 (2007).
    • (2007) Transplantation , vol.83 , pp. 1098-1106
    • Uss, E.1    Yong, S.L.2    Hooibrink, B.3    van Lier, R.A.4    ten Berge, I.J.5
  • 71
    • 0742322207 scopus 로고    scopus 로고
    • Acceleration of apoptosis in CD4+CD8+ thymocytes by rapamycin accompanied by increased CD4+CD25+ T cells in the periphery
    • Tian, L., Lu, L., Yuan, Z., Lamb, J.R. & Tam, P.K. Acceleration of apoptosis in CD4+CD8+ thymocytes by rapamycin accompanied by increased CD4+CD25+ T cells in the periphery. Transplantation 77, 183-189 (2004).
    • (2004) Transplantation , vol.77 , pp. 183-189
    • Tian, L.1    Lu, L.2    Yuan, Z.3    Lamb, J.R.4    Tam, P.K.5
  • 72
    • 23944439945 scopus 로고    scopus 로고
    • Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer
    • Chan, S. et al. Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer. J. Clin. Oncol. 23, 5314-5322 (2005).
    • (2005) J. Clin. Oncol , vol.23 , pp. 5314-5322
    • Chan, S.1
  • 73
    • 1542398693 scopus 로고    scopus 로고
    • Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
    • Atkins, M.B. et al. Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J. Clin. Oncol. 22, 909-918 (2004).
    • (2004) J. Clin. Oncol , vol.22 , pp. 909-918
    • Atkins, M.B.1
  • 74
    • 33748363166 scopus 로고    scopus 로고
    • A phase 3, randomized, 3-arm study of temsirolimus (TEMSR) or interferon-alpha (IFN) or the combination of TEMSR+IFN in the treatment of first-line, poor-risk patients with advanced renal cell carcinoma (adv RCC)
    • Hudes, G. et al. A phase 3, randomized, 3-arm study of temsirolimus (TEMSR) or interferon-alpha (IFN) or the combination of TEMSR+IFN in the treatment of first-line, poor-risk patients with advanced renal cell carcinoma (adv RCC). J. Clin. Oncol. (Meeting Abstracts) 24, LBA4 (2006).
    • (2006) J. Clin. Oncol. (Meeting Abstracts) , vol.24
    • Hudes, G.1
  • 75
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    • Hudes, G. et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N. Engl. J. Med. 356, 2271-2281 (2007).
    • (2007) N. Engl. J. Med , vol.356 , pp. 2271-2281
    • Hudes, G.1
  • 76
    • 0033557578 scopus 로고    scopus 로고
    • Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells
    • Hosoi, H. et al. Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells. Cancer Res. 59, 886-894 (1999).
    • (1999) Cancer Res , vol.59 , pp. 886-894
    • Hosoi, H.1
  • 77
    • 1642540093 scopus 로고    scopus 로고
    • Rapamycin induces the fusion-type independent downregulation of the EWS/FLI-1 proteins and inhibits Ewing's sarcoma cell proliferation
    • Mateo-Lozano, S., Tirado, O.M. & Notario, V. Rapamycin induces the fusion-type independent downregulation of the EWS/FLI-1 proteins and inhibits Ewing's sarcoma cell proliferation. Oncogene 22, 9282-9287 (2003).
    • (2003) Oncogene , vol.22 , pp. 9282-9287
    • Mateo-Lozano, S.1    Tirado, O.M.2    Notario, V.3
  • 78
    • 16844366544 scopus 로고    scopus 로고
    • Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma
    • Wan, X., Mendoza, A., Khanna, C. & Helman, L.J. Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma. Cancer Res. 65, 2406-2411 (2005).
    • (2005) Cancer Res , vol.65 , pp. 2406-2411
    • Wan, X.1    Mendoza, A.2    Khanna, C.3    Helman, L.J.4
  • 79
    • 28844480101 scopus 로고    scopus 로고
    • mTOR regulates cell survival after etoposide treatment in primary AML cells
    • Xu, Q., Thompson, J.E. & Carroll, M. mTOR regulates cell survival after etoposide treatment in primary AML cells. Blood 106, 4261-4268 (2005).
    • (2005) Blood , vol.106 , pp. 4261-4268
    • Xu, Q.1    Thompson, J.E.2    Carroll, M.3
  • 80
    • 0037207525 scopus 로고    scopus 로고
    • Rapamycin-induced G1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and survivin
    • Decker, T. et al. Rapamycin-induced G1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and survivin. Blood 101, 278-285 (2003).
    • (2003) Blood , vol.101 , pp. 278-285
    • Decker, T.1
  • 81
    • 33846516354 scopus 로고    scopus 로고
    • Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma
    • Haritunians, T. et al. Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma. Leukemia 21, 333-339 (2007).
    • (2007) Leukemia , vol.21 , pp. 333-339
    • Haritunians, T.1
  • 82
    • 33745095268 scopus 로고    scopus 로고
    • Targeting the Akt/mammalian target of rapamycin pathway for radiosensitization of breast cancer
    • Albert, J.M., Kim, K.W., Cao, C. & Lu, B. Targeting the Akt/mammalian target of rapamycin pathway for radiosensitization of breast cancer. Mol. Cancer Ther. 5, 1183-1189 (2006).
    • (2006) Mol. Cancer Ther , vol.5 , pp. 1183-1189
    • Albert, J.M.1    Kim, K.W.2    Cao, C.3    Lu, B.4
  • 83
    • 20244365941 scopus 로고    scopus 로고
    • The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation
    • Beuvink, I. et al. The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. Cell 120, 747-759 (2005).
    • (2005) Cell , vol.120 , pp. 747-759
    • Beuvink, I.1
  • 84
    • 19944431403 scopus 로고    scopus 로고
    • Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse models
    • Lee, L. et al. Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse models. Genes Chromosomes Cancer 42, 213-227 (2005).
    • (2005) Genes Chromosomes Cancer , vol.42 , pp. 213-227
    • Lee, L.1
  • 85
    • 33748499592 scopus 로고    scopus 로고
    • Rapamycin induces regression of endometriotic lesions by inhibiting neovascularization and cell proliferation
    • Laschke, M.W. et al. Rapamycin induces regression of endometriotic lesions by inhibiting neovascularization and cell proliferation. Br. J. Pharmacol. 149, 137-144 (2006).
    • (2006) Br. J. Pharmacol , vol.149 , pp. 137-144
    • Laschke, M.W.1
  • 86
    • 13944281689 scopus 로고    scopus 로고
    • Inhibitory effect of rapamycin on corneal neovascularization in vitro and in vivo
    • Kwon, Y.S., Hong, H.S., Kim, J.C., Shin, J.S. & Son, Y. Inhibitory effect of rapamycin on corneal neovascularization in vitro and in vivo. Invest. Ophthalmol. Vis. Sci. 46, 454-460 (2005).
    • (2005) Invest. Ophthalmol. Vis. Sci , vol.46 , pp. 454-460
    • Kwon, Y.S.1    Hong, H.S.2    Kim, J.C.3    Shin, J.S.4    Son, Y.5
  • 87
    • 20144363954 scopus 로고    scopus 로고
    • Antileukemic activity of rapamycin in acute myeloid leukemia
    • Recher, C. et al. Antileukemic activity of rapamycin in acute myeloid leukemia. Blood 105, 2527-2534 (2005).
    • (2005) Blood , vol.105 , pp. 2527-2534
    • Recher, C.1
  • 88
    • 20044396552 scopus 로고    scopus 로고
    • Activity of sirolimus in patients with myelodysplastic syndrome - results of a pilot study
    • Platzbecker, U. et al. Activity of sirolimus in patients with myelodysplastic syndrome - results of a pilot study. Br. J. Haematol. 128, 625-630 (2005).
    • (2005) Br. J. Haematol , vol.128 , pp. 625-630
    • Platzbecker, U.1
  • 89
    • 33644827461 scopus 로고    scopus 로고
    • Rapamycin causes regression of astrocytomas in tuberous sclerosis complex
    • Franz, D.N. et al. Rapamycin causes regression of astrocytomas in tuberous sclerosis complex. Ann. Neurol. 59, 490-498 (2006).
    • (2006) Ann. Neurol , vol.59 , pp. 490-498
    • Franz, D.N.1
  • 90
    • 4143135132 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled trial of oral sirolimus for restenosis prevention in patients with in-stent restenosis: The Oral Sirolimus to Inhibit Recurrent In-stent Stenosis (OSIRIS) trial
    • Hausleiter, J. et al. Randomized, double-blind, placebo-controlled trial of oral sirolimus for restenosis prevention in patients with in-stent restenosis: the Oral Sirolimus to Inhibit Recurrent In-stent Stenosis (OSIRIS) trial. Circulation 110, 790-795 (2004).
    • (2004) Circulation , vol.110 , pp. 790-795
    • Hausleiter, J.1
  • 91
    • 0141765805 scopus 로고    scopus 로고
    • Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery
    • Moses, J.W. et al. Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery. N. Engl. J. Med. 349, 1315-1323 (2003).
    • (2003) N. Engl. J. Med , vol.349 , pp. 1315-1323
    • Moses, J.W.1
  • 92
    • 33645769011 scopus 로고    scopus 로고
    • The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease
    • Shillingford, J.M. et al. The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc. Natl. Acad. Sci. USA 103, 5466-5471 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 5466-5471
    • Shillingford, J.M.1
  • 93
    • 0037382861 scopus 로고    scopus 로고
    • Rapamycin attenuates load-induced cardiac hypertrophy in mice
    • Shioi, T. et al. Rapamycin attenuates load-induced cardiac hypertrophy in mice. Circulation 107, 1664-1670 (2003).
    • (2003) Circulation , vol.107 , pp. 1664-1670
    • Shioi, T.1
  • 94
    • 26044478426 scopus 로고    scopus 로고
    • Rapamycin ameliorates experimental autoimmune myocarditis
    • Maeda, K. et al. Rapamycin ameliorates experimental autoimmune myocarditis. Int. Heart J. 46, 513-530 (2005).
    • (2005) Int. Heart J , vol.46 , pp. 513-530
    • Maeda, K.1
  • 95
    • 2542422760 scopus 로고    scopus 로고
    • Mammalian target of rapamycin positively regulates collagen type I production via a phosphatidylinositol 3-kinase-independent pathway
    • Shegogue, D. & Trojanowska, M. Mammalian target of rapamycin positively regulates collagen type I production via a phosphatidylinositol 3-kinase-independent pathway. J. Biol. Chem. 279, 23166-23175 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 23166-23175
    • Shegogue, D.1    Trojanowska, M.2
  • 96
    • 0035991346 scopus 로고    scopus 로고
    • The rapamycin analogue SDZ RAD attenuates bleomycin-induced pulmonary fibrosis in rats
    • Simler, N.R. et al. The rapamycin analogue SDZ RAD attenuates bleomycin-induced pulmonary fibrosis in rats. Eur. Respir. J. 19, 1124-1127 (2002).
    • (2002) Eur. Respir. J , vol.19 , pp. 1124-1127
    • Simler, N.R.1
  • 97
    • 19444366644 scopus 로고    scopus 로고
    • Long-term treatment of bile duct-ligated rats with rapamycin (sirolimus) significantly attenuates liver fibrosis: Analysis of the underlying mechanisms
    • Biecker, E. et al. Long-term treatment of bile duct-ligated rats with rapamycin (sirolimus) significantly attenuates liver fibrosis: analysis of the underlying mechanisms. J. Pharmacol. Exp. Ther. 313, 952-961 (2005).
    • (2005) J. Pharmacol. Exp. Ther , vol.313 , pp. 952-961
    • Biecker, E.1
  • 98
    • 27744489524 scopus 로고    scopus 로고
    • Rapamycin ameliorates proteinuria-associated tubulointerstitial inflammation and fibrosis in experimental membranous nephropathy
    • Bonegio, R.G. et al. Rapamycin ameliorates proteinuria-associated tubulointerstitial inflammation and fibrosis in experimental membranous nephropathy. J. Am. Soc. Nephrol. 16, 2063-2072 (2005).
    • (2005) J. Am. Soc. Nephrol , vol.16 , pp. 2063-2072
    • Bonegio, R.G.1
  • 99
    • 0036566266 scopus 로고    scopus 로고
    • Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy
    • Ravikumar, B., Duden, R. & Rubinsztein, D.C. Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum. Mol. Genet. 11, 1107-1117 (2002).
    • (2002) Hum. Mol. Genet , vol.11 , pp. 1107-1117
    • Ravikumar, B.1    Duden, R.2    Rubinsztein, D.C.3
  • 100
    • 2642586352 scopus 로고    scopus 로고
    • Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
    • Ravikumar, B. et al. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat. Genet. 36, 585-595 (2004).
    • (2004) Nat. Genet , vol.36 , pp. 585-595
    • Ravikumar, B.1
  • 101
    • 0041335573 scopus 로고    scopus 로고
    • Rapamycin causes down-regulation of CCR5 and accumulation of anti-HIV beta-chemokines: An approach to suppress R5 strains of HIV-1
    • Heredia, A. et al. Rapamycin causes down-regulation of CCR5 and accumulation of anti-HIV beta-chemokines: an approach to suppress R5 strains of HIV-1. Proc. Natl. Acad. Sci. USA 100, 10411-10416 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 10411-10416
    • Heredia, A.1
  • 102
    • 0035887446 scopus 로고    scopus 로고
    • Human immunodeficiency virus 1 envelope glycoprotein complex-induced apoptosis involves mammalian target of rapamycin/FKBP12-rapamycin-associated protein-mediated p53 phosphorylation
    • Castedo, M. et al. Human immunodeficiency virus 1 envelope glycoprotein complex-induced apoptosis involves mammalian target of rapamycin/FKBP12-rapamycin-associated protein-mediated p53 phosphorylation. J. Exp. Med. 194, 1097-1110 (2001).
    • (2001) J. Exp. Med , vol.194 , pp. 1097-1110
    • Castedo, M.1
  • 103
    • 3342958797 scopus 로고    scopus 로고
    • The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
    • Harrington, L.S. et al. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J. Cell. Biol. 166, 213-223 (2004).
    • (2004) J. Cell. Biol , vol.166 , pp. 213-223
    • Harrington, L.S.1
  • 104
    • 4544220704 scopus 로고    scopus 로고
    • Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
    • Um, S.H. et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431, 200-205 (2004).
    • (2004) Nature , vol.431 , pp. 200-205
    • Um, S.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.