Subtype-selective expression of the five somatostatin receptors (hSSTR1- 5) in human pancreatic islet cells: A quantitative double-label immunohistochemical analysis

Diabetes

Volumn 48, Issue 1, 1999, Pages 77-85

  Kumar, Ujendra ^a   Sasi, Ramakrishnan ^a   Suresh, Sundar ^c   Patel, Amit ^c   Thangaraju, Muthusamy ^a   Metrakos, Peter ^b   Patel, Shutish C ^c   Patel, Yogesh C ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b ROYAL VICTORIA HOSPITAL   (Canada)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; INSULIN; RECEPTOR SUBTYPE; SOMATOSTATIN RECEPTOR; SOMATOSTATIN RECEPTOR 5; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL TYPE; CHO CELL; CONTROLLED STUDY; FLUORESCENCE; GLUCAGON RELEASE; HUMAN; HUMAN TISSUE; INSULIN RELEASE; NEUROMODULATION; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION;

ANIMALS; CELL LINE; GLUCAGON; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN; ISLETS OF LANGERHANS; ISOMERISM; RABBITS; RECEPTORS, SOMATOSTATIN; SOMATOSTATIN; SUBSTRATE SPECIFICITY; TISSUE DISTRIBUTION;

EID: 0032908805     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.1.77     Document Type: Article

References (37)

1. Reichlin S: Somatostatin. N Engl J Med 309:1495-1501, 1556, 1563, 1983
2. Patel YC, Liu J-L, Galanopoulou AS, Papachristou DN: Production, action, and degradation of somatostatin. In The Handbook of Physiology: The Endocrine Pancreas and Regulation of Metabolism. Jefferson LS, Cherrington AD, Eds. New York, Oxford University Press, In press
3. Patel YC, Srikant CB: Somatostatin receptors. Trends Endocrinol Metab 8:398-405, 1997
4. Reisine T, Bell GI: Molecular biology of somatostatin receptors. Endocr Rev 16:427-442, 1995
5. Patel YC, Srikant CB: Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hSSTR1-5). Endocrinology 135:2814-2817, 1994
6. Hukovic N, Panetta R, Kumar U, Patel YC: Agonist-dependent regulation of cloned human somatostatin receptor types 1-5 (hSSTR1-5): subtype selective internalization or upregulation. Endocrinology 137:4046-4049, 1996
7. Nouel D, Gaudriault G, Houle M, Reisine T, Vincent JP, Mazella J, Beaudet A: Differential internalization of somatostatin in COS-7 cells transfected with SST1 and SST2 receptor subtypes: a confocal microscopic study using novel fluorescent somatostatin derivatives. Endocrinology 138:296-306, 1997
8. Hipkin RW, Friedman J, Clark RB, Eppler CM, Schonbrunn A: Agonist-induced desensitization, internalization, and phosphorylation of the SST2A somatostatin receptor. J Biol Chem 27:13869-13876, 1997
9. Roth A, Kreienkamp HJ, Meyerhoff W, Richter D: Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization. J Biol Chem 38:23769-23774, 1997
10. Lamberts SWJ, Van Der Lely AJ, de Herder WW: Drug therapy: octreotide. N Engl J Med 334:246-254, 1996
11. Koerker DJ, Ruch W, Chideckel E, Palmer J, Goodner CJ, Ensinck J, Gale CC: Somatostatin: hypothalamic inhibitor of the endocrine pancreas. Science 184:482-483, 1974
12. Dubois MP: Immunoreactive somatostatin is present in discrete cells of the endocrine pancreas. Proc Natl Acad Sci U S A 72:1340-1343, 1975
13. Mandarino L, Stenner D, Blanchard W, Nissen S, Gerich J, Ling N, Brazeau P, Bohlen P, Esch F, Guillemin R: Selective effects of somatostatin-14, -25, and -28 on in vitro insulin and glucagon secretion. Nature 291:76-77, 1981
14. Philippe J: Somatostatin inhibits insulin-gene expression through a post-transcriptional mechanism in a hamster islet cell line. Diabetes 42:244-249, 1993
15. Kendall DM, Poitout V, Olson LK, Sorenson KL, Robertson RP: Somatostatin coordinately regulates glucagon gene expression and exocytosis in HIT-15 cells. J Clin Invest 96:2496-2502, 1995
16. Williams G, Fuessl H, Kraenzlin M, Bloom SR: Postprandial effects of SMS201-995 on gut hormones and glucose tolerance. Scand J Gastroenterol 21 (Suppl. 119):73-83, 1985
17. Ipp E, Rivier J, Dobbs RE, Brown M, Vale W, Unger RH: Somatostatin analog inhibits somatostatin release. Endocrinology 104:1270-1273, 1979
18. Patel YC, Amherdt M, Orci L: Quantitative electron microscopic autoradiography of insulin-, glucagon-, and somatostal in-binding sites on islets. Science 217:1155-1156, 1982
19. Reubi JC, Rivier J, Perrin M, Brown M, Vale W: Specific high-affinity binding sites for somatostatin-28 on pancreatic B-cells: differences with brain somatostatin receptors. Endocrinology 110:1049-1051, 1982
20. Sullivan SJ, Schononbrunn A: Distribution of somatostatin receptors in RINm5F cells. Endocrinology 122:1137-1145, 1988
21. Amherdt M, Patel YC, Orci L: Selective binding of somatostatin-14 and somatostatin-28 to islet cells revealed by quantitative electron microscopic autoradiography. J Clin Invest 80:1455-1458, 1987
22. Amherdt M, Patel YC, Orci L: Binding and internalization of somatostatin, insulin, and glucagon by cultured rat islet cells. J Clin Invest 84:412-417, 1989
23. Thermos K, Meglasson MD, Nelson J, Lounsbury KM, Reisine T: Pancreatic β-cell Somatostatin receptors. Am J Physiol 259:E216-E224, 1990
24. Maletti M, Andersson M, Marie JC, Rosselin G, Mutt V: Solubilization and partial purification of somatostatin-28-preferring receptors from hamster pancreatic beta cells. J Biol Chem 267:15620-15625, 1992
25. Grigorakis SI, Panetta R, Patel YC: Expression of mRNA for Somatostatin receptor (SSTR) subtypes 1-5 in islets and differential downregulation of SSTR2 mRNA by SST agonists (Abstract). Diabetes 44 (Suppl. 1):132A, 1995
26. Hunyady B, Hipkin RW, Schonbrunn A, Mezey E: Immunohistochemical localization of somatostatin receptor SST2A in the rat pancreas. Endocrinology 138:2632-2635, 1997
27. Kumar U, Laird D, Srikant CB, Escher E, Patel YC: Expression of the five Somatostatin receptor (SSTR1-5) subtypes in rat pituitary somatotrophes: quantitative analysis by double-label immunofluorescence confocal microscopy. Endocrinology 138:4473-4476, 1997
28. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685, 1970
29. Helboe L, Moller M, Novregaard L, Schiodt M, Stidsen CE: Development of selective antibodies against the human somatostatin receptor subtypes SST1-SST5. Mol Br Res 49:82-88, 1997
30. Mezey E, Hunyady B, Mitra S, Hayes E, Liu Q, Schaeffer J. Schonbrunn A: Cell-specific expression of the SSTR2A and SSTR5 somatostatin receptors in the rat anterior pituitary. Endocrinology 139:414-419, 1998
31. Patel YC, Panetta R, Escher E, Greenwood MT, Srikant CB: Expression of multiple somatostatin receptor genes in AtT-20 cells: evidence for a novel somatostatin-28-selective receptor subtype. J Biol Chem 269:1506-1509, 1994
32. Dournaud P, Gu YZ, Schonbrunn A, Marinella J, Tannenbaum GS, Beaudet A: Localization of the somatostatin receptor SST2A in rat brain using a specific antipeptide antibody. J Neurosci 16:4468-4478, 1996
33. O'Carroll A, Krempel K: Widespread distribution of somatostatin receptor messenger ribonucleic acids in rat pituitary. Endocrinology 136:5224-5227, 1995
34. Gouldson PR, Reynolds CA: Simulations on dimeric peptides: evidence for domain swapping in G-protein-coupled receptors? Biochem Soc Trans 25:1066-1071, 1997
35. Rocheville M, Hukovic N, Patel YC: Functional dimerization of the human somatostatin receptor subtype 5 (hSSTR5) (Abstract). Program of the 80th Annual Meeting of the U.S. Endoccrine Society, New Orleans, LA, 24-27 June 1998, p. 113
36. Skamene A, Patel YC: Infusions of graded concentrations of somatostatin-14 in man: pharmacokinetics and differential inhibitory effects on pituitary and islet hormones. Clin Endocrinol 20:555-564, 1984
37. Bauer W, Briner U, Doepfner W, Haller R, Huguenin R, Marbach P, Petcher IP, Pless J: SMS 201-995: a very potent and selective octapeptide analogue of somatostatin with prolonged action. Life Sci 31:1133-1140, 1982