Fatty acid-induced effect on glucagon secretion is mediated via fatty acid oxidation

Diabetes/Metabolism Research and Reviews

Volumn 23, Issue 3, 2007, Pages 202-210

  Hong, Jing ^a   Jeppesen, Per Bendix ^a   Nordentoft, Iver ^a   Hermansen, Kjeld ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Alpha TC1 6 cells; Carnitine palmitoyl transferase 1; Fatty acids; Glucagon; Proliferation; Triglyceride

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE; ETOMOXIR; FATTY ACID; GLUCOSE; MESSENGER RNA; TRIACYLGLYCEROL;

AEROBIC METABOLISM; ARTICLE; CELL CULTURE; CELL FUNCTION; CELL PROLIFERATION; FATTY ACID OXIDATION; GENE EXPRESSION; GLUCAGON RELEASE; HUMAN; HUMAN CELL; OXIDATION; PANCREAS ISLET ALPHA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; CARNITINE O-PALMITOYLTRANSFERASE; DNA; EPOXY COMPOUNDS; FATTY ACIDS; GENE EXPRESSION REGULATION; GLUCAGON; GLUCAGON-SECRETING CELLS; MICE; OLEIC ACID; OXIDATION-REDUCTION; PALMITIC ACID; TRIGLYCERIDES; TUMOR CELLS, CULTURED;

EID: 33947321456     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.663     Document Type: Article

References (43)

1. Swenne I. Pancreatic beta-cell growth and diabetes mellitus. Diabetologia 1992; 35: 193-201.
2. Sjoholm A. Diabetes mellitus and impaired pancreatic beta-cell proliferation. Intern Med 1996; 239: 211-220.
3. Rane SG, Reddy EP. Cell cycle control of pancreatic beta cell proliferation. Front Biosci 2000; 5: D1-19.
4. Yaney GC, Corkey BE. Fatty acid metabolism and insulin secretion in pancreatic beta cells. Diabetologia 2003; 46: 1297-1312.
5. Dubois M, Kerr-Conte J, Gmyr V, et al. Non-esterified fatty acids are deleterious for human pancreatic islet function at physiological glucose concentration. Diabetologia 2004; 47: 463-469.
6. Zhou YP, Grill VE. Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 1994; 93: 870-876.
7. Prentki M, Joly E, El Assaad W, Roduit R. Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes. Diabetes 2002; 51(Suppl. 3): S405-S413.
8. Xiao J, Gregersen S, Kruhoffer M, Pedersen SB, Orntoft TF, Hermansen K. The effect of chronic exposure to fatty acids on gene expression in clonal insulin-producing cells: studies using high density oligonucleotide microarray. Endocrinology 2001; 142: 4777-4784.
9. Xiao J, Gregersen S, Pedersen SB, Hermansen K. Differential impact of acute and chronic lipotoxicity on gene expression in INS-1 cells. Metabolism 2002; 51: 155-162.
10. Raz I, Eldor R, Cernea S, Shafrir E. Diabetes: insulin resistance and derangements in lipid metabolism. Cure through intervention in fat transport and storage. Diabetes Metab Res Rev 2005; 21: 3-14.
11. Zhou YT, Shimabukuro M, Lee Y, et al. Enhanced de novo lipogenesis in the leptin-unresponsive pancreatic islets of prediabetic Zucker diabetic fatty rats: role in the pathogenesis of lipotoxic diabetes. Diabetes 1998; 47: 1904-1908.
12. Haber EP, Ximenes HM, Procopio J, Carvalho CR, Curi R, Carpinelli AR. Pleiotropic effects of fatty acids on pancreatic beta-cells. J Cell Physiol 2003; 194: 1-12.
13. Unger RH, Orci L. The essential role of glucagon in the pathogenesis of diabetes mellitus. Lancet 1975; 1: 14-16.
14. Hong J, Abudula R, Chen J, et al. The acute effect of fatty acids on glucagon secretion is influenced by their chain length, spatial configuration and degree of unsaturation: Studies in vitro. Metabolism 2005; 54: 1329-1336.
15. Olofsson CS, Salehi A, Gopel SO, Holm C, Rorsman P. Palmitate stimulation of glucagon secretion in mouse pancreatic alpha-cells results from activation of L-type calcium channels and elevation of cytoplasmic calcium. Diabetes 2004; 53: 2836-2843.
16. Bollheimer LC, Landauer HC, Troll S, et al. Stimulatory short-term effects of free fatty acids on glucagon secretion at low to normal glucose concentrations. Metabolism 2004; 53: 1443-1448.
17. Gremlich S, Bonny C, Waeber G, Thorens B. Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels. J Biol Chem 1997; 272: 30261-30269.
18. Hong J, Chen L, Jeppesen PB, Nordentoft I, Hermansen K. Stevioside counteracts the alpha cell hypersecretion caused by long-term palmitate exposure. Am J Physiol Endocrinol Metab 2006; 290: E416-E422.
19. McGarry JD, Sen A, Esser V, Woeltje KF, Weis B, Foster DW. New insights into the mitochondrial carnitine palmitoyltransferase enzyme system. Biochimie 1991; 73: 77-84.
20. Chen S, Ogawa A, Ohneda M, Unger RH, Foster DW, McGarry JD. More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic beta-cell signaling. Diabetes 1994; 43: 878-883.
21. Hamaguchi K, Leiter EH. Comparison of cytokine effects on mouse pancreatic alpha-cell and beta-cell lines. Viability, secretory function, and MHC antigen expression. Diabetes 1990; 39: 415-425.
22. Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH. Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci USA 1994; 91: 10878-10882.
23. Andreescu S, Sadik OA, McGee DW. Effect of natural and synthetic estrogens on a549 lung cancer cells: correlation of chemical structures with cytotoxic effects. Chem Res Toxicol 2005; 18: 466-474.
24. Debard C, Laville M, Berbe V, et al. Expression of key genes of fatty acid oxidation, including adiponectin receptors, in skeletal muscle of type 2 diabetic patients. Diabetologia 2004; 47: 917-925.
25. Hugl SR, White MF, Rhodes CJ. Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells. J Biol Chem 1998; 273: 17771-17779.
26. McGirr R, Ejbick CE, Carter DE, et al. Glucose dependence of the regulated secretory pathway in alphaTC1-6 cells. Endocrinology 2005; 146: 4514-4523.
27. Kisanuki K, Kishikawa H, Araki E, et al. Expression of insulin receptor on clonal pancreatic alpha cells and its possible role for insulin-stimulated negative regulation of glucagon secretion. Diabetologia 1995; 38: 422-429.
28. Diao J, Asghar Z, Chan CB, Wheeler MB. Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells. J Biol Chem 2005; 280: 33487-33496.
29. Mizusawa N, Hasegawa T, Ohigashi I, et al. Differentiation phenotypes of pancreatic islet beta- and alpha-cells are closely related with homeotic genes and a group of differentially expressed genes. Gene 2004; 331: 53-63.
30. Wang J, Webb G, Cao Y, Steiner DF. Contrasting patterns of expression of transcription factors in pancreatic alpha and beta cells. Proc Natl Acad Sci U S A 2003; 100: 12660-12665.
31. Dumonteil E, Ritz-Laser B, Magnan C, Grigorescu I, Ktorza A, Philippe J. Chronic exposure to high glucose concentrations increases proglucagon messenger ribonucleic acid levels and glucagon release from InR1G9 cells. Endocrinology 1999; 140: 4644-4650.
32. Unger RH. Lipotoxic diseases. Annu Rev Med 2002; 53: 319-336.
33. Koyama K, Chen G, Lee Y, Unger RH. Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia of obesity. Am J Physiol 1997; 273: E708-E713.
34. Cnop M, Hannaert JC, Hoorens A, Eizirik DL, Pipeleers DG. Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation. Diabetes 2001; 50: 1771-1777.
35. Lee Y, Hirose H, Zhou YT, Esser V, McGarry JD, Unger RH. Increased lipogenic capacity of the islets of obses rats: a role in the pathogenesis of NIDDM. Diabetes 1997; 46: 408-413.
36. Hardy S, St-Onge GG, Joly E, Langelier Y, Prentki M. Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40. J Biol Chem 2005; 280: 13285-13291.
37. Calder PC, Bond JA, Bevan SJ, Hunt SV, Newsholme EA. Effect of fatty acids on the proliferation of concanavalin A-stimulated rat lymph node lymphocytes. Int J Biochem 1991; 23: 579-588.
38. Doi O, Doi F, Schroeder F, Alberts AW, Vagelos PR. Manipulation of fatty acid composition of membrane phospholipid and its effects on cell growth in mouse LM cells. Biochim Biophys Acta 1978; 509: 239-250.
39. Assimacopoulos-Jeannet F, Thumelin S, Roche E, Esser V, McGarry JD, Prentki M. Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic beta-cell line INS-1. J Biol Chem 1997; 272: 1659-1664.
40. Heilbronn L, Smith SR, Ravussin E. Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus. Int J Obes Relat Metab Disord 2004; 28(Suppl. 4): S12-S21.
41. Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest 1999; 103: 1489-1498.
42. Louet JF, Le May C, Pegorier JP, Decaux JF, Girard J. Regulation of liver carnitine palmitoyltransferase I gene expression by hormones and fatty acids. Biochem Soc Trans 2001; 29: 310-316.
43. Louet JF, Hayhurst G, Gonzalez FJ, Girard J, Decaux JF. The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4 alpha and cAMP-response element-binding protein (CREB). J Biol Chem 2002; 277: 37991-38000.