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Volumn 199, Issue 1, 2008, Pages 5-19

Physiology of the pancreatic α-cell and glucagon secretion: Role in glucose homeostasis and diabetes

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; [3 CYANO 6 (1,1 DIMETHYLPROPYL) 4,5,6,7 TETRAHYDRO 1 BENZOTHIEN 2 YL] 2 ETHYLBUTANAMIDE; AMYLIN; ANTIDIABETIC AGENT; ANTISENSE OLIGODEOXYNUCLEOTIDE; BAY 27 9955; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 DERIVATIVE; GLUCAGON RECEPTOR; GLUCAGON RECEPTOR ANTAGONIST; IMIDAZOLINE DERIVATIVE; ION CHANNEL; LIRAGLUTIDE; MONOCLONAL ANTIBODY; PHENTOLAMINE; PRAMLINTIDE; SITAGLIPTIN; SOMATOSTATIN; SOMATOSTATIN DERIVATIVE; SULFONYLUREA DERIVATIVE; TOLBUTAMIDE; UNCLASSIFIED DRUG; VILDAGLIPTIN;

EID: 55049124487     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-08-0290     Document Type: Review
Times cited : (299)

References (153)
  • 2
    • 0034001450 scopus 로고    scopus 로고
    • Autonomic regulation of islet hormone secretion - implications for health and disease
    • Ahren B 2000 Autonomic regulation of islet hormone secretion - implications for health and disease. Diabetologia 43 393-410.
    • (2000) Diabetologia , vol.43 , pp. 393-410
    • Ahren, B.1
  • 3
    • 0019961237 scopus 로고
    • Influences of gastro-intestinal polypeptides and glucose oil glucagon secretion induced by cholinergic stimulation
    • Ahren B & Lundquist I 1982 Influences of gastro-intestinal polypeptides and glucose oil glucagon secretion induced by cholinergic stimulation. Hormone and Metabolic Research 14 529-532.
    • (1982) Hormone and Metabolic Research , vol.14 , pp. 529-532
    • Ahren, B.1    Lundquist, I.2
  • 4
    • 0023229994 scopus 로고
    • Sympathetic nerve stimulation versus pancreatic norepinephrine infusion in the dog: 1). Effects on basal release of insulin and glucagon
    • Ahren B, Veith RC & Taborsky GJ Jr 1987 Sympathetic nerve stimulation versus pancreatic norepinephrine infusion in the dog: 1). Effects on basal release of insulin and glucagon. Endocrinology 121 323-331.
    • (1987) Endocrinology , vol.121 , pp. 323-331
    • Ahren, B.1    Veith, R.C.2    Taborsky Jr, G.J.3
  • 5
    • 0037471369 scopus 로고    scopus 로고
    • Islet amyloid polypeptide inhibits glucagon release and exerts a dual action on insulin release from isolated islets
    • Akesson B, Panagiotidis G, Westermark P & Lundquist I 2003 Islet amyloid polypeptide inhibits glucagon release and exerts a dual action on insulin release from isolated islets. Regulatory Peptides 111 55-60.
    • (2003) Regulatory Peptides , vol.111 , pp. 55-60
    • Akesson, B.1    Panagiotidis, G.2    Westermark, P.3    Lundquist, I.4
  • 6
    • 0033567989 scopus 로고    scopus 로고
    • Inhibition of glycogenolysis in primary rat hepatocytes by 1, 4-dideoxy-1,4-imino-D-arabinitol
    • Andersen B, Rassov A, Westergaard N & Lundgren K 1999 Inhibition of glycogenolysis in primary rat hepatocytes by 1, 4-dideoxy-1,4-imino-D-arabinitol. Biochemical Journal 342 545-550.
    • (1999) Biochemical Journal , vol.342 , pp. 545-550
    • Andersen, B.1    Rassov, A.2    Westergaard, N.3    Lundgren, K.4
  • 7
    • 0016425917 scopus 로고
    • Effect of lipids on glucagon secretion in man
    • Andrews SS, Lopez-S A & Blackard WG 1975 Effect of lipids on glucagon secretion in man. Metabolism 24 35-44.
    • (1975) Metabolism , vol.24 , pp. 35-44
    • Andrews, S.S.1    Lopez-S, A.2    Blackard, W.G.3
  • 8
    • 0020686597 scopus 로고
    • Glucose regulation of glucagon secretion independent of B cell activity
    • Asplin C, Raghu P, Doman T & Palmer JP 1983 Glucose regulation of glucagon secretion independent of B cell activity. Metabolism 32 292-295.
    • (1983) Metabolism , vol.32 , pp. 292-295
    • Asplin, C.1    Raghu, P.2    Doman, T.3    Palmer, J.P.4
  • 9
    • 33847012550 scopus 로고    scopus 로고
    • Bailey SJ, Ravier MA & Rutter GA 2007 Glucose-dependent regulation of gamma-aminobutyric acid (GABA A) receptor expression in mouse pancreatic islet alpha-cells. Diabetes 56 320-327.
    • Bailey SJ, Ravier MA & Rutter GA 2007 Glucose-dependent regulation of gamma-aminobutyric acid (GABA A) receptor expression in mouse pancreatic islet alpha-cells. Diabetes 56 320-327.
  • 11
    • 0019205614 scopus 로고
    • Functional activation by glucagon of glucose 6-phosphatase and gluconeogenesis in the perfused liver of the fetal guinea pig
    • Band GC & Jones CT 1980 Functional activation by glucagon of glucose 6-phosphatase and gluconeogenesis in the perfused liver of the fetal guinea pig. FEBS Letters 119 190-194.
    • (1980) FEBS Letters , vol.119 , pp. 190-194
    • Band, G.C.1    Jones, C.T.2
  • 12
    • 0033850226 scopus 로고    scopus 로고
    • Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells
    • Barg S, Galvanovskis J, Gopel SO, Rorsman P & Eliasson L 2000 Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells. Diabetes 49 1500-1510.
    • (2000) Diabetes , vol.49 , pp. 1500-1510
    • Barg, S.1    Galvanovskis, J.2    Gopel, S.O.3    Rorsman, P.4    Eliasson, L.5
  • 13
    • 0023589251 scopus 로고
    • Role of hyperglucagonemia in maintenance of increased rates of hepatic glucose output in type II diabetics
    • Baron AD, Schaeffer L, Shragg P & Kolterman OG 1987 Role of hyperglucagonemia in maintenance of increased rates of hepatic glucose output in type II diabetics. Diabetes 36 274-283.
    • (1987) Diabetes , vol.36 , pp. 274-283
    • Baron, A.D.1    Schaeffer, L.2    Shragg, P.3    Kolterman, O.G.4
  • 19
    • 0021263283 scopus 로고
    • Defective glucose counterregulation after subcutaneous insulin in noninsulin-dependent diabetes mellitus. Paradoxical suppression of glucose utilization and lack of compensatory increase in glucose production, roles of insulin resistance, abnormal neuroendocrine responses, and islet paracrine interactions
    • Bolli GB, Tsalikian E, Haymond MW, Cryer PE & Gerich JE 1984 Defective glucose counterregulation after subcutaneous insulin in noninsulin-dependent diabetes mellitus. Paradoxical suppression of glucose utilization and lack of compensatory increase in glucose production, roles of insulin resistance, abnormal neuroendocrine responses, and islet paracrine interactions, Journal of Clinical Investigation 73 1532-1541.
    • (1984) Journal of Clinical Investigation , vol.73 , pp. 1532-1541
    • Bolli, G.B.1    Tsalikian, E.2    Haymond, M.W.3    Cryer, P.E.4    Gerich, J.E.5
  • 20
    • 0001922249 scopus 로고
    • Anatomy of the islet of Langerhans
    • Ed. E Samols. New York: Raven Press
    • Bonner-Weir S 1991 Anatomy of the islet of Langerhans. In The Endocrine Pancreas, pp 15-28. Ed. E Samols. New York: Raven Press.
    • (1991) The Endocrine Pancreas , pp. 15-28
    • Bonner-Weir, S.1
  • 22
    • 0024823328 scopus 로고
    • Three-dimensional imaging of intact isolated islets of Langerhans with confocal microscopy
    • Brelje TC, Scharp DW & Sorenson RL 1989 Three-dimensional imaging of intact isolated islets of Langerhans with confocal microscopy. Diabetes 38 808-814.
    • (1989) Diabetes , vol.38 , pp. 808-814
    • Brelje, T.C.1    Scharp, D.W.2    Sorenson, R.L.3
  • 24
    • 33144467088 scopus 로고    scopus 로고
    • The unique cytoarchitecture of human pancreatic islets has implications for islet cell function
    • Cabrera O, Berman DM, Kenyon NS, Ricordi C, Berggren PO & Caicedo A 2006 The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. PNAS 103 2334-2339.
    • (2006) PNAS , vol.103 , pp. 2334-2339
    • Cabrera, O.1    Berman, D.M.2    Kenyon, N.S.3    Ricordi, C.4    Berggren, P.O.5    Caicedo, A.6
  • 27
    • 0035023581 scopus 로고    scopus 로고
    • The glucagonoma syndrome: A review of its features and discussion ofnew perspectives
    • Chastain MA 2001 The glucagonoma syndrome: a review of its features and discussion ofnew perspectives. American Journal of the Medical Sciences 321 306-320.
    • (2001) American Journal of the Medical Sciences , vol.321 , pp. 306-320
    • Chastain, M.A.1
  • 29
    • 0024511329 scopus 로고
    • Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM
    • Consoli A, Nurjhan N, Capani F & Gerich J 1989 Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM. Diabetes 38 550-557.
    • (1989) Diabetes , vol.38 , pp. 550-557
    • Consoli, A.1    Nurjhan, N.2    Capani, F.3    Gerich, J.4
  • 30
    • 0036020278 scopus 로고    scopus 로고
    • Hypoglycaemia: The limiting factor in the glycaemic management of Type I and Type II diabetes
    • Cryer PE 2002 Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetes. Diabetologia 45 937-948.
    • (2002) Diabetologia , vol.45 , pp. 937-948
    • Cryer, P.E.1
  • 31
    • 0036752957 scopus 로고    scopus 로고
    • Plasma amino acid levels with a note on membrane transport: Characteristics, regulation, and metabolic significance
    • Cynober LA 2002 Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance. Nutrition 18 761-766.
    • (2002) Nutrition , vol.18 , pp. 761-766
    • Cynober, L.A.1
  • 33
    • 4344713643 scopus 로고    scopus 로고
    • Effect of intravenous infusion of exenatide (synthetic exendin-4) on glucose-dependent insulin secretion and counterregulation during hypoglycemia
    • Degn KB, Brock B, Juhl CB, Djurhuus CB, Grubert J, Kim D, Han J, Taylor K, Fineman M & Schmitz O 2004 Effect of intravenous infusion of exenatide (synthetic exendin-4) on glucose-dependent insulin secretion and counterregulation during hypoglycemia. Diabetes 53 2397-2403.
    • (2004) Diabetes , vol.53 , pp. 2397-2403
    • Degn, K.B.1    Brock, B.2    Juhl, C.B.3    Djurhuus, C.B.4    Grubert, J.5    Kim, D.6    Han, J.7    Taylor, K.8    Fineman, M.9    Schmitz, O.10
  • 34
    • 0032545293 scopus 로고    scopus 로고
    • The changes in adenine nucleotides measured in glucose-stimulated rodent islets occur in beta cells but not in alpha cells and are also observed in human islets
    • Detimary F, Dejonghe S, Ling Z, Pipeleers D, Schuit F & Henquin JC 1998 The changes in adenine nucleotides measured in glucose-stimulated rodent islets occur in beta cells but not in alpha cells and are also observed in human islets. Journal of Biological Chemistry 273 33905-33908.
    • (1998) Journal of Biological Chemistry , vol.273 , pp. 33905-33908
    • Detimary, F.1    Dejonghe, S.2    Ling, Z.3    Pipeleers, D.4    Schuit, F.5    Henquin, J.C.6
  • 35
    • 12344302029 scopus 로고    scopus 로고
    • Significance of prohormone convertase 2, PC2, mediated initial cleavage at the proglucagon interdomain site, Lys70-Arg71, to generate glucagon
    • Dey A, Lipkind GM, Rouille Y, Norrbom C, Stein J, Zhang C, Carroll R & Steiner DF 2005 Significance of prohormone convertase 2, PC2, mediated initial cleavage at the proglucagon interdomain site, Lys70-Arg71, to generate glucagon. Endocrinology 146 713-727.
    • (2005) Endocrinology , vol.146 , pp. 713-727
    • Dey, A.1    Lipkind, G.M.2    Rouille, Y.3    Norrbom, C.4    Stein, J.5    Zhang, C.6    Carroll, R.7    Steiner, D.F.8
  • 36
    • 25844492048 scopus 로고    scopus 로고
    • Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic α-cells
    • Diao J, Asghar Z, Chan CB & Wheeler MB 2005 Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic α-cells. Journal of Biological Chemistry 280 33487-33496.
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 33487-33496
    • Diao, J.1    Asghar, Z.2    Chan, C.B.3    Wheeler, M.B.4
  • 38
    • 0028883204 scopus 로고
    • Failure of glucagon suppression contributes to postprandial hyperglycaemia in IDDM
    • Dinneen S, Alzaid A, Turk D & Rizza R 1995 Failure of glucagon suppression contributes to postprandial hyperglycaemia in IDDM. Diabetologia 38 337-343.
    • (1995) Diabetologia , vol.38 , pp. 337-343
    • Dinneen, S.1    Alzaid, A.2    Turk, D.3    Rizza, R.4
  • 39
    • 0031767702 scopus 로고    scopus 로고
    • Insulin, but not glucose lowering corrects the hyperglucagonemia and increased proglucagon messenger ribonucleic acid levels observed in insulinopenic diabetes
    • Dumonteil E, Magnan C, Ritz-Laser B, Meda P, Dussoix P, Gilbert M, Ktorza A & Philippe J 1998 Insulin, but not glucose lowering corrects the hyperglucagonemia and increased proglucagon messenger ribonucleic acid levels observed in insulinopenic diabetes. Endocrinology 139 4540-4546.
    • (1998) Endocrinology , vol.139 , pp. 4540-4546
    • Dumonteil, E.1    Magnan, C.2    Ritz-Laser, B.3    Meda, P.4    Dussoix, P.5    Gilbert, M.6    Ktorza, A.7    Philippe, J.8
  • 40
    • 0033304853 scopus 로고    scopus 로고
    • Chronic exposure to high glucose concentrations increases proglucagon messenger ribonucleic acid levels and glucagon release from InR1G9 cells
    • Dumonteil E, Ritz-Laser B, Magnan C, Grigorescu I, Ktorza A & Philippe J 1999 Chronic exposure to high glucose concentrations increases proglucagon messenger ribonucleic acid levels and glucagon release from InR1G9 cells. Endocrinology 140 4644-4650.
    • (1999) Endocrinology , vol.140 , pp. 4644-4650
    • Dumonteil, E.1    Ritz-Laser, B.2    Magnan, C.3    Grigorescu, I.4    Ktorza, A.5    Philippe, J.6
  • 41
    • 0034464534 scopus 로고    scopus 로고
    • Glucose regulates proinsulin and prosomatostatin but not proglucagon messenger ribonucleic acid levels in rat pancreatic islets
    • Dumonteil E, Magnan C, Ritz-Laser B, Ktorza A, Meda P & Philippe J 2000 Glucose regulates proinsulin and prosomatostatin but not proglucagon messenger ribonucleic acid levels in rat pancreatic islets. Endocrinology 141 174-180.
    • (2000) Endocrinology , vol.141 , pp. 174-180
    • Dumonteil, E.1    Magnan, C.2    Ritz-Laser, B.3    Ktorza, A.4    Meda, P.5    Philippe, J.6
  • 42
    • 34250854205 scopus 로고    scopus 로고
    • The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes arid therapeutic implications
    • Dunning BE & Gerich JE 2007 The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes arid therapeutic implications. Endocrine Reviews 28 253-283.
    • (2007) Endocrine Reviews , vol.28 , pp. 253-283
    • Dunning, B.E.1    Gerich, J.E.2
  • 43
    • 24944577486 scopus 로고    scopus 로고
    • Alpha cell function in health and disease: Influence of glucagon-like peptide-1
    • Dunning BE, Foley JE & Ahrén B 2005 Alpha cell function in health and disease: influence of glucagon-like peptide-1. Diabetologia 48 1700-1713.
    • (2005) Diabetologia , vol.48 , pp. 1700-1713
    • Dunning, B.E.1    Foley, J.E.2    Ahrén, B.3
  • 46
    • 20044374696 scopus 로고    scopus 로고
    • β-cell secretory products activate α-cell ATP-dependent potassium channels to inhibit glucagon release
    • Franklin I, Gromada J, Gjinovci A, Theander S & Wollheim CB 2005 β-cell secretory products activate α-cell ATP-dependent potassium channels to inhibit glucagon release. Diabetes 54 1808-1815.
    • (2005) Diabetes , vol.54 , pp. 1808-1815
    • Franklin, I.1    Gromada, J.2    Gjinovci, A.3    Theander, S.4    Wollheim, C.B.5
  • 49
    • 33751563702 scopus 로고    scopus 로고
    • Role of endogenous amyhn in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187
    • Gedulin BR, Jodka CM, Herrmann K & Young AA 2006 Role of endogenous amyhn in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187. Regulatory Peptides 137 121-127.
    • (2006) Regulatory Peptides , vol.137 , pp. 121-127
    • Gedulin, B.R.1    Jodka, C.M.2    Herrmann, K.3    Young, A.A.4
  • 50
    • 0037417984 scopus 로고    scopus 로고
    • Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice
    • Gelling RW, Du XQ, Dichmann DS, Romer J, Huang H, Cui L, Obici S, Tang B, Holst JJ, Fledelius C et al. 2003 Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice. PNAS 100 1438-1443.
    • (2003) PNAS , vol.100 , pp. 1438-1443
    • Gelling1    RW, D.X.2    Dichmann, D.S.3    Romer, J.4    Huang, H.5    Cui, L.6    Obici, S.7    Tang, B.8    Holst, J.J.9    Fledelius, C.10
  • 51
    • 0343986289 scopus 로고    scopus 로고
    • Voltage-gated and resting membrane currents recorded from β-cells in intact mouse pancreatic islets
    • Gopel S, Kanno T, Barg S, Galvanovskis J & Rorsman P 1999 Voltage-gated and resting membrane currents recorded from β-cells in intact mouse pancreatic islets. Journal of Physiology 521 717-728.
    • (1999) Journal of Physiology , vol.521 , pp. 717-728
    • Gopel, S.1    Kanno, T.2    Barg, S.3    Galvanovskis, J.4    Rorsman, P.5
  • 52
    • 0034325594 scopus 로고    scopus 로고
    • Pacch-clamp characterisation of somatostatin-secreting delta-cells in intact mouse pancreatic islets
    • Gopel SO, Kanno T, Barg S & Rorsman P 2000 Pacch-clamp characterisation of somatostatin-secreting delta-cells in intact mouse pancreatic islets. Journal of Physiology 528 497-507.
    • (2000) Journal of Physiology , vol.528 , pp. 497-507
    • Gopel, S.O.1    Kanno, T.2    Barg, S.3    Rorsman, P.4
  • 54
    • 33745165968 scopus 로고    scopus 로고
    • Glucose induces glucagon release pulses antisynchronous with insulin and sensitive to purinoceptor inhibition
    • Grapengiesser E, Salehi A, Qader SS & Hellman B 2006 Glucose induces glucagon release pulses antisynchronous with insulin and sensitive to purinoceptor inhibition. Endocrinology 147 3472-3477.
    • (2006) Endocrinology , vol.147 , pp. 3472-3477
    • Grapengiesser, E.1    Salehi, A.2    Qader, S.S.3    Hellman, B.4
  • 56
    • 0030731946 scopus 로고    scopus 로고
    • Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels
    • Gremlich S, Bonny C, Waeber G & Thorens B 1997 Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels. Journal of Biological Chemistry 272 30261-30269.
    • (1997) Journal of Biological Chemistry , vol.272 , pp. 30261-30269
    • Gremlich, S.1    Bonny, C.2    Waeber, G.3    Thorens, B.4
  • 58
    • 0035449109 scopus 로고    scopus 로고
    • Somatostatin inhibits exocytosis in rat pancreatic α-cells by Gi2-dependent activation of calcineurin and depriming of secretory granules
    • Gromada J, Hoy M, Buschard K, Salehi A & Rorsman P 2001 Somatostatin inhibits exocytosis in rat pancreatic α-cells by Gi2-dependent activation of calcineurin and depriming of secretory granules. Journal of Physiology 535 519-532.
    • (2001) Journal of Physiology , vol.535 , pp. 519-532
    • Gromada, J.1    Hoy, M.2    Buschard, K.3    Salehi, A.4    Rorsman, P.5
  • 59
    • 9444266572 scopus 로고    scopus 로고
    • + channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-I- mouse alpha-cells
    • + channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-I- mouse alpha-cells. Diabetes 53 (Suppl 3) S181-S189.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 3
    • Gromada, J.1    Ma, X.2    Hoy, M.3    Bokvist, K.4    Salehi, A.5    Berggren, P.O.6    Rorsman, P.7
  • 60
    • 33846856711 scopus 로고    scopus 로고
    • Alpha-cells ofthe endocrine pancreas: 35 years of research but the enigma remains
    • Gromada J, Franklin I & Wollheim CB 2007 Alpha-cells ofthe endocrine pancreas: 35 years of research but the enigma remains. Endocrine Reviews 28 84-116.
    • (2007) Endocrine Reviews , vol.28 , pp. 84-116
    • Gromada, J.1    Franklin, I.2    Wollheim, C.B.3
  • 61
    • 0035158210 scopus 로고    scopus 로고
    • Differential effects of glucagon-like peptide-1 (7-36)amide versus cholecystokinin on arginine-induced islet hormone release in vivo and in vitro
    • Guenifi A, Ahren B & Abdel-Halim SM 2001 Differential effects of glucagon-like peptide-1 (7-36)amide versus cholecystokinin on arginine-induced islet hormone release in vivo and in vitro. Pancreas 22 58-64.
    • (2001) Pancreas , vol.22 , pp. 58-64
    • Guenifi, A.1    Ahren, B.2    Abdel-Halim, S.M.3
  • 63
    • 0043268762 scopus 로고    scopus 로고
    • Vesicular inhibitory amino acid transporter is present in glucagon-containing secretory granules in alphaTC6 cells, mouse clonal alpha-cells, and alpha-cells of islets of Langerhans
    • Hayashi M, Otsuka M, Morimoto R, Muroyama A, Uehara S, Yamamoto A & Moriyama Y 2003a Vesicular inhibitory amino acid transporter is present in glucagon-containing secretory granules in alphaTC6 cells, mouse clonal alpha-cells, and alpha-cells of islets of Langerhans. Diabetes 52 2066-2074.
    • (2003) Diabetes , vol.52 , pp. 2066-2074
    • Hayashi, M.1    Otsuka, M.2    Morimoto, R.3    Muroyama, A.4    Uehara, S.5    Yamamoto, A.6    Moriyama, Y.7
  • 65
    • 0028932514 scopus 로고
    • Differences in glucose transporter gene expression between rat pancreatic alpha- and beta-cells are correlated to differences in glucose transport but not in glucose utilization
    • Heimberg H, De Vos A, Pipeleers D, Thorens B & Schuit F 1995 Differences in glucose transporter gene expression between rat pancreatic alpha- and beta-cells are correlated to differences in glucose transport but not in glucose utilization. Journal of Biological Chemistry 270 8971-8975.
    • (1995) Journal of Biological Chemistry , vol.270 , pp. 8971-8975
    • Heimberg, H.1    De Vos, A.2    Pipeleers, D.3    Thorens, B.4    Schuit, F.5
  • 69
    • 24344458875 scopus 로고    scopus 로고
    • The short-term effect of fatty acids on glucagon secretion is influenced by their chain length, spatial configuration, and degree of unsaturation: Studies in vitro
    • Hong J, Abudula R, Chen J, Jeppesen PB, Dyrskog SEU, Xiao J, Colombo M & Hermansen K 2005 The short-term effect of fatty acids on glucagon secretion is influenced by their chain length, spatial configuration, and degree of unsaturation: studies in vitro. Metabolism 54 1329-1336.
    • (2005) Metabolism , vol.54 , pp. 1329-1336
    • Hong, J.1    Abudula, R.2    Chen, J.3    Jeppesen, P.B.4    Dyrskog, S.E.U.5    Xiao, J.6    Colombo, M.7    Hermansen, K.8
  • 72
    • 0030996381 scopus 로고    scopus 로고
    • Immunohistochemical localization of somatostatin receptor SST2A in the rat pancreas
    • Hunyady B, Hipkin RW, Schonbrunn A & Mezey E 1997 Immunohistochemical localization of somatostatin receptor SST2A in the rat pancreas. Endocrinology 138 2632-2635.
    • (1997) Endocrinology , vol.138 , pp. 2632-2635
    • Hunyady, B.1    Hipkin, R.W.2    Schonbrunn, A.3    Mezey, E.4
  • 75
    • 0036066641 scopus 로고    scopus 로고
    • Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes
    • Juhl CB, Hollingdal M, Sturis J, Jakobsen G, Agerso H, Veldhuis J, Porksen N & Schmitz O 2002 Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes. Diabetes 51 424-429.
    • (2002) Diabetes , vol.51 , pp. 424-429
    • Juhl, C.B.1    Hollingdal, M.2    Sturis, J.3    Jakobsen, G.4    Agerso, H.5    Veldhuis, J.6    Porksen, N.7    Schmitz, O.8
  • 79
    • 0032908805 scopus 로고    scopus 로고
    • Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: A quantitative double-label immunohistochemical analysis
    • Kumar U, Sasi R, Suresh S, Patel A, Thangaraju M, Metrakos P, Patel SC & Patel YC 1999 Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis. Diabetes 48 77-85.
    • (1999) Diabetes , vol.48 , pp. 77-85
    • Kumar, U.1    Sasi, R.2    Suresh, S.3    Patel, A.4    Thangaraju, M.5    Metrakos, P.6    Patel, S.C.7    Patel, Y.C.8
  • 80
    • 0029003144 scopus 로고
    • Covalent control of6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase: Insights into autoregulation of a bifunctional enzyme
    • Kurland IJ & Pilkis SJ 1995 Covalent control of6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase: insights into autoregulation of a bifunctional enzyme. Protein Science 4 1023-1037.
    • (1995) Protein Science , vol.4 , pp. 1023-1037
    • Kurland, I.J.1    Pilkis, S.J.2
  • 81
    • 0033304547 scopus 로고    scopus 로고
    • Oral glibenclamide suppresses glucagon secretion during insulin-induced hypoglycemia in patients with type 2 diabetes
    • Landstedt-Hallin L, Adamson U & Lins PE 1999 Oral glibenclamide suppresses glucagon secretion during insulin-induced hypoglycemia in patients with type 2 diabetes. Journal of Clinical Endocrinology and Metabolism 84 3140-3145.
    • (1999) Journal of Clinical Endocrinology and Metabolism , vol.84 , pp. 3140-3145
    • Landstedt-Hallin, L.1    Adamson, U.2    Lins, P.E.3
  • 82
    • 0034078505 scopus 로고    scopus 로고
    • Islet dysfunction in insulin resistance involves impaired insulin secretion and increased glucagon secretion in postmenopausal women with impaired glucose tolerance
    • Larsson H & Ahren B 2000 Islet dysfunction in insulin resistance involves impaired insulin secretion and increased glucagon secretion in postmenopausal women with impaired glucose tolerance. Diabetes Care 23 650-657.
    • (2000) Diabetes Care , vol.23 , pp. 650-657
    • Larsson, H.1    Ahren, B.2
  • 83
    • 0021993895 scopus 로고
    • Multiple effects of leucine on glucagon, insulin, and somatostatin secretion from the perfused rat pancreas
    • Leclercq-Meyer V, Marchand J, Woussen-Colle MC, Giroix MH & Malaisse WJ 1985 Multiple effects of leucine on glucagon, insulin, and somatostatin secretion from the perfused rat pancreas. Endocrinology 116 1168-1174.
    • (1985) Endocrinology , vol.116 , pp. 1168-1174
    • Leclercq-Meyer, V.1    Marchand, J.2    Woussen-Colle, M.C.3    Giroix, M.H.4    Malaisse, W.J.5
  • 84
    • 26844491714 scopus 로고    scopus 로고
    • Electrophysiological characterization of pancreatic islet cells in the mouse insulin promoter-green fluorescent protein mouse
    • Leung YM, Ahmed I, Shen L, Tsushima RG, Diamant NE, Hara M & Gaisano HY 2005 Electrophysiological characterization of pancreatic islet cells in the mouse insulin promoter-green fluorescent protein mouse. Endocrinology 146 4766-4775.
    • (2005) Endocrinology , vol.146 , pp. 4766-4775
    • Leung, Y.M.1    Ahmed, I.2    Shen, L.3    Tsushima, R.G.4    Diamant, N.E.5    Hara, M.6    Gaisano, H.Y.7
  • 85
    • 33645869578 scopus 로고    scopus 로고
    • Insulin regulates islet α-cell function by reducing KATP channel sensitivity to adenosine 5′-triphosphate inhibition
    • Leung YM, Ahmed I, Shen L, Gao X, Hara M, Tsushima RG, Diamant NE & Gaisano HY 2006 Insulin regulates islet α-cell function by reducing KATP channel sensitivity to adenosine 5′-triphosphate inhibition. Endocrinology 147 2155-2162.
    • (2006) Endocrinology , vol.147 , pp. 2155-2162
    • Leung, Y.M.1    Ahmed, I.2    Shen, L.3    Gao, X.4    Hara, M.5    Tsushima, R.G.6    Diamant, N.E.7    Gaisano, H.Y.8
  • 86
    • 12744259876 scopus 로고    scopus 로고
    • Beta-cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1
    • Li Y, Cao X, Li LX, Brubaker PL, Edlund H & Drucker DJ 2005 Beta-cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1. Diabetes 54 482-491.
    • (2005) Diabetes , vol.54 , pp. 482-491
    • Li, Y.1    Cao, X.2    Li, L.X.3    Brubaker, P.L.4    Edlund, H.5    Drucker, D.J.6
  • 87
    • 42549128732 scopus 로고    scopus 로고
    • Long-term hyperglucagonaemia induces early metabolic and renal phenotypes of Type 2 diabetes in mice
    • Li XC, Liao TD & Zhuo JL 2008 Long-term hyperglucagonaemia induces early metabolic and renal phenotypes of Type 2 diabetes in mice. Clinical Science 114 591-601.
    • (2008) Clinical Science , vol.114 , pp. 591-601
    • Li, X.C.1    Liao, T.D.2    Zhuo, J.L.3
  • 89
    • 1442343000 scopus 로고    scopus 로고
    • A store-operated mechanism determines the activity of the electrically excitable glucagon-secreting pancreatic alpha-cell
    • Liu YJ, Vieira E & Gylfe E 2004 A store-operated mechanism determines the activity of the electrically excitable glucagon-secreting pancreatic alpha-cell. Cell Calcium 35 357-365.
    • (2004) Cell Calcium , vol.35 , pp. 357-365
    • Liu, Y.J.1    Vieira, E.2    Gylfe, E.3
  • 93
    • 33748753770 scopus 로고    scopus 로고
    • Oscillatory membrane potential response to glucose in islet beta-cells: A comparison of islet-cell electrical activity in mouse and rat
    • Manning Fox JE, Gyulkhandanyan AV, Satin LS & Wheeler MB 2006 Oscillatory membrane potential response to glucose in islet beta-cells: a comparison of islet-cell electrical activity in mouse and rat. Endocrinology 147 4655-4663.
    • (2006) Endocrinology , vol.147 , pp. 4655-4663
    • Manning Fox, J.E.1    Gyulkhandanyan, A.V.2    Satin, L.S.3    Wheeler, M.B.4
  • 97
    • 0023008693 scopus 로고
    • Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing
    • Mojsov S, Heinrich G, Wilson IB, Ravazzola M, Orci L & Habener JF 1986 Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. Journal of Biological Chemistry 261 11880-11889.
    • (1986) Journal of Biological Chemistry , vol.261 , pp. 11880-11889
    • Mojsov, S.1    Heinrich, G.2    Wilson, I.B.3    Ravazzola, M.4    Orci, L.5    Habener, J.F.6
  • 98
    • 27844448098 scopus 로고    scopus 로고
    • Regulation of glucagon secretion at low glucose concentrations: Evidence for adenosine triphosphate-sensitive potassium channel involvement
    • Munoz A, Hu M, Hussain K, Bryan J, Aguilar-Bryan L & Rajan AS 2005 Regulation of glucagon secretion at low glucose concentrations: evidence for adenosine triphosphate-sensitive potassium channel involvement. Endocrinology 146 5514-5521.
    • (2005) Endocrinology , vol.146 , pp. 5514-5521
    • Munoz, A.1    Hu, M.2    Hussain, K.3    Bryan, J.4    Aguilar-Bryan, L.5    Rajan, A.S.6
  • 99
    • 0033563173 scopus 로고    scopus 로고
    • Homologous and heterologous asynchronicity between identified alpha-, beta- and delta-cells within intact islets of Langerhans in the mouse
    • Nadal A, Quesada I & Soria B 1999 Homologous and heterologous asynchronicity between identified alpha-, beta- and delta-cells within intact islets of Langerhans in the mouse. Journal of Physiology 517 85-93.
    • (1999) Journal of Physiology , vol.517 , pp. 85-93
    • Nadal, A.1    Quesada, I.2    Soria, B.3
  • 100
    • 0036959991 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers
    • Nauck MA, Heimesaat MM, Behle K, Holst JJ, Nauck MS, Ritzel R, Hufner M & Schmiegel WH 2002 Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers. Journal of Clinical Endocrinology and Metabolism 87 1239-1246.
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , pp. 1239-1246
    • Nauck, M.A.1    Heimesaat, M.M.2    Behle, K.3    Holst, J.J.4    Nauck, M.S.5    Ritzel, R.6    Hufner, M.7    Schmiegel, W.H.8
  • 101
    • 7044249536 scopus 로고    scopus 로고
    • Palmitate stimulation of glucagon secretion in mouse pancreatic alpha-cells results from activation of L-type calcium channels and elevation of cytoplasmic calcium
    • Olofsson CS, Salehi A, Gopel SO, Holm C & Rorsman P 2004 Palmitate stimulation of glucagon secretion in mouse pancreatic alpha-cells results from activation of L-type calcium channels and elevation of cytoplasmic calcium. Diabetes 53 2836-2843.
    • (2004) Diabetes , vol.53 , pp. 2836-2843
    • Olofsson, C.S.1    Salehi, A.2    Gopel, S.O.3    Holm, C.4    Rorsman, P.5
  • 102
    • 26844556580 scopus 로고    scopus 로고
    • Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cells
    • Olsen HL, Theander S, Bokvist K, Buschard K, Wollheim CB & Gromada J 2005 Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cells. Endocrinology 146 4861-4870.
    • (2005) Endocrinology , vol.146 , pp. 4861-4870
    • Olsen, H.L.1    Theander, S.2    Bokvist, K.3    Buschard, K.4    Wollheim, C.B.5    Gromada, J.6
  • 103
    • 0022893651 scopus 로고
    • Sulfonylurea-induced inhibition of glucagon secretion from the perfused rat pancreas: Evidence for a direct, non-paracrine effect
    • Ostenson CG, Nylen A, Grill V, Gutniak M & Efendic S 1986 Sulfonylurea-induced inhibition of glucagon secretion from the perfused rat pancreas: evidence for a direct, non-paracrine effect. Diabetologia 29 861-867.
    • (1986) Diabetologia , vol.29 , pp. 861-867
    • Ostenson, C.G.1    Nylen, A.2    Grill, V.3    Gutniak, M.4    Efendic, S.5
  • 104
    • 0036896935 scopus 로고    scopus 로고
    • Intrahepatic islet transplantation in type 1 diabetic patients does not restore hypoglycemic hormonal counterregulation or symptom recognition after insulin independence
    • Paty BW, Ryan EA, Shapiro AM, Lakey JR & Robertson RP 2002 Intrahepatic islet transplantation in type 1 diabetic patients does not restore hypoglycemic hormonal counterregulation or symptom recognition after insulin independence. Diabetes 51 3428-3434.
    • (2002) Diabetes , vol.51 , pp. 3428-3434
    • Paty, B.W.1    Ryan, E.A.2    Shapiro, A.M.3    Lakey, J.R.4    Robertson, R.P.5
  • 105
    • 0031813480 scopus 로고    scopus 로고
    • Histidine availability alters glucagon gene expression in murine alphaTC6 cells
    • Paul GL, Waegner A, Gaskins HR & Shay NF 1998 Histidine availability alters glucagon gene expression in murine alphaTC6 cells. Journal of Nutrition 128 973-976.
    • (1998) Journal of Nutrition , vol.128 , pp. 973-976
    • Paul, G.L.1    Waegner, A.2    Gaskins, H.R.3    Shay, N.F.4
  • 107
    • 0035195977 scopus 로고    scopus 로고
    • Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans
    • Petersen KF & Sullivan JT 2001 Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans. Diabetologia 44 2018-2024.
    • (2001) Diabetologia , vol.44 , pp. 2018-2024
    • Petersen, K.F.1    Sullivan, J.T.2
  • 108
    • 0028873948 scopus 로고
    • Islet-specific proteins interact with the insulin-response element of the glucagon gene
    • Philippe J, Morel C & Cordier-Bussat M 1995 Islet-specific proteins interact with the insulin-response element of the glucagon gene. Journal of Biological Chemistry 270 3039-3045.
    • (1995) Journal of Biological Chemistry , vol.270 , pp. 3039-3045
    • Philippe, J.1    Morel, C.2    Cordier-Bussat, M.3
  • 110
    • 0033499813 scopus 로고    scopus 로고
    • Different effects of tolbutamide and diazoxide in alpha, beta-, and delta-cells within intact islets of Langerhans
    • Quesada I, Nadal A & Soria B 1999 Different effects of tolbutamide and diazoxide in alpha, beta-, and delta-cells within intact islets of Langerhans. Diabetes 48 2390-2397.
    • (1999) Diabetes , vol.48 , pp. 2390-2397
    • Quesada, I.1    Nadal, A.2    Soria, B.3
  • 112
    • 33646200451 scopus 로고    scopus 로고
    • Different metabolic responses in α-β, and δ-cells of the islet of Langerhans monitored by redox confocal microscopy
    • Quesada I, Todorova MG & Soria B 2006a Different metabolic responses in α-β, and δ-cells of the islet of Langerhans monitored by redox confocal microscopy. Biophysical Journal 90 2641-2650.
    • (2006) Biophysical Journal , vol.90 , pp. 2641-2650
    • Quesada, I.1    Todorova, M.G.2    Soria, B.3
  • 114
    • 34548127883 scopus 로고    scopus 로고
    • The GluCre-ROSA26EYFP mouse: A new model for easy identification of living pancreatic alpha-cells
    • Quoix N, Cheng-Xue R, Guiot Y, Herrera PL, Henquin JC & Gilon P 2007 The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic alpha-cells. FEBS Letters 581 4235-4240.
    • (2007) FEBS Letters , vol.581 , pp. 4235-4240
    • Quoix, N.1    Cheng-Xue, R.2    Guiot, Y.3    Herrera, P.L.4    Henquin, J.C.5    Gilon, P.6
  • 116
    • 20044394745 scopus 로고    scopus 로고
    • Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic alpha-cells
    • Ravier MA & Rutter GA 2005 Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic alpha-cells. Diabetes 54 1789-1797.
    • (2005) Diabetes , vol.54 , pp. 1789-1797
    • Ravier, M.A.1    Rutter, G.A.2
  • 117
  • 119
    • 33846694046 scopus 로고    scopus 로고
    • Comparison of vildagliptin and rosiglitazone monotherapy in patients with type 2 diabetes: A 24-week, double-blind, randomized trial
    • Rosenstock J, Baron MA, Dejager S, Mills D & Schweizer A 2007 Comparison of vildagliptin and rosiglitazone monotherapy in patients with type 2 diabetes: a 24-week, double-blind, randomized trial. Diabetes Care 30 217-223.
    • (2007) Diabetes Care , vol.30 , pp. 217-223
    • Rosenstock, J.1    Baron, M.A.2    Dejager, S.3    Mills, D.4    Schweizer, A.5
  • 120
    • 0024573737 scopus 로고
    • Sensitivity of rat pancreatic A and B cells to somatostatin
    • Schuit FC, Derde MP & Pipeleers DG 1989 Sensitivity of rat pancreatic A and B cells to somatostatin. Diabetologia 32 207-212.
    • (1989) Diabetologia , vol.32 , pp. 207-212
    • Schuit, F.C.1    Derde, M.P.2    Pipeleers, D.G.3
  • 123
    • 0032877316 scopus 로고    scopus 로고
    • Impact of lack of suppression of glucagon on glucose tolerance in humans
    • Shah P, Basu A, Basu R & Rizza R 1999 Impact of lack of suppression of glucagon on glucose tolerance in humans. American Journal of Physiology 277 E283-E290.
    • (1999) American Journal of Physiology , vol.277
    • Shah, P.1    Basu, A.2    Basu, R.3    Rizza, R.4
  • 127
    • 0028037616 scopus 로고
    • Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes
    • Slavin BG, Ong JM & Kern PA 1994 Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes. Journal of Lipid Research 35 1535-1541.
    • (1994) Journal of Lipid Research , vol.35 , pp. 1535-1541
    • Slavin, B.G.1    Ong, J.M.2    Kern, P.A.3
  • 129
    • 0035650534 scopus 로고    scopus 로고
    • Convergence of pre- and postsynaptic influences on glucosensing neurons in the ventromedial hypothalamic nucleus
    • Song Z, Levin BE, McArdle JJ, Bakhos N & Routh VH 2001 Convergence of pre- and postsynaptic influences on glucosensing neurons in the ventromedial hypothalamic nucleus. Diabetes 50 2673-2681.
    • (2001) Diabetes , vol.50 , pp. 2673-2681
    • Song, Z.1    Levin, B.E.2    McArdle, J.J.3    Bakhos, N.4    Routh, V.H.5
  • 130
    • 33750877987 scopus 로고    scopus 로고
    • Immunoneutralization of endogenous glucagon reduces hepatic glucose output and improves long-term glycemic control in diabetic ob/ob mice
    • Sorensen H, Brand CL, Neschen S, Holst JJ, Fosgerau K, Nishimura E & Shulman GI 2006 Immunoneutralization of endogenous glucagon reduces hepatic glucose output and improves long-term glycemic control in diabetic ob/ob mice. Diabetes 55 2843-2848.
    • (2006) Diabetes , vol.55 , pp. 2843-2848
    • Sorensen, H.1    Brand, C.L.2    Neschen, S.3    Holst, J.J.4    Fosgerau, K.5    Nishimura, E.6    Shulman, G.I.7
  • 131
    • 0034465470 scopus 로고    scopus 로고
    • Somatostatin inhibits insulin and glucagon secretion via two receptor subtypes: An in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice
    • Strowski MZ, Parmar RM, Blake AD & Schaeffer JM 2000 Somatostatin inhibits insulin and glucagon secretion via two receptor subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice. Endocrinology 141 111-117.
    • (2000) Endocrinology , vol.141 , pp. 111-117
    • Strowski, M.Z.1    Parmar, R.M.2    Blake, A.D.3    Schaeffer, J.M.4
  • 133
    • 0029891226 scopus 로고    scopus 로고
    • Low level cyclic adenosine 3′,5′-monophosphate accumulation analysis of [des-His1, des- Phe6, Glu9] glucagon-NH2 identifies glucagon antagonists from weak partial agonists/antagonists
    • Van Tine BA, Azizeh BY, Trivedi D, Phelps JR, Houslay MD, Johnson DG & Hruby VJ 1996 Low level cyclic adenosine 3′,5′-monophosphate accumulation analysis of [des-His1, des- Phe6, Glu9] glucagon-NH2 identifies glucagon antagonists from weak partial agonists/antagonists. Endocrinology 137 3316-3322.
    • (1996) Endocrinology , vol.137 , pp. 3316-3322
    • Van Tine, B.A.1    Azizeh, B.Y.2    Trivedi, D.3    Phelps, J.R.4    Houslay, M.D.5    Johnson, D.G.6    Hruby, V.J.7
  • 134
    • 0036724723 scopus 로고    scopus 로고
    • The prevalent Glu23Lys polymorphism in the potassium inward rectifier 6.2 (KIR6.2) gene is associated with impaired glucagon suppression in response to hyperglycemia
    • Tschritter O, Stumvoll M, Machicao F, Holzwarth M, Weisser M, Maerker E, Teigeler A, Haring H & Fritsche A 2002 The prevalent Glu23Lys polymorphism in the potassium inward rectifier 6.2 (KIR6.2) gene is associated with impaired glucagon suppression in response to hyperglycemia. Diabetes 51 2854-2860.
    • (2002) Diabetes , vol.51 , pp. 2854-2860
    • Tschritter, O.1    Stumvoll, M.2    Machicao, F.3    Holzwarth, M.4    Weisser, M.5    Maerker, E.6    Teigeler, A.7    Haring, H.8    Fritsche, A.9
  • 136
    • 1842423000 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor Type 4 is involved in autoinhibitory cascade for glucagon secretion by α-cells of islet of Langerhans
    • Uehara S, Muroyama A, Echigo N, Morimoto R, Otsuka M, Yatsushiro S & Moriyama Y 2004 Metabotropic glutamate receptor Type 4 is involved in autoinhibitory cascade for glucagon secretion by α-cells of islet of Langerhans. Diabetes 53 998-1006.
    • (2004) Diabetes , vol.53 , pp. 998-1006
    • Uehara, S.1    Muroyama, A.2    Echigo, N.3    Morimoto, R.4    Otsuka, M.5    Yatsushiro, S.6    Moriyama, Y.7
  • 137
    • 0016423677 scopus 로고
    • The essential role of glucagon in the pathogenesis of diabetes mellitus
    • Unger RH & Orci L 1975 The essential role of glucagon in the pathogenesis of diabetes mellitus. Lancet 1 14-16.
    • (1975) Lancet , vol.1 , pp. 14-16
    • Unger, R.H.1    Orci, L.2
  • 138
    • 34047096301 scopus 로고    scopus 로고
    • Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells
    • Vieira E, Salehi A & Gylfe E 2007 Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells. Diabetologia 50 370-379.
    • (2007) Diabetologia , vol.50 , pp. 370-379
    • Vieira, E.1    Salehi, A.2    Gylfe, E.3
  • 139
    • 0026043527 scopus 로고
    • Regulation of fatty-acid metabolism by pancreatic hormones in cultured human hepatocytes
    • Vons C, Pegorier JP, Girard J, Kohl C, Ivanov MA & Franco D 1991 Regulation of fatty-acid metabolism by pancreatic hormones in cultured human hepatocytes. Hepatology 13 1126-1130.
    • (1991) Hepatology , vol.13 , pp. 1126-1130
    • Vons, C.1    Pegorier, J.P.2    Girard, J.3    Kohl, C.4    Ivanov, M.A.5    Franco, D.6
  • 141
    • 0023041534 scopus 로고
    • Activation of two signal-transduction systems in hepatocytes by glucagon
    • Wakelam MJO, Murphy GJ, Hruby VJ & Houslay MD 1986 Activation of two signal-transduction systems in hepatocytes by glucagon. Nature 323 68-71.
    • (1986) Nature , vol.323 , pp. 68-71
    • Wakelam, M.J.O.1    Murphy, G.J.2    Hruby, V.J.3    Houslay, M.D.4
  • 143
    • 1842422955 scopus 로고    scopus 로고
    • Glucose inhibition of glucagon secretion from rat α-cells is mediated by GABA released from neighboring β-cells
    • Wendt A, Birnir B, Buschard K, Gromada J, Salehi A, Sewing S, Rorsman P & Braun M 2004 Glucose inhibition of glucagon secretion from rat α-cells is mediated by GABA released from neighboring β-cells. Diabetes 53 1038-1045.
    • (2004) Diabetes , vol.53 , pp. 1038-1045
    • Wendt, A.1    Birnir, B.2    Buschard, K.3    Gromada, J.4    Salehi, A.5    Sewing, S.6    Rorsman, P.7    Braun, M.8
  • 144
    • 34249930188 scopus 로고    scopus 로고
    • Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet
    • Winzell MS, Brand CL, Wierup N, Sidelmann UG, Sundler F, Nishimura E & Ahren B 2007 Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet. Diabetologia 50 1453-1462.
    • (2007) Diabetologia , vol.50 , pp. 1453-1462
    • Winzell, M.S.1    Brand, C.L.2    Wierup, N.3    Sidelmann, U.G.4    Sundler, F.5    Nishimura, E.6    Ahren, B.7
  • 149
    • 33646161943 scopus 로고    scopus 로고
    • Inhibition of glucagon secretion
    • Young A 2005 Inhibition of glucagon secretion. Advances in Pharmacology 52 151-171.
    • (2005) Advances in Pharmacology , vol.52 , pp. 151-171
    • Young, A.1
  • 150
    • 0029973985 scopus 로고    scopus 로고
    • Imidazoline compounds stimulate insulin release by inhibition of K(ATP) channels and interaction with the exocytotic machinery
    • Zaitsev SV, Efanov AM, Efanova IB, Larsson O, Ostenson CG, Gold G, Berggren PO & Efendic S 1996 Imidazoline compounds stimulate insulin release by inhibition of K(ATP) channels and interaction with the exocytotic machinery. Diabetes 45 1610-1618.
    • (1996) Diabetes , vol.45 , pp. 1610-1618
    • Zaitsev, S.V.1    Efanov, A.M.2    Efanova, I.B.3    Larsson, O.4    Ostenson, C.G.5    Gold, G.6    Berggren, P.O.7    Efendic, S.8
  • 151
    • 0035140273 scopus 로고    scopus 로고
    • Expression and distribution of lactate/monocarboxylate transporter isoforms in pancreatic islets and the exocrine pancreas
    • Zhao C, Wilson MC, Schurit F, Halestrap AP & Rutter GA 2001 Expression and distribution of lactate/monocarboxylate transporter isoforms in pancreatic islets and the exocrine pancreas. Diabetes 50 361-366.
    • (2001) Diabetes , vol.50 , pp. 361-366
    • Zhao, C.1    Wilson, M.C.2    Schurit, F.3    Halestrap, A.P.4    Rutter, G.A.5
  • 152
    • 34047099750 scopus 로고    scopus 로고
    • Zinc, not insulin, regulates the rat alpha-cell response to hypoglycemia in vivo
    • Zhou H, Zhang T, Harmon JS, Bryan J & Robertson RP 2007a Zinc, not insulin, regulates the rat alpha-cell response to hypoglycemia in vivo. Diabetes 56 1107-1112.
    • (2007) Diabetes , vol.56 , pp. 1107-1112
    • Zhou, H.1    Zhang, T.2    Harmon, J.S.3    Bryan, J.4    Robertson, R.P.5
  • 153
    • 34250895793 scopus 로고    scopus 로고
    • Reversal of defective glucagon responses to hypoglycemia in insulin-dependent autoimmune diabetic BB rats
    • Zhou H, Zhang T, Oseid E, Harmon J, Tonooka N & Robertson RP 2007b Reversal of defective glucagon responses to hypoglycemia in insulin-dependent autoimmune diabetic BB rats. Endocrinology 148 2863-2869.
    • (2007) Endocrinology , vol.148 , pp. 2863-2869
    • Zhou, H.1    Zhang, T.2    Oseid, E.3    Harmon, J.4    Tonooka, N.5    Robertson, R.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.