Chapter 13 Oxygen as a Direct and Indirect Biological Determinant in the Vasculature

Methods in Enzymology

Volumn 444, Issue , 2008, Pages 285-304

  Huang, Yan ^a   Giordano, Frank J ^a  

^a Vascular Biology and Translation Program ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEME OXYGENASE 1; HEME OXYGENASE 2; HYDROGEN PEROXIDE; HYPOXIA INDUCIBLE FACTOR 1; OXYGEN; POTASSIUM CHANNEL; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4;

ANEURYSM; ANGIOGENESIS; BLOOD VESSEL FUNCTION; HUMAN; HYPOXIA; MITOCHONDRION; MOLECULAR MECHANICS; OXYGEN BLOOD LEVEL; OXYGEN CONSUMPTION; OXYGEN SENSING; OXYGEN TRANSPORT; PARACRINE SIGNALING; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; STENT; VASOCONSTRICTION; VASODILATATION;

ANIMALS; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; OXYGEN; SIGNAL TRANSDUCTION; VASODILATION;

EID: 55449136999     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(08)02813-9     Document Type: Review

References (72)

1. Abbott J.D., Huang Y., Liu D., Hickey R., Krause D.S., and Giordano F.J. Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury. Circulation 110 (2004) 3300-3305
2. Adachi T., Ishikawa K., Hida W., Matsumoto H., Masuda T., Date F., Ogawa K., Takeda K., Furuyama K., Zhang Y., Kitamuro T., Ogawa H., et al. Hypoxemia and blunted hypoxic ventilatory responses in mice lacking heme oxygenase-2. Biochem. Biophys. Res. Commun. 320 (2004) 514-522
3. Archer S.L., Gomberg-Maitland M., Maitland M.L., Rich S., Garcia J.G., and Weir E.K. Mitochondrial metabolism, redox signaling, and fusion: A mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer. Am. J. Physiol. 294 (2008) H570-H578
4. Cheema A.N., Hong T., Nili N., Segev A., Moffat J.G., Lipson K.E., Howlett A.R., Holdsworth D.W., Cole M.J., Qiang B., Kolodgie F., Virmani R., et al. Adventitial microvessel formation after coronary stenting and the effects of SU11218, a tyrosine kinase inhibitor. J. Am. Coll. Cardiol. 47 (2006) 1067-1075
5. Choke E., Cockerill G.W., Dawson J., Chung Y.L., Griffiths J., Wilson R.W., Loftus I.M., and Thompson M.M. Hypoxia at the site of abdominal aortic aneurysm rupture is not associated with increased lactate. Ann. N. Y. Acad. Sci. 1085 (2006) 306-310
6. Cornfield D.N., Reeve H.L., Tolarova S., Weir E.K., and Archer S. Oxygen causes fetal pulmonary vasodilation through activation of a calcium-dependent potassium channel. Proc. Natl. Acad. Sci. USA 93 (1996) 8089-8094
7. Delp M.D., and O'Leary D.S. Integrative control of the skeletal muscle microcirculation in the maintenance of arterial pressure during exercise. J. Appl. Physiol. (Bethesda) 97 (2004) 1112-1118
8. Duncker D.J., and Merkus D. Acute adaptations of the coronary circulation to exercise. Cell Biochem. Biophys. 43 (2005) 17-35
9. Feigl E.O. Coronary physiology. Physiol. Rev. 63 (1983) 1-205
10. Finkel T. Redox-dependent signal transduction. FEBS Lett. 476 (2000) 52-54
11. Giaccia A., Siim B.G., and Johnson R.S. HIF-1 as a target for drug development. Nat. Rev. 2 (2003) 803-811
12. Giaccia A.J., Simon M.C., and Johnson R. The biology of hypoxia: The role of oxygen sensing in development, normal function, and disease. Genes Dev. 18 (2004) 2183-2194
13. Giordano F.J. Oxygen, oxidative stress, hypoxia, and heart failure. J. Clin. Invest. 115 (2005) 500-508
14. Giordano F.J., Gerber H.P., Williams S.P., VanBruggen N., Bunting S., Ruiz-Lozano P., Gu Y., Nath A.K., Huang Y., Hickey R., Dalton N., Peterson K.L., et al. A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function. Proc. Natl. Acad. Sci. USA 98 (2001) 5780-5785
15. Gordan J.D., and Simon M.C. Hypoxia-inducible factors: Central regulators of the tumor phenotype. Currt. Opin. Genet. Dev. 17 (2007) 71-77
16. Goyal P., Weissmann N., Grimminger F., Hegel C., Bader L., Rose F., Fink L., Ghofrani H.A., Schermuly R.T., Schmidt H.H., Seeger W., and Hänze J. Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species. Free Radic. Biol. Med. 36 (2004) 1279-1288
17. Griendling K.K., and Ushio-Fukai M. NAD(P)H oxidase: Role in cardiovascular biology and disease. Circ Res. 86 (2000) 494-501
18. Gurney A.M., Osipenko O.N., MacMillan D., McFarlane K.M., Tate R.J., and Kempsill F.E. Two-pore domain K channel, TASK-1, in pulmonary artery smooth muscle cells. Circ. Res. 93 (2003) 957-964
19. Haase V.H., Glickman J.N., Socolovsky M., and Jaenisch R. Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc. Natl. Acad. Sci. USA 98 (2001) 1583-1588
20. Hickey M.M., and Simon M.C. Regulation of angiogenesis by hypoxia and hypoxia-inducible factors. Curr. Top. Dev. Biol. 76 (2006) 217-257
21. Hogg D.S., Davies A.R., McMurray G., and Kozlowski R.Z. K(V)2.1 channels mediate hypoxic inhibition of I(KV) in native pulmonary arterial smooth muscle cells of the rat. Cardiovas. Res. 55 (2002) 349-360
22. Hoshi T., and Lahiri S. Cell biology. Oxygen sensing: It's a gas Science 306 (2004) 2050-2051
23. Huang Y., Hickey R.P., Yeh J.L., Liu D., Dadak A., Young L.H., Johnson R.S., and Giordano F.J. Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart. FASEB J. 18 (2004) 1138-1140
24. Jaakkola P., Mole D.R., Tian Y.M., Wilson M.I., Gielbert J., Gaskell S.J., Kriegsheim A.V., Hebestreit H.F., Mukherji M., Schofield C.J., Maxwell P.H., Pugh C.W., et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292 (2001) 468-472
25. Jo D.Y., Rafii S., Hamada T., and Moore M.A. Chemotaxis of primitive hematopoietic cells in response to stromal cell-derived factor-1. J. Clin. Invest. 105 (2000) 101-111
26. Kaelin W.G. Proline hydroxylation and gene expression. Annu. Rev. Biochem. 74 (2005) 115-128
27. Kang T.M., Park M.K., and Uhm D.Y. Characterization of hypoxia-induced [Ca2+]i rise in rabbit pulmonary arterial smooth muscle cells. Life Sci. 70 (2002) 2321-2333
28. Kang T.M., Park M.K., and Uhm D.Y. Effects of hypoxia and mitochondrial inhibition on the capacitative calcium entry in rabbit pulmonary arterial smooth muscle cells. Life Sci. 72 (2003) 1467-1479
29. Karshovska E., Zernecke A., Sevilmis G., Millet A., Hristov M., Cohen C.D., Schmid H., Krotz F., Sohn H.Y., Klauss V., Weber C., and Schober A. Expression of HIF-1alpha in injured arteries controls SDF-1alpha mediated neointima formation in apolipoprotein E deficient mice. Arterioscler. Thromb. Vasc. Biol. 27 (2007) 2540-2547
30. Kudo F.A., Muto A., Maloney S.P., Pimiento J.M., Bergaya S., Fitzgerald T.N., Westvik T.S., Frattini J.C., Breuer C.K., Cha C.H., Nishibe T., Tellides G., et al. Venous identity is lost but arterial identity is not gained during vein graft adaptation. Arteriosclerosis, thrombosis, and vascular biology 27 (2007) 1562-1571
31. Lahiri S., Roy A., Baby S.M., Hoshi T., Semenza G.L., and Prabhakar N.R. Oxygen sensing in the body. Prog. Biophys. Mol. Biol. 91 (2006) 249-286
32. Lei L., Mason S., Liu D., Huang Y., Marks C., Hickey R., Jovin I.S., Pypaert M., Johnson R.S., and Giordano F.J. Hypoxia inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein. Mol. Cell Biol. 28 (2008) 3790-3803
33. Maxwell P.H., Wiesener M.S., Chang G.W., Clifford S.C., Vaux E.C., Cockman M.E., Wykoff C.C., Pugh C.W., Maher E.R., and Ratcliffe P.J. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399 (1999) 271-275
34. Morita T., Perrella M.A., Lee M.E., and Kourembanas S. Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP. Proc. Natl. Acad. Sci. USA 92 (1995) 1475-1479
35. Moudgil R., Michelakis E.D., and Archer S.L. Hypoxic pulmonary vasoconstriction. J. Appl. Physiol. (Bethesda) 98 (2005) 390-403
36. Moulton K.S., Heller E., Konerding M.A., Flynn E., Palinski W., and Folkman J. Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice. Circulation 99 (1999) 1726-1732
37. Moulton K.S., Vakili K., Zurakowski D., Soliman M., Butterfield C., Sylvin E., Lo K.M., Gillies S., Javaherian K., and Folkman J. Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis. Proc. Natl. Acad. Sci. USA 100 (2003) 4736-4741
38. Nakano D., Hayashi T., Tazawa N., Yamashita C., Inamoto S., Okuda N., Mori T., Sohmiya K., Kitaura Y., Okada Y., and Matsumura Y. Chronic hypoxia accelerates the progression of atherosclerosis in apolipoprotein E-knockout mice. Hypertens. Res. 28 (2005) 837-845
39. Ortega-Saenz P., Pascual A., Gómez-Díaz R., and López-Barneo J. Acute oxygen sensing in heme oxygenase-2 null mice. J. Gen. Physiol. 128 (2006) 405-411
40. Osipenko O.N., Tate R.J., and Gurney A.M. Potential role for kv3.1b channels as oxygen sensors. Circ. Res. 86 (2000) 534-540
41. Paffett M.L., and Walker B.R. Vascular adaptations to hypoxia: Molecular and cellular mechanisms regulating vascular tone. Essays Biochem. 43 (2007) 105-119
42. Peng Y.J., Yuan G., Ramakrishnan D., Sharma S.D., Bosch-Marce M., Kumar G.K., Semenza G.L., and Prabhakar N.R. Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia. J. Physiol. 577 (2006) 705-716
43. Rajagopalan S., Olin J., Deitcher S., Pieczek A., Laird J., Grossman P.M., Goldman C.K., McEllin K., Kelly R., and Chronos N. Use of a constitutively active hypoxia-inducible factor-1alpha transgene as a therapeutic strategy in no-option critical limb ischemia patients: Phase I dose-escalation experience. Circulation 115 (2007) 1234-1243
44. Rankin E.B., and Giaccia A.J. The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ. 15 (2008) 678-685
45. Safran M., and Kaelin Jr. W.G. HIF hydroxylation and the mammalian oxygen-sensing pathway. J. Clin. Invest. 111 (2003) 779-783
46. Schaper W., and Scholz D. Factors regulating arteriogenesis. Arterioscler. Thromb. Vasc. Biol. 23 (2003) 1143-1151
47. Schioppa T., Uranchimeg B., Saccani A., Biswas S.K., Doni A., Rapisarda A., Bernasconi S., Saccani S., Nebuloni M., Vago L., Mantovani A., Melillo G., et al. Regulation of the chemokine receptor CXCR4 by hypoxia. J. Exp. Med. 198 (2003) 1391-1402
48. Scholz D., Cai W.J., and Schaper W. Arteriogenesis, a new concept of vascular adaptation in occlusive disease. Angiogenesis 4 (2001) 247-257
49. Semenza G.L. Hydroxylation of HIF-1: Oxygen sensing at the molecular level. Physiology (Bethesda) 19 (2004) 176-182
50. Semenza G.L. O2-regulated gene expression: Transcriptional control of cardiorespiratory physiology by HIF-1. J. Appl. Physiol. 96 (2004) 1173 1117; discussion 1170-1172
51. Semenza G.L. Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia-inducible factor 1. Exp. Physiol. 91 (2006) 803-806
52. Seshiah P.N., Weber D.S., Rocic P., Valppu L., Taniyama Y., and Griendling K.K. Angiotensin II stimulation of NAD(P)H oxidase activity: Upstream mediators. Circ. Res. 91 (2002) 406-413
53. Shibahara S., Han F., Li B., and Takeda K. Hypoxia and heme oxygenases: oxygen sensing and regulation of expression. Antioxid. Redox Signal. 9 (2007) 2209-2225
54. Sundaresan M., Yu Z.X., Ferrans V.J., Irani K., and Finkel T. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 270 (1995) 296-299
55. Tang N., Wang L., Esko J., Giordano F.J., Huang Y., Gerber H.P., Ferrara N., and Johnson R.S. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell. 6 (2004) 485-495
56. Tang X.D., Garcia M.L., Heinemann S.H., and Hoshi T. Reactive oxygen species impair Slo1 BK channel function by altering cysteine-mediated calcium sensing. Nat. Struct. Mol. Biol. 11 (2004) 171-178
57. Tune J.D. Control of coronary blood flow during hypoxemia. Adv. Exp. Med. Biol. 618 (2007) 25-39
58. Ushio-Fukai M. Localizing NADPH oxidase-derived ROS. Sci. STKE 2006 (2006) re8
59. Vincent K.A., Shyu K.G., Luo Y., Magner M., Tio R.A., Jiang C., Goldberg M.A., Akita G.Y., Gregory R.J., and Isner J.M. Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor. Circulation 102 (2000) 2255-2261
60. Vorp D.A., Lee P.C., Wang D.H., Makaroun M.S., Nemoto E.M., Ogawa S., and Webster M.W. Association of intraluminal thrombus in abdominal aortic aneurysm with local hypoxia and wall weakening. J. Vasc. Surg. 34 (2001) 291-299
61. Waypa G.B., Chandel N.S., and Schumacker P.T. Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing. Circ. Res. 88 (2001) 1259-1266
62. Waypa G.B., Guzy R., Mungai P.T., Mack M.M., Marks J.D., Roe M.W., and Schumacker P.T. Increases in mitochondrial reactive oxygen species trigger hypoxia-induced calcium responses in pulmonary artery smooth muscle cells. Circ. Res. 99 (2006) 970-978
63. Waypa G.B., Marks J.D., Mack M.M., Boriboun C., Mungai P.T., and Schumacker P.T. Mitochondrial reactive oxygen species trigger calcium increases during hypoxia in pulmonary arterial myocytes. Circ. Res. 91 (2002) 719-726
64. Waypa G.B., and Schumacker P.T. O(2) sensing in hypoxic pulmonary vasoconstriction: The mitochondrial door re-opens. Respir. Physiol. Neurobiol. 132 (2002) 81-91
65. Waypa G.B., and Schumacker P.T. Hypoxic pulmonary vasoconstriction: redox events in oxygen sensing. J. Appl. Physiol. (Bethesda) 98 (2005) 404-414
66. Waypa G.B., and Schumacker P.T. Oxygen sensing in hypoxic pulmonary vasoconstriction: Using new tools to answer an age-old question. Exp. Physiol. 93 (2008) 133-138
67. Weir E.K., Hong Z., Porter V.A., and Reeve H.L. Redox signaling in oxygen sensing by vessels. Resp. Physiol. Neurobiol. 132 (2002) 121-130
68. Weir E.K., López-Barneo J., Buckler K.J., and Archer S.L. Acute oxygen-sensing mechanisms. N. Engl. J. Med. 353 (2005) 2042-2055
69. Williams S.E., Wootton P., Mason H.S., Bould J., Iles D.E., Riccardi D., Peers C., and Kemp P.J. Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel. Science 306 (2004) 2093-2097
70. Wolin M.S. Interactions of oxidants with vascular signaling systems. Arterioscler. Thromb. Vasc. Biol. 20 (2000) 1430-1442
71. Wolin M.S., Ahmad M., and Gupte S.A. Oxidant and redox signaling in vascular oxygen sensing mechanisms: Basic concepts, current controversies, and potential importance of cytosolic NADPH. Am. J. Physiol. 289 (2005) L159-L173
72. Yu A.Y., Shimoda L.A., Iyer N.V., Huso D.L., Sun X., McWilliams R., Beaty T., Sham J.S., Wiener C.M., Sylvester J.T., and Semenza G.L. Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha. J. Clin. Invest. 103 (1999) 691-696