Different metabolic responses in α-, β-, and δ-cells of the islet of langerhans monitored by redox confocal microscopy

Biophysical Journal

Volumn 90, Issue 7, 2006, Pages 2641-2650

  Quesada, Ivan ^a   Todorova, Mariana G ^a   Soria, Bernat ^a  

^a MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; FLAVINE ADENINE NUCLEOTIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM METABOLISM; CALCIUM SIGNALING; CELL ISOLATION; CELL POPULATION; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; HORMONE RELEASE; IMMUNOCYTOCHEMISTRY; METABOLIC ACTIVATION; METABOLIC REGULATION; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; NON INVASIVE MEASUREMENT; NONHUMAN; OXIDATION REDUCTION REACTION; PANCREAS CELL; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PANCREAS ISLET DELTA CELL; RAT; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 33646200451     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1529/biophysj.105.069906     Document Type: Article

References (55)

1. Kanno, T., S. O. Gopel, P. Rorsman, and M. Wakui. 2002. Cellular function in multicellular system for hormone-secretion: electrophysiological aspect of studies on α-, β- and δ-cells of the pancreatic islet. Neurosci. Res. 42:79-90.
2. 2+, cAMP and phospholipid-derived messengers in coupling mechanisms of insulin secretion. Physiol. Rev. 67:1185-1248.
3. Barg, S. 2003. Mechanisms of exocytosis in insulin-secreting β-cells and glucagon-secreting α-cells. Pharmacol. Toxicol. 92:3-13.
4. Nadal, A., I. Quesada, and B. Soria. 1999. Homologous and heterologous asynchronicity between identified α-, β- and δ-cells within intact islets of Langerhans in the mouse. J. Physiol. 517:85-93.
5. 2+ responses in rat pancreatic α-cells. Life Sci. 71:81-89.
6. 2+ signaling. Endocrinology. 137:693-697.
7. 2+ oscillations in glucagon-producing 2-cells by insulin/glucose and amino acids. Biochim. Biophys. Acta. 1310:212-216.
8. 2+ oscillations in pancreatic islet cells secreting glucagon and somatostatin. Biochem. Biophys. Res. Commun. 208:644-649.
9. Gopel, S. O., T. Kanno, S. Barg, and P. Rorsman. 2000. Patch-clamp characterisation of somatostatin-secreting δ-cells in intact mouse pancreatic islets. J. Physiol. 528:497-507.
10. + channels. J. Physiol. 528:509-520.
11. Quesada, I., A. Nadal, and B. Soria. 1999. Different effects of tolbutamide and diazoxide in α, β and δ cells within intact islets of Langerhans. Diabetes. 48:2390-2397.
12. i oscillations in mouse pancreatic islets of Langerhans recorded in vivo. FEBS Lett. 477:33-36.
13. Sanchez-Andres, J. V., A. Gomis, and M. Valdeolmillos. 1995. The electrical activity of mouse pancreatic β-cells recorded in vivo shows glucose-dependent oscillations. J. Physiol. 486:223-228.
14. Kennedy, E. D., and C. B. Wollheim. 1998. Role of mitochondrial calcium in metabolism-secretion coupling in nutrient-stimulated insulin release. Diabetes Metab. 24:15-24.
15. Bennett, B. D., T. L. Jetton, G. Ying, M. A. Magnuson, and D. W. Piston. 1996. Quantitative subcellular imaging of glucose metabolism within intact pancreatic islets. J. Biol. Chem. 271:3647-3651.
16. Civelek, V. N., J. T. Deeney, K. Kubik, V. Schultz, K. Tornheim, and B. E. Corkey. 1996. Temporal sequence of metabolic and ionic events in glucose-stimulated clonal pancreatic β-cells (HIT). Biochem. J. 315:1015-1019.
17. Maechler, P., and C. B. Wollheim. 2001. Mitochondrial function in normal and diabetic β-cells. Nature. 414:807-812.
18. Pertusa, J. A., R. Nesher, N. Kaiser, E. Cerasi, J. C. Henquin, and J. C. Jonas. 2002. Increased glucose sensitivity of stimulus-secretion coupling in islets from Psammomys obesus after diet induction of diabetes. Diabetes. 51:2552-2560.
19. Ashcroft, F. M., D. E. Harrison, and S. J. Ashcroft. 1984. Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells. Nature. 312:446-448.
20. i oscillations due to bursting electrical activity in single pancreatic islets. Pflugers Arch. 418:417-422.
21. i in single mouse pancreatic islet cells. J. Physiol. 455:173-186.
22. Masters, B. R., and B. Chance. 1993. Redox confocal imaging: intrinsic fluorescent probes of cellular metabolism. In Fluorescent and Luminescent Probes for Biological Activity. W. T. Mason, editor. Academic Press, London. 44-57.
23. 2+ transients that modulate nuclear function. Proc. Natl. Acad. Sci. USA. 99:9544-9549.
24. + channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse α-cells. Diabetes. 53:S181-S189.
25. Liu, Y. J., E. Vieira, and E. Gylfe. 2004. A store-operated mechanism determines the activity of the electrically excitable glucagon-secreting pancreatic α-cell. Cell Calcium. 35:357-365.
26. Patterson, G. H., S. M. Knobel, P. Arkhammar, O. Thastrup, and D. W. Piston. 2000. Separation of the glucose-stimulated cytoplasmic and mitochondrial NAD(P)H responses in pancreatic islet β cells. Proc. Natl. Acad. Sci. USA. 97:5203-5207.
27. 2+ release in rats via mitochondria-dependent and -independent mechanisms. J. Physiol. 550:765-783.
28. Duchen, M. R. 1999. Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death. J. Physiol. 516:1-17.
29. Ainscow, E. K., C. Zhao, and G. A. Rutter. 2000. Acute over-expression of lactate dehydrogenase-A perturbs β-cell mitochondrial metabolism and insulin secretion. Diabetes. 49:1149-1155.
30. Sekine, N., V. Cirulli, R. Regazzi, L. J. Brown, E. Gine, J. Tamarit-Rodriguez, M. Girotti, S. Marie, M. J. MacDonald, C. B. Wollheim, and G. A. Rutter. 1994. Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic β-cells. Potential role in nutrient sensing. J. Biol. Chem. 269:4895-4902.
31. Unger, R. H. 1985. Glucagon physiology and pathophysiology in the light of new advances. Diabetologia. 28:574-578.
32. Detimary, P., S. Dejonghe, Z. Ling, D. Pipeleers, F. Schuit, and J. C. Henquin. 1998. The changes in adenine nucleotides measured in glucose-stimulated rodent islets occur in β cells but not in a cells and are also observed in human islets. J. Biol. Chem. 273:33905-33908.
33. Gorus, F. K., W. J. Malaisse, and D. G. Pipeleers. 1984. Differences in glucose handling by pancreatic α- and β-cells. J. Biol. Chem. 259:1196-1200.
34. Heimberg, H., A. De Vos, D. Pipeleers, B. Thorens, and F. Schuit. 1995. Differences in glucose transporter gene expression between rat pancreatic α- and β-cells are correlated to differences in glucose transport but not in glucose utilization. J. Biol. Chem. 270:8971-8975.
35. Pipeleers, D. G., P. A. In't Veld, M. Van de Winkel, E. Maes, F. C. Schuit, and W. Gepts. 1985. A new in vitro model for the study of pancreatic α and β cells. Endocrinology. 117:806-816.
36. Gopel, S., Q. Zhang, L. Eliasson, X. S. Ma, J. Galvanovskis, T. Kanno, A. Salehi, and P. Rorsman. 2004. Capacitance measurements of exocytosis in mouse pancreatic α-, β- and δ-cells within intact islets of Langerhans. J. Physiol. 556:711-726.
37. Rocheleau, J. V., W. S. Head, and D. W. Piston. 2004. Quantitative NAD(P)H/flavoprotein autofluorescence imaging reveals metabolic mechanisms of pancreatic islet pyruvate response. J. Biol. Chem. 279:31780-31787.
38. i responses in isolated rat pancreatic B cells. Adv. Exp. Med. Biol. 426:227-230.
39. Gilon, P., J. C. Jonas, and J. C. Henquin. 1994. Culture duration and conditions affect the oscillations of cytoplasmic calcium concentration induced by glucose in mouse pancreatic islets. Diabetologia. 37:1007-1014.
40. Gonzalez, A., M. P. Granados, G. M. Salido, and J. A. Pariente. 2003. Changes in mitochondrial activity evoked by cholecystokinin in isolated mouse pancreatic acinar cells. Cell. Signal. 15:1039-1048.
41. Duchen, M. R., P. A. Smith, and F. M. Ashcroft. 1993. Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic β-cells. Biochem. J. 294:35-42.
42. Hope, K. M., P. O. Tran, H. Zhou, E. Oseid, E. Leroy, and R. P. Robertson. 2004. Regulation of α-cell function by the β-cell in isolated human and rat islets deprived of glucose: the "switch-off" hypothesis. Diabetes. 53:1488-1495.
43. Ishihara, H., P. Maechler, A. Gjinovci, P. L. Herrera, and C. B. Wollheim. 2003. Islet β-cell secretion determines glucagon release from neighbouring α-cells. Nat. Cell Biol. 5:330-335.
44. Wendt, A., B. Birnir, K. Buschard, J. Gromada, A. Salehi, S. Sewing, P. Rorsman, and M. Braun. 2004. Glucose inhibition of glucagon secretion from rat α-cells is mediated by GABA released from neighboring β-cells. Diabetes. 53:1038-1045.
45. Barg, S., J. Galvanovskis, S. O. Gopel, P. Rorsman, and L. Eliasson. 2000. Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting α-cells. Diabetes. 49:1500-1510.
46. Ravier, M. A., and G. A. Rutter. 2005. Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic α-cells. Diabetes. 54:1789-1797.
47. ATP channel. J. Physiol. 528:405.
48. Schuit, F., A. De Vos, S. Farfari, K. Moens, D. Pipeleers, T. Brun, and M. Prentki. 1997. Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in β cells. J. Biol. Chem. 272:18572-18579.
49. Heimberg, H., A. De Vos, K. Moens, E. Quartier, L. Bouwens, D. Pipeleers, E. Van Schaftingen, O. Madsen, and F. Schuit. 1996. The glucose sensor protein glucokinase is expressed in glucagon-producing α-cells. Proc. Natl. Acad. Sci. USA. 93:7036-7041.
50. Yamada, K., M. Nakata, N. Horimoto, M. Saito, H. Matsuoka, and N. Inagaki. 2000. Measurement of glucose uptake and intracellular calcium concentration in single, living pancreatic β-cells. J. Biol. Chem. 275:22278-22283.
51. Bai, L., X. Zhang, and F. K. Ghishan. 2003. Characterization of vesicular glutamate transporter in pancreatic α - and β -cells and its regulation by glucose. Am. J. Physiol. Gastrointest. Liver Physiol. 284:G808-G814.
52. Wang, J., Y. Cao, and D. F. Steiner. 2003. Regulation of proglucagon transcription by activated transcription factor (ATF) 3 and a novel isoform, ATF3b, through the cAMP-response element/ATF site of the proglucagon gene promoter. J. Biol. Chem. 278:32899-32904.
53. Fujitani, S., T. Ikenoue, M. Akiyoshi, T. Maki, and T. Yada. 1996. Somatostatin and insulin secretion due to common mechanisms by a new hypoglycemic agent, A-4166, in perfused rat pancreas. Metabolism. 45:184-189.
54. Efendic, S., F. Enzmann, A. Nylen, K. Uvnas-Wallensten, and R. Luft. 1979. Effect of glucose/sulfonylurea interaction on release of insulin, glucagon, and somatostatin from isolated perfused rat pancreas. Proc. Natl. Acad. Sci. USA. 76:5901-5904.
55. Melroe, G. T., M. M. Ehrman, J. D. Kittilson, and M. A. Sheridan. 2000. Glucose regulates pancreatic preprosomatostatin I expression. FEBS Lett. 465:115-118.